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Směrovaná polymerní léčiva
Říhová, Blanka
Unwanted side effect of anticancer treatment could be eliminated by affinity therapy. It is necessary to find targeting system which deliver drugs specifically to tumor site. Polymeric conjugates based on N-(2-hydroxypropyl)methacrylamide are new generation polymeric anti-cancer drugs with enhanced cytostatic activity, but minimalized unwanted side effects.
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Ligninolytické enzymy rodu Trametes
Tomšovský, Michal ; Homolka, Ladislav
Eighty-four strains belonging to four species of the genus Trametes Fr. (T. versicolor, T. hirsuta, T. ochracea and T. cervina) collected in different localities and on different substrates were screened for laccase production and eight of them with their monokaryotic derivates were then examined in more detail for their ability to produce also other lignin-modifying enzymes (manganese peroxidase and lignin peroxidase). Production variability was relatively high and no significant correlation was found between the origin of the strains (locality, substrate) and the enzyme production. Dikaryons of all three species (but not of all their strains) exhibited LiP activity, which was not detected in the respective monokaryons.
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Rpg1p/eIF3a se spojuje s mitochondriemi v Saccharomyces cerevisiae
Hašek, Jiří ; Janatová, Ivana ; Špryngar, Martin ; Wolinski, H. ; Kohlwein, S. D.
RPG1/TIF32, the essential gene of Saccharomyces cerevisiae, encodes eIF3a subunit of the translation initiation factor 3. We show here that both temperature sensitive mutant of Rpg1 strongly differ in their distribution at permissive temperature, distribution of the Rpg1-1-GFP fusion is cytosolic, the fusion protein Rpg1-2-GFP was accumulated in large cytosolic aggregates. Using the life image analysis with confocal laser scanning microscope we found that these granules could be inherited to daughter cells and obviously associate with mitochondria.
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