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Creating a knowledge base for the diagnosing of diseases
Macháček, Daniel ; Steinerová, Kateřina (referee) ; Jirsík, Václav (advisor)
This bachelor thesis is focused on problematic of creation knowledge base. It is describing basics of expert systems, their function and possible usage in modern world. In result of this thesis is knowlenge base in web aplication NPS able to diagnose diseases of hematology-oncology and that is proving possibility for use in real life. Knowledge base was created in cooperation with experts in the medical field and contains real data.
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Control system of active magnetic bearing
Kolařík, František ; Vetiška, Jan (referee) ; Houška, Pavel (advisor)
Thesis deals with active magnetic bearing (AMB) levitation control design. Its prototype was done in FSI collaboration with FEKT VUT Brno. The research is focused on communication tools and mathematical model making as well as general AMB issues. Based on this the control design is done an experimentally verified.
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Anti-Money Laundering in the Tax Consultancy Office
Krejčí Reková, Eliška ; Kába, Daniel (referee) ; Polák, Michal (advisor)
Thesis deals with application of anti-money-laundering legislature in tax attorney environment. A general theory of money laundering is discussed and legal requirements on tax attorney are presented resulting from act 253/2008 Coll. on selected measures against legitimization of proceeds of crime and financing of terrorism "Anti-money-laundering Act". Selected tax Attorney Company is then analyzed in terms of anti-money-laundering clauses and their practical application. Finally a specific AML internal control system is created with suggestions on implementation in this company.
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System for Anti-Money Laundering Risks Management
Uhrín, Peter ; Kreslíková, Jitka (referee) ; Bartík, Vladimír (advisor)
The aim of this work is to create a module for anti-money laundering risk management. The module should allow downloading and subsequent processing of a financial sanction database issued by the European commission in cooperation with the European Banking Federation and further manage its own blacklist. This module should be subsequently integrated into the existing information system of the company Platební instituce Roger, a.s. This module will allow easier screening of subjects against the financial sanction database, at the same time will provide the tools to create its own screening criteria and, last but not least, it will also allow inspection of the exposition of individual subjects. The resulting module will be implemented in Python programming language, using SQLAlchemy library for working with the database and Web2py framework for integrating the AML module into the company information system.
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Bank identity and electronic identification under the AML Act
Pochman, Petr ; Boháč, Radim (advisor) ; Martiník, Pavel (referee)
Bank identity and electronic identification under the AML Act Author: Petr Petr Pochman The aim of the thesis is to describe in detail the whole process, the legal basis and the reason for the existence of the procedure of using the bank identity, which is a form of electronic identification under the AML Act, but also to assess whether this procedure does not offer various risks or shortcomings, taking into account the existing other identification options. Identification in general has been gaining importance in the last few years, with the need for accurate identification of persons appearing in various situations, from the opening of a bank account, to the buying and selling of securities by securities dealers and nowadays also in the activities of real estate agents. The frequency of uses in which identification is carried out is increasing year by year for the average person (one of the most recent cases of the widespread use of identification is the real estate activity already mentioned). At the same time, the identification process is becoming more digital and user-friendly, especially with the use of the aforementioned bank identity. The increase in the frequency and, in some respects, simplification of the identification process may lead to an increase in certain security risks, both on the part...
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The role of somatic mutations in the pathogenesis of myelodysplastic syndrome
Minařík, Ľubomír ; Stopka, Tomáš (advisor) ; Žák, Pavel (referee) ; Beličková, Monika (referee)
9 Abstract: Myelodysplastic syndromes (MDS) are a set of severe hematological diseases characterized by ineffective clonal hematopoiesis in the bone marrow, leading to cytopenia in the peripheral blood, the development of transfusion dependence and a high risk of progression to acute myeloid leukemia (AML). The disease is caused by genetic and epigenetic changes leading to the development of pathological stem cells that are unable to mature sufficiently in the bone marrow into blood elements. These changes vary widely between patients, which is reflected in different clinical manifestations, response to treatment, overall survival and, last but not least, this heterogeneity represents a challenge for the study of this disease. The present dissertation is aimed at studying the pathophysiological manifestations and consequences of selected genetic alterations, especially somatic mutations of key genes and other functional units of the genome, in relation to the clinical course of MDS and transformation to AML. Therapy of high-risk MDS is currently based on hypomethylating drugs including 5- azacytidine (AZA). Treatment leads to prolongation of disease progression to AML, but this fate is irreversible for the vast majority of patients whose prognosis becomes hopeless at this point. Results of genetic analysis...
