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Separation and determination of pharmaceutically important compounds using electrophoretic methods
Hamoudová, Rafífa ; Pospíšilová, Marie (advisor) ; Nobilis, Milan (referee) ; Jokl, Vladimír (referee)
This thesis deals with the use of electrophoretic methods in the analysis of pharmaceutically important compounds. In the theoretical part, the classification of capillary electrophoretic techniques is discussed. Capillary zone electrophoresis (CZE, capillary isotachophoresis (ITP), micellar elektrokinetic chromatography (MEKC), microemulsion elektrokinetic chromatography (MEEKC), isoelectric focusation (IEF), capillary electrochromatography (CEC) and capillary gel electrophoresis (CGE) are described. Further, on-line pre-concentration methods are described. Particular attention is given to the on-line combination of capillary isotachophoresis with capillary zone electrophoresis using column coupling arrangement. This combination enables the improvement of the selectivity of separation and the improvement of the limit of detection of analytes present in complex matrices of biological and environmental origin. Afterwards, the results of the experimental analyses are presented: 1. The first paper deals with the use of CZE in the analysis of ibuprofen and flurbiprofen in pharmaceuticals. Separation was carried out in a fused silica capillary (60 cm x 100 m I.D effective length 45 cm) at 30 kV with UV detection at 232 nm. The optimized background electrolyte was 20mM N-(2- acetamido)-2-aminoethanesulfonic acid...
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Podmínky optimálního řazení dávek u dvou procesorů
Černý, Jan ; Pelikán, Jan (advisor) ; Černý, Michal (referee)
Práce se zabývá charakterizací flowshop problému ? problému optimálního řazení dávek u dvou procesorů a měla by posloužit jako zdroj informací o této problematice. Jsou zde zavedeny jednotlivé teorémy, obnoveny některé základní pojmy, používané při definování částečného uspořádání a vztahující se k analýze intervalové struktury. Dále jsou zde náhledy na dvě konkrétní intervalové struktury pro F2|prmu|Cmax problém a vyloženo několik postačujících podmínek optimality, začínající u částečné intervalové struktury a končící u obecných, celých případů.
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Abuse of dominant position in EC Law and US Law
Funta, Rastislav ; Svoboda, Pavel (advisor) ; Smolek, Martin (referee) ; Tichý, Luboš (referee)
Competition/antitrust law rules are neccessarry for optimal functioning of the common market with its four fundamental freedoms (free movement of goods, capital, services and persons). Competition as a contention for superiority in the market place and antitrust as a study of competition mean more or less the same. Because markets are increasingly becoming multinational, lawyers and lawmakers can no longer content themselves with understanding only the antitrust/competition law of their nation. This study will discuss the most relevant issues of competition law (abuse of dominant position) in the European Union in comparison to the US American antitrust law: abuse of dominant position, how should the competition/antitrust law act by the abuse of dominant position by companies with a major market share as well as with the concentration appraisal which is one of the fundamental basis for the abuse in general. Throughout the different chapters it refers to several similarities and differences between the EU and U.S. systems. Substantial sub-part of the dissertation is the sanctions solution which are laid down by abuse of competition-legal rules as well as the development of the abuse of dominant position/competition law perspective. The aim of the competition legal regulation is not only the protection and...
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Optimization of capital structure and shareholder's investment return
Kudela, Petr ; Marinič, Pavel (advisor) ; Genža, Jiří (referee)
Management of most of the companies pays substantially less attention to structure of raising capital, than to investing it. Sometimes managers forget that the value of the company can be increased not only through proper investments but also through choosing the right proportion of capital structure. There are many theories dealing with this issue. The best known, Miller-Modigliani theory considers as an optimal capital structure the one with the lowest weighted average cost of capital. This thesis is based on these theories and tries to apply them on Czech firm and its Brazilian daughter company.
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Analysis of the communication mix of the Memos Software s.r.o. company
Pikartová, Ivana ; Zamazalová, Marcela (advisor) ; Kudláček, Petr (referee)
The thesis is focused on the analysis of the communication mix of Memos Software s.r.o. company which develops the custom software. Before the main analysis the theoretical part takes place in which the traditional components of the communication mix are explained. After that the attention is oriented on the communication mix which is done through the internet. In the practical part the analyzed company is introduced and after that the contemporary status of its communication mix is being described. Based on the analysis in the end of this thesis the recommendations are given with the aim to retrieve the imperfections and to optimize the communication mix of this company.
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Application of the Theory of Statistics to Controlling Processes
Strašák, Tomáš ; Zichová, Jitka (referee) ; Koch, Roman (advisor)
This dissertation is considered to statistical control of call center. There are suggested a possible description of the center and identify key parameters which influence its performance on the base of measured informations. In this work is describe construction of a call center model which is used for generation specified scenarios of incoming phonecalls. This experimental data are analyzed, main factors which influence its efficienty are determined and principles which realization can be reached given targets are described. Basic attention lead to maximization of benefit and consequetive estimation optimal amount of operators. These principles as same as estimated dependances subserve as decision-making knowledge what amount of operators and theirs expedient combinations is optimal and for estimation of impact to efficiency and call center function in a case of making changes.
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Method of Fixed Assets Financing under the conditions of risk and uncertainty
Vaculová, Lucie ; Čechovský, Jiří (referee) ; Zinecker, Marek (advisor)
Diploma thesis deals with the issue of choosing the right form of financing in the risk and uncertainty conditions - by bank loan or finance leasing. The leasing principle, contemporary condition of the Czech leasing market and the factors influencing the price of the financial leasing are reviewed at first. Then the attention is transfered to bank loans and their diversification. To finish the theorical data I´m featuring the methods of comparing both forms of financing and defining the risks. The aim of diploma thesis is choosing which of two forms of financing is preferable for the enterprise who wants to buy new goods vehicle for its business.
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Optimization of Wage Costs in a selected Organization
Štraitová, Libuše ; Stejskalová, Irena (advisor) ; Hejda, Jan (referee)
The diploma thesis deals with optimization of personal costs, mainly consisting of wage costs in organizations. The thesis is divided into theoretical and practical part. The theoretical part comprises description of individual cost components of personal costs incl. calculation examples and impact on tax deduction. The main aim of this thesis is to characterize procedures and methods of personal costs optimization in companies. Special attention had been paid to procedures and methods of optimization of personal costs that arising in companies focusing on publishing. The practical part deals with analysis of personal costs in the company of Litmedia a.s. and development thereof in the last five years. The results were compared with personal costs in a different undertaking engaged in similar activities. The final part assesses the impact of optimization of overall personal costs on the results of an organization and proposes recommendations on how to increase cost effectiveness while achieving goals of the given company.
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Analysis of Traffic in Turnov
Nováková, Andrea ; Mervart, Michal (advisor) ; Sandleiterová, Lucie (referee)
In this thesis on the theme Analysis of traffic in Turnov I focus on traffic in the environs of Turnov. The greatest attention is given to the public transport. The main objective of this thesis is evaluation of current traffic conditions in Turnov and consequential proposals to improve the situation. In the theoretical part I focus on specification the basic terms I frequently use in this bachelor´s thesis
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