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Preparation of catalysts derived from cyclopentadiene and their use in organic synthesis
Reiberger, Róbert
Chiral acidic catalysts are extremely useful for the synthesis of enantioenriched small molecules, however, these catalysts require challenging preparation. This work is focused on the preparation of readily affordable chiral Brønsted acid catalysts containing of 1,2,3,4,5-pentamethylcarboxycyclopentadiene (PCCP) or carboxytetracyanocyclopentadiene (CTCCP) scaffolds. Aromatic stabilization of conjugated PCCP or CTCCP anion is key factor of potent acidity of these compounds. A set of catalyst was prepared via transesterification or amidation of PCCP or via alkylation/desulfurylation reaction of tetracyanodithiine with chiral tosylacetates. Effectiveness of these catalysts has been shown on direct aminalization of aldehydes leading to a stereoselective formation of tetrahydroquinazolinones in excellent yields, even 99 % and with enantioselectivity of reaction up to 84 % e.e. Key words Organocatalysis, Brønsted acids, cyclopentadiene, PCCP, CTCCP, aminalization, aminals, tetrahydroquinazolinones, asymmetic synthesis.
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From microstructures to large-scale crustal deformations in collisional orogen: multidisciplinary approach
Franěk, Jan ; Schulmann, Karel (advisor) ; Faryad, Shah Wali (referee) ; Stünitz, Holger (referee) ; Whitechurch, Hubert (referee)
The thesis aims to compile response of deep-seated rocks to continental collision in the root zone of Variscan orogen exposed in Bohemian Massif. It treats the orogenic processes from the scale of microscopic grains constituting rocks through scale of individual outcrops to an overall view of ~4000 km2 large domain of the high-grade rocks. The thesis is divided into three chapters. The first represents an article summarizing study of structurally most complex area - Blanský les granulite massif - published in the Mineralogy and Petrology journal (2006). The second chapter unravels regional evolution of the south Bohemian Moldanubian domain and correlates the presented results with suitable studies from other orogenic regions or with numerical models of continental collisions. The related article will be submitted to Tectonics journal in June 2007. The last section focuses on the mechanisms of deformation in the felsic granulites and extrapolates the results to rheology of the Variscan lower crust and behavior of common felsic rocks under HT HP conditions. The corresponding paper will be submitted to Journal of Metamorphic Geology in the autumn 2007. The Bohemian massif represents the easternmost exposure of Variscan orogen in Europe. During the 380-300 Ma complex subduction - collision a ~300km...
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Use of transition metal catalyzed reactions in synthesis of biologic active compouds
Novák, Petr ; Kotora, Martin (advisor) ; Veselý, Jan (referee) ; Čermák, Jan (referee) ; Pour, Milan (referee)
