|
Influence of Trigger Point in Acromial Part of Deltoid Muscle on Lateral Humeral Epicondyalgia
Cibulková, Iva ; Vařeková, Jitka (advisor) ; Kyralová, Marie (referee)
Influence of Trigger Point in Acromial Part of Deltoid Muscle on Lateral Humeral Epicondyalgia Objective: The theoretical part brings the anatomical and kinesiological description of humeral joint including the muscles of humeral girdle. It also describes the humeral-scapular rhythm and dynamic stabilization of scapula, i.e. the basic kinematical girdles of the upper arm. The practical part focuses on the occurrence of trigger point (TrP) in the acromial part of the deltoid. Consequently, an examination and evaluation of pain in the area of radial epicondyle was performed both before and after removing TrP by physiotherapy - combined therapy. Method: The experiment was carried out within a group of patients. Patients suffering from radial epicondyalgia were examined by means of combined therapy on Phyaction device and later TrP was removed from the acromial part of the deltoid. The pain was evaluated on a visual analogue scale. The results thus received were processed and used at the conclusion of the work. Results: The presence of TrP in acromial part of the deltoid was confirmed in cases where pain in the area of humeral radial epicondyle had been reported. It was partly confirmed that the intensity of the pain had been significantly lowered in the area of radial epicondyle after removing TrP from...
|
|
Genotypizace ApoE u dětí
Weinfurterová, Radka ; Štaud, František (advisor) ; Nachtigal, Petr (referee)
The purpose of this study was to find out how genotype of apolipoprotein E influences blood levels of LDL cholesterol, HDL cholesterol and triglycerides in children. In our study there was found out that apo E genotype has a significant influence on apo E levels, total cholesterol levels and levels of LDL and HDL cholesterol. Subjects with allele apo E4 had significantly higher levels of LDL cholesterol and subjects who carried allele E2 had conversely lower level of LDL cholesterol. These outcomes corresponded with previously made studies.
|
|
The effect of genetic factors on the pharmacokinetics of drugs
Šlosárková, Petra ; Červený, Lukáš (referee) ; Štaud, František (advisor)
The interindividual differences of activity of biotransformation enzymes play an important role in drug's pharmacokinetics; their are significantly influenced both by external factors (such as age, gender, weight, diet) and genetic disposition. The presence of single nucleotide polymorphisms (SNPs) and mutations at a genes coding drug-metabolising enzymes can cause a major change of the metabolism and drug effects. In this study was evaluated an influence of enzyme CYP2C9 polymorphisms on the pharmacokinetic parameters of Nurofen forte containing racemic mixture of ibuprofen in 20 healthy Czech volunteers (men, Caucasian population, age 21-40 years). The presence of the CYP2C9*1/*1 genotype was found in 17 individuals, the CYP2C9*1/*2 genotype in 2 individuals and the CYP2C9*3/*3 genotype in 1 individual. No statistically significant difference of pharmacokinetic parameters was observed between CYP2C9*1/*1 and CYP2C9*1/*2 genotypes. AUC(0-inf) and t1/2 were higher by 113% and 90%, respectively and clearance was lower by 54% in subject with CYP2C9*3/*3 genotype compared to subjects CYP2C9*1/*1 and CYP2C9*1/*2. The individuals with CYP2C9*3/*3 genotype have increased risk of adverse drug reaction (ulceration, gastroduodenal bleeding) after long time nonsteroidal anti-inflamatory drugs use. The...
|
|
The study of influence inositolhexaphosphate on proliferation and apoptosis in cells isolated out of colorectal cancer
Hašková, Pavlína ; Šimůnek, Tomáš (advisor) ; Rudolf, Emil (referee)
Introduction: Apoptosis - programmed cell death significantly participates in maintaining of tissue homeostasis. Its alteration is leading to cancer disease. Inositolhexaphosphate (IP6) is naturally occurring substance that is present in most legumes, cereals and seems. IP6 and its lower phosphorylated forms are also found in most mammalian cells, where they assist in regulatory a variety of important cellular function (including regulation of cell cycle). Methods: This work has been engaged in the study of influence IP6 on apoptosis in cells isolated out of colorectal cancer by in vitro quantification enzymatic activity of caspase 3 in cell extract. Results: It has proved by the Student's t-test that IP6 statistically significant influence apoptosis in cells isolated out of colorectal cancer.
