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Genetic and clinical correlates in hypertrophic cardiomyopathy
Čurila, Karol ; Gregor, Pavel (advisor) ; Málek, Ivan (referee) ; Krejčí, Jan (referee)
Hypertrophic cardiomyopathy (HCM) is a hereditary disease, which is caused by mutations in genech coding for proteins of carcomere of heart muscle. Disease is characterised by wide genotypic and fenotypic heterogeneity. Since the 90-th of 20-th century, when the first mutation responsible for HCM was identified, many research was done in detecting the correlation between mutant gene and clinical picture of the affected patient. As the first in Czech republic, we determined the frequencies of 4 most common genes in HCM in czech patients. We figured out, that spectrum of mutations is somehow different from another populations. We didn't find any correlation between specific gene mutation and morfologic and clinical characteristics of affected subjects. In our study with AT-1 receptor blocker - candesartan, we demostrated positive effect of candesartan on level of hypertrophy and function of the left heart ventricle and clinical symptoms of the patients with HCM.
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Possibilities and limits of tobacco dependence counseling and smoking cessation among patients in the medium-term alcohol addiction residential treatment
Krejčí, Jan ; Kulhánek, Adam (advisor) ; Volfová, Anna (referee)
Background: Despite most studies have long term and repeatedly confirmed that the prevalence of smoking among individuals treated with other primary addiction is two to four times higher than in the general population, most services do not provide some form of smoking cessation. Smoking cessation is not clearly grounded in these services. An important aspect for the integration and implementation of smoking cessation programs in addiction treatment services are opinions and attitudes of the workers themselves. These opinions and attitudes are very often ambivalent and perceived as controversial. Attitudes and opinions can determine the possibilities and limits of working with the smoking cessation during the treatment of other primary addictions. Aims: The study has four research objectives that reflect the results of theoretical-critical analysis. To map the opinions and attitudes of employees of medium-term institutional treatment of addiction to the smoking cessation within the issue of other primary addiction. To find out whether workers in medium-term institutional treatment for addiction perceive smoking as less harmful than the use of other addictive substances. To determine whether workers in medium-term institutional treatment for addiction perceive smoking cessation as part of the...
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Mobile Application "Paramedic doggy" - Unexpected Event
Krejčí, Jan ; Milet, Tomáš (referee) ; Chlubna, Tomáš (advisor)
The aim of this thesis is to design and implement a simple educational mobile application for children which, in the form of a game, shows how to proceed in a model emergency situation (train accident). Firstly, the thesis describes general principles of providing first aid in an emergency situation as well as its training. Secondly, the thesis clarifies characteristic features of educational digital games, analyses already existing solutions and describes Unity game engine. Based on information acquired so far, the educational game is designed and implemented in Unity. The method and the results of the testing are presented in the conclusion. The final version of the game is ready for publishing.
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Milling machine CNC control
Krejčí, Jan ; Benešl, Tomáš (referee) ; Bradáč, Zdeněk (advisor)
This diploma thesis deals with rebuild of manual drill-mill machine BF20L into CNC mill machine, 3D model of that and eventual control using PLC. All axes are powered by stepper motors, with encoders, connected to control cards and industrial computer from company Beckhoff. For this control is made full switchboard, supplemented by electrical wiring diagram. Program control along with visualization is made in software TwinCAT 3. Drill-mill machine can be controlled manually or automatically by program.
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New diagnostic and therapeutic aspects of inflammatiory cardiomyopathy
Kuchynka, Petr ; Šimek, Stanislav (advisor) ; Krejčí, Jan (referee) ; Gregor, Pavel (referee)
Introduction: Inflammatory cardiomyopathy (DCMi) represents a non-familial form of dilated cardiomyopathy (DCM) and endomyocardial biopsy (EMB) is crucial for its diagnosis. Aims: To assess the prevalence of DCMi in patients with DCM of unclear origin, to evaluate the significance of serological tests for antibodies against infectious cardiotrophic agents and to analyze the effect of specific therapy guided by EMB results. Methods: EMB was performed in 56 subjects (mean age 52 ± 10 years) with DCM of unclear etiology and left ventricular (LV) ejection fraction (EF) < 40% with a history of heart failure less than 1 year. EMB samples were analyzed by immunohistochemistry, polymerase chain reaction (PCR) and electron microscopy. Results: Immunohistochemical examination revealed myocardial inflammation in 26 patients (46%), the PCR method detected genome of microbial agents in 32 patients (57%). Electron microscopy showed the presence of particles of microbial agents in 41 patients (73%). Serological blood tests found no IgM antibody positivity against any of the investigated microbial agents. Targeted antibiotic therapy in patients with evidence of Borrelia burgdorferi (Bb) genome in the EMB led to a reduction in LV size, improvement of LV EF and alleviate symptoms of heart failure. Conclusion: DCMi...
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Optimality of function spaces for a weighted integral operator
Krejčí, Jan ; Pick, Luboš (advisor) ; Nekvinda, Aleš (referee)
This thesis studies questions related to the boundedness of the integral op- erator T : f → 1 t wf∗ , where w is a given non-increasing function and f∗ is a non-increasing rearrange- ment of a function f. The main goal is to characterize the optimal range for the operator and a given domain and conversely optimal domain for a given range. These results are then illustrated on particular examples. Lastly, some necessary conditions for the existence of optimal space are given. 1
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Novel echocardiographic and magnetic resonance methods in diagnostics of cardiac amyloidosis.
Fikrle, Michal ; Paleček, Tomáš (advisor) ; Hutyra, Martin (referee) ; Krejčí, Jan (referee)
Amyloidosis is a term used for a whole group of diseases caused by deposition of a substance called amyloid into different tissues. Amyloid may be produced by a range of pathologic processes. Heart affliction is typical for only several types of amyloidoses. Heart involvement is then the patient`s prognosis major limiting factor. Diagnosis of heart amyloidosis is difficult especially for nonspecific symptoms and nonspecific findings obtained during common diagnostic procedures. The aim of this thesis was to evaluate usefulness of novel diagnostic methods, namely cardiac magnetic resonance with gadolinium enhancement and a simplified echocardiographic evaluation of left ventricular longitudinal strain, in diagnosing amyloid cardiomyopathy. In our first study we examined 22 patients with light chain amyloidosis by echocardiography and also with cardiac magnetic resonance with late gadolinium enhancement. We compared morphologic and functional parameters acquired by magnetic resonance examination, which is considered a gold standard for morphologic and functional measurements, with values obtained by echocardiographic measurement. Afterwards we evaluated the presence and eventually pattern of late gadolinium enhancement during cardiac magnetic resonance exam. From acquired data we conclude that the...
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Open-Source Implementation Of Smart Home Gateway For Z-Wave Protocol
Krejci, Jan
Z-Wave protocol is one of the most popular wireless protocols for home automation or smart home. However, in recent years there have been only few studies on practical measurements of this protocol. There are several manufacturers on the market, implying a vast array of devices, as well as deploying a commercial solution to the home is expensive and mostly focused on a single manufacturer’s portfolio. In this article, we designed and implemented our own Z-Wave home gateway for a smart home system based on open source software. We verified the feasibility of the proposed gate using the prototype and evaluated its performance according to the execution time of the command. We also discussed the limitations of the Z-Wave protocol based on our experience.
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Retrofit Of Miling Machine
Krejčí, Jan
This thesis deals with rebuild of manual milling machine BF20L into CNC milling machine and control using PLC. All axes are powered by stepper motors and controled by Beckhoff equipment and industrial computer C6015-0010. For digital control is used TwinCAT3 software and structured text as a standart PLC language.
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