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Apartment building
Šedivý, Adam ; Kučera, Radim (referee) ; Sobotka, Jindřich (advisor)
The aim of the bachelor’s work is composition of project documentation for the constrution building of apartment building. Object is situated on the cadastral area of Město Náměšť nad Oslavou, number of builing plot is 780/189-190. Builing plot is located in new houses area. Terain is slightly sloping. In the apartment building there are 3 above-ground floor and 1 belowground floor. In the below-groun floor there are situated cellars, storage spaces and technical spaces. In the above-ground floor there are situated flats and two medical offices. Structural system of this builing is wall system. External wall is composed of vertically performe block Heluz. Floor structure is designed as a cast-in-place two way reinforced slab. Staircase is designet as cast-in-place reinforced contstruction too. Roofing of object is composed of flat roof. Floor construction are designed as floating floor.
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Detached House
Pícha, Libor ; Kučera, Radim (referee) ; Smolka, Radim (advisor)
It is a new family house with workroom which has its own entrance. The house is situated in the South Bohemian region in the town called Veselí nad Lužnicí, cadastral area Veselí nad Lužnicí. The building consists of two floors. Both are aboveground. Ground plan consists of three contiguous rectangles. The family house with workroom is covered with a gable roof. The building is designed from the structural system Heluz.
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Detached House Svobodových
Svoboda, Martin ; Kučera, Radim (referee) ; Smolka, Radim (advisor)
Abstract This bachelor's thesis deal with processing of the desing documentation in state of documentatoin for construction of detached house. Desing documentation is not complete as prescribed No. 62/2013 Coll., Amending Decree No. 499/2006 Coll., on Contructoin documentatoin. It includes only part A (Data Accompanyning Report), B (Summary techical report), C (Situational drawings), D.1.1 (Architectural an Building solutions), D.1.3 (Fire safety solutions) of Appendix 6 of this Decree. Further is processed thermal-technical partial basement and two above ground floors. Building is based on flat terrain in Bruntál for inhabitation 4 - 5 family members.
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System Proposal for the Use of Low-potential Heat
Kučera, Roman ; Bartoň, Jan (referee) ; Mastný, Petr (advisor)
This bachelor thesis deals with the problematics of a low-potential heat from the energetics point of view. It also deals with the sources and subsequent use of the low-potential heat. First of all, the thesis mentions the origin of these sources and also describes where they can be found. Also the technologies, that are able to utilize this heat, like heat pumps and solar collectors, are mentioned in this part of the thesis. In its next part, the bachelor thesis deals with use of the waste heat for heating and production of electrical energy. In the last part, the thesis presents the project that introduces a specific concept of the system for object heating from the waste heat.
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Detached house with a bakery in Kosov, district Šumperk
Bílková, Andrea ; Kučera, Radim (referee) ; Štěpánek, Ladislav (advisor)
This bachelor’s thesis deals with the processing of project documentation for threestorey, semi-basement, detached house with bakers in Kosov. The building is designed slightly sloping terrain. The baker is located on the ground floor and has its own entrance separated from the residential part. The residential part is made of cellars in the basement, garage and utility room on the ground floor, a larger residential unit on the second floor and the attic flat on the third floor.
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Apartment building
Škrdlová, Aneta ; Kučera, Radim (referee) ; Sobotka, Jindřich (advisor)
The subject of the bachelor thesis is the design and development of project documentation for the construction of a residential building. It is an object with four above-ground floors, which at each level recede and create terraces. There are 7 apartments in the building, one of which is for people with limited mobility. Part of the ground floor is a shop. About 16 parking spaces. The roof is designed as a single-layer flat with a duo order of layers. The object is designed by POROTHERM
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Use of HPLC-HRMS for the study of tacrine group compounds potentially useful in the therapy of Alzheimer's disease.
