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Selected Methods of Mortality Analysis Focused on Adults and the Oldest Age-groups
Hulíková Tesárková, Klára
Selected methods of mortality analysis focused on adults and the oldest age-groups Abstract Questions about human life span, longevity and mortality in general are natural to almost everyone. This Doctoral Thesis deals with one central question - whether some limit of human life span or of its improvements exists. It is rather a methodological work, therefore its aim is to introduce not only relevant theories but above all the methods usable in the mortality analysis focused on adults or the oldest-old. At the beginning the most important theories and opinions of scientist dealing with mortality are introduced. In the first half of the analytical part mainly the traditional and basic approaches are included. The theme of life tables is opened by an analysis of its construction in the Czech Republic, together with its possible modifications. As a result the independent macro code for the SAS software is attached in the electronic Appendix. This macro enables to calculate the unknown parameters of selected mortality laws by the method of weighted non-linear least squares and to produce the smoothed and extrapolated values of mortality rates. Using the individual life durations, life tables according to education attainment were constructed (also attached in the electronic Appendix). In the second half of the...
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Structure and dynamics of electronic defects in liquid water
Maršálek, Ondřej ; Jungwirth, Pavel (advisor) ; Horáček, Jiří (referee) ; Pittner, Jiří (referee)
Title: Structure and dynamics of electronic defects in liquid water Author: Ondřej Maršálek Institute: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic Supervisor: prof. Mgr. Pavel Jungwirth, DSc. Supervisor's e-mail address: pavel.jungwirth@uochb.cas.cz Abstract: In this thesis we present ab inito molecular dynamics simulations of two different electronic defects in water. Photoionization of liquid water produces a cationic hole, which undergoes ultrafast dynamics and forms the hydrated proton and the hydroxyl radical as its products. We study both the dynamics and spectroscopy of this process. The hydrated electron is a key intermediate in radiation chemistry of aqueous systems. We simulate its equilibrium properties in anionic water clusters as well as the dynamics of vertical electron attachment to cold and warm clusters. The hydrated electron reacts with a hydrated proton to form a hydrogen atom. We examine this reaction at a finite temperature in a larger cluster as well as in more detail in a smaller cluster. Because both of the electronic defects studied here are challenging open-shell species, we put emphasis on benchmarking and testing our computational setup. Six published articles are attached to the thesis. Keywords: density functional theory,...
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The effect of prenatal MA exposure and crossfostering on functional changes in laboratory rat
Hrubá, Lenka ; Šlamberová, Romana (advisor) ; Tejkalová, Hana Barbora (referee) ; Šulcová, Alexandra (referee)
The aim of our study was to investigate the impact of prenatal methamphetamine (MA) exposure and cross-fostering on development of rat pups during preweaning period and on behavior, anxiety, cognitive function and nociception in adulthood. Mothers were daily exposed to injection of MA (5 mg/kg) or saline (S) approximately for 9 weeks: three weeks prior to impregnation, throughout the entire gestation period and for 23 days of lactation. Control females (C) did not receive any injection. On postnatal day (PD) 1, pups were cross-fostered so that each mother received some of her own and some of the pups of mother with the other two treatments. We obtained 9 experimental groups (C/C, C/S, C/MA, S/C, S/S, S/MA, MA/C, MA/S, MA/MA). Pups were tested during postnatal development by means of following behavioral tests: negative geotaxis, tail pull, righting reflex on surface and in mid-air, rotarod and bar-holding and were examined for physiological maturation. In adulthood, males and females rats were tested in the Open field (OF) and in the Elevated plus maze (EPM) for behavior and anxiety and in the Plantar test for thermal nociception. Adult male rats were tested on cognitive function in the Morris water maze (MWM). In adult female rats, phases of the estrous cycle were recognized and compared. Our...
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Formation of runoff from snow cover in the Otava River headstream area
Pospíšil, Jan ; Jeníček, Michal (referee) ; Kocum, Jan (advisor)
Diploma thesis solves the snow hydrology issue applied to model catchments of Rokytka and Ptačí Brook situated in central part of Šumava mountains, concretely in the upper Otava River basin representing the source area of extreme runoff episodes formation. Results of snow cover field surveyfrom 2007/2008 and 2008/2009 winter periods are presented. Their main goal was to describe the spatial variability of snow cover characteristics and its spatial distribution by means of GIS software and to enable an estimation precising of water reserves retained in snow. Outcomes are confronted with the snow melting analysis, with hourly and daily air temperatures and with detailed analysis of snow cover vertical profile that is important for consecutive runoff modelling during spring period using Degree-Day method. Powered by TCPDF (www.tcpdf.org)
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Opensource solution for small ISP
Vomáčko, Vít ; Palovský, Radomír (advisor) ; Pavlíček, Luboš (referee)
Focus of this work is to create a comprehensive look at open source solutions to enable small companies to make up their ISP routing infrastructure. Aims to explore the available alternatives for routing software and related services. Then describe the important features and characteristics which are taken from real operation of such a solution and analyze it in parts. Shows how to modify other standard Linux distribution to offer the necessary functionality. Describes the security mechanisms to prevent its further spread of the complexity of the system and degrade its performance. Outlining how to address the monitoring infrastructure as well as running services it provides to customers. It also tries to show which areas are not sufficiently operational and offers suggestions for further work in developing such a solution. Working mainly draws on the experience gained from long-term effort to launch the best solution, but do not tie the hands of its creators and allow colleagues to avoid various failures and shutdowns.
