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Selected Members of the Habsburg Dynasty and their Mental Disorders
Grunclová, Kateřina ; Ehler, Edvard (advisor) ; Vančata, Václav (referee)
This Bachelor thesis presents research into occurring mental illnesses in celected members of the Habsburg dynasty, with an effort to best consretise them from the original historical background and to compare them with current knowledge. At the same time, it will describe the marriage policy that cintributed to the emergence of mental illness in individual members. The aim of the work is to get acquainted with the Habsburg dynasty, characterize the mental disorders occurring in this magnificent dynasty and evaluate the manifestations of individual diseases.
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Hereditary monogenic health disorders in canine breeds in relation to breeding
ORSÁKOVÁ, Kamila
This thesis deals with problematic of prevalence of single-gene disorders for various dog breeds. The goal was to discover the groups of dog breed with the highest prevalence of single-gene disorders and discover which of these disorders tends to affects most of the dog breeds. We have evaluated 23 closely related groups of dog breeds (Parkerová et al. 2017) with the appearance of some single-gene disorder as we predicted based on our analysis based on OMIA database dated to year 2018-2020. The analysis showed us that the Neuronal Ceroid Lipofuscinosis (NCL) and Progressive Rod-Cone Degeneration (PRCD) affecting most of the dog breeds. We also discovered that the genetically closely related dog breed group 20T, which contains 16 dog breeds, suffers from over 49 types of single-gene disorders. We also discovered that the Border Collie is the dog breed with the highest single-gene disorder prevalence in previously mentioned group 20T. This dog breed is affected by 9 disorders at least. In our analysis the dog breed Labrador Retriever and German Shepherd are suffering from most types of single-gene disorder (more than 15). These dog breeds are one of the most common dog breeds in Czech Republic. This finding supports the hypothesis that the popular dog breeds tends to have better mapped genome and are subjects of testing more often. This thesis provides the characteristic of selected dog breeds. The genetic specifications also contains the recommended breeding method parameters for the minimization of disorders in population.
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Charles Darwin and darwinism in Finnish Literature
Hanušová, Jitka ; Dlask, Jan (advisor) ; Parente Čapková, Viola (referee)
Name: Jitka Hanušová School: Faculty of Arts, Charles University in Prague, Department: Institute of Linguistics and Finno-Ugric Studies Title: Charles Darwin and darwinism in Finnish Literature Supervisor: Mgr. Jan Dlask, Ph.D. Number of pagess: 68 Nubmber of characters: 118 580 Keywords: Charles Darwin, darwinism, social darwinism, Finnish Literature, race, heredity, social class This diploma deals with evolutionary theories of Charles Darwin and examines its arrival to Finland, its spreading there and mentions the first references in the Finnish periodicals, public and especially in literature during 1860-1920. The topic is viewed through a cultural-historical context which consists of influences of evolutionary theories, social darwinism, racial theories, heredity research, or distinctions between social classes. The special emphasis is placed on reflections of the main aspects of this context in the Finnish literature, mainly in the works of Minna Canth, T. Pakkala, L. Onerva, Toivo Tarvas and Maila Talvio.
