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Image Registration - Application in ophthalmology and ultrasonography
Harabiš, Vratislav ; Matula,, Petr (referee) ; Zemčík, Pavel (referee) ; Kolář, Radim (advisor)
Image registration is widely used in clinical practice. However image registration and its~evaluation is still challenging especially with regards to new possibilities of various modalities. One of these areas is contrast-enhanced ultrasound imaging. The time-dependent image contrast, low signal-to-noise ratio and specific speckle pattern make preprocessing and image registration difficult. In this thesis a method for registration of images in ultrasound contrast-enhanced sequences is proposed. The method is based on automatic fragmentation into image subsequences in which the images with similar characteristics are registered. The new evaluation method based on comparison of perfusion model is proposed. Registration and evaluation method was tested on a flow phantom and real patient data and compared with a standard methods proposed i literature. The second part of this thesis contains examples of application of image registration in~ophthalmology and proposition for its improvement. In this area the image registration methods are widely used, especially landmark based image registration method. In this thesis methods for landmark detection and its correspondence estimation are proposed.
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Analysis of Retinal Image Data to Support Glaucoma Diagnosis
Odstrčilík, Jan ; Kybic, Jan (referee) ; Matula,, Petr (referee) ; Kolář, Radim (advisor)
Fundus kamera je široce dostupné zobrazovací zařízení, které umožňuje relativně rychlé a nenákladné vyšetření zadního segmentu oka – sítnice. Z těchto důvodů se mnoho výzkumných pracovišť zaměřuje právě na vývoj automatických metod diagnostiky nemocí sítnice s využitím fundus fotografií. Tato dizertační práce analyzuje současný stav vědeckého poznání v oblasti diagnostiky glaukomu s využitím fundus kamery a navrhuje novou metodiku hodnocení vrstvy nervových vláken (VNV) na sítnici pomocí texturní analýzy. Spolu s touto metodikou je navržena metoda segmentace cévního řečiště sítnice, jakožto další hodnotný příspěvek k současnému stavu řešené problematiky. Segmentace cévního řečiště rovněž slouží jako nezbytný krok předcházející analýzu VNV. Vedle toho práce publikuje novou volně dostupnou databázi snímků sítnice se zlatými standardy pro účely hodnocení automatických metod segmentace cévního řečiště.
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Advanced processing of ophthalmologic videosequences of retinal images
Říha, Pavel ; Odstrčilík, Jan (referee) ; Jan, Jiří (advisor)
The diploma thesis deals with registration and analysis of images from the experimental low-cost fundus camera that reaches a low SNR (around 10 dB) and low temporal and spatial resolution. The aim of the diploma tesis is to explore the possibilities of digital processing leading to the creation of a videosequence that has real benefits for medical diagnostics. The well-known program elastix is used for registration. Preprocessing filters and interpolation are implemented in Matlab. The program provides a wide range of setting options, out of which many combinations were tested and evaluated. To assess the accuracy achieved, spatial variations in the detected motion of blood-vessels are evaluated. Best results with a precision below 0.3 px were achieved by using a band-pass filter, a~suitably sized mask, rigid registration and a metric of the mutual information. Test sequences were registered precisely enough both for visual assessment and basic computational analysis. Registered sequences and the developed application that both can be used in the further development of the experimental camera are the main contributions of the diploma thesis.
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Texture Analysis of Ophthalmologic Images
Kaňka, Jan ; Odstrčilík, Jan (referee) ; Jan, Jiří (advisor)
This thesis is concerned with creating of software for textural analysis of retinal images by statistic method called co-occurrence matrices as possible alternative method to detection of lesion of retina by the glaucoma diseases. The Glaucoma diseases without well-timed diagnostics and consequential treatment leads to blindness. The retinal images captured by fundus camera are common, easily processable and modern devices are able to make images of 10 Mpix resolution and bigger, what specifies outputs of analytic software. Method of co-occurrence analysis is simple and effective statistic. But computing demandingness, showing up with growing objective quality, comming up as disadvantage.