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HPLC Method Development for Determination of Vitamin E in Geladrink Preparation
Švestková, Petra ; Chocholouš, Petr (referee) ; Šatínský, Dalibor (advisor)
A HPLC method was developed for the determination of content of vitamine E acetate in preparation Geladrink Forte pulverized drink - pineapple. The method is based on using Chromolith Performance RP-18e column (100 x 4.6 mm) and UV detection at 290 nm. The vitamine E acetate was separated in the presence of internal standard tocol from ballast matrix. It was used isocratic elution of the mobile phase methanol:water (98:2) at a flow-rate of 1.5 ml/min. There was temperature 30 řC during the measurement. The system enabled successful separation in time less than 5 min. The retention time of tocol was 2.337 min and the retention time of vitamine E acetate was 4.271 min. The chromatographic resolution between tocol and vitamine E acetate was 7.515. The method was applied to analysis of vitamine E acetate in preparation Chondrotin - MSM 2600. Developed concentrations of vitamine E acetate were re-count on content of vitamine E that the producer declared. Keywords: vitamine E acetate, HPLC, Geladrink, Chondrotin - MSM 2600
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HPLC Method for Determination of Lamotrigine and Related Substances in Tablets
Foltinská, Blanka ; Kastner, Petr (advisor) ; Sochor, Jaroslav (referee)
HPLC method for determination of lamotrigine and related substances in tablets Rigorous thesis Mgr. Blanka Foltinská Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Drug Control The method for determination of purity and stability of lamotrigine was optimized. Lamotrigine was exposed to such conditions to reach its degradation into degradation products which are also possible impurities of lamotrigine. Several chromatography columns were tested and the composition of mobile phase was optimized. Chromatography column Waters Spherisorb 5 µm Phenyl, 4,6 x 250mm was chosen and mobile phase containing acetonitril : phosphate buffer ( 1,4 g K2HPO4 /l) 35:65, final pH of the mobile phase was adjusted to 6.0 by orthophosphoric acid. Flow rate was 1 ml/min, injected volume 20 µl, column temperature 25žC and UV detection at 309 nm. Linearity of this method was tested under these conditions. This method was worked up to enable its using in determination of content of lamotrigine and related substances in tablets containing lamotrigine. Validation parameters of this method were tested.
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HPLC method development for determination of active compounds in Arpalit preparation.
Švestková, Petra ; Šatínský, Dalibor (advisor) ; Pospíšilová, Marie (referee)
A HPLC method was developed for the separation and determination of the substances fenoxycarb and permethrin. The method is based on using HS F5 column (10 x 4 mm, 3 μm particle) and UV detection at 225 nm. The compounds were separated using isocratic elution of the mobile phase acetonitril - water (65:35) at a flow-rate of 1,0 ml/min. There was temperature 70 řC during the measurement. The system enabled successful separation of both compounds in time less than 5 min. The retention time of fenoxycarb was 1,53 min and the retention time of permethrin was 3,68 min. The chromatographic resolution between both compounds was 11,012. The method was applied to analysis of the active substances fenoxycarb and permethrin in veterinary preparations Arpalit® Neo mechanical spray, Arpalit® Neo spray a Arpalit® Neo foam. Developed method was compared with the method available on Department of Analytical Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University in Prague (HPLC, Chromolith Performance RP-18, 100 x 4,6 mm, gradient elution of mobil phase acetonitril + water/acetonitril (60:40), flow rate 1,0 ml/min, temperature 30 řC, analysis time 11 min). Keywords: fenoxycarb, permethrin, HPLC
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Age of the swimmers in the Master Championships in finswimming between 20002-2008
Prokšová, Barbora ; Čechovská, Irena (referee) ; Pokorná, Jitka (advisor)
Title: Age of the swimmers in the Master Championships in finswimming between 2002 - 2008. Objective of the thesis: The objective of the thesis is to state the age structure of finswimmers in the World Championships between 2002 - 2008, in surface finswimming, Apnea, Immersion, and open water finswimming. Method: Basic statistical method was used to assess the data. Via the computer data process, the list of the actual representation of age categories amongst the finswimmers in the championships between 2002 - 2008 in all swimming events was acquired. Results: Submited work records are showing the list of age categories amongst the finswimmers in the championships in all swimming events of male and female between 2002 - 2008. Key words: age of swimmers, sport training, sport efficacy, sport-diving.
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Purpose and rationality in the theory of action: Max Weber, Talcott Parsons and an outline of an alternative
Horák, Vít ; Balon, Jan (advisor) ; Urban, Jan (referee)
Submitted thesis examines the role of the notion of end (purpose) in the theory of action and how reaching an end can be considered as rational. Underlying motive is an intuition of the Frankfurt school that identified modern society as irationally rational. By supplementing the notion of end with a dimension of its latitude - the spectrum of possibilities that are open for an action - I try to diferentiate it and enable a multi-dimensional