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Use of epidural spinal cord stimulation to influence motor and autonomic functions after complete spinal cord injury
Fořtová, Martina ; Rybka, Vojtěch (advisor) ; Krausová, Lucie (referee)
Title: Use of epidural spinal cord stimulation to influence motor and autonomic functions after complete spinal cord injury The main objective: The main aim of the bachelor thesis was to investigate the use of epidural spinal cord stimulation (eSCS) to influence motor and autonomic functions in an individual with complete spinal cord injury. We investigated whether it is possible to stimulate individual segments in the lumbosacral spinal cord after electrode implantation to restore voluntary lower limb movements and subsequently standing. We also investigated the effect on the autonomic nervous system, spasticity or trunk stability. Methods: An individual with a complete spinal cord lesion was selected for the study and implanted with a spinal cord stimulator with a 32-lead electrode inserted into the spinal canal at the L1-L2 level. The entire therapy lasted 9 months. Four examinations were performed. Before the start of the therapy, then after three and six months and the exit examination was performed after nine months of stimulation. During the examination, stimulation programs were set up primarily to stimulate muscle groups in the lower limbs. Once a certain level of control and muscle strength was achieved, stimulation was started in the sitting position, and as stability and strength...
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Pregnancy in woman with spinal cord injury from perspective of occupational therapist
Moravcová, Kateřina ; Hradilová, Iva (advisor) ; Rotbartová, Eliška (referee)
Title: Pregnancy in woman with spinal cord injury from perspective of occupational therapist Abstract: This bachelor thesis is dedicated to identifying the area of occupational therapist support and the use of occupational therapy during pregnancy in women with spinal cord injury to achieve self-sufficiency and influence quality of life during this period. It also looks at defining areas where increased assistance is needed compared to the pre-pregnancy and trimester conditions. The theoretical part focuses on the areas of counselling as one of the occupational therapist's job responsibilities, which includes items of planning, preparation, education and training in the areas of preparation for childcare, preparation for the delivery room, preparation of compensatory aids, focus on quality of life and psyche of the pregnant woman with spinal cord injury and ADL training. In the practical part, the thesis uses a questionnaire as a method of data collection. The questionnaire focuses on general information about the pregnant woman, and mainly on personal activities of daily life, assistance and occupational therapy intervention. It showed that in pregnant women with spinal cord lesions, self-sufficiency in ADL decreases as pregnancy progresses, being lowest in the third trimester. This is highest for...
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Menstruation after spinal cord injury and its impact on woman's life from the perspective of an occupational therapist
Pilařová, Štěpánka ; Hradilová, Iva (advisor) ; Rejtarová, Anna (referee)
BACHELOR THESIS ABSTRACT Name: Štěpánka Pilařová Supervisor: Bc. Iva Hradilová Consultant: MUDr. Karla Kotková Title: Menstruation after spinal cord injury and its impact on woman's life from the perspective of an occupational therapist Abstract: This bachelor thesis, written under the auspices of the Paraple Center, addresses the issue of menstruation in women with spinal cord injuries from the perspective of an occupational therapist. The aim of the thesis is to examine the impact of menstruation on the daily activities of this group of women and to propose ways in which occupational therapy can contribute to addressing menstrual management in women with spinal cord injuries. The theoretical part of the thesis provides an overview of knowledge about spinal cord injuries, menstruation, and their interrelationship. It also describes the possibilities of occupational therapy intervention in the area of menstrual management in women with spinal cord injuries. In the practical part, research was conducted using an online questionnaire survey, which was carried out on the survio.com platform. This method provided valuable information about the experiences and needs of women with spinal cord injuries in the area of menstrual management. A total of 34 respondents completed the questionnaire, and all responses...
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Comparison of Bioimpedance Methods for Measuring Body Composition in Individuals with Spinal Cord Injury
Szmitková, Lenka ; Majorová, Simona (advisor) ; Vařeková, Jitka (referee)
Title: Comparison of Bioimpedance Methods for Measuring Body Composition in Individuals with Spinal Cord Injury Objectives: The aim of the thesis was to analyze and compare the differences in the diagnosis of total body water, fat-free mass, and body fat between the multifrequency bioimpedance devices InBody S10 and Bodystat Quadscan 4000 in a group of people with spinal cord injury. Methods: A total of 17 people (8 women and 9 men) aged 28 to 64 years with a diagnosis of complete and incomplete spinal cord injury participated in the research. The body composition of the subjects was measured using the multifrequency bioimpedance devices Bodystat Quadscan 4000 and InBody S10 in this order, with a few minutes interval. The measurements were always carried out at the same workplace under the same conditions. Results: Significant differences were found in the complete set between the resulting values of total body water, fat-free mass, and body fat from the InBody S10 and Bodystat Quadscan 4000 devices. By comparing the results of body composition depending on gender, significant differences were demonstrated in the determination of selected body composition parameters between the InBody S10 and Bodystat Quadscan 4000 devices only in the male subgroup, but not in the female subgroup. KEYWORDS Body...
