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Innovation and Interaction: Relationships between Global Production Networks and Regional Innovation Systems in Czechia
Horák, Petr ; Květoň, Viktor (advisor) ; Ženka, Jan (referee) ; Dvouletý, Ondřej (referee)
- 6 - Abstract The aim of this dissertation was to expand the knowledge on the relationships between the quality of regional innovation systems (RIS) and the localization of firms within global production networks (GPNs) in Czechia. A key aspect was to understand the interaction between the different firms involved in GPNs and their R&D collaboration. The thesis also focused on different aspects of leading firms in GPNs according to their urban and rural localisation. Given the importance of RIS quality for innovation processes, the effects of R&D support on firm competitiveness were examined in the context of regional effects. Furthermore, the paper analyzes the effect of the different innovation performance of regions on knowledge spillovers through patent offshoring. The findings of this dissertation expand the understanding of the interactions between RIS and GPN, contribute to a broader understanding of economic geography, and suggest future research avenues. First, it shows that more interconnected firms (with GPNs) and subcontractors without autonomy are not significantly linked by publicly supported in R&D collaborations. Second, intensive involvement in collaborative R&D provides resilience to economic shocks. Third, leading firms in Czechia differ significantly depending on their location, with...
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Building Energy Performance Certificate
Tokarčíková, Jana ; Vyhlídalová, Karolína (referee) ; Horák, Petr (advisor)
The bachelor's thesis deals with building energy performance certificate of the Vítkov apartment building. The theoretical part is focused on thermal insulation systems and insulation materials. The calculation part carries about an analysis of the energy needs and flows of the building together with the energy evaluation of apartment building. This part continues with the design of five revitalisation arrangements, which are assessed according to energy, economic and environmental assessments. The project part contains six energy performance certificates of assessed building.
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Design of a heating system for a multifunctional house
Barták, Jiří ; Horák, Petr (referee) ; Vyhlídalová, Karolína (advisor)
The bachelor thesis is divided into the theoretical, computational and project part. In the theoretical part, I deal with the design and description of the ground - water heat pump for the object. In the computational part, I deal with the design of the heating system and a hot water preparation in the building of the multifunctional house Rezidence Chelčická in České Budějovice. The building has four floors. On the first floor there is a commercial premises with garages and on the remaining floors there are residential units. The building is designed with a water-ground heat pump, indirect heating tank for hot water preparation and heating of the building is provided by floor convectors, plate and pipe units. The last part of the project includes a technical report and drawings for the specified object.
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Larval cestodes and tumors: characterization of antibody response and cross-reactivity
Vajs, Vojtěch ; Horák, Petr (advisor) ; Panská, Lucie (referee)
In recent years there have been developments in research concerning the effect of certain species of helminths on cancer. For example, a preventative infection with these parasites is capable of slowing or completely preventing the development of certain cancers in experimental models. In our preliminary experiments, the suppressive effect of the infection with Taenia crassiceps and Mesocestoides corti on melanoma cancer cells was discovered. Primary infection with these tapeworms has been able to suppress and completely prevent the growth and metastasis of the B16F10 melanoma cell line. Parasites affect the immune system of their hosts with their presence and products. It was therefore the subject of this work to explore one of the ways how these tapeworms may achieve this effect - cross-reactivity of antibodies with tapeworm and cancer cell antigens. First the antibody response of the mouse organism to the tapeworm infection was examined in C57BL/6J inbred and ICR outbred strains. The growth of immunoglobulin levels was measured with ELISA within the first five weeks post infection, upon which the antigens, with which these immunoglobulins react, were specified with the help of Western blot. After this, these reacting antigens were localised in the tapeworm organism with immunohistochemical...
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Immune response of the paratenic host to Toxocara canis infection, possible influence on the course of experimental autoimmune encephalomyelitis
Novák, Jan ; Horák, Petr (advisor) ; Fajfrlík, Karel (referee) ; Ditrich, Oleg (referee)
i Univerzita Karlova 1. lékařská fakulta Studijní program: Doktorské studijní programy v biomedicíně Studijní obor: Biochemie a patobiochemie RNDr. Jan Novák Imunitní odpověď paratenického hostitele na infekci Toxocara canis, možné ovlivnění průběhu experimentální autoimunitní encefalomyelitidy Immune response of the paratenic host to Toxocara canis infection, possible influence on the course of experimental autoimmune encephalomyelitis Abstrakt dizertační práce Školitel: prof. RNDr. Petr Horák, Ph.D. Konzultant: prof. RNDr. Libuše Kolářová, CSc. Praha, 2022 ii ABSTRACT The most complex interactions between host and infectious agent are generated during helminth infections, which represent a significant source of serious health problems worldwide. Because many helminths migrate after entering the host, these infections are characterized by the gradual development of a range of clinical symptoms. These are not only due to the damage to various organs but also to the modified host's immune response. The published studies show that, on the one hand, the immune response is stimulated in order to eliminate the parasite, but on the other hand, helminths possess a number of mechanisms that may lead to immune modulation and thus ensure their long-term survival in the host. An indirect consequence of such a...
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Environmentally Advanced Library
Burýšková, Jana ; Vyhlídalová, Karolína (referee) ; Horák, Petr (advisor)
The main aim of the Master‘s project is to design a library and a cafe in Příbram. The project is divided into three parts. The first part deals with architectural and structural design. The second with technical building services and the third with thermal imaging. The building has a basement and two above-ground floors. The building is founded on foundation strips. The building is designed with load-bearing brick walls and pre-stressed slabs Spiroll. The roof is a flat intensive green roof. The building envelope is insulated with mineral wool. In the building there is air a conditioning and a cooling system. As a heat source, a pressure-independent heat exchanger unit connected to the local hot water pipe will be used. A part of the electricity consumption is covered by photovoltaics. In the third part there are images from a thermal camera for some libraries. Imagines were evaluated if there are thermal bridges in the measured libraries. The project was carried out in the AutoCAD programme.
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Aspects of an experimental solution with the use of geothermal energy in Balneotherapy
Miček, Denis ; Horák, Petr (referee) ; Kabele, Karel (referee) ; Hirš, Jiří (advisor)
The Earth, our home planet is world unlike any other. The third planet from the sun is the only place in the known universe confirmed to host life. We, the humans always headed up to reach set up goals, innovate our technologies and way of living. The fact that, we had never been aware of is that this race to our bright and modern future is destroying our home. By this time, the global temperature arises by 1,9 oC since 1880, 427 gigatons of ice sheets were melted and there are 414 ppm of carbon dioxide particles in our atmosphere. As the trend is changing and we are above to think in green way of living, there is necessity to set up roadmaps and actions plans to stop, eventually decrease the damage which was already caused. The European union started to measure and provide actions plans to decrease the pollution and production of greenhouse gases since the year 1990 – which was set up as reference year for comparison to progress. This arrangement forced the countries to start evaluating the current statuses of their public and industrial sectors in terms of climate changes and provide climate plans for reducing the greenhouse gases. The most important part of climate action plans is to involve the renewable sources of energy into all public and industrial sectors and in this way start the green way of living. Therefore, the investigation and proper understanding of this problems must be the main focus of technical universities and scientific sectors. This dissertation thesis is the summit of 8 years studies and investigation in field of renewable sources of energy, mainly focused on geothermal energy which production in year 2002 was 0 GWh. The main goal is to experimentally analyze designed solutions, elaborated within master and bachelor thesis in real operation of Balneotherapy departments at Slovak Health Spa Piestany, Slovakia from energy, economic and environmental point of view, to set up energy, aqua management and fully understand the way of involvin
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