National Repository of Grey Literature 248 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
The immune response of naïve mice infected with the neuropathogenic schistosome Trichobilharzia regenti
Macháček, Tomáš ; Horák, Petr (advisor) ; Bilej, Martin (referee) ; Schabussova, Irma (referee)
Helminth neuroinfections represent a serious health issue, but the mechanisms of the host immune response often remain neglected despite the fact they might contribute to pathogenesis. This is partly due to the unavailability of clinical samples and the lack of suitable laboratory models. Herein, I focused on the characterization of several aspects of the immune response of mice infected with the neuropathogenic avian schistosome Trichobilharzia regenti. After the percutaneous infection of mice (accidental hosts), most T. regenti schistosomula are entrapped and eliminated in the skin, but the parasite antigens initiating the protective immune reaction are not known. Our in vitro experiments revealed that T. regenti cathepsin B2, a cysteine peptidase used for the skin penetration, activates bone marrow-derived dendritic cells much stronger than the parasite homogenate, suggesting its role in initiating the mixed type1/2 host immune response. However, some schistosomula manage to escape from the skin and continue their migration to the spinal cord. Here they crawl preferentially within the white matter which we demonstrated by the robust 3D imaging techniques, ultramicroscopy and micro-CT. The invasion of the spinal cord is accompanied by striking hypertrophy of astrocytes and microglia. We showed...
Influence of tissue helminths on the development of cancers in model organisms
Schreiber, Manfred ; Horák, Petr (advisor) ; Kolářová, Libuše (referee)
Mesocestoides corti and Taenia crassiceps are tapeworms, larvae of which are characterized by their ability to reproduce asexually. In this work, the effect of infection by M. corti and T. crassiceps in BALB/c, C57BL/6J and ICR mice on the growth and metastasis of B16F10 melanoma tumors was investigated. Although an increase in metastatic activities was observed after intravenous administration of melanoma cells to M. corti-infected mice, both tapeworms showed a strong suppressive effect on the size and number of tumors and metastases formed when the cells were administered intraperitoneally. This, in some cases, led to a complete elimination of tumor cells. In vitro cultivation of B16F10 cells in the presence of larval excretory-secretory products led to a decrease in their viability but an increase in their migration ability. Flow cytometry proved that M. corti infection has an effect on the increased number and proportion of macrophage populations in the peritoneum of ICR mice. Our work confirmed the anti-tumor effect of T. crassiceps infection in mice and introduced M. corti as a new helminth species capable of influencing cancer. Key words: helminths, cestodes, cancers, Mesocestoides corti, Taenia crassiceps
Solar hot water storage tank
Vyhlídalová, Karolína ; Vranayová,, Zuzana (referee) ; Hirš, Jiří (referee) ; Horák, Petr (advisor)
The solar hot water storage tank is off great importance in the solar collector array. It allows transformed energy accumulation thus deals with the inconsistency between supply and demand. The suitable design of the storage tank can improve system efficiency. The storage capacity represents the balance between the amount of stored hot water and the tank's heat losses. The design of the storage capacity is based on three hypotheses. The coverage of hot water demand by solar energy, the ratio between storage capacity and solar thermal collector area and the prediction that the storage capacity corresponds to one- to twofold hot water demand. The purpose of this thesis is to share an understanding of the solar storage tanks design and to improve the design through numerical simulation, experimentations and general calculations. It also focuses on the confirmation of the used hypotheses and determination of the best way to design the solar storage tank for general practice and further potential discussions. The simulation model has three variables – the storage capacity, collector area and the number of occupants. The intent is to find the interdependence of these three variables. The purpose of the simulations is to modify the design of the solar tank based on the mutual influence of studied parameters. The modifications are performed based on the users' needs.
Energy self-sufficient mountain guesthouse
Hánl, Jiří ; Rubinová, Olga (referee) ; Horák, Petr (advisor)
The aim of this master project is to design an off-grid nearly-zero energy mountain guesthouse. First, the building structure is designed. It is a two-storeys building with roof made of lattice trusses. On first floor is dining room, kitchen, playroom and office. On second floor are guest rooms and an owner´s flat. The vertical load-bearing structures are designed from ceramic blocks. Horizontal load-bearing structures are designed from reinforced concrete monolithic slab. The building envelope is insulated with ETICS. Second, HVAC, lighting, photovoltaics and use of rainwater is designed. TZB system controlled remotely with a PC or cellphone are designed. Third, energy study is made. The project is developed using CAD (drawings), DEKsoft (thermal calculations) and Atrea Duplex (air conditioning design).
Heating and cooling systems in a multifunctional building
Fuksa, Lukáš ; Horák, Petr (referee) ; Formánek, Marian (advisor)
The master´s thesis is about the design of heating and cooling of a multifunctional house. The building is functionally divided into parts of shops, administration and apartments. Thesis describes various cooling options and basic types and functions of air conditioning systems. Three variants of the system at the level for expanded building permits and their evaluation are developed. The selected variant is developed at the project level for the construction.
