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Military Physical Training in the Historical Context of the Evolution of Society
Valtová, Hana ; Stančík, Vladimír (advisor) ; Přívětivý, Lubomír (referee)
Title of thesis: Army physical training in the historical context of society development A Military Physical Training in Historical Context of Evolution Society Aim: The aim of this study is to provide a comprehensive overview of the development of physical exercise with a focus on elements of the Army physical training in relation to the contemporary context, with placing emphasis on development in the Czech lands in the 19th century. A method: The work was conceived as a developmental study the phenomenon of military physical training in historical the context of social development with partial use of the methods of historical research. foundation scientific approach has been criticism of external and internal, as well as methods were used: direct, indirect induction, progressive, retrospective, comparative. Keywords: The company, army, army physical training Překladač Google pro firmy:Translator Toolkit Powered by TCPDF (www.tcpdf.org)
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Genetic Regulation of Limb Development
Šnajdr, Pavel ; Grim, Miloš (advisor) ; Peterka, Miroslav (referee) ; Slípka, Jaroslav (referee)
Lx in SHR.Lx rat manifests in homozygotes as hindlimb preaxial polydactyly. We showed that a 2,964-bp deletion in Plzf (Promyelocytic leukemia zinc finger) intron 2 is the only candidate for Lx. The deletion removes the most deeply conserved CNE with putative regulatory influence on Plzf expression. Using in situ hybridization we found reduced expression pattern of Plzf in Lx/Lx limb and anterior expansion of expression domains of Plzf targets Hoxd10-13 genes and Bmp2, in the absence of ectopic Shh expression. Rat hd manifests in homozygotes as reduction or loss of digits II and III on both hind and forelimb and impairment of spermatogenesis leading to male infertility. We showed that hd mutation is caused by an insertion of an endogenous retrovirus into intron 10 of the Cntrob gene resulting in the translation of a truncated protein. In situ hybridization showed that expression of cartilage condensation marker Sox9, and Bmp receptor Bmpr1b is absent from the distal parts of the digit condensations II and III. Studying spermatogenesis we showed that centrobin (protein of Cntrob) localizes to the centrosome, manchette, and the marginal ring of the spermatid acroplaxome. Mutant spermatids show a disruption of head-tail coupling apparatus leading to spermatid decapitation . We demonstrated distinct...
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Chinese Economic System: Market Economy or State Capitalism?
Bejkovský, Jan ; Jiránková, Martina (advisor) ; Stuchlíková, Zuzana (referee) ; Fárek, Jiří (referee) ; Kříž, Martin (referee)
This dissertation deals with the nature of the Chinese economic system. The first chapter focuses on the global economy and seeks to define the main economic systems prevailing in it, ie. Anglo-Saxon, Continental and Asian-developmental. Compared to these systems defined as market economies, the dissertation consequently analyses and defines a system of state capitalism and the main elements of it. The following part of the dissertation is focused on the historical Chinese approaches to economic governance of the country and attempts to identify those historical approaches that are still relevant and influential in modern Chinese economy. The third chapter analyses the Chinese economic system and the role of the state in it; it also examines the government's approach to the ownership of state enterprises and the overall extent of state ownership in the Chinese economy. The final chapter examines the different types of state subsidies to domestic, often state, enterprises in China. As an example of the various subsidies a case study on the automotive industry is used.
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Using finite element method for modelling of movement and stress of vocal folds during setting to phonation position
Šíbl, Michal ; Šidlof,, Petr (referee) ; Švancara, Pavel (advisor)
This Master´s thesis deals with use of finite element method for modeling motion and stress of vocal folds during setting to phonation position. The thesis contains a description of the relevant anatomical structures and of the closely related formation of the human voice. A list of some previously published models of the function of human vocal folds follows. A part of my work was to create a model of geometry of the larynx using CATIA V5 and PTC Creo 2.0 on the basis of data acquired by MRI (magnetic resonance imaging). After that the model was converted into the calculation system Ansys Workbench 15.0 and, for solving contact problems, into Ansys Classic 15.0. To solve given problems, these programs use the finite element method (FEM). Solution was carried out for six different variants simulating individual motions of cartilages, corresponding to the activation of individual muscles. For each variant, the movements and stresses in the soft tissue of the vocal folds were evaluated. For variants with activation of IA, TA and LCA muscle it was also evaluated the contact pressure between the vocal folds. Finally, the thesis mentions the preparation of the model for the activation of the vocal folds movement by the muscles of the larynx.
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Stress-strain Analysis of Chosen Spinal Fixation Device
Prášilová, Eva ; Valášek, Jiří (referee) ; Marcián, Petr (advisor)
The degenerative and traumatic injuries of a spine are very frequent. In those cases it is necessary to stabilize the corresponding spine segment using a spine implant. The spinal implants are rigid or flexible, the latter known as dynamic ones in medical practice. In this thesis, the problems of the physiological spinal segment and the segment with implant were solved using the computational modelling (finite element method). Computational model consists of 4 lumbar vertebrae L2 – L5, intervertebral discs, joints and spinal implants. The spinal segment was loaded by the force 400N and 200N, than by force 200N together with bending moments 2,5Nm and 5Nm depending of the motion. The displacement of the whole system, contact pressure of cartilages, equivalent strain in cancellous bone and equivalent stress in the implant were analyzed. The deformation of the physiological model and the model with the implant are comparable, but the bone tissue of the model with the implant is dramatically more loaded in vicinity of the screws.
