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Repeatable Torque Load Equipment Design for Vehicle Steering System Testing
Novák, Pavel ; Ludvík, Jan (referee) ; Ramík, Pavel (advisor)
The object of this work is design braking device with high repeatability and reproducibility that is used to analyse the measurement system. I developed this work in cooperation with TRW-DAS Dačice a.s. At the beginning, I made a search of the chassis system, testing of ball joints and steering. Furthermore, I made search of the MSA and the types of braking devices. The rest of the work is focused on the design and the thermal analysis of braking device. Then there are the actual test.
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Useless Things
Maloušková, Drahomíra ; Jeřábková, Edith (referee) ; Artamonov, Vasil (advisor)
Useless things. I normally use trash things like pattern in painting still life. My father suffers from obsessive compulsive disorder – accumulation of things. In addition to painting, I also work with objects themselves. My interest also closely related to how the concepts of the subject, object and artifact are appliing in contemporary art. There are the tradition of imitation fact, principle of ready-made, the issue of technical reproducibility and virtual reality of things in history of art. As a central theme of my thesis, I selected the part of bodywork Tatra 613, which carries all the testimony about ,,useless and hopeless "situation in which it is located. It is also an object monumental and visually very aesthetic. Yet it is not my intention to settle for the principle of redy-made. Asked about artwork as intermediaries art and its seemingly useless producing and reproducing, I want to try to create another such usless situation. That's why I make a cardboard copy (1: 1) of this object. I also make video with motive 3D copy of the same object. I like to create some voltage between that useless object and valuable art practice. I think, it does not just mean such futility when these objects will be viewed as an art.
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Determination of chlorides in pharmaceutical substances
Čutová, Michaela ; Pharm.Dr.Tomáš Schenk (referee) ; Omelková, Jiřina (advisor)
The topic of this bachelor work is a validation of the method for „Determination of chlorides in pharmaceutical substance“ is made in a form of validation of an analythical method. This titration method with potentiometric indication was developed in a company Sicor and it is used for determination of the residual chlorides volume in the substance called Pemetrexed. Validation is a process which assess suitability of a given analythic system for gaining relevant data (results). Validation constists of four tests: precision, reproducibility, lineraity and test of solution stability, although the test of reproducibility was realized in other laboratory (QC). For determnination of the chlorides was applyed titrator 716 DMS Titrino with argent combined electrode. For a data evaluation were used software tiamo 1.1 and MS Excel.
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Quality assessment of pneumatic linear drives
Pecl, Tomáš ; Jankových, Róbert (referee) ; Budík, Tomáš (advisor)
This Master’s thesis deals with the evaluation of quality pneumatic linear drives. The theoretical part describes the problems in the field of pneumatic cylinders and statistical methods to perform the analysis. The practical part includes the execution and evaluation of the statistical analysis of the measurement process and pneumatic cylinders, also brings recommendations to optimize the measurement process. The methods used included analysis Gage R & R, Analysis control charts and data analysis using the process capability. The study was made for the purpose of improving test equipment Norgren Ltd. Used computer programs was Minitab Statistical Software and MS Excel.
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Verification of basic parameters of complete blood count using analyser Sysmex XT 4000i, result comparison of patients' samples with analyser Sysmex XT 2000i in accredited laboratory.
MOUČKOVÁ, Lenka
Central Laboratories of Strakonice Hospital, joint stock company, are accredited according to CSN EN ISO 15189 Medical laboratories - Particular requirements of quality and competence. Requirements of verification and validation of methods emerge from this accreditation. Results of validation and verification processes are used to evaluate the uncertainty of measurement and assessment for continuity and comparability of measurement results. Introduction of a new type of automated hematology analyzer Sysmex XT-4000i in Central laboratories in Strakonice Hospital, joint stock company, in the hematology and blood storage section, requires verification and validation of basic examined blood count parameters on hematology analyzer Sysmex XT-4000i.The theme of the work is based on the requirements of CSN EN ISO 15189 and SOPO-C-06 Method validation/verification procedure for introducing laboratory hematology analyzer. Measurements of the basic parameters of blood count , namely leukocytes, erythrocytes, platelets, hemoglobin, hematocrit and mean corpuscular volume were done according to this document. Measurements of these parameters were used to evaluate a precision in terms of repeatability, precision in terms of reproducibility and accuracy. Parameters leukocytes, erythrocytes, platelets, hemoglobin, hematocrit and mean corpuscular volume were measured from twenty patient samples at two concentration levels to evaluate the precision in terms of repeatability. Basic parametres of blood count validated in EHK process were measured to evaluate the precision in terms of reproducibility. Reference materials e-check level 1 and e-check level 2 from Sysmex manufacturer were used as hematology control materials which moved within the physiological range. Measurements of these two reference materials were carried out daily during 20 days in a singlet. These measurements were used as the basis to calculate basic statistical parameters, the variational coefficient of repeatability and the variational coefficient of reproducibility from which variational analytical coefficient was calculated. The variational coefficient of reproducibility was used to compare methods of investigated parameters to the data specified by the manufacturer of the analyzer, as the manufacturer of the analyzer does not give the variational coefficient of repeatability. To estimate the validity, basic parametres of blood counts were measured to control materials from the company SEKK, Ltd.These materials are used to measure performance parametres. Validity measurements were used to calculate basic statistical parameters of which bias was calculated. It served to calculate the total analytical error of a laboratory and also it served to be compared to the total maximum error recommended by the company SEKK Ltd. in 2012. Passing-Bablock regression analysis was used to compare hematology analyzer Sysmex XT-2000i and hematology analyzer Sysmex XT-4000i, namely to compare the existing and the introducing analyzer and to compare open and closed mode of the introducing analyzer Sysmex XT-4000i. To compare analyzer Sysmex XT-4000i and Sysmex XT-2000i, which was regarded as referential, 40 patient samples were measured in a closed mode. To compare open and closed modes of analyzer Sysmex XT-4000i, 168 patient samples were measured. The measured values of all basic parameters were evaluated using MedCalc programme. The study showed that the device Sysmex XT-4000i meets the criteria required by CSN EN ISO 15189 Medical laboratories - Particular requirements for quality and competence and SOPO-C-06 Method validation/verification procedure for introducing laboratory hematology analyzer in Central laboratories Strakonice Hospital, Inc. section of hematology and blood storage. Comparison of the new hematology analyzer Sysmex XT-4000i to the current Sysmex XT-2000i showed that both analyzers are comparable.
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