=:.;3,a -l-D TÚ. ED rr 6l cl , =-a- i.=o'sEt 'J*a 3*'Bšs BíE;f ĚEE EtgN-VAI =>,--E=:_itrtrtro.=9{ eás-'f;* z- šF E á.3E ; E í-8€ čč HE.,= ššE€Ě ls;Ě šř ; l 'F st = 9=.ěE-| EE.řb'3 €Ei 'EĚ:c* Ev1' EsBEE EEiEo96 i E : ; E Éi ž=? =s.s .srb sEž:ňbob.eř=.= ,! ÉřĚŤĚi=:: s : á'íŤEE ^j :=Ei- .\l \C - +o C.l EcN š.Ea sEP!.á P>,9 ě*; E.E = á\cE = F"E 'c;.9 eo éH -B .=.r =o*oq Xr*ě-.:='aE-ea,N.== š'F5! -:o-ts4tr'tr ;'EE E'é.9'ó ř E:.J: E UE ř r= g;Ě;.9 ; l; ;E=€ i:;Ěgá Ěiř :E á:[gĚá Ě;i Ég g;:;,; ts'g" gŤ *.E =:*; Eáá št E;gigs ř,$: bat ř+::Ěá ::; ;EE:tE=Ěi Eš.tr F.*E ě;Zs3E Ešr g;ř E ei€iš:E -áĚ* č.šE E íšÉ"Š€Í9ĚF €ř\J _: = 6 E 6 ač oi Ě E. 5 r; C } r- =Ía-t3 --Ť3 :.- =.>D =3 ==a> 3- =! ====O >1 ,4, =sa€ = =-- 1 9- ==! 2? =A -. 7- \-> =;?Ja z= =\= I ='ac č ? o 8." xq }š .J :1. NU a! .e9 gÚ; 'P c.- -c o-C>N0 ae .o o-Ó NCp:0 I I rcY 'gJ o !, >, .Ý ť*ĚF c)E E9p .= ,? = 'al Ť9 o ř9.; 6.bPxH7 '=o ť óE- Ěgřtr-' I.>r =a)Yi:oi ,=ro >a.x >5 >'troxÉx.^c ir'Eo 5' SF A* ^i-noĚ oo o) '79 x.= *6xo x!. ě5 .Eo >9 .9á EBb Y> .oo O= sx ií oo C.)É Y() x o0 oL o ň x c* (ť? oa oo. tr(.) ,žg oo H \oo Er .es řg 3óAJ .!J =v(UH Eó!1 oY .Y : ;'i EEĚJEP TSE>-,FO E otr ot -9žxvY.:tr>- Fqg B Hr(u Řotro-!v ý r (H6ř OEH ^^ :ě g .Er* tr'E- 9x-x: vo ažro aóa>.Oo!níl€
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INFLUENCES ON THE MASTER OF THE ST. GEORGE ALTARPIECE
Černá, Alena ; Royt, Jan (advisor) ; Klípa, Jan (referee)
The presented bachelor thesis deals with the impact of Netherlandish art on the work of an anonymous painter known as the Master of the St. George Altarpiece. Under the influence of Netherlandish realism he introduced in his main work, the Marian altarpiece called of St George, the first spatially unified landscape in Bohemian art along with other motives that draw inspiration from the Netherlandish painting of the post-Eyck era. He was head of a workshop most likely located in Prague that produced other works such as the Thun triptych or the St. Barbara altarpiece, in which the rendering of pictorial space goes even further. After an examination of the artist's body of work an attempt is made to trace the sources of the Neherlandish motives in his paintings and examine what role played his stylistic background in such a transmission. Keywords Master of the St. George altarpiece, Death of the Virgin, 15th century painting, Nuremberg, Prague, Master E.S., influence of Netherlandish art, ars nova
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Preparation of catalysts derived from cyclopentadiene and their use in organic synthesis
Reiberger, Róbert ; Veselý, Jan (advisor) ; Kotora, Martin (referee)
Chiral acidic catalysts are extremely useful for the synthesis of enantioenriched small molecules, however, these catalysts require challenging preparation. This work is focused on the preparation of readily affordable chiral Brønsted acid catalysts containing of 1,2,3,4,5-pentamethylcarboxycyclopentadiene (PCCP) or carboxytetracyanocyclopentadiene (CTCCP) scaffolds. Aromatic stabilization of conjugated PCCP or CTCCP anion is key factor of potent acidity of these compounds. A set of catalyst was prepared via transesterification or amidation of PCCP or via alkylation/desulfurylation reaction of tetracyanodithiine with chiral tosylacetates. Effectiveness of these catalysts has been shown on direct aminalization of aldehydes leading to a stereoselective formation of tetrahydroquinazolinones in excellent yields, even 99 % and with enantioselectivity of reaction up to 84 % e.e. Key words Organocatalysis, Brønsted acids, cyclopentadiene, PCCP, CTCCP, aminalization, aminals, tetrahydroquinazolinones, asymmetic synthesis.
