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Analysis of changes in an approach to state's rating after the financial crisis
Horáková, Eva ; Blahová, Naďa (advisor) ; Šíma, Ondřej (referee)
This thesis deals with globalisation of markets. It focuses on examining the economic crisis of 2008 and 2010 and on how individual countries can cope with deteriorating of macroeconomic values, especially with financial implications of this situation. The thesis also examines credit rating agencies as indicators of financial soundness of investment instruments, to which is often reffered as to culprits of the crisis for their reaction to the development of the mortgage market. The thesis defines the rating in the concept of sovereign states and describes the market of credit rating agencies. It further evaluates individual rating agencies and practices in the context of the crisis, bringing a comprehensive picture of the role they played at the beginning of the crisis. It also attempts to outline more points of view on the previously unilaterally and predominantly negatively perceived issue of reputation of credit rating agencies.
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Mercury Electrodes as Tools for Voltammetric Determination of Biologically Active Organic Compounds and for Detection of Their Interaction with DNA
Horáková, Eva ; Vyskočil, Vlastimil (advisor) ; Ludvík, Jiří (referee) ; Vytřas, Karel (referee)
The main aim of this work was to use traditional mercury electrodes for the development of voltammetric methods of determination of organic xenobiotics and for the electrochemical study of the interaction between double-stranded deoxyribonucleic acid (DNA) and these compounds. In relation to my previous research work (conducted in the framework of my diploma thesis), firstly, 4-nitrobiphenyl (4-NBP), the suspected carcinogen, was studied. Interaction of DNA with 4-NBP was studied using differential pulse voltammetry (DPV), cyclic voltammetry (CV), and chronocoulometry at a hanging mercury drop electrode (HMDE), and using CV and alternating current voltammetry at a DNA modified HMDE. Using CV, the reduction mechanism was investigated. The interaction of DNA with 4-aminobiphenyl (4-ABP), a metabolite of 4-NBP, and 4-NBP reduction intermediates was studied. It was found that the interaction of DNA with 4-NBP or 4-ABP results in a formation of a DNA aggregate with these analytes. The second studied analyte was methyl violet 2B (MV). For determination of MV in a buffered solution were used: direct current tast polarography and differential pulse polarography at a dropping mercury electrode, and direct current voltammetry, DPV, and differential pulse adsorptive stripping voltammetry (DPAdSV) at HMDE. The...
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Mercury Electrodes as Tools for Voltammetric Determination of Biologically Active Organic Compounds and for Detection of Their Interaction with DNA
Horáková, Eva
The main aim of this work was to use traditional mercury electrodes for the development of voltammetric methods of determination of organic xenobiotics and for the electrochemical study of the interaction between double-stranded deoxyribonucleic acid (DNA) and these compounds. In relation to my previous research work (conducted in the framework of my diploma thesis), firstly, 4-nitrobiphenyl (4-NBP), the suspected carcinogen, was studied. Interaction of DNA with 4-NBP was studied using differential pulse voltammetry (DPV), cyclic voltammetry (CV), and chronocoulometry at a hanging mercury drop electrode (HMDE), and using CV and alternating current voltammetry at a DNA modified HMDE. Using CV, the reduction mechanism was investigated. The interaction of DNA with 4-aminobiphenyl (4-ABP), a metabolite of 4-NBP, and 4-NBP reduction intermediates was studied. It was found that the interaction of DNA with 4-NBP or 4-ABP results in a formation of a DNA aggregate with these analytes. The second studied analyte was methyl violet 2B (MV). For determination of MV in a buffered solution were used: direct current tast polarography and differential pulse polarography at a dropping mercury electrode, and direct current voltammetry, DPV, and differential pulse adsorptive stripping voltammetry (DPAdSV) at HMDE. The...
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Voltammetric Determination of Genotoxic Nitrobiphenyls
Horáková, Eva ; Vyskočil, Vlastimil (advisor) ; Navrátil, Tomáš (referee)
The presented diploma thesis is devoted to study of determination of 4-nitrobiphenyl (4-NBP) in model river water by DC voltammetry (DCV) and differential pulse voltammetry (DPV) at m-AgSAE (diploma thesis relates to bachelor thesis, in it DCV and DPV methods for determination of 4-NBP in deionized water were developed). Limit of determination (LOD) is 2·10-7 mol·l-1 by DCV and 4·10-7 mol·l-1 by DPV. The adsorptive stripping DPV (AdSDPV) technique was tested to archive lower LOD the AdSDPV, optimal conditions were not found. Electrochemical behavior of 2-nitrobiphenyl (2-NBP) at m-AgSAE was studied. Optimal conditions for its determination by both techniques DCV and DPV were found in methanol-0,01 mol·l-1 LiOH (1:9) and in this medium peak current dependence in 1·10-7 mol·l-1 to 1·10-4 mol·l-1 2-NBP (LOD ≈ 2·10-7 mol·l-1 by DCV and 1·10-7 mol·l-1 by DPV) concentration range was measured. Developed methods were successfully tested for determination of 2-NBP in drinking and river water samples. For both mediums obtained LODs were 2·10-7 mol·l-1 by DCV and 1·10-7 mol·l-1 by DPV. AdSDPV technique was unsuccessfully tested to achieve lower LOD. Optimal conditions for simultaneous determination of 4-NBP and 2-NBP by DPV technique at m-AgSAE were found: methanol-0,25 mol·l-1 acetate buffer (pH = 6,0) 3:7....
