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Bioanthropology: a transdisciplinary project of Gregory Bateson
Kučera, Marek ; Soukup, Václav (advisor) ; Patočka, Jiří (referee) ; Soukup, Martin (referee)
Marek K u č e r a Bioanthropology: A Transdisciplinary Project of Gregory Bateson ABSTRACT The dissertation thesis deals with the work of Anglo-American anthropologist and cybernetician Gregory Bateson. It follows Danish biologist Jesper Hoffmeyer in seeing it as an example of a bioanthropological approach, the approach being defined as a position that sees mind as a particular example of nature that is in a deep sense itself minded. Besides the necessary biographical section the thesis consists of two major parts. The first one consists in exposition of Bateson's anthropological and psychiatric concepts, the second one represents an evaluation and interpretation of Bateson's final synthesis at the highest level of abstraction: the notion of equivalence of biological and epistemological realms of explanation. The major aim of the thesis is to present Bateson's work as a way of integration of humanities and social sciences with biological science that represents an alternative to sociobiological and other neo-darwinian approaches. KEY WORDS: Bateson, bioanthropology, evolution, mind
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Screening of New Iron - and Copper - Chelating Substances - in vivo and in vitro Studies
Říha, Michal ; Mladěnka, Přemysl (advisor) ; Patočka, Jiří (referee) ; Tůmová, Lenka (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Michal Říha, MSc. First Supervisor: Assoc. Prof. Přemysl Mladěnka, Ph.D. Second Supervisor: Prof. Radomír Hrdina, M.D., Ph.D. Title of Doctoral Thesis: Screening of new iron- and copper-chelating substances - in vivo and in vitro studies Iron and copper are essential trace elements which play a role in a series of physiological processes in human organism. Homeostasis of these transition metals is meticulously regulated since free or loosely bound iron and copper can catalyse the production of free radicals. Hereditary hemochromatosis, transfusion hemosiderosis and Wilson's disease are associated with absolute iron and copper overload in the organism. Transition metal chelators have crucial significance for the treatment of these states. There are several other diseases with documented involvement of iron and/or copper in their pathophysiology. Examples are primarily neurodegenerative diseases, cardio- vascular diseases, tumours and diabetes mellitus. Various chelating compounds are examined in these possible indications. The aim of this doctoral thesis was to perform a screening of iron- and copper- chelating substances and to study their properties in detail using in vitro and...
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The city as a home. A culturological approach to global problems
Kuška, Martin ; Ortová, Jitka (advisor) ; Patočka, Jiří (referee) ; Czumalo, Vladimír (referee)
The thesi s enti tled The Ci ty a s a Home: A Cul turological Approach to Global Problems (Město jako domov: Kulturologický přistup ke globálním problémům) deals wi th the topical issue of the impact of globalization processes. Globalization is understood as a process of socio-cultural change. Attention is devoted to ci ti es in particular, because they represent in concentrated form the majority of the processes of sociocul tural changes, which at the same time consti tute the ma in global problems of the present day. The problematic nature of a study of globalization processes consists of the difficulty of grasping this complex development, which goes beyond the boundaries of individual social-science disciplines. Nevertheless, each particular academic perspecti ve observes in i ts own area of interest an entire spectrum of repercussions ensuing from globalization proces ses. Consequently, the thing that i s being moni tored i s the establishment of an interdisciplinary approach in the study of the city wi thin the ambit of the so-called Chicago School, whereby sociology implemented the methods of scientific ecology and an approach known as human ecology subsequently emerged, which synthesizes the knowledge of social science and reflects the localized nature and direct integration of soci o-cul tural...
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Molecular biology investigation of somatostatin receptors in diagnostics of pituitary tumors
Drastíková, Monika ; Beránek, Martin (advisor) ; Fryšák, Zdeněk (referee) ; Patočka, Jiří (referee)
Molecular biology investigation of somatostatin receptors in diagnostics of pituitary tumors The overwhelming majority of pituitary tumors are benign, with 25-30% of them representing clinically non-functioning pituitary adenomas (NFA). The treatment of choice for NFA is transsphenoidal neurosurgery. However, the procedure is often not completely successful and frequently tumor remnants remain, resulting in regrow over the long-term follow-up period. This fact has led to the development of new therapy strategies using pharmacological treatment: somatostatin analogs (SA) and estrogen receptor modulators. SA are effectively used in the treatment of acromegaly, neuroendocrine tumors and Cushing's disease. In contrast, pharmacological treatment of NFA has for the most part been unsuccessful. Low SA effectiveness could be associated with the variable expression of target receptors on the adenomas. The aim of the study was to determine the somatostatin (SSTR subtypes 1-5) and estrogen receptor 1 (ER1) expression profile. To obtain more complex receptor profile expression in the pituitary, we also investigated dopamin receptor 2 (D2R). Methods The group of patients was made up of 105 men and 101 women (20-87 years old; median 61). 144 samples were NFA, 44 growth hormone secreting (GHomas), 9 corticotrophin...