Novák, Martin ; Kučera, Radim (advisor) ; Hroch, Miloš (referee) ; Lísa, Miroslav (referee)
1 Abstract Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Mgr. Martin Novák Supervisor - specialist: doc. Mgr. et Mgr. Rafael Doležal, Ph.D. Supervisor: doc. PharmDr. Radim Kučera, Ph.D. Title: Use of HPLC-HRMS for the study of tacrine group compounds potentially useful in the therapy of Alzhemier's disease. High-performance liquid chromatography coupled with high-resolution mass spectrometry (HPLC-HRMS) is an analytical technique very often used in the new drugs development. This technique is widely used, from the confirmation of the proposed structure and identification of present impurities, through the assessment of absorption, distribution, metabolism and excretion to the monitoring of poisoning and intoxications. In the theoretical part, the presented dissertation thesis is focused on the basic characteristics of Alzheimer's disease, its currently available treatment and new treatment strategies. In addition, attention is paid to areas closely related to the experimental part, namely: the study of pharmacokinetics, analytical tools for determining pharmacokinetic parameters, liquid chromatography, mass spectrometry and the specifics of the bioanalytical methods. The experimental work is in the commented form of...
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Chiral separations of borane cluster compounds.
Horáček, Ondřej ; Kučera, Radim (advisor) ; Šatínský, Dalibor (referee) ; Bednář, Petr (referee)
Univerzita Karlova, Farmaceutická fakulta v Hradci Králové Katedra farmaceutické chemie a farmaceutické analýzy Kandidát: Mgr. Ondřej Horáček Školitel: doc. PharmDr. Radim Kučera, Ph.D. Název: Chirální separace klastrových sloučenin boru Anorganické trojrozměrné klastrové sloučeniny boru se staly předmětem zájmu vědců zejména díky svým zajímavým vlastnostem, např. výjimečné tepelné, biologické a chemické stabilitě, neobvyklé třístředodové dvouelektronové vazbě a trojrozměrné aromaticitě. Podtřídou boranových klastrů jsou karborany, které mají v kleci inkorporován alespoň jeden atom uhlíku, čímž kombinují vlastnosti anorganických a organických látek v jedné molekule. Atom uhlíku umožňuje modifikaci klastru různými organickými substituenty, což vede k existenci nepřeberného množství derivátů. Z tisíců těchto sloučenin byly důkladně zkoumány deriváty aniontového bis(dikarbolidu) kobaltu ([Co(C2B9H11)2]- ), a to zejména ve farmaceutické chemii, chemii materiálů, elektrochemii a analytické chemii. Zvýšený zájem o [Co(C2B9H11)2]- je obvykle vysvětlován jeho rozpustností ve vodě, chemickou a biologickou stabilitou, nízkou toxicitou, skrytým amfifilním charakterem a podobností s chemií ferrocenu. Mnoho derivátů [Co(C2B9H11)2]- uvedených v literatuře je chirálních. Navzdory jejich potenciálnímu využití ve...
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LC-MS monitoring of selected antimicrobial compounds in waters
Krupka, Dominik ; Kučera, Radim (advisor) ; Kastner, Petr (referee)
5 Abstract Charles University Phaculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Dominik Krupka Supervisor: doc. PharmDr. Radim Kučera, Ph.D. Consultant: Ing. Martin Ferenčík Title of diploma thesis: LC-MS monitoring of selected antimicrobial compounds in waters The monitoring of residues of human and veterinary antibiotics in surface water is gaining more and more importance due to the increasing resistance of bacteria. This work deals with the modificate of an HPLC-MS/MS method to obtain pilot data on the occurrence of antibiotics in surfaces water. The method is focused on the analysis of 30 antibiotics from the groups of β-lactams, macrolides, lincosamides, amphenicols, fluoroquinolones, tetracyclines and sulfonamides. The method was performed on a UHPLC instrument Agilent 1200 Infinity series with MS Agilent model 6495 triple Quad. Separation of antibiotics was performed on reverse phase using gradient elution and tandem mass spectrometry. An electrospray in both positive and negative polarity was used to ionize the analytes. The method was used for the pilot analysis of surface water samples in the Czech Republic. Samples from 15 rivers and streams were analysed. The most frequently found antibiotics were sulfomethoxazole and...
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