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Life with pulmonary hypertension observed in the IKEM, Prague
KLOPOTOVÁ, Michaela
This undergraduate work deals with the issue of pulmonary hypertension monitored in clients at the Institute of Clinical and Experimental Medicine (IKEM) in Prague. The theoretical portion deals with the comprehensive issue of pulmonary hypertension {--} its aetiology, pathogenesis, pathophysiology, epidemiology, classification, clinical picture, examination methods, therapy and prognosis. It also covers its health and social aspect, which is further divided into its health and social impact. The health and social aspect is divided into health and illness, health support, prevention and quality of life. The health impact focuses on nutrition, physical activity, natural medications, colds and depression. The social aspect explores the social effects on health, illness and social benefits for clients with pulmonary hypertension. The practical portion of this work presents the results from a quantitative questionnaire carried out with clients monitored at IKEM Prague between 1 July 2008 and 28 February 2009. The purpose of the questionnaire was to establish whether patients with pulmonary hypertension often suffer from depression, whether the illness affects their health and social status and whether clients have sufficient information about pulmonary hypertension. The results show that the objectives were fulfilled. It has been proved that clients with pulmonary hypertension suffer from depression, their health and social status is also affected by the illness and most of them have sufficient information about pulmonary hypertension. This work can serve as a well-arranged source of information for different cardiology departments that deal with pulmonary hypertension. I am sure that the clients themselves would like to see the results of this work, let alone the Association of Pulmonary Hypertension Patients. This association follows not only specialized literature, but also the quality of life of and benefits for people with pulmonary hypertension.
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Systém odměňování v malém IT podniku
Novotný, Lukáš ; Dvořáková, Zuzana (advisor) ; Cetkovský, Pavel (referee)
The topic of this thesis is reward management and its application in a small-sized IT enterprise. Its goals are to properly document and describe current reward system in the company, evaluate the system and recommend improvements for the system. The first two goals are reached via thorough research of the company through semi-structured interviews, employee satisfaction survey, participant observation and document examination and the last one by applying principles from the current literature and education to the results of the two previous goals. The findings are that the reward system, despite growing organically instead of designed, is relatively effective in some areas, but needs improvement in other areas. The main improvement areas are motivation by contingent pay, communication management and performance management. Relatively well working rewards are especially non-financial reward connected to the work environment and work itself.
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Clustering and regression analysis of micro panel data
Sobíšek, Lukáš ; Pecáková, Iva (advisor) ; Komárek, Arnošt (referee) ; Brabec, Marek (referee)
The main purpose of panel studies is to analyze changes in values of studied variables over time. In micro panel research, a large number of elements are periodically observed within the relatively short time period of just a few years. Moreover, the number of repeated measurements is small. This dissertation deals with contemporary approaches to the regression and the clustering analysis of micro panel data. One of the approaches to the micro panel analysis is to use multivariate statistical models originally designed for crosssectional data and modify them in order to take into account the within-subject correlation. The thesis summarizes available tools for the regression analysis of micro panel data. The known and currently used linear mixed effects models for a normally distributed dependent variable are recapitulated. Besides that, new approaches for analysis of a response variable with other than normal distribution are presented. These approaches include the generalized marginal linear model, the generalized linear mixed effects model and the Bayesian modelling approach. In addition to describing the aforementioned models, the paper also includes a brief overview of their implementation in the R software. The difficulty with the regression models adjusted for micro panel data is the ambiguity of their parameters estimation. This thesis proposes a way to improve the estimations through the cluster analysis. For this reason, the thesis also contains a description of methods of the cluster analysis of micro panel data. Because supply of the methods is limited, the main goal of this paper is to devise its own two-step approach for clustering micro panel data. In the first step, the panel data are transformed into a static form using a set of proposed characteristics of dynamics. These characteristics represent different features of time course of the observed variables. In the second step, the elements are clustered by conventional spatial clustering techniques (agglomerative clustering and the C-means partitioning). The clustering is based on a dissimilarity matrix of the values of clustering variables calculated in the first step. Another goal of this paper is to find out whether the suggested procedure leads to an improvement in quality of the regression models for this type of data. By means of a simulation study, the procedure drafted herein is compared to the procedure applied in the kml package of the R software, as well as to the clustering characteristics proposed by Urso (2004). The simulation study demonstrated better results of the proposed combination of clustering variables as compared to the other combinations currently used. A corresponding script written in the R-language represents another benefit of this paper. It is available on the attached CD and it can be used for analyses of readers own micro panel data.
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Internal equity principle in the context of company strategy
Kopecký, Martin ; Nový, Ivan (advisor) ; Háša, Stanislav (referee) ; Blažek, Ladislav (referee)
The thesis deals with the scientific problem of the link between the strategic management and the compensation system using the principle of internal equity. The work is based on two pillars, namely the qualitative research and own proposed solution. The first part of the thesis describes the qualitative research and the possibilities and the synergistic effects of linking business strategy and compensation system. The qualitative research is performed as a multi-case study and investigates the phenomenon in the practice of three companies from various markets (the Czech Republic, Slovakia and Bosnia and Hercegovina) and industries (finance, IT/Telco and FMCG). The research tries to find answers to the four research questions: How does business strategy influence compensation process? How can compensation support the realization of a business strategy? How can business strategy be linked with a compensation system within the principle of internal equity? How can compensation reinforce the strategic function of the human resources management? The research is based on the study of theoretical sources as well as on practical fieldwork. The qualitative research itself uses qualitative research methods for data collection, such as observations, questionnaires, and document analysis. The population questioned was top managers, line managers and representatives of HR department. In total, 142 interviews were performed by a single person. The collected data were analyzed and the triangulation was applied. The findings were summarized and generalized into a final report that brings answers to the research questions above. The research brings valuable findings used in the second, design part of the thesis. The own proposed solution consists of two main models. The first one is a simplified scheme of the compensation system and the second one is a model of strategic segmentation of jobs. The first model could be used successfully in the business practice as well as in education. The second model of the strategic job segmentation brings answer to the question of synergistic linking of business strategy and the compensation system within the principle of internal equity. The model brings valuable findings and a foundation for further theoretical research and its further development. The model also brings practical solution to the design of related policies and processes in the strategic management of human resources. By the design of both proposed models the main objectives of the thesis were achieved.
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Support for Unemployed People Aged Under 30 Years at Entry to the Labor Market
ŠABARTOVÁ, Alžběta
The Bachelor Thesis deals with the problems of unemployment benefits for people at the age up to 30 when entering the employment market. Unemployment is currently one of the serious problems in the world. The reduction in the number of unemployed people is one of the political priorities. The meaning of work as a job is taking an irreplaceable position for the life within our culture. Job loss has a considerable influence on social as well as personal life of an individual. The age is playing a significant role when seeking a job. Especially the time connected with the beginning of the career. School leavers who apply for their first job are concerned. They have no working experience, no practice, and they have so far had no possibility to acquire the basic work habits. A disharmony between zero experience and excessive earnings demands belongs to other root causes of the lack of interest in giving work opportunity to school leavers. Employment Office plays an irreplaceable role for the mediation of job and the consultancy. To solve unemployment within each target group, active and passive labour policies are available. The situation of the specific target group is stimulated especially through single programs and projects. The theoretical part pays attention to the definition and objectification of the unemployment-related terms and the analysis of labour market in Ceske Budejovice. Observations of a number of authors who are dealing with these problems and the related issues are summarized herein. The empirical part is formed by observations from own investigation. Two job-related targets have been set. The first target is to analyse the ideas the young people aged up to thirty, living in the district of Ceske Budejovice, have of their employment. The other target is to analyse the employers´ ideas of giving work to school leavers and young people. In order to fulfil the above targets, two investigative questions have been put: 1: Young peoples´ ideas of earning possibilities are unrealistic. 2: Employers find the European Social Fund helpful in giving work to young people. For the purpose of answering the investigative questions a qualitative research method, namely a case study the study of a few cases was selected. Interviewing was chosen as the most suitable method of data gathering. Initially, ten participants aged up to thirty were interviewed. At the time of interviewing, all of the participants were registered at the Employment Office in Ceske Budejovice and were taking part in a retraining scheme arranged by the Employment Office. When talking with young people I found that their gross commencing salary is expected to amount to approx. 16 200 CZK. The other selective group comprised five employers in Ceske Budejovice. It emerged from the interviews that one of the companies does not utilize the programs and projects announced by the European Social Fund at all. Two of the companies complain about excessive administration. One of the employers must always carefully consider its ability to satisfy the involvement conditions. Some negative feelings also appeared about the frequent changing the blank forms, a low number of announced projects for a particular business branch. The programs being related to deepening knowledge and staff training were most appreciated. The results of the Thesis will give the Employment Office a feedback on the utilization of the European Social Fund by employers and will help in adjusting the conditions for further projects being prepared.
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IT requirements management of insurance company
Dvorský, Petr ; Bruckner, Tomáš (advisor) ; Jungmannová, Barbora (referee)
The first part of thesis deals with theoretical knowledge, thus defining the concepts of recommendations from the field of requirements management. The second part focuses on the identification, analysis and subsequend design solutions to problems arising from working with the requirements. Methods for identifying problems are carried out workshop, participant observation and interviews with employees from the IT sector of the insurance company. The outputs of this work are proposals for improving requirements management, some of them are successfully applied in Kooperativa. The first draft, which was applied to create a process library. Further, of four different types of prioritization was selected and applied method that is defined by ITIL. Other outputs are design of new user interface of requirements software and starting to design a Change Advisory Board, which is compared to ITIL enhanced with additional features. Further was established Business Consultant Department, which has task of efficiently collecting client requirements and the supporting documents were created for this department.
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Immunological profile of patients with multiple sclerosis
Šubjak, David ; Fišerová, Anna (advisor) ; Růžičková, Šárka (referee)
Immunological profile of multiple sclerosis patients Abstrakt Multiple sclerosis is an autoimmune neurodegenerative disease affecting predominantly the white matter of the CNS and the spinal cord. The mechanism of disease progression is not yet fully understood. In this study we focused on a comparison of selected immunological markers between patients with multiple sclerosis who were naïve newly diagnosed, subsequently treated with Avonex (IFNβ1a) and healthy donors. The T cells (particulary cytotoxic CD8+ T cells) are the major population involved in pathogenesis of MS causing the demyelization of axons. Subpopulation of CD161+ Th cells has a potential to be very important in this process. We focused on the role of NK cells phenotype and function in autoimmune response of patients and their changes during the therapeutic intervention. Using flow cytometry we analyzed the distribution of NK, NKT, T cells and monocytes with special regard to the expression of CD161 and NKG2D molecules on their surface. We observed increase counts of CD161+ cells in subpopulations NK CD56bright , NK CD56dim , Th, Tc CD8bright , Tc CD8dim and decrease counts of NKG2D+ cells in subpopulations NK CD56bright , NK CD56dim , NKT, Th, Tc CD8bright , Tc CD8dim and monocytes. The decreased cytotoxic activity of NK cells in naïve MS...
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CRM System Optimization
Fučík, Ivan ; Mildeová, Stanislava (advisor)
This thesis is focused on CRM solutions in small and medium-sized organizations with respect to the quality of their customer relationship. The main goal of this work is to design an optimal CRM solution in the environment of real organization. To achieve this goal it is necessary to understand the theoretical basis of several topics, such as organizations and their relationship with customers, CRM systems, their features and trends. On the basis of these theoretical topics it is possible to analyze current CRM solution in the organization. From the data obtained by the methods of observation and controlled interview it was possible to prepare a design for optimal CRM solution. This optimal solution comes also from user and organization requirements. The optimal CRM solution saves time and costs associated with current CRM solution and replaces existing and ineffective CRM tools.
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Forms of advertising on social networks and consumer protection
Žďárský, Jiří ; Vavrečka, Jan (advisor) ; Štěpánek, Petr (referee)
The theme of this thesis are forms of advertising on social networks and consumer protection. The main informational source is above all research of specialized literature, articles, online or other sources in connection with author's own observations and analysis of the respective legislation and ultimately the comparison with author's gained professional experience. The result of this work is a comprehensive overview and introduction to the law of social networks and advertising, demonstration of the importance and significance of this topic and finally evaluation of the effectiveness of legislation that protects consumers in the environment of social networks.
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: Investigation of lymphocyte populations in the porcine small intestine
Kárová, Kristýna ; Šinkora, Marek (advisor) ; Javorková, Eliška (referee)
8 ABSTRACT Historically pig is allocated to a group of animals which use certain parts of their small intestine to acquire a fully developed primary B cell reperoire. Development of such primary repertoire is independent on the antigen presence and resembles the primary lymphopoietic activity of avian bursa of Fabricius. However, some findings concernig the pig's alignment in the above mentioned group suggest otherwise. This graduation thesis is focused on the investigtion of lymphocyte populations and subpopulations in the small intestine of germ-free and conventional piglets. The aim is to determine whether the percentage amounts of lymphocyte populations is dependent on the intestinal colonization. Using Flow Cytometry the significant differences between individual samples were assesed allowing us to conclude which parts of the small intestine could possibly be used for the development of B cell repertoire. Moreover, the status of isotype switching of B lymphocytes isolated from different intestinal parts was determined by the means of PCR analysis. Our data suggest that the small intestine colonization has a crucial role in development of all the main lymphocyte populations as well as some of their subpopulations. The greatest influence of colonization was observed concerning B lymphocytes and their...
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