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Testing of new potencial substances for the treatment of Alzheimer's Disease
Drtinová, Lucie ; Pohanka, Miroslav (advisor) ; Patočka, Jiří (referee) ; Mokrý, Milan (referee)
University of Defence in Brno Faculty of Military Health Sciences in Hradec Králové Department of Toxikology and Centre of Advanced Studies Student: Mgr. Lucie Drtinová Supervisor: pplk. doc. RNDr. Miroslav Pohanka, Ph. D., DSc Title of Disertation: Testing of new potencial substances for the treatment of Alzheimer's Disease Alzheimer's disease (AD) is the most common form of dementia which is manifested especially by loss of short-term memory, spatial disorientation, progressive loss of cognitive function and progressive deterioration of intellect. It is estimated about 36 million (mostly AD) people worldwide suffer from dementia and this number continues to grow. AD is unpredictable, multifactorial disease of unknown origin and casual therapy. In most post- mortem investigated brains, loss of nerve tissue, oxidative damage induced by inflammation and neuronal decay, extracellular aggregated amyloid beta in amyloid plaque and hyperphosphorylated tau protein tangles were discovered. This disease always ends lethally after 2-10 years from diagnosis. At present, the only available drugs for AD are for symptomatic treatment and most treated patients build a tolerance to them over time. The effect of drugs used in the treatment of AD is based on inhibition of acetylcholinesterase (AChE) (donepezil,...
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Marketing and PR of czech floorball clubs from 2013 to 2018
Patočka, Jiří ; Halada, Jan (advisor) ; Turková, Kateřina (referee)
The bachelor thesis deals with the topic of marketing development of Czech floorball clubs. The general marketing and PR activities in the sport field are examined and then examples from the Czech floorball environment are shown. Although still a young sport, floorball is experiencing its development period, is financially affordable and its popularity grows rapidly. There is an increase in the number of both players and fans in the individual clubs, and in the Czech Republic it is on its way to the top and is currently approaching the status of professional sport that enables players to earn by playing it. The development of marketing and PR in Czech floorball clubs is also related to this development of florball. Therefore, the thesis focuses on the Czech elite clubs from the top floorball competitions, such as the historically most successful Czech club Tatran Střešovice, the purely women's club TIGERS FLORBAL JIŽNÍ MĚSTO, the young but progressive club BLACK ANGELS, but also includes situation of clubs from regional competitions such as for example Lokomotiva Rakovník. The thesis analyses various possibilities of marketing including social networking, merchandising or interesting marketing activities run by clubs from the floorball Super League. In the final part, the thesis offers...
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Screening of New Iron - and Copper - Chelating Substances - in vivo and in vitro Studies
Říha, Michal ; Mladěnka, Přemysl (advisor) ; Patočka, Jiří (referee) ; Tůmová, Lenka (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Michal Říha, MSc. First Supervisor: Assoc. Prof. Přemysl Mladěnka, Ph.D. Second Supervisor: Prof. Radomír Hrdina, M.D., Ph.D. Title of Doctoral Thesis: Screening of new iron- and copper-chelating substances - in vivo and in vitro studies Iron and copper are essential trace elements which play a role in a series of physiological processes in human organism. Homeostasis of these transition metals is meticulously regulated since free or loosely bound iron and copper can catalyse the production of free radicals. Hereditary hemochromatosis, transfusion hemosiderosis and Wilson's disease are associated with absolute iron and copper overload in the organism. Transition metal chelators have crucial significance for the treatment of these states. There are several other diseases with documented involvement of iron and/or copper in their pathophysiology. Examples are primarily neurodegenerative diseases, cardio- vascular diseases, tumours and diabetes mellitus. Various chelating compounds are examined in these possible indications. The aim of this doctoral thesis was to perform a screening of iron- and copper- chelating substances and to study their properties in detail using in vitro and...