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Tool for Detection and Correction of Images with Diseased Eye Retinas
Jochlík, Jakub ; Semerád, Lukáš (referee) ; Drahanský, Martin (advisor)
Loss or partial loss of eye sight can have major effect on quality of person's life. One of the most common diseases, which causes loss or partial loss of eye sight are diabetic retinopathy and age releated macular degeneration. Both of these diseases can be prevented or mediated by early detection and proper treatment. The fundus camera, which is used to capture eye retina, has had major effect on increasing quality and speed of early detection. Images captured by fundus camera can be automatically analyzed in order to detect any possible signs of retina damage. This thesis proposes one possible way of automating this process. First part of this thesis describes eye, its diseases and capturing technology. Second part then proposes way of automating detection process and its implementation. Lastly, the results are evaluated.
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Deep learning methods for vessel and optic disc segmentation in ophthalmologic sequences
Rozhoňová, Andrea ; Odstrčilík, Jan (referee) ; Hesko, Branislav (advisor)
The aim of the following thesis was to study the issue of optical disc and retinal vessels segmentation in ophthalmologic sequences. The theoretical part of the thesis summarizes the principles of different approaches in the field of deep learning, which are used in connection with the given issue. Based on the theoretical part, methods for optical disk segmentation and retinal vessel segmentation based on the convolutional neural networks Linknet, PSPNet, Unet and MaskRCNN are proposed. The practical part of the thesis deals with the description of their implementation and subsequent evaluation.
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Creation of knowledge base
Šiška, Jiří ; Musilová,, Lenka (referee) ; Jirsík, Václav (advisor)
This bachelor's thesis is focused on design and creation of a knowledge base for the NPS diagnostic expert system with a focus on the diagnosis of ectatic corneal diseases. Part of the work is also to introduce the reader to knowledge engineering and the properties of expert systems, their characteristic features and their applications.
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Advanced registration of image sequences from video-ophthalmoscope
Dufková, Barbora ; Chmelík, Jiří (referee) ; Kolář, Radim (advisor)
This master's thesis deals with the issue of registration of ophthalmic video sequences. It describes basic geometric transformations that can be used for registration. The basic methods of image registration are also presented, from which the most suitable variant for this application is selected. This is then implemented using a script created in the MATLAB environment. The proposed method is further evaluated objectively using the brightness profile method, using mutual information and correlation, and using retinal vessel skeleton. The effect of polynomial transformation on registration and possible optimizations of the algorithm are discussed.
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Employment of People with visaul disabilities in Historical Context
Havelková, Veronika ; Mužáková, Monika (advisor) ; Šumníková, Pavlína (referee)
In my bachelor thesis I will concentrate on the evaluation of information on employment of people with the visual impairments in the 19th - 20 century, especially through the activities associations for the blind and institutes of the time. I also mentioned the historical evolution years of the 19th - 20 century, because of the blind understand the life situation and understand the reasons for the formation of blind associations, which concetrate on job placement of person with visual disabilities. Next I rate the traditional crafts, that were typical for people the with visual impairments.
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Patient quality of life with glaucoma
Hašková, Martina ; Jirkovský, Daniel (advisor) ; Králíčková, Jana (referee)
This thesis deals with the quality of life of patients with glaucoma. Its aim is to introduce professional and general public with difficulties and changes that these patients throughout their lives restricted. The theoretical part briefly defines quality of life describes the basic characteristics of glaucoma. The practical part describes its own investigation, which took place from June to November 2015 in the eye clinic Regional hospital Kladno. A total of 83 patients were enrolled. For data collection method was chosen a questionnaire which included items the standardized questionnaires NEI-VFQ-25 and GQL-15 and items characterizing the respondent. From his own survey shows that in the sample of respondents can be observed significant differences in responses by gender, age, treatment with glaucom disease and the level of the highest educational attainment. The thesis also gives a brief description and results of studies already exist on the same or similar subject.
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