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Generalized limits of affine functions
Holub, Aleš ; Spurný, Jiří (advisor) ; Holický, Petr (referee)
We construct a co-analytic filter on the set of finite sequences of natural numbers, which allows us to obtain a strongly affine function of arbitrary Borel class from compact convex subset of locally convex space through single limit process (by this filter) applied to countable system of affine continuous functions. Conversely we show that function obtainted as result of such process is necessarily Borel and strongly affine. Further we generalize this method using metrizable reduction approach for Baire functions on non-metrizable spaces. Last chapter covers similar result for bi-analytic functions on separable metrizable spaces.
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The structure of human being and the possibility of mystical experience. A Thomistic view.
Peroutka, David ; Kohut, Pavel Vojtěch (referee) ; Sousedík, Stanislav (referee)
David Peroutka The structure of human being and the possibility of mystical experience. A Thomistic view In the present investigation I try to explicate the Thomistic concept of soul as a principle of psychosomatic unity of man. Among powers or "potencies" of the soul we find "inner senses" which are to be well differentiated from the intellect. Such a distinction allows us to proof the spirituality of human soul and also to explain the possibility and the nature of spiritual and mystical experience. A paradigmatic testimony of such an experience we find in the writings of S. Teresa of Avila. In order to interpret her spiritual texts we need also well understand the distinction between the sensory appetitive powers, i.e. emotive powers, and the spiritual appetitive power, which is the will. Teresa does not lead us from the sphere of intellect to that of emotionality, as commonly seen, rather in the opposite sense: the center of gravity of spiritual life moves from the sphere of imagination and emotionality to that of the intellect and the will. In the contemplative prayer the will is fixed in the mystery of God through mediation of divinely illuminated intellect. And it is the will that engages, finally, also the sensory part of the soul.
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Childbirth formerly and today
SVOBODOVÁ, Kateřina
This bachelor paper deals with the development of obstetrics since the very beginnings when all connected with birthgiving was tinged with something ``mysterious, empirical{\crqq} up to the present day when obstetrics is grounded on many facts. The care for the birthgiving woman is continuously innovated. First, the birthgiving woman was taken care of by older women of her family who had already given birth to their children and had therefore experience they could pass further. Nowadays it is the midwives who take care of the woman during her delivery. As well as in the past women close to the birthgiving woman the midwives are with the woman and they try to make the delivery easier for her. The development is still progressing but there is still the fact that a delivery is a situation when health is at stake, for both the newborn and the woman. The survey aimed at drawing an outline of the development of the care provided to the birthgiving woman. The methodology of the paper is a semi conducted interview. The first variant of the interview was prepared for woman who gave birth 50 years ago, 20-25 years ago and for woman who gave birth 7 years ago. The second variant was prepared for midwives without the difference of age. When interviewing women having given birth 20-25 years ago I was very surprised by their unified opinion. They agreed on the fact that the care for them and the attitude of the medical personal was inadequate to them. They were very malcontent. Mostly they complain about the first stage, when they had to lie on the bed, mostly with a drip-feeding. On the other hand women having given birth 50 years ago were satisfied with the care they had during their delivery. The greatest satisfaction is however declared by women who gave birth 7 years ago, who consider the medical personnel obliging and regardful. Especially they speak about the possibility of movement which was not allowed to women 20 years ago. The interviews with midwifes confirm that the development in obstetrics is progressing. Midwives who entered their employment after 1990 claim that competencies are increasing while older midwives claim the contrary, they say that at the beginning of their carreer their competences were greater than they are today. However all midwives agree that women nowadays are more informed on delivery than they used to be. Unfortunately, they are sometimes overinformed so that they do not know what to choose. Therefore the midwives recommend prenatal courses organised by the materninty clinic where it is the midwife of the particular clinic who informs women on possibilities and procedures which are recommended and carried out at the clinic. The survey has therefore shown, that the care for birthgiving woman is improving. And women are very satisfied at present.
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Hybrid databases
Hušek, Radek ; Mareš, Martin (advisor) ; Lokoč, Jakub (referee)
This thesis presents design and implementation of a data structure, which tries to combine advantages of both databases and regular data structures. Main advantages of databases we try to retain are data persistence through storing data on a hard disk and working with data using transactions which allows us parallel access without danger of inconsistency. From data structures we borrow the implementation as a library of functions and the aim on simplicity and storing data in memory. Our implementation is built around the concept of (software) transactional memory; all data are stored on hard drive as log of operations. 1
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Receptors of NK cells
Hernychová, Lucie ; Novák, Petr (advisor) ; Pavlů, Barbora (referee)
NK cells play an important role as a part of the innate immune system, they however share many common features with cells of the adaptive immune system and they can modulate their functions as well. NK cells recognize non-self molecules (induced by viral infection or tumor transformation) through a wide variety of receptors on the cell surface. They also express receptors specific for their own structures, MHC glycoproteins. NK cells distinguish infected or transformed cells according to the quantity of these molecules on the target cell surface. Then NK cells allow apoptotic signals to cause cell death or the tolerance is established. They also promote inflammatory responses by the production of cytokines and chemokines. NK receptors can be grouped into activating, inhibitory, adhesion, cytokine, and chemokine receptors depending on their function. Based on interactions with appropriate ligands, NK cells exert cytotoxicity or they are inhibited. Moreover, their functions are influenced by the cytokine microenvironment. NK receptors can be also divided into C-type lectin and immunoglobulin superfamilies according to the structure. Ly49, NKG2/CD94 and NKR-P1 are receptor families that belong to the C-type lectin glycoproteins. These molecules have a type II transmembrane protein orientation and they...