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Molecular biology investigation of somatostatin receptors in diagnostics of pituitary tumors
Drastíková, Monika ; Beránek, Martin (advisor) ; Fryšák, Zdeněk (referee) ; Patočka, Jiří (referee)
Molecular biology investigation of somatostatin receptors in diagnostics of pituitary tumors The overwhelming majority of pituitary tumors are benign, with 25-30% of them representing clinically non-functioning pituitary adenomas (NFA). The treatment of choice for NFA is transsphenoidal neurosurgery. However, the procedure is often not completely successful and frequently tumor remnants remain, resulting in regrow over the long-term follow-up period. This fact has led to the development of new therapy strategies using pharmacological treatment: somatostatin analogs (SA) and estrogen receptor modulators. SA are effectively used in the treatment of acromegaly, neuroendocrine tumors and Cushing's disease. In contrast, pharmacological treatment of NFA has for the most part been unsuccessful. Low SA effectiveness could be associated with the variable expression of target receptors on the adenomas. The aim of the study was to determine the somatostatin (SSTR subtypes 1-5) and estrogen receptor 1 (ER1) expression profile. To obtain more complex receptor profile expression in the pituitary, we also investigated dopamin receptor 2 (D2R). Methods The group of patients was made up of 105 men and 101 women (20-87 years old; median 61). 144 samples were NFA, 44 growth hormone secreting (GHomas), 9 corticotrophin...
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Testing of new potencial substances for the treatment of Alzheimer's Disease
Drtinová, Lucie ; Pohanka, Miroslav (advisor) ; Patočka, Jiří (referee) ; Mokrý, Milan (referee)
University of Defence in Brno Faculty of Military Health Sciences in Hradec Králové Department of Toxikology and Centre of Advanced Studies Student: Mgr. Lucie Drtinová Supervisor: pplk. doc. RNDr. Miroslav Pohanka, Ph. D., DSc Title of Disertation: Testing of new potencial substances for the treatment of Alzheimer's Disease Alzheimer's disease (AD) is the most common form of dementia which is manifested especially by loss of short-term memory, spatial disorientation, progressive loss of cognitive function and progressive deterioration of intellect. It is estimated about 36 million (mostly AD) people worldwide suffer from dementia and this number continues to grow. AD is unpredictable, multifactorial disease of unknown origin and casual therapy. In most post- mortem investigated brains, loss of nerve tissue, oxidative damage induced by inflammation and neuronal decay, extracellular aggregated amyloid beta in amyloid plaque and hyperphosphorylated tau protein tangles were discovered. This disease always ends lethally after 2-10 years from diagnosis. At present, the only available drugs for AD are for symptomatic treatment and most treated patients build a tolerance to them over time. The effect of drugs used in the treatment of AD is based on inhibition of acetylcholinesterase (AChE) (donepezil,...
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Screening of New Iron - and Copper - Chelating Substances - in vivo and in vitro Studies
Říha, Michal ; Mladěnka, Přemysl (advisor) ; Patočka, Jiří (referee) ; Tůmová, Lenka (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Michal Říha, MSc. First Supervisor: Assoc. Prof. Přemysl Mladěnka, Ph.D. Second Supervisor: Prof. Radomír Hrdina, M.D., Ph.D. Title of Doctoral Thesis: Screening of new iron- and copper-chelating substances - in vivo and in vitro studies Iron and copper are essential trace elements which play a role in a series of physiological processes in human organism. Homeostasis of these transition metals is meticulously regulated since free or loosely bound iron and copper can catalyse the production of free radicals. Hereditary hemochromatosis, transfusion hemosiderosis and Wilson's disease are associated with absolute iron and copper overload in the organism. Transition metal chelators have crucial significance for the treatment of these states. There are several other diseases with documented involvement of iron and/or copper in their pathophysiology. Examples are primarily neurodegenerative diseases, cardio- vascular diseases, tumours and diabetes mellitus. Various chelating compounds are examined in these possible indications. The aim of this doctoral thesis was to perform a screening of iron- and copper- chelating substances and to study their properties in detail using in vitro and...
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