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The role of banks in the fight against money laundering and financing of terrorism
Pultarová, Hana ; Kotáb, Petr (advisor) ; Kohajda, Michael (referee)
Money laundering and terrorist financing are serious problems that may not only disrupt the stability and reputation of financial institutions, but also affect a wide range of individuals. Therefore, this kind of conduct can be punished as a crime, including the active involvement of banks in money laundering. However, the diploma thesis focuses mainly on preventive measures introduced by the provisions of administrative law. The role of a well-functioning banking system is essential for the effective suppression of money laundering and financing of terrorism. Banks are the most frequent reporters of suspicious transactions and the bank services are used by wide range of persons. The role of banks is mainly determined by their designation as obliged entities by the Act no. 253/2008 Coll., on certain measures against the legalization of proceeds of crime and terrorist financing. The obligations arising out of this act are put into context with the Czech Banking Act and with regulations governing payments and implementation of international sanctions, including directly applicable laws of the European Union. The importance of the bank services is also caused by the regulation of cash payments. In connection with the activities of banks, the thesis reflects selected changes that will be introduced by...
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The Legal Regulation of Banking Activities
Martinů, Katrin ; Kotáb, Petr (advisor) ; Sejkora, Tomáš (referee)
The Legal Regulation of Banking Activities Abstract The subject of this diploma thesis is the legal regulation of the activities of banks. Emphasis is placed on newly regulated areas and topical areas in respect to legislative changes. The primary aim of the thesis is to analyse areas related to the activities of banks and to assess the suitability and sufficiency or redundancy of the legal regulation of the selected areas in terms of the scope and depth of regulation. In this context, the work is complemented by proposals de lege ferenda. The first section is devoted to the subjects of banking regulation. Within this part, the term "bank" is defined, including the assessment of online banks. After that, supervisors, namely the Czech National Bank and the European Banking Authority, are presented together with an outline of their functions. The following section covers the general basis of the regulation of bank activities. The sources of regulation are described, and the objectives and reasons for and against regulation are outlined. A description of processes for entering and exiting the banking sector are included, with a more detailed analysis of procedures for obtaining a banking license. The third section contains an analysis of the selected obligations of banks arising from the legislation regulating...
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Cytokine networks and their impact on the immune profile of acute myeloid leukemia (AML) patients
Ptáček, Antonín ; Musil, Jan (advisor) ; Fišer, Karel (referee)
Acute myeloid leukemia (AML) is a malignant hematological disorder characterized by aberrant expansion of blasts in the bone marrow and peripheral blood. The immune system protects the body from leukemia by eliminating transformed cells. However, in AML, the abilities of immune cells are affected both by direct contact between leukemic cells and effector cells, as well as by cytokines, metabolites and other soluble proteins that, together with the cells, form the specific AML microenvironment. The effects of cytokines and other soluble molecules in the AML microenvironment are not sufficiently described yet. This thesis aimed to optimize and implement a multiparametric flow cytometry panel for the measurement of cell populations and to implement multiparametric assays for the analysis of cytokine levels, chemokines and other soluble proteins in plasma. The following goal was to use these methods to characterize the frequency and functional phenotype of cell populations and the levels of the soluble proteins and to describe their influence on disease severity and overall survival of the patients. We also tried to find novel biomarkers of the immune escape of leukemic cells. In patients, we observed a suppressive microenvironment with aberrant levels of soluble receptors and other proteins. This...
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Assessment of AML/CFT Practices and Suspicious Activity Reporting in the European Union member states
Vandasová, Daniela ; Pečená, Magda (advisor) ; Šíla, Jan (referee)
i Abstract This thesis presents an analysis of potential drivers of the numbers of suspi- cious transactions as precursors to money laundering conducted on the Euro- pean Union Member States between 2016 and 2021, and subsequently assesses the efficiency of the existing list of EU-recognized predicate offences to money laundering and financing of terrorism during this time period. Another con- tribution of this thesis is the consideration of the COVID-19 pandemic and assessment of its potential effects. This thesis used a newly compiled dataset containing EU-recognized predicate offences, enforcement factors, and macroe- conomic indicators. Based on the results of this analysis, the main drivers of suspicious transaction levels in the European Union between 2016 and 2021 were drug-related offences and the presence of the global pandemic of COVID- 19. Subsequently it was concluded that the list of predicate offences as recog- nized by the European Union was possibly not efficient in identifying plausible streams of money laundering during the analyzed period. Policy recommenda- tions that could arise from this analysis include promoting consistent reporting of indicators used in international legislation to allow for the development of a stronger data-based structure for further policy evaluation and...
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