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Between the Landscape and the City
Váchová, Veronika ; Nový, Vítězslav (referee) ; Žalmanová, Petra (advisor)
The goal of the project was to design an entrance building to the Faculty of Science of Palacky University. The building should fulfill the needs of the students and teachers, everything that is not available to them, especially a larger representative space, where the students and teachers could meet is definitely missed here.
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Alzheimer's disease from the perspective of family members
Vachová, Veronika ; Štefančíková, Mariana (advisor) ; Šolínová, Petra (referee)
Name and surname of the author: Veronika Vachová Institution: Charles University Faculty of Medicine in Hradec Králové, Department of Social Medicine, Department of Nursing Title: Alzheimer's disease from the perspective of family members Supervisor: PhDr. Mariana Štefan íková PhD., PhD. Number of pages: 76 Number of attachements: 5 Year of defense: 2022 Keywords: Alzheimer's disease, family members, sanitary facilities, family load, family dynamics The bachelor's thesis deals with the subject of Alzheimer's disease from the perspective of family members. It focuses on how family members are cared for. The theoretical part is divided into three chapters which are about Alzheimer's disease, family load, and family dynamics. The practical part contains qualitative research. The research was carried out using a semi-structured interviews with family members. The goal was to get information on what the family members needed and how to improve communication between nursing staff and family members. The information gathered may point to what could be changed in the social facility.
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DNA damage response in Huntington disease
Vachová, Veronika ; Šolc, Petr (advisor) ; Roth, Jan (referee)
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, which leads to loss of striatal neurons in basal ganglias. It is characterized by involuntary movements and progressive cognitive impairment. HD is a relatively rare disease and the prevalence is approximately 0,01 % of the population of Western European. HD is caused by a CAG repeat expansion in the huntingtin gene (HTT). This mutation results in an elongated stretch of glutamin. Mutant huntingtin (mHTT) expression leads to accumulation of DNA double-strand breaks (DSB) due to reduced ability of effective reparation, which contributes to the pathogenesis of HD, however this mechanism is not fully understood. There are several angles of view how mHTT impaires DNA damage response (DDR). Some studies say that the expression of the mHTT initiates excessive activation of the DDR including p53 signaling pathway leading to apoptosis. Other studies represent results for dysfunction of non-homologous end joining after recognition of DSB or that the cell is not able to recognize DSB. All theories would explain cell death as a consequence of high level of unrepaired DNA damage. The understanding of these mechanisms is important for the development of therapeutical strategies. Key words: Huntington's disease, huntingtin, DNA...
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Optimization of processing of documents in library of Bohuslav Martinu Institute
Váchová, Veronika ; Stöcklová, Anna (advisor) ; Kolínová, Pavlína (referee)
This thesis describes the library of the Bohuslav Martinu Institute. First, there is described history and a current activities of the Institute. The main topic of this work is to decompose the library system of the local library and the information center. There are described static elements (the library collection in detail, catalogues and the library equipment) and dynamic elements (aquisition, organisation and services). The practical part contains a description of current state of cataloguing of documents and a proposal for minor improvements. Powered by TCPDF (www.tcpdf.org)
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Evidence based medicine information support at the Psychiatric clinic of the 1st Faculty of Medicine of Charles University and general University Hospital in Prague
Váchová, Veronika ; Jarolímková, Adéla (advisor) ; Bouzková, Helena (referee)
The thesis focuses on the use of Evidence Based Medicine (EBM) methods and principles at the Psychiatric Clinic of the First Faculty of Medicine of Charles University and the General University Hospital in Prague. There is a theoretical introduction to EBM - its origin and development, EBM information resources as well as general basic principles of this approach to work with clinical evidence. Part of this work introduces the history and current activities of the Psychiatric Clinic and the related Psychiatric Association of the Czech Medical Association of J. E. Purkyně. The practical part of the thesis describes the preparation of research and its results. Based on semi-structured interviews with physicians of the Psychiatric Clinic, the results of this research represents their current attitude towards EBM and use of EBM methods in their daily work. The aim of the thesis is also a proposal to raise awareness of EBM information sources in the form of information materials and educational seminars.
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Between the Landscape and the City
Váchová, Veronika ; Nový, Vítězslav (referee) ; Žalmanová, Petra (advisor)
The goal of the project was to design an entrance building to the Faculty of Science of Palacky University. The building should fulfill the needs of the students and teachers, everything that is not available to them, especially a larger representative space, where the students and teachers could meet is definitely missed here.
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DNA damage response in mammalian oocytes
Vachová, Veronika ; Šolc, Petr (advisor) ; Nevoral, Jan (referee)
During early embryonic development oocytes are arrested in prophase I of the first meiotic division, in which they can persist for years. After reaching sexual maturity and the luteinizing hormon surge resumption of meiosis and meiotic maturation occur. Oocytes are arrested again at metaphase of the second meiotic division. At this stage they are ovulated and waiting for a fertilisation. Oocytes are during their development exposed to factors that cause DNA damage, of which DNA double-strand breaks (DSBs) are the most serious threat. The maintaining of genome integrity is crucial for quality of oocytes, fertility and proper embryonic development. The mechanism of the oocyte response to DSBs presence is not fully understood and it seems to differ from somatic cells. We assume that DSBs are repaired during meiotic maturation probably by a mechanism of homologous recombination (HR). In this thesis we focuse on essencial recombinase RAD51, which participates in the repair by HR. We found that RAD51 inhibition leads to an increase of segregation errors in anaphase I. Using high resolution live cell imaging we observed chromosomal fragments and anaphase bridges. Immunofluorescence detection of DSBs-marker γH2AX showed increased amount of DSBs in prophase I and MII stage after RAD51 inhibition. Our data...
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DNA damage response in Huntington disease
Vachová, Veronika ; Šolc, Petr (advisor) ; Roth, Jan (referee)
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, which leads to loss of striatal neurons in basal ganglias. It is characterized by involuntary movements and progressive cognitive impairment. HD is a relatively rare disease and the prevalence is approximately 0,01 % of the population of Western European. HD is caused by a CAG repeat expansion in the huntingtin gene (HTT). This mutation results in an elongated stretch of glutamin. Mutant huntingtin (mHTT) expression leads to accumulation of DNA double-strand breaks (DSB) due to reduced ability of effective reparation, which contributes to the pathogenesis of HD, however this mechanism is not fully understood. There are several angles of view how mHTT impaires DNA damage response (DDR). Some studies say that the expression of the mHTT initiates excessive activation of the DDR including p53 signaling pathway leading to apoptosis. Other studies represent results for dysfunction of non-homologous end joining after recognition of DSB or that the cell is not able to recognize DSB. All theories would explain cell death as a consequence of high level of unrepaired DNA damage. The understanding of these mechanisms is important for the development of therapeutical strategies. Key words: Huntington's disease, huntingtin, DNA...
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Optimization of processing of documents in library of Bohuslav Martinu Institute
Váchová, Veronika ; Stöcklová, Anna (advisor) ; Kolínová, Pavlína (referee)
This thesis describes the library of the Bohuslav Martinu Institute. First, there is described history and a current activities of the Institute. The main topic of this work is to decompose the library system of the local library and the information center. There are described static elements (the library collection in detail, catalogues and the library equipment) and dynamic elements (aquisition, organisation and services). The practical part contains a description of current state of cataloguing of documents and a proposal for minor improvements. Powered by TCPDF (www.tcpdf.org)
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