|
Srovnání komerčních BI nástrojů s nástroji OpenSource
Okleštěk, Petr ; Novotný, Ota (advisor) ; Tlapák, Jiří (referee)
Cílem této diplomové práce je porovnat komerční a OpenSource Business Intelligence řešení pro střední podnik. Za účelem srovnání byl vybrán databázový server MS SQL Server s Analysis Services a dva možné způsoby nasazení OpenSource technologií. Prvním z nich je komplexní BI řešení od společnosti Insight Strategy a.s. ?The Bee?. Druhým způsobem je řešení pomocí dílčích aplikací nalezených na Internetu a to pomocí aplikací Keetle, Firebird, Mondrian a Openi. Jednotlivá řešení jsou porovnána na základě předem stanovených a popsaných metrik. Hlavním cílem je ověření na fiktivní firmě zda OpenSource BI řešení fungují a mohou nahradit komerční řešení a zda je to z finanční stránky výhodné.
|
|
Molecular and Biochemical Features of Threee Enzymes that May Serve as New Drug Targets in Cryptosporidium Parvum
Čtrnáctá, Vlasta ; Staňková, Marie (advisor) ; Kraml, Jiří (referee) ; Nečas, Emanuel (referee)
Molecular and biochemical features of three enzymes that may serve as new drug targets in Cryptosporidium parvum Cryptosporidium parvum is a unicellular, obligatory and intracellular parasite belonging to the Phylum Apicomplexa. This parasite can infect both humans and animals, causing an acute diarrhea in immunocompetent persons, and a chronic life threatening infection in immunocompromised individuals. Although many drugs, to combat this parasite, have been empirically tested, there is no completely effective therapy to treat cryptosporidiosis in humans or animals. In recent years, the completion of the genome sequencing projects in C. parvum and C. hominis along with advances in molecular methods have significantly helped to increase our general understanding of the C. parvum metabolic machinery. However, our knowledge concerning many specific pathways and enzymes in Cryptosporidium is still limited. Their better understanding in this organism would aid in experimentation of new drugs and new strategy development to treat cryptosporidiosis in humans and animals. In this dissertation, three essential metabolic enzymes of C. parvum have been tested: Pyruvate:NADP + oxidoreductase (PNO) is a unique, core metabolic enzyme, responsible for converting pyruvate to acetyl-CoA. It is a rare fusion of an...
|
|
Microbiota of the digestive tract of bees and related insect and the influencing facftors
Hroncová, Zuzana ; Havlík, Jaroslav (advisor) ; Kalous, Lukáš (referee)
This thesis consists of six research chapters, out of which, five have already been published in research journals, 1 is in the process of submission and the last chapter presents original unpublished confidential data in the process of manuscript preparation.
The research presented in this thesis concerns the complex mechanisms of bees and wasps immune system focused on microbiota as component of immunity. As shown in the introduction, highly social and managed species of bees like honey bees and bumble bees, play key roles in natural and agricultural ecosystems worldwide. Recent losses of bees have been attributed to pesticide exposure, poor nutrition, increased parasite loads and habitat degradation. Over the past several years, governments, beekeepers, and the general public worldwide have become concerned by increased losses of honey bee colonies, calling for more research on how to keep colonies healthy. Our main aim was to explore the complex mechanisms of bees and related species gut bacterial populations, their links to insect immunity and investigate the opportunities for an intervention. Part of our aim was to characterise the bumble bee and wasp gut microbiota using 16S RNA sequencing in a search for potentially novel bacterial species.
We have tried to explain how microbiome interacts with the host and showed that major members of these communities appear to benefit the host. The simple gut communities of social bees present ideal model systems to investigate the underlying evolutionary and genetic processes of such interactions. Information based on our results may help in the design of proper probiotic supplementation strategies with respect to physiological conditions in the honey bee gut.
|
|
Reproduction failure as a counterstrategy against potential infanticide
Ivanková, Lucia ; Bartoš, Luděk (advisor) ; Adéla, Adéla (referee)
The domestic cat is along with the dog recently the most common and popular pet. Unlike the dog the cat kept her appearance and nature without major changes despite long years of domestication. She has been highly adaptive to extremely variable conditions.
Beeing a prolific species she breeds succesfully in wide range of enviromental conditions and in a large spectrum of climatic conditions from subarctic to tropical regions. She reproduces successfully in urban colonies in high density of thousands of cats per square kilometre as well as in arctic regions with the population density equal to one cat per square kilometre. Mating strategy varies from promiscuous behaviour, through polygyny/polyandry system, to monogamy.
The infanticide in felinae is a common reproductive strategy. Male kills dependent offspring sired by another male in order to hasten the female oestrus and to reproduce with her himself. In domestic cats the infanticide attracts long-lasting discussion. However, in reality reports on the incidence of infanticide has been scarce.
