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Heterochromatin variants of the human karyotype
Michalová, Michaela ; Šípek, Antonín (advisor) ; Forman, Martin (referee)
Chromosomes are cell structures consist of chromatin, out of which one kind is a constitutive heterochromatin, which contains non-coding sequences only and is transcriptionally inactive. Heterochromatin blocks consist of highly repetitive sequences of satellite DNAs, which allows the parts to be variable. The largest areas of heterochromatin can be found at long arms of chromosomes 1, 9, 16 and Y, but heterochromatin areas also affect the variability of the short arms of acrocentric chromosomes 13 - 15, 21 and 22. This bachelor thesis based on a number of scientific essays summarizes findings about heterochromatic variants, their occurrence, frequency, possibilities of examining as well as their clinical significance in today's world. It mainly highlights their possible connection with reproductive failures and contradictory results of individual observations. Contemporary results show the importance of new laboratory methods (molecularly cytogenetic), which can be used in specifying and more detailed sorting of findings, which were previously tagged as harmless variants according to less accurate banding methods. The summarization implies that emphasis should be put on the study of clinical meaning of heterochromatic variations. These can influence the progress of meiosis and thus trigger...
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The Possition of Catholic against the Magisterium versus Own Conscience in the Questions of Assisted Reproduction
MALACHOVSKÁ, Jana
The thesis deals with the dilemma of the believer and the position of the Catholic Church on assisted reproduction. It describes the origins of human life, reflections on its origins, and mentions the need for its protection and the preservation of dignity, as well as referring to the Church's view of its creation in marriage. It points out the issue of infertility and possible ways of its solution, including assisted reproduction. There is emphasized the rejection of the Catholic Church's assisted reproduction and its thorough explanation from the churches of the documents. The final chapter offers possible solutions to fulfilling the desire for a child that are morally acceptable, including both the methods of natural parenting planning and the possibility of alternative family care but also the accepting the fact of childlessness.
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Immunological causes of male infertility
Stiborová, Martina ; Brynychová, Iva (advisor) ; Dostálová, Pavla (referee)
Infertility is defined as the inability to persuade a child after one year of regular unprotected contact, occurs in about 15% of partner couples. In addition to genetic, anatomical, hormonal and infectious causes, the importance of immunopathological mechanisms that contribute to infertility is 15%. The immune system is designed to protect the body's intrinsic stability and respond to so-called "dangerous" signals that can be induced by sperm as autoantigens for men and alloantigens for woman. A healthy individual has protective mechanisms in place to protect sperm from possible attack of the immune system. Failure of protective mechanisms and the natural immune system can result in antibodies against sperm. Antibodies against sperm proteins negatively affect sperm fertilization and are one of the main causes of infertility. This paper describes the possible occurrence of anti-sperm antibodies in both sexes. It also describes the development of sperm, immunological properties of the male and female sexual tract, and briefly summarizes the properties of anti-sperm antibodies and the treatment of immunological infertility. Key words: Reproduction, infertility, sperm cells, antisperm antibodies, autoimmunity
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The Human Embryo in the Perspective of Reproductive Medicine
Halabicová, Věra ; Ovečka, Libor (advisor) ; Matějek, Jaromír (referee) ; Opatrný, Dominik (referee)
Title: The Human Embryo in the Perspective of Reproductive Medicine. Since when one begins to be a human person? In this work, we take into account the issues, which in most cases lead many people to resort to the reproductive medicine, which generally is referred to as the infertility problems. But in some techniques, the reproductive medicine loses up to 80% of human embryos. In the minds of many people, the human embryo is seen only as a cluster of cells. However, is it really just a cluster of cells, or is it already a person at an early stage of development? As far as one is already man, is he now also the human being, of whom are in our Western culture related rights, especially the right to life? Could we then say with a clear conscience that with these techniques we are acting ethically? We dividend our work into six chapters. In the first and second chapter, we will be briefly acquainted with the issues of infertility, of the reproductive medicine techniques, with the development of the human embryo and with handling of the embryos in the course of these techniques. In the third charter, we will present the two major ethical models in our cultural area that have a different point of view on the status of the human embryo. In the fourth chapter, we will look at how to the question of the...
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Legal aspects of assisted reproduction
Thalerová, Nicol ; Hendrychová, Michaela (referee) ; Frinta, Ondřej (referee)
Reproductive Medicine currently represents one of the fastest growing medical fields. The birth of Louise Joy Brown as the first baby conceived in vitro fertilization or in vitro, is considered being the historic milestone in development of the treatement methods in assised reproducion. Ethical discussions regarding the admissibility of these methods have developed as a result of technological advance of the infertility treatment. Adequate response of applicable law was required on the currant state of medicine which resulted in the need to regulate legally this field whether it's about establishing of assumption of fatherhood with regard to determination of fatherhood of a child conceived through artificial insemination, as well as determination of the basic conditions for the access to assisted reproductive techniques. Originally, the legislation of artificial insemination was defined only in the implementing regulation of the Ministry of Health, as the reproductive technologies were entirely new area. Today, the area of assisted reproduction is regulated in Act no. 373/2011. This thesis deals with the regulation of the assisted reproduction and it focuses on the controversial methods and procedures which are based on child sex selection, gamete donation and donor anonymity and also it deals with...
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Effect of selected endocrine disruptors on the male mouse reproductive system in vivo
Žatecká, Eva ; Pěknicová, Jana (advisor) ; Kubelka, Michal (referee) ; Kaňka, Jiří (referee)
In our environment there are many compounds which can negatively influence humans and wildlife. Every day, a vast number of environmental pollutants are released into our environment and there is no way to avoid their exposure. Some of these compounds can even mimic endogenous hormones and interfere with our endocrine system (so called endocrine disruptors), which is the key regulatory system controlling almost all physiological processes in human and animal bodies. Also the reproductive system is largely regulated by various hormones, and their proper function is crucial for gamete formation, fertilization and embryo development. Environmental pollutants are therefore considered as one of the possible causes of increased infertility in human population. This prompted us to study the effect of two endocrine disruptors (tetrabromobisphenol A - TBBPA, and zearalenone - ZEA) on the male mouse reproductive system in vivo. According to our results, TBBPA is able to induce apoptosis as well as changes in the expression of selected testicular genes and sperm protamination. Our results also suggest that permanent exposure to TBBPA slightly enhances its effect in the next generation, depending on whether the parents have been affected or not. We hypothesized that differential protamination of the sperm DNA...
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Relation locus of control on prevalence of depresivity by infertil person
Blašková, Ivana ; Loneková, Katarína (advisor) ; Hrachovinová, Tamara (referee)
This master thesis deals with infertility and its treatment. Both in the theoretical and empirical part, it focuses on the female aspects of the issue. The theoretical part summarizes an overview of key information important to understand the presented problems. We define the terms, describe the psychological and physiological causes of infertility, the process of treatment of infertility and aspects thereof. We focus on the depression rate related to infertility and its treatment, furthermore, we deal with type locus of control related to the experienced rate of depression. Our aim in the empirical part is to describe the depression rate, type of locus of control within the two samples of women acquired by us and capture the possible connections. The sample is made of 58 women who are currently undergoing a treatment for infertility and of the control group, which is made of 58 healthy women. To collect the data, we used the Beck Depression Inventory BDI-II, the Rotter's Internal- External Scale and the anamnestic questionnaire. Based on acquired data, we found out some specifity in depression rate and type of locus of control within our samples of women.
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