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Enhancing axon regeneration and neuroplasticity after spinal cord injury: Bridging the gap between development and disease
Štěpánková, Kateřina ; Machová Urdzíková, Lucia (advisor) ; Balaštík, Martin (referee) ; Rokyta, Richard (referee)
Enhancing axon regeneration and neuroplasticity after spinal cord injury: Bridging the gap between development and disease ABSTRACT The precise wiring of the adult mammalian central nervous system (CNS) is determined during axon growth, guidance and neuroplasticity during and shortly after development. This intricate system is unable to regenerate when the adult spinal cord is injured. It's not well understood how to translate what is known about developmental processes into therapies for spinal cord injury (SCI). Therefore, effective therapies are difficult to find. This thesis aims to fill an important gap in our understanding of how developmental strategies for axonal growth and plasticity are exploited in SCI regeneration. In particular, we will contrast two approaches: (i) reducing the inhibitory environment that forms around the lesion, and (ii) exploiting the inhibitory environment for regeneration by forcing the overexpression of an appropriate integrin isoform in sensory neurons and allowing axons to grow on this environment. In this thesis, Aim 1, we used 4- methylumbelliferone (4-MU) to reduce the inhibitory environment formed around the lesion. The first step was to assess the potential adverse effects of long-term treatment. Using immunohistochemistry, proteomics, biomechanics, qPCR,...
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Importance of personal assistance for people with physical disabilities in supporting independent living
Černá, Kateřina ; Hájková, Vanda (advisor) ; Zakouřilová, Hana (referee)
The bachelor thesis focuses on the significance of personal assistance for individuals with physical disabilities in supporting independent living. The author initially delves into the theoretical definition of spinal cord injury in the cervical spine area from a health perspective, followed by a social perspective, where the self-concept of the individual and the regaining of independence after spinal cord injury are discussed. In the third chapter, the focus shifts to the implementation of independent living for individuals with spinal cord injuries and further defines the significance of personal assistance as a means of independent living. The aim of the bachelor thesis is to describe the experience of an individual with tetraplegia utilizing personal assistance for independent living. Authentic testimonies from four respondents with spinal cord injuries were obtained through the selection of a qualitative methodological approach and the method of semi-structured interviews. The collected data was subsequently analyzed using phenomenological interpretative analysis. The research findings provide conclusions regarding the overall scope and nature of personal assistance needed for independent living, as well as the methods and current possibilities of utilizing personal assistance. The research...
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Implants for nervous system
Kuruc, Lukáš ; Zatloukal, Miroslav (referee) ; Sedlaříková, Marie (advisor)
This thesis deals with implants for nervous system. The first part of this thesis focuses on theoretical analysis of this issue, makes reader familiar with seriousness of spinal cord injury, its treatments options and regeneration with hydrogel implants. The second part describes experimental manufacturing of implants, testing patency and summary of their properties.
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Live-in personal assistance for people with quadriplegia
Pařízková, Kateřina ; Pavlová, Ilona (advisor) ; Čichoň, Rostislav (referee)
Author: Bc. Kateřina Pařízková Title: Live-in Personal Assistance for Individuals with Quadriplegia Objectives: The aim of the thesis is to find out if the live-in assistance described below would be in demand by quadriplegics in the Czech Republic and if there would be social service workers who would be interested to do the work following the British model. The outcome of this work could help to improve the quality of care for people with quadriplegia and quality of their life. Methods: In the research section, a quantitative research analysis is conducted using two surveys of their own design, one for individuals with quadriplegia and another for social service workers. This information will help ascertain whether individuals with quadriplegia in the Czech Republic currently avail themselves of personal assistant services and whether they would be receptive to adopting the widely utilized British Live-in system. The results are supplemented with data from social workers in the Czech Republic who provided information about their interest in performing Live-in assistance through a questionnaire survey. Results: The first survey involved 284 respondents aged 18-65 years. Within this survey, it was found that social service workers liked the mentioned position of Live-in assistant. They positively...
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Axon, in development and injury
Polčanová, Zuzana ; Kárová, Kristýna (advisor) ; Novák, Ondřej (referee)
The cytoskeletal structure of growth cones plays an important role in both the development of the nervous system and during periods of axon re- generation. The growth cone is a highly dynamic structure located at the tip of growing axons, providing navigation and movement. Signalling cascades are activated that lead to the regulation of the growth cone cytoskeleton, defining its displacement, rotation, or collapse. Despite advances in under- standing guidance cues and their mechanisms of action, knowledge of what happens to the nervous system after injury is lacking. Unlike axons in the peripheral nervous system (PNS), that are able to regenerate after neuronal injury, axons in the central nervous system (CNS) loose regenerative ability as they mature. Unravelling the mechanisms of axon guidance, together with their behaviour after axotomy and regeneration, is extremely important for the understanding of CNS injuries and to provide treatment of these injuries in the future.
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