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Hereditary Mitochondrial Disorders Caused by Oxidative Phosphorylation Disfunction
Hanušová, Eva ; Ehler, Edvard (advisor) ; Pavlasová, Lenka (referee)
Hereditary Mitochondrial Disorders Caused by Oxidative Phosphorylation Dysfunction This bachelor thesis deals with problems of hereditary mitochondrial disorders that are caused by various dysfunctions of proteins in oxidative fosforylation known as OXPHOS complex. Following recherche provides the reader with information about the genom and the structure of mitochondria where the OXPHOS is realized and about its structure and progress. I describe basic facts about various mutations in nuclear and mitochondrial DNA that negatively affect function of OXPHOS complex and the biogenesis of mitochondria. The focus of this work is to summarize the newest data of individual diseases - their clinical manifestation, etiopatogenesis, prevalance in population and its possible treatment and prevention. Key words: hereditary, mtDNA, mitochondrial diseases, OXPHOS complex
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The genetics of type II diabetes
Svobodová, Kristýna ; Ehler, Edvard (advisor) ; Pavlasová, Lenka (referee)
The bachelor thesis The genetics of type II diabetes is compound of several chapter. The major part is general characteristic of diabetes, diagnostics and pathogenesis. The thesis includes history of diabetes too. The last two chapters are focus on genetics. There are many knowledges which have been gained so far and objects future studies. Very interesting is chapter about genetics studies in variol continents, studies of ethnic groups. Key words Diabetes mellitus I., Diabetes mellitus II., disease, genetics, gen, locus, genome-wide association studies, heritability
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Heredity influence and motor development in preschool children
Ctiborová, Petra ; Bunc, Václav (advisor) ; Švagrová, Klára (referee)
Title: Heredity influence and motor development in preschool children Objectives: Objective of this work is evaluation of heredity of movement evolution according to available literature. Methods: Thesis has a recherche character. Information for our research were found in available scholar and internet sources. The thesis is divided into two parts. In the first part there are clarified basic terms about heredity, motor development and genetic determination. The second part is focused on particular life periods of kids up to 6 years old and their motor development in their life periods. Results: Current motorics of preschool children is significantly genetically determined. Literature corresponds in about 50% of determination. Keywords: heredity, development, motoric
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DNA - topic for biology or chemistry?
Andělová, Denisa ; Drda Morávková, Alena (advisor) ; Rajsiglová, Jiřina (referee)
This work is focused in teaching DNA. The aim is to determine whether the subject matter of the nucleic acids rather biological in nature, or rather the nature of thechemical. The work is concerned with explaining the concept of nucleic acid and its types and functions, as well as view into the history of teaching about DNA and analyzing the current situation in the CR and abroad. Finally, the opinions of teachers are devoted to assessing and evaluating the results of some studies.
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Neural and Genetic Basis of Epilepsy
Figelová, Tereza ; Ehler, Edvard (advisor) ; Pavlasová, Lenka (referee)
This thesis describes neural and genetic basis of epilepsy, addresses the distribution of epileptic sezuries, which genes affect epilepsy and the connection between epilepsy and the nervous system. The thesis is based on data collection from scientific books, partly from data published by hospitals. Its focus is getting from the general expressions to the cellular level of the problem, which is necessary to clarify the epileptic principles. It also deals with the genetic nature of epilepsy, as it is with the inheritance of the disease and deals in more detail with early infantile epileptic. The beginning of work is about basic information of epilepsy. Next, it looks into the mechanisms that influence the emergence of epilepsy. Continues to look at the structures in the brain associated with epilepsy. And at the end, it deels with genetic nature of epilepsy. A brochure was created for this work, where basic information about epilepsy can be found, first aid for an epileptic seizure and early infantile epileptic encephalopathy is discussed in paragraphs.
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Hierarchy and human behavior. BDSM as an alternative sexual behaviour.
Jozífková, Eva ; Weiss, Petr (advisor) ; Bob, Petr (referee) ; Zvěřina, Jaroslav (referee)
Preferences for sexual arousal by overstated dominance and submission in sex is categorized as F65.5, sadomasochism, according to ICD, but this behaviour is called BDSM among the general public. The ground of these preferences could be ultimately biological. These preferences reflect behavioural strategy which enables to gain higher reproductive success. Men and women who were sexually aroused by a submissive partner had more male relatives than men and women with other preferences. Contrary to the women, the dominant men reported themselves as more attractive. Women who were aroused by a higher-ranking partner considered themselves more attractive. Sons of couples in which was hierarchical disparity had more siblings than sons of "equal" couples or couples with no hierarchical disparity. Daughters of hierarchically disparate couples had more brothers than daughters of "both dominant" partners. Concurrently, number and gender of offspring as well as self- reported attractiveness are likely to be criteria of the reproductive success in humans. It is also interesting that hierarchically disparate couples, without regard to gender of higher-ranking partner, reached higher reproductive success than "equal" couples. Individuals who preferred higher- or lower-ranking partner were also aroused by...
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