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Molekulárně cytogenetická analýza kryptických chromozomových přestaveb
Kindlová, Markéta ; Kočárek, Eduard (vedoucí práce) ; Musilová, Jana (oponent)
Mikrodeleční syndromy se v populaci objevují s vysokou incidencí, nejčastější je DiGeorgeův syndrom s incidencí 1 : 4 000. Dalšimi relativně častými syndromy jsou Williamsův-Beurenův syndrom, Millerův-Diekerův syndrom, syndrom delece 1p36 a další. Většina těchto syndromů způsobuje svým nositelům vážné klinické obtíže. Včasná a spolehlivá diagnóza pak může pomoci v léčbě postiženého pacienta (edukace, chirurgická korekce, rehabilitace, farmakoterapie) či v prenatální diagnostice. K analýze kryptických chromozomových aberací, které tyto syndromy způsobují, dnes nejčastěji používáme metodu FISH (fluorescenční in situ hybridizace) či metody založené na PCR (polymerázová řetězová reakce).
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Mezinárodní úmluva CMR - aktuální otázky
Musilová, Jana ; Pauknerová, Monika (vedoucí práce) ; Brodec, Jan (oponent)
The international carriage of goods takes up a significant position in time of developing business relations and in fact it is not even possible to imagine the interstate commerce without it. In the European continent it is the international carriage of goods by road which is preferred for its availability, flexibility and easy utility. With the view of standardizing the conditions governing the contract for the international carriage of goods by road the Convention on the Contract for the International Carriage of Goods by Road (CMR) was adopted at Geneva 19 May 1956 (registered ex officio on 2 July 1961, United nations - Treaty Series 1961). This convention came into force on 2 July 1961 (for the former Czechoslovak Socialistic Republic on 3 December 1974). Fifty-five Contracting Parties have accessed it till this time. After more than 50 years from the time of its adoption the CMR Convention remains respectable internationally and it is still a broadly applicable and stable regulation. It was amended once only by The Protocol to The Convention on The Contract for the International Carriage of Goods by Road (CMR) done at Geneva 5 July 1978. Within the application of the CMR Convention it is still possible to find a lot of questions at issue, the author of this work deals with the most up-to-date...
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Pathways Identification In The Gram-Positive Bacterium Aneurinibacillus Species H1
Musilová, Jana
Here, we present the first insight into the Gram-positive, promising polyhydroxyalkanoatesproducer Aneurinibacillus species H1. Both static and dynamic properties are described inthis paper with the aim on identification of pathways occurring in the organism. The genome consistsof a circular, 3,663,644 bp long chromosome and contains 4,654 protein-coding sequences and129 RNAs in total. The GC content is 44.8%. Functional properties identification showed that CDSdivide into 26 categories with the most prevalent Amino Acids and Derivatives group. Pathwaysinference revealed 201 pathways. The most represented group is metabolic pathways, which is furtherdivided into 12 groups.
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Metody predikce sekundární struktury RNA
Polzerová, Nikola ; Musilová, Jana (oponent) ; Jurečková, Kateřina (vedoucí práce)
Tato bakalářská práce pojednává o sekundární struktuře RNA a konkrétně se zaměřuje na její predikci. Popisuje nejrůznější elementy sekundární struktury a představuje některé metody predikce. V rámci bakalářské práce byly implementovány tři výpočetní metody predikce v programovacím prostředí MATLAB. Konkrétně se jedná o algoritmus Nussinové, Zukerův algoritmus a metodu Crumple. Implementované algoritmy přistupovaly k predikci buď na základě maximalizace bázových párů, nebo minimalizace volné energie. Jejich funkce byla ověřena na vytvořeném datasetu a výsledky byly srovnány se známou sekundární strukturou.
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Network Analysis Of Drugs Used To Treat Schizophrenia
Musilová, Jana
The aim of this study is a designation of a multitarget drug for a treatment of schizophrenia with the least number of adverse drug interactions. Using Cytoscape software and DrugBank database we have examined currently used schizophrenia drugs and their targets in human body. The acquired knowledge led to a design of an antipsychotic type of a drug chemically based on benzenoids or azacyclic compounds with better overall characteristics.
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Signaling Pathway For Butanol Production In Clostridium Beijerinckii Nrrl B-598
Musilová, Jana
In this study, we bring the first dynamic model of signaling pathway for butanol production in sporulating, solvent-producing bacterium, Clostridium beijerinckii NRRL B-598. The model allows to study functions of individual genes involved in the production of solvents and acids. We used an open platform Cell Collective for designing the model and stored it under the name ‘Signaling Pathway for Butanol Production in Clostridium beijerinckii NRRL B-598’ version 1.0 (https://research.cellcollective.org/?dashboard=true#36604:1/signaling-pathway-for-butanol-production-inclostridium-beijerinckii-nrrl-b598/10) in publicly available repository of Cell Collective.
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Signaling Pathway for Butanol Production in Solventogenic Clostridium Bacteria
Musilová, Jana ; Škutková, Helena (oponent) ; Sedlář, Karel (vedoucí práce)
The diploma thesis is dedicated to studying signaling pathway for butanol production in Clostridium bacteria. The first part addresses the signaling pathways modeling by means of systems biology. The thesis follows the description of the data acquisition for signaling pathways modeling and modifying with the main focus on techniques for the detection of gene expression, products and phenotype. The third section is to obtain a basic model of a signaling pathway involved in butanol production in solventogenic clostridia. The final point and main goal is to create a dynamic model of butanol production signaling pathway in the Clostridium beijerinckii NRRL B-598 strain, its evaluation by static and dynamic analysis and comparison with biological data.
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