|
|
ANCA-Associated Vasculitides : Complex Diagnostic Approach
Hrušková, Zdenka ; Posová, Helena (advisor) ; Stříž, Ilja (referee) ; Žák, Aleš (referee)
Objectives: The aim of this study was to assess cellular immunity parameters in patients with ANCA (Anti-Neutrophil Cytoplasmic Autoantibodies)-associated vasculitides (AAV) at different stages of the disease, with different treatment modalities, and with respect to the long-term prognosis of the patients. Methods: We examined 69 patients with AAV, 30 healthy individuals and 20 patients with chronic kidney disease. Using flow cytometry, the following markers were assessed in peripheral blood cells: surface molecules (CD4, CD8, CD3, CD19, CD80, CD86, HLA-DR, CD28, CXCR3, CCR5, CD30 and CRTH2) and intracellular cytokines (interferon gamma (IFN), tumor necrosis factor alpha (TNF), interleukin (IL)-2 and IL-4 in CD3+ T cells and IL-10 and IL-12 in monocytes). Results: Patients with AAV had decreased total number of lymphocytes, CD4+ cells, and CD4+CD45RA+ cells compared to healthy controls (p<0.001). Active patients had increased CD30 and CRTH2 expression (p<0.05). Increased CCR5 expression persisted in remission. Increased HLA-DR expression, expansion of CD28 subpopulation and increased IFN production were noted in remission but not in active disease. Patients in remission who developed a relapse during follow-up had significantly lower IL-10 production than those without relapse (p<0.01). Conclusions: Taken...
|
|
The right to life and the death penalty
Peleška, František ; Kudrna, Jan (referee) ; Suchánek, Radovan (advisor)
114 Right to life and the death penalty - Summary Perhaps no other topic has been subject to so many heated discussions like the topic of my thesis, in which there is a conflict between everyone's fundamental human right, namely the right to life on the one part, and the state's right to impose death penalty on some individuals that have committed a been convicted of certain crimes on the other part. Both advocates for and objectors to death penalty list many arguments for and against the capital punishment. As results from the conclusions I made in my thesis, some of the retentionists' arguments are seriously flawed. I was not able to prove the deterrent effect of death penalty and the related generally preventive function of capital punishment in relation to the most serious crimes. On the contrary, there are many cases where nations that do not have capital punishment in their legal systems have a lower level of the most serious criminality than nations using death penalty. The clear-up rate and the inevitability of punishment have a bigger effect than the harshness of punishment. The argument that the public opinion is significantly in favour of death penalty and thus the abolition of death penalty could result in less trust in the law is also very weak. A high level of support for capital punishment in...
|
|
Parliamentary Elections and the Stock Markets: Evidence from CEE countries
Bláhovec, Tomáš ; Štiková, Radka (advisor) ; Turnovec, František (referee)
The thesis deals with electoral and partisan cycles in stock returns of nine CEE countries and checks consistency of observed cycles with efficient market hypothesis. The evidence mostly supports possibility of political influence on stock markets, but the effects often have opposite sign than hypothesized. Electoral cycle has been found in Estonia and Hungary, while returns in four other countries are significantly lower before elections. Markets more often exhibit left-wing premium, it is significant in the Czech Republic, Lithuania and Romania. The results are similar between nominal and real returns. Both cycles are also considered significant for the panel of countries. Moreover, cycles are hardly explainable by macroeconomic conditions, which indicates market inefficiency. This is confirmed by analysis of volatility, which reveals that risk does not correspond to changes in returns induced by the cycles.