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From microstructures to large-scale crustal deformations in collisional orogen: multidisciplinary approach
Franěk, Jan ; Schulmann, Karel (advisor) ; Faryad, Shah Wali (referee) ; Stünitz, Holger (referee) ; Whitechurch, Hubert (referee)
The thesis aims to compile response of deep-seated rocks to continental collision in the root zone of Variscan orogen exposed in Bohemian Massif. It treats the orogenic processes from the scale of microscopic grains constituting rocks through scale of individual outcrops to an overall view of ~4000 km2 large domain of the high-grade rocks. The thesis is divided into three chapters. The first represents an article summarizing study of structurally most complex area - Blanský les granulite massif - published in the Mineralogy and Petrology journal (2006). The second chapter unravels regional evolution of the south Bohemian Moldanubian domain and correlates the presented results with suitable studies from other orogenic regions or with numerical models of continental collisions. The related article will be submitted to Tectonics journal in June 2007. The last section focuses on the mechanisms of deformation in the felsic granulites and extrapolates the results to rheology of the Variscan lower crust and behavior of common felsic rocks under HT HP conditions. The corresponding paper will be submitted to Journal of Metamorphic Geology in the autumn 2007. The Bohemian massif represents the easternmost exposure of Variscan orogen in Europe. During the 380-300 Ma complex subduction - collision a ~300km...
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Use of transition metal catalyzed reactions in synthesis of biologic active compouds
Novák, Petr ; Kotora, Martin (advisor) ; Veselý, Jan (referee) ; Čermák, Jan (referee) ; Pour, Milan (referee)
=:.;3,a -l-D TÚ. ED rr 6l cl , =-a- i.=o'sEt 'J*a 3*'Bšs BíE;f ĚEE EtgN-VAI =>,--E=:_itrtrtro.=9{ eás-'f;* z- šF E á.3E ; E í-8€ čč HE.,= ššE€Ě ls;Ě šř ; l 'F st = 9=.ěE-| EE.řb'3 €Ei 'EĚ:c* Ev1' EsBEE EEiEo96 i E : ; E Éi ž=? =s.s .srb sEž:ňbob.eř=.= ,! ÉřĚŤĚi=:: s : á'íŤEE ^j :=Ei- .\l \C - +o C.l EcN š.Ea sEP!.á P>,9 ě*; E.E = á\cE = F"E 'c;.9 eo éH -B .=.r =o*oq Xr*ě-.:='aE-ea,N.== š'F5! -:o-ts4tr'tr ;'EE E'é.9'ó ř E:.J: E UE ř r= g;Ě;.9 ; l; ;E=€ i:;Ěgá Ěiř :E á:[gĚá Ě;i Ég g;:;,; ts'g" gŤ *.E =:*; Eáá št E;gigs ř,$: bat ř+::Ěá ::; ;EE:tE=Ěi Eš.tr F.*E ě;Zs3E Ešr g;ř E ei€iš:E -áĚ* č.šE E íšÉ"Š€Í9ĚF €ř\J _: = 6 E 6 ač oi Ě E. 5 r; C } r- =Ía-t3 --Ť3 :.- =.>D =3 ==a> 3- =! ====O >1 ,4, =sa€ = =-- 1 9- ==! 2? =A -. 7- \-> =;?Ja z= =\= I ='ac č ? o 8." xq }š .J :1. NU a! .e9 gÚ; 'P c.- -c o-C>N0 ae .o o-Ó NCp:0 I I rcY 'gJ o !, >, .Ý ť*ĚF c)E E9p .= ,? = 'al Ť9 o ř9.; 6.bPxH7 '=o ť óE- Ěgřtr-' I.>r =a)Yi:oi ,=ro >a.x >5 >'troxÉx.^c ir'Eo 5' SF A* ^i-noĚ oo o) '79 x.= *6xo x!. ě5 .Eo >9 .9á EBb Y> .oo O= sx ií oo C.)É Y() x o0 oL o ň x c* (ť? oa oo. tr(.) ,žg oo H \oo Er .es řg 3óAJ .!J =v(UH Eó!1 oY .Y : ;'i EEĚJEP TSE>-,FO E otr ot -9žxvY.:tr>- Fqg B Hr(u Řotro-!v ý r (H6ř OEH ^^ :ě g .Er* tr'E- 9x-x: vo ažro aóa>.Oo!níl€
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