Analysis of boundary conditions of ground heat exchangers
Floreková, Skarleta ; Horák, Petr (referee) ; Hirš, Jiří (advisor)
Diplomová práca,, ,,Analysis of boundary conditions of ground heat exchangers,, je primárne zameraná na analýzu okrajových podmienok a hlavných faktorov vplývajúcich na spoľahlivý návrh a prestup tepla plošného zemného výmenníka v oblasti geotermálnych aktivít na kúpeľnom ostrove v Piešťanoch. Posúdenie možných vplyvov na životné prostredie, ako je napríklad vznik tepelných zmien v dôsledku extrakcie tepla vrátane zamŕzania pôdy v okolí potrubia a potenciálneho znečistenia podzemných vôd je taktiež rozoberané. Súčasťou tejto záverečnej práce boli spracované tri numerické analýzy metódou konečných prvkov pomocou softvéru COMSOL Multiphysics 5.6., ktoré sa môžu vyskytnúť v tejto konkrétnej oblasti. Prvá numerická analýza je podrobená štúdii dynamických procesov plošného zemného výmenníka tepla a zeminy nasýtenou vodou pri konštantnej teplotnej okrajovej podmienke pôdy. Dynamický proces zemného výmenníka tepla a nasýteného podložia pri nestálej teplotnej okrajovej podmienke je skúmaný v druhej numerickej analýze. Posledná analýza je vyhotovená na posúdenie prevádzky plošného zemného výmenníka tepla s možnosťou prúdenia podzemnej vody v rovnakej vrstve. Vďaka týmto numerickým štúdiám a výsledkom dynamických tepelných modelov, každá prípadová štúdia obsahuje rozloženie teplôt v zemine, výstupné teploty z výmenníka a vlastný čiastočný záver.
Solar collector type influence on the heating solar water tank
Čunderlík, Marek ; Horák, Petr (referee) ; Vyhlídalová, Karolína (advisor)
The diploma thesis deals in the theoretical part with various types of sys-tems for the preparation of hot water and specifies the types of solar sys-tems. In the calculation part, it solves the design of kindergarten heating by a system of heating elements. It also solves two variants of hot water preparation in the hot water tank. The design also includes all the equip-ment needed for the proper functioning of the heating system. The exper-imental part compares flat panel and evacuated tube solar collectors.
Renovation of the building with respect to energy demands
Balíková, Anna ; Vyhlídalová, Karolína (referee) ; Horák, Petr (advisor)
The diploma thesis deals with the solutions of the renovation of a panel apartment building with regard to energy efficiency. The theoretical part deals with heat pumps. The acquired knowledge was subsequently applied in the computational part, where the energy assessment of the current state of the apartment building and the design of two possible variants of renovation are addressed. The aim of the first variant is the renovation of the building to meet classification class C using the possible funds. The second variant is focused on the technical equipment of the building and primary energy from renewable sources, so that the apartment building reaches classification class A. Both proposed variants are assessed from both an energy and financial point of view. The project part then contains certificates of energy intensity of individual variants of the building.
Systems of energy efficient buildings
Šlampová, Kateřina ; Horák, Petr (referee) ; Počinková, Marcela (advisor)
The topic of this diploma thesis is systems of energy efficient buildings with a focus on the building envelope. The first theoretical part describes the quantities that we consider when designing the building envelope. The second half of the theoretical part is with reference to the experimental part of the thesis focused on a special type of vertical perimeter structure, namely walls with live vegetation installed from the outside of the structure. The second, practical part of this work, deals with the design of heating and hot water supply for a multifunctional building. The design is elaborated in two variants - heating by means of radiators in the first variant and in the second variant by means of floor heating for residential units of the solved building. The third part define an experiment, which had the task of comparing the measured quantities on two types of vertical perimeter structures, namely a structure with growing greenery from the outside and an identical structure only without a layer of greenery. At the same time, the task was to check the possible influence of the applied greenery on heat losses, and thus the design of the heating system.
Nearly-zero energy Kindergarten
Ryšavý, Daniel ; Vyhlídalová, Karolína (referee) ; Horák, Petr (advisor)
The master project is consists of three parts. The aim of the first and second part is to design kindergarten building, its technical equipment and management systems. The third part deals with energy, financial and environmental comparison of different wall construction composition. The kindergarten is single-storey building without basement and is located in Náchod, Czech Republic. Building is based on strip footing and structural system is masonry wall system with flat roof. Material of both load-bearing and non-bearing walls are sand-lime blocks. External walls are insulated by external thermal insulation composite system. Vertical structures are designed from prestressed Spiroll concrete floor slabs. The roof is designed as a warm flat half-intensive green roof. The building site contains also outdoor parking lot and a garden with a playground and a pond.

National Repository of Grey Literature : 248 records found   1 - 10nextend  jump to record:
See also: similar author names
22 HORÁK, Pavel
39 HORÁK, Petr
4 Horák, Patrik
22 Horák, Pavel
22 Hořák, Pavel
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