|
|
Analysis of usury legislation
Červenková, Tereza ; Lechner, Tomáš (advisor) ; Jurčík, Radek (referee)
The project analyzes current legislation on usury in the Czech Republic and the financial literacy of the adult population. On 1 Dec. 2016, an amended Act on Consumer Loans entered into force and this project examines it. The project compares Czech legislation on usury with selected European Union countries. Czech legislation is similar with German and Portugal legislation, especially in terms of civil law. The most effective legislation can be considered in Spain, which explicitly stipulates allowed interest rate limits. Based on that, Czech legislation on usury should be adjusted. The research results show a correlation between respondents' highest-achieved level of education and their financial literacy levels. The research also finds that the number of court distraints (property seizures) and the willingness to borrow money is lower among respondents with university-level education than for respondents with secondary and basic school education. When comparing our findings with research by STEM/MARK dating from 2010, it is clear that the financial literacy of the adult population in the Czech Republic has not changed significantly since that time.
|
|
Taxation of income from dependent services in Norway and in Czech republic
Chadraba, Filip ; Sedmihradská, Lucie (advisor) ; Martínková, Lenka (referee)
The reason for making this bachelor thesis for me was interest in finding out in which of the selected countries employees bear more of a tax burden, thus in what country employees have a higher disposable income. I have set an aim to describe theoretically the taxation of income from dependent service in the Norwegian tax system after reform in 2016. Special attention is also dedicated to rights of citizens of the European Economic Area who work in the Kingdom of Norway. Source of information was especially the Norwegian Tax Administration website. In the practical part I have focused on comparing the average tax burden according to OECD methodology in both countries in the current year 2016. The actual calculated results of average tax burden were in addition compared with the average tax burden which were published by the OECD in book called Taxing Wages 2015. Examples also serve as a demonstration of the algorithm for calculating tax in the Czech Republic and the Kingdom of Norway. Calculated results showed that employees, except for one type of household, pay more to the public budget in the Kingdom of Norway than in the Czech Republic. The tax burden of households is significantly affected by child benefit. Households with children have lower average tax burden. Personal income taxes are constructed in each country quite differently. On one hand the Czech tax system prefers tax credits, on the other hand the Norwegian tax system, where is huge redistribution of wealth, prefers deductions.
|
|
Growth of human adipose-derived stem cells on Ti-6Al-4V alloy with various surface modifications
Kročilová, Nikola ; Bačáková, Lucie ; Pařízek, Martin ; Havlíková, Jana ; Motarjemi, H. ; Molitor, M. ; Gabor, R. ; Marvan, J.
Adipose-derived stem cells (ASCs) are of a great importance for bone tissue engineering. We compared ASCs obtained by liposuction under two pressures (-200 mmHg and -700 mmHg). The number and proliferation activity of cells isolated under -700 mmHg (ASC-H) were higher than in cells isolated under -200 mmHg (ASC-L). However, the ASC-L was more active in osteogenic differentiation, as manifested by a higher intensity of fluorescence of alkaline phosphatase and osteocalcin in these cells. The adhesion and growth of ASCs were then studied on Ti-6Al-4V samples either unmodified (K, roughness parameter R-a = 280 nm) or modified by shot blasting and tarnishing A, R-a = 200 nm), vibratory finishing (B, R-a = 100 nm) and vibratory finishing, shot blasting and polishing (C, R-a = 80 nm). All modified samples were more wettable than the K samples. On day 1 after seeding, the size of cell spreading area on some modified samples was lower than on K samples, namely on B samples in ASC-L, on B and C in ASC-H and on A in control MG-63 cells. On day 3, the cell number on some modified samples became higher than on K samples, namely on C samples (ASC-L), on B (ASC-H) and on B and C s (MG-63 cells). On day 7, the numbers of ASC-H and MG-63 cells on all modified samples evened out and became significantly higher than on K samples. On ASC-L samples, the highest cell numbers were obtained on A samples. Thus, all studied modifications of Ti-6Al-4V enhanced growth of ASCs and human osteoblast-like MG-63 cells.
|
guest ::
