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Mechanizmy regulace signální transdukce povrchovými proteiny leukocytu*.
Štěpánek, Ondřej ; Brdička, Tomáš (advisor) ; Brábek, Jan (referee) ; Vomastek, Tomáš (referee)
The core of the doctoral thesis "Regulation of signal transduction by leukocyte surface proteins" consists of three publications in international peer-reviewed journals dealing with leukocyte signaling both at the level of individual signaling pathways and in the context of a multicellular organism. Most attention is paid to signaling via the T cell receptor (TCR), which plays a central role in the development and function of T cells and represents a key signaling pathway for proper function of the adaptive component of the immune system. Transmembrane protein tyrosine phosphatase CD148 was considered a negative regulator of TCR signaling through dephosphorylation of LAT and PLCγ1 proteins. This study brings evidence that CD148 is able to modulate signaling also at the level of Lck, both positively and negatively. The net effect of CD148 activity on the TCR signaling is determined by the intracellular biochemical context, notably, the presence of another tyrosine phosphatase CD45. The second project dealt with the characterization of a transmembrane adaptor protein PRR7. This adapter inhibits TCR signaling via down-regulation of the intracellular Lck and cell surface TCR levels. The research concerning the signaling in the environment of a multicellular organism is represented by the analysis of...
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Virtualization of Public Administration Institute
Štěpánek, Ondřej ; Janoušek, Vladimír (referee) ; Neuwirth, Bernard (advisor)
This thesis deals with the virtualization of servers and computer workstations, which has recently been the cornerstone of modern data centers. The practical part is focused on selecting the most appropriate solutions for specific problems in the implementation of virtualization administration. At the same time the present work evaluates the possibility for other organizations.
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Backpressure Steam Turbine
Kubiš, Zdeněk ; Ondřej, Štěpánek (referee) ; Štěpánek, Ondřej (referee) ; Fiedler, Jan (advisor)
The theme of the master’s thesis is to design a 60 MW single-casing steam turbine for the two-stage district water heating. The turbine is designed for cogeneration cycle, has four uncontrolled extractions and the outlet down to the heater. First, there is the thermodynamic calculation of the turbine operation with 100 % steam mass flow. Further, the detailed design of flow part with the strength calculation of blades and diaphragms is drawn. By the end of the thesis, the required operations are compared and corresponding heat balancing diagrams are listed. The thesis also includes a turbine longitudinal section.
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Condensation Steam Turbine for Combi-cycle
Pavlíček, Martin ; Ing.Ondřej Štěpánek (referee) ; Fiedler, Jan (advisor)
This thesis named Cosdensing steam turbine in combi-cycle deals with the calculation of thermal balancing scheme and the design of turbine. This double body steam turbine with combined HP-IP part and double-flow LP part does not have any additional samples of technological steam. LP part has two side outputs to the water-cooled condensers. There is a basic calculation of force effects on the LP part at operation. The thesis also includes a drawing of a longitudinal cut of LP part and its layout, including positron of the condensers.
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Trends in Mobile Marketing
Chocholová, Petra ; Karlíček, Miroslav (advisor) ; Štěpánek, Ondřej (referee)
The principal aim of this thesis is to assess the state of the mobile marketing as of the first quarter of 2011 and to discuss various scenarios of the future development. This thesis defines the terms "mobile marketing" and "mobile advertising" and identifies the main players in the industry. It explores the main categories of mobile advertising such as mobile messaging, in-content and mobile internet advertising. Later, it analyzes the latest trends in the industry and describes in detail the advancements in QR tagging, location based advertising and augmented reality.
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Development Trends in Retailing - Shelf Ready Packaging
Štěpánek, Ondřej ; Filipová, Alena (advisor) ; Zeman, Jiří (referee)
This thesis focuses on a progressive packaging technique in retailing which is called Shelf Ready Packaging (SRP). It is concerned with a discussion of characteristics and potential of this method and brings views of key interested parties. Several types of Shelf Ready Packaging are described and their main advantages and disadvantages are analysed. In the thesis there is briefly explained the implementation process of the technology in a supplying firm. Attention is also paid to the role of logistics in retailing and its current trends.
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Dodací parita a její vliv na stanovení ceny - INCOTERMS v posledním znění
Štěpánek, Ondřej ; Malý, Josef (advisor) ; Jelínková, Eva (referee)
Úkolem INCOTERMS je poskytnutí souboru mezinárodních obchodních pravidel, které se zabývají výkladem nejpoužívanějších obchodních doložek v mezinárodním obchodu. Pravidla jsou vypracovávána a vydávána Mezinárodní obchodní komorou v Paříži. Jejich použití zajišťuje určitou standardizaci a zamezuje rozdílným výkladům dodacích parit v jednotlivých zemích. INCOTERMS 2000 jsou zatím poslední vydanou verzí a jejich hlavním posláním je přizpůsobení se moderním směrům, jimiž se mezinárodní obchod ubírá. Jde především o liberalizaci mezinárodního obchodu, o změny v mezinárodní přepravě a o stále se rozvíjející elektronickou výměnu dat (např. systém EDI).
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