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Maintaining dignity for patients in coma at ARO, ICU
Horáková, Eva ; Chloubová, Helena (advisor) ; Herbrichová, Andrea (referee)
This thesis deals with the saturation of the needs of patients in coma. The challenge was to find not only theoretical knowledge of respondents about the needs of man, but especially the higher saturation of psychosocial needs. Work deals with cultural, ethnic and religious diversity of patients and their influence on the patient's dignity. Especially in the health care problems and terminal care. It focuses on the most frequent nursing interventions, which cause disruption of intimacy and thus the stage and dying. In the research part, we try to confirm the objectives and hypotheses using quantitative research methods questionnaire. Quantitative results following qualitative research using observation of randomly selected nurses. From the research showed that nurses do not have sufficient theoretical knowledge of the theory of human needs, and therefore very rarely saturate other than physiological needs. Dignity of a sick person is impaired primarily in health care. Communication not only with the patient, but family is poor and annoying the nurses.
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Voltammetric Determination of 4-Nitrobiphenyl at a Mercury Meniscus Modified Silver Solid Amalgam Electrode
Horáková, Eva ; Schwarzová, Karolina (referee) ; Barek, Jiří (advisor)
The presented bachelor thesis is devoted to study of electrochemical behavior of 4-nitrobiphenyl (4-NBP) and to finding of optimum conditions for its' determination using direct current voltammetry (DCV) and differential pulse voltammetry (DPV) at a mercury meniscus modified silver solid amalgam electrode (m-AgSAE). The aim was to achieve the lowest possible limit of determination and to verify the applicability of the newly developed method for determination of 4-NBP in model samples of drinking water. Methanol-acetate buffer pH 4,8 (3:7) was found as an optimum medium for the determination of 4 NBP at a m-AgSAE in deionized water. During DCV it is not necessary to apply electrochemical regeneration of the working electrode, during DPV it is proper to apply following regeneration potentials: Ereg,1 = 0 mV, Ereg,2 = -1300 mV. The concentration dependence of the peak current was found to be linear for both methods for 10-5, 10-6 and 10-7 mol∙l-1 concentration ranges. The limit of determination of 4-NBP both by DCV and by DPV is 2∙10-7 mol∙l-1. The optimum medium for the determination of 4-NBP in drinking water is the mixture of the sample and acetate buffer pH 4,8 in the 9:1 ratio.. During DCV regeneration was not applied, during DPV it was applied with the following regeneration potentials: Ereg,1...
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Workflow analysis of the selected organization
Horáková, Eva ; Zelená, Veronika (advisor) ; Hajdíková, Taťána (referee)
The final thesis is focused on the topic of process management and its development in time. Business Process Management and workflow, are described in the thesis as well as its specification and classification. The paper compares these two concepts. The thesis also works with the methodology of ARIS and Balanced Scorecard which are applied in the selected process of the organization. The process is built on the BPMN notation which is also described in the thesis. The aim of the thesis is to examine and to analyze selected process of the organization with specific methodology, to specify potential problems in the process and to suggest possible solution.
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Analysis of Corporate Performance Using Mathematical Modelling and Computer System to the Support of Organization's Strategic Management
Horáková, Eva ; Švehla, Michal (referee) ; Chvátalová, Zuzana (advisor)
The main goal of this diploma thesis is to analyse financial productivity of a chosen company, to find deficiencies and suggest possibilities for improvement of the situation. First there is theoretical part consisting of an introduction of chosen financial indicators, such as profitability, indebtedness etc., and also a description of Maple, programme used for mathematical exercises. In the practical part there is a description of Brno company TRON, the business objective of which is LED lighting. The financial indocators are made in the programme Maple, the balance and also profit and loss accounts for a few consecutive years are analysed, from which we can determine the financial situation of the company. The result should help the chosen company with future decisions.
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