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Evidence (disclosure) in civil proceedings
Trojan, Tomáš ; Macková, Alena (advisor) ; Pohl, Tomáš (referee)
As a topic of my thesis I chose one of the fundamental topics of the civil procedure, because in the evidence in civil proceedings the court gets the grounds for a fair decision in the matter. Although it may seem classical, the topic is still very important because of modern trends and frequent amendments of the Civil Procedure Code. The issues related to evidence procedure are not only interesting, but also essential for practice, because the final judgment relies upon various pleadings of the parties and activity of the court. Due to its extent and significance, the topic cannot be fully covered by one thesis, and thus during elaboration of the thesis I divided it in two sections. The first section examines the general problems connected with evidence in civil proceedings and the second section deals with selected issues of evidence in civil proceedings, respective burdens and phases of the evidence procedure. In the first section I tried to define the term evidence and the subject of the evidence by finding what does and what does not belong therein. This section also addresses identical statements of the parties. Further I focused on institutes that facilitate the evidence in civil proceedings. Among these I examined legal fictions which allow to bring in a decision even where some statements...
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Morphological feattures of ice wedge polygons in arctic zone.
Kysilka, Tomáš ; Křížek, Marek (advisor) ; Treml, Václav (referee)
Morphological features of ice wedge polygons in arctic zone Abstract This bachelor thesis deals with the subject of ice-wedge polygons including theirs morphological characteristics and conditions prerequisite for their creation. The paper states the conditions which allow and inhibit frost cracking of the ground. First part presents the conclusions of scientific literature published on the topic of permafrost, frost cracking, ice- wedges and ice-wedge polygons. Consequently the paper discusses the relation of ice-wedge polygons morphology to climate and lithology. Further the thesis analyzes morphological characteristics of ice-wedge polygonal net localized at southwest part of Banks Island, Canadian Arctic Archipelago. Acquired data and conclusions are confronted with published periglacial literature. Keywords: ice-wedge, ice-wedge polygons, frost cracking, permafrost, Banks Island, arctic zone
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The value of neurohormonal activation assessment for treatment monitoring in congestive heart failure
Kubánek, Miloš ; Málek, Ivan (advisor) ; Špinarová, Lenka (referee) ; Pudil, Radek (referee)
Summary: Congestive heart failure (CHF) is associated with neurohormonal activation (NHA) which contributes to further progression of disease. Measurement of NHA has been used for diagnosis and prognostic stratification in CHF. Aims: The aim of this academic disertation was to analyze the value of NHA for treatment monitoring in CHF. We studied the relationship between NHA and pulmonary hypertension in compensated CHF using B-type natriuretic peptide (BNP) and big endothelin-1 (big ET-1). The rationale was to minimize repeated right heart catheterizations in candidates for orthotopic heart transplantation. A similar design had the second clinical study which used N-terminal pro-B- type natriuretic peptide (NT-proBNP) as a marker of NHA. In the third clinical study, we evaluated whether basal levels and/or change in NHA during treatment predict clinical efficacy of cardiac resynchronization therapy (CRT). We supposed that BNP and big ET-1 might be better predictors of outcome than standard methods of follow-up. Results: 1. Natriuretic peptides correlated with hemodynamic parameters better than big ET-1. An isolated measurement of BNP or NT-proBNP did not allow a reliable assessment of pulmonary hypertension or left ventricular filling pressure, respectively. On the other hand, serial evaluation of...
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External rating and validation
Lapešová, Michaela ; Pečená, Magda (advisor) ; Horváth, Roman (referee)
The growing importance of external rating may draw increased attention to the reliability of credit risk evaluation. The aim of this thesis is to analyze a contemporary external rating position as an instrument for evaluation of a subject's ability to meet its obligations. The study provides theoretical foundations of credit risk modeling as well as empirical application to a collected data set. For the sake of validation of a selected rating system a simple default study is presented on the basis of this data set. Limited information allows just for a brief survey of short rating history in the Czech Republic. The world rating history is comprehensive and it becomes an integral part of clients' creditworthiness assessment within the New Basel Capital Accord. With its growing importance the rating has been recently facing criticism. The thesis focuses mainly on the comments on the cyclical tendencies of rating and provides and empirical analysis using data from Visegrad group countries. Powered by TCPDF (www.tcpdf.org)
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Evaluation of activity of potentional antifungal substances through the use of microdilution broth method I.
Nitraiová, Jindřiška ; Paterová, Pavla (referee) ; Vejsová, Marcela (advisor)
1. Abstract Jindřiška Nitraiová Evaluation of activity of potentional antifungal substances through the use of microdilution broth method I Diplomová práce Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové Farmacie The aim of the thesis was a screening of activity of new potentional antifungal substances. For testing of substances was used the microdilution broth method. This method allows a routine assesment of MIC of a larger amount of antimycotics and also complete strains. The compounds for the strains Candida albicans, C. tropicalis, C. glabrata, C. krusei, Trichosporon beigelii, Aspergillus fumigatus, Absidia corymbifera a Trichophyton mentagrophytes were tested. The derivates of pyrazinedicarbamide, pyrazinedicarbothioamide, pyrazole-1- carboxylate, hydrazinecarboxylate, diazene-1,2-dicarboxamide and cyclohexanone did not show any antimycotic effectiveness. On the contrary the derivates of benzamide and benzenecarbothioamide showed a good antimycotic activity against all the testing strains. In the group of other substances, it means the derivates of pyrazinecarboxamide, pyrazinecarbothioamide, pyrazine-anilides, pyrazine-2-amine, pyrazine-2-carbohydrazide and pyrazine-2,5-dicarbonitrile and thiazolidine-4-one, some substances were effective but some had no effect. The derivates of...
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