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The phenomenon of dementia in the context of human rights
Mužáková, Monika ; Titzl, Boris (advisor) ; Stejskal, Bohumil (referee) ; Kysučan, Jaroslav (referee)
The main aim of the doctoral thesis is to contribute to the better knowledge of the means by which the notion of the phenomenon "developmental disabilities" (mental disabilities) was created in the past, and which existential opportunities result from this for the life of a mentally challenged person. What does this phenomenon mean for us today? How do we understand the questions related to the existential needs of mentally challenged people in the context of human rights? I searched for the clarification of the ways by which the phenomenon of mental disability was shaped throughout the history of the development of the views of the human mind, body and soul. That is the reason why I define the notion of mental disability from the point of the views of the human mind and in connection with simultaneous growth in the knowledge of human body. Chapter II is shaped by my study of principal human experience with mental differences since mythical notions of a human being. I devote my attention to the ancient knowledge of the substance of mental diseases, derived from the attempts of the first scientific, rational studies of human body. The Middle Ages enriched the care for people with mental impairment - among which the mental disability was also ranked though in phenomenology undistinguished, - by the element of...
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Functional analysis of invertebrate (Branchiostoma floridae) promoters in heterologous systems
Gurská, Daniela ; Kozmik, Zbyněk (advisor) ; Krylov, Vladimír (referee)
Understanding the mechanisms of transcriptional regulation and the constraints that operate in gene promoter sequences is the key step in understanding the evolutionary conservation of transcriptional regulation. It is well known that regulatory regions with the same expression outputs do not have to share the sequence similarity. The most important elements in regulatory sequences are transcription factor binding sites and their position relocation does not usually influence the expression output. The least complex transcriptional regulation is characteristic for housekeeping genes. For their expression they require only basal core promoter elements (sometimes only CpG islands are sufficient) and general transcription factors, so they can be transcribed easily and immediately whenever they are needed. In this study we focused on transcriptional regulation of invertebrate amphioxus (Branchiostoma floridae) housekeeping genes in vertebrate systems. We prepared a set of constructs with amphioxus regulatory regions for testing their activity in different mammalian cell lines and a set of constructs with the same amphioxus regulatory regions for observing their spatial recognition in developing medaka fish embryo. We found that half of investigated amphioxus regulatory regions are recognized by...
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Biomechanical studies of knee jointarthroplasty
Zděblo, Jakub ; Valášek, Jiří (referee) ; Florian, Zdeněk (advisor)
The presented diploma thesis deals with stress-strain analysis of the intact human knee joint and the knee joint after reconstruction using fixation plate. Finite element method is used to determine the biomechanical response of the knee under loading with the FE software Ansys. The three-dimensional finite element model is consisted of bony structures (femur and tibia) which were created using computed tomography (CT) data, articular cartilages and both menisci. Model of the locking plate (LCP) was created based on producer's technical guide. Three models of the knee joint with LCP fixation plate are created for three different sizes of condylar fragment based on the intact model. On all variants is applied loading corresponding to maximum loading in a gait cycle. The results show that reconstruction of the knee joint with locking plate has no effect on changing in contact pressure on tibial plateau.
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DNA-binding properties of the CSL proteins of Schizosaccharomyces pombe
Ptáčková, Martina ; Půta, František (advisor) ; Doležal, Pavel (referee)
As the effector component of the Notch signaling pathway the transcription factors of the CSL family (CBF1/RBP-Jκ/Suppressor of Hairless/Lag-1) are essential for many developmental processes in metazoan organisms, but they can function also independently of Notch. Recently, their presence was proved in fungal organisms lacking the Notch pathway as well as most of the known metazoan interacting partners. Cbf11 and Cbf12, the CSL proteins of the unicellular yeast Schizosaccharomyces pombe, were determined experimentally as non-essential nuclear transcription factors, which regulate cell adhesion, extracellular material production, colony morphology, septation and daughter cell separation, coordination of nuclear and cell division, and ploidy maintenance in an antagonistic way. The responsive genes of these factors are not known yet. In this study, genes of S. pombe, whose promoter regions represent potential direct targets for the Cbf proteins binding, were predicted. The binding of the Cbf11 and Cbf12 proteins, and of a truncated version Cbf12∆N to CSL response elements contained in the regulatory regions of selected S. pombe genes was tested in vitro by EMSA, and consequently, in the case of the Cbf11 protein, also in vivo by ChIP. Cbf11 and Cbf12∆N recognize specifically the response elements in...
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Control system for filling and emtying of yoghurt tank in standard S88 based on automation elements SIMATIC family.
Hudousek, Tomáš ; Weber, Martin (referee) ; Pásek, Jan (advisor)
I made my thesis for APV Brno company. The thesis is divided into three parts. The first part concentrated on managing the work with the developmental environment SIMATIC S7 and mastering quite a large S88 norm of the company. The second part focused on the adjustment of the program module of the S88 norm for filling, stirrng and emptying of the yoghurt tank. The third part was to create a program for SCADA device, which is used for monitoring and controlling of the technology. From the point of view of utility in other applications a great importace for APV company was the creation of the graphic interface of the control module for SCADA device and to connect it to a new S88 norm.
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