One of the possible female counter-strategies is pregnancy block, known as a Bruce effect. The mated female blocks the blastocyte implantation when facing the treath of possible infanticide to avoid waste of energy by delivering offspring with poor chance for survival. Based on the questionnaire survey we have estimated the possibility of reproduction failure in a situation of potential male infanticide. From data which we have obtained we could not yet check the advanced hypothesis due to lack of variation and very few recorded cases of reproduction failure. On the other hand, we have accumulated extended information of the cat reproduction. In the future we are planning to collect more data in order to be able to test properly the hypothesis.
|
|
Fungal genetics, genome evolution and use of flow cytometry in study of DNA
Würtherlová, Tereza ; Kostovčík, Martin (referee) ; Kolařík, Miroslav (advisor)
The fungal genome is a dynamically changing structure. By its remodelling, the organism can respond to the environmental changes and develop itself. The genome expansion is often accompanied by transition to parasitic or mutualistic way of life. The genome expansion can be caused by the multiplication of some chromosomes (aneuploidisation), the whole genome duplication (polyploidisation) or the spreading of repetitive sequences. The impact of genome size to the ecology and life strategy of the organisms is more and more studied in recent years. In mycology, nevertheless, it escapes sufficient attention. The flow cytometry (FCM) is a modern and progressively developing method that enables to determine the genome size and estimate CG/AT base ratio. The combination of FCM with knowledge of the fungal ecology and forces that form the genome enable to discover a general trends of the evolutionary processes. My study summarises knowledge about the processes leading to changes in the size/structure of the fungal genome, the correlations with genome size and presents the principle of flow cytometry and its application in mycology.
|
| |
|
Rekultivace a management nepřírodních biotopů v České republice
Česká zemědělská univerzita v Praze, Praha ; Geologický ústav AV ČR, v. v. i., Praha ; Ústav pro ekopolitiku, o.p.s., Praha ; Zavadil, Vít ; Volf, Ondřej ; Starý, Josef ; Straka, Jakub ; Sádlo, Jiří ; Rambousek, Petr ; Přikryl, Ivo ; Lepšová, Anna ; Godány, Josef ; Frouz, Jan ; Farkač, Jan ; Vrabec, Vladimír ; Cílek, Václav ; Gremlica, Tomáš
Základními cíli projektu je zastavit pokles biologické rozmanitosti a navrhnout opatření pro podporu udržitelného užívání zdrojů a podpořit plnění Strategie udržitelného rozvoje. V rámci řešení projektu proběhnou terénní biologické a ekologické průzkumy nepřírodních biotopů v ČR, bude zhodnocena kvalita těchto biotopů a jejich významu pro ochranu biologické rozmanitosti v kulturní krajině, bude provedena srovnávací analýza vlivu klasických technických způsobů a environmentálně šetrných způsobů rekultivací. Bude zpracována "Metodika s návrhy nových ekologicky i ekonomicky efektivních a environmentálně šetrných postupů a způsobů rekultivací a managementu nepřírodních biotopů v České republice". Témata řešená v roce 2007: Kritéria pro výběr lokalit. 4. Výsypky, haldy a těžebny z geologického pohledu. Metodiky a stručné rešerše k jednotlivým skupinám zkoumaných organismů vyskytujících se v nepřírodních biotopech. Vyšší houby (Macromycetes). Cévnaté rostliny (Tracheophyta). Metodika výzkumů hmyzu a bezobratlých živočichů. Měkkýši (Mollusca). Pancířníci (Oribatei). Střevlíkovití brouci (Coleoptera: Carabidae). Motýli (Lepidoptera). Blanokřídlí žahadloví (Hymenoptera: Aculeata). Mravenci (Formicidae). Obojživelníci (Amphibia). Plazi (Reptilia). Ptáci (Aves). Savci (Mammalia). Soubor lokalit pro finální výběr nepřírodních biotopů. Analýza typů a rozsahu lokalit poškozených činností člověka. Základní charakteristika vybraných nepřírodních biotopů.
|
|
Cellular Protein Transport and Its Role in Patogenesis
Najdrová, Vladimíra ; Doležal, Pavel (advisor) ; Uzlíková, Magdalena (referee)
The main topic of this thesis are the protein secretion processes in several important human parasites - Toxoplasma gondii, Plasmodium falciparum, Trypanosoma cruzi, Leishmania spp. and Giardia intestinalis. Described here are the parasite's and the host proteins which participate in the pathogenic processes involving the protein secretion. As shown here, the protein secretion into the host environment is one of key tools serving the parasite to survive within and manipulate the host organism. Interestingly, different parasitic organisms use functionally and evolutionary distinct strategies to fulfill this aim. Key words secretory pathway, translocon, signal sequence, Toxoplasma gongii, Plasmodium falciparum, Trypanosoma cruzi, Leishmania spp., Giardia intestinalis
|
|
The effect of urbanization on life-history strategies in birds
Houšková, Karolína ; Sedláček, Ondřej (advisor) ; Poláková, Simona (referee)
Urbanisation process is recently a wide-spread process that causes high-impact environmental transformation. Habitats affected by urbanization tend to change substantially and ongoing changes influence organisms living in this environment. Urban environment modifies many abiotic conditions (e.g. temperature, artificial light and noise) and biotic factors (e.g. food supply, parasite prevalence, predation pressure) in comparison to natural habitats. In this manner, especially urban bird populations have recently gained broad attention by an increasing number of ecologists. Urban avoiders - typically sensitive and specialized bird species often vanish from urbanized landscapes. However, many bird species were able to colonize urban environment and coexist successfully with man. Populations of birds living in such a new type of environment show many characteristics different from populations living in original habitats. The objective of this work is to review current studies about changes of life strategies in urban bird populations such as modifications of acoustic signals, differences in reproductive and food ecology and physiological or behavioural responses.
|
|
Proposal for a Business Plan - a Bee Farm
Gross, Jan ; Vrána, Michal (referee) ; Zinecker, Marek (advisor)
The bachelor's thesis concerns with creating of a business plan for establishing a Bee farm which will be situated in Zárubice in Vysočina area and will be carried on a trade. The proposal of business plan is based on theoretical knowledge and on compiled analysis (SWOT) and chooses convenient strategies for for the needs of customers and create a value added creation for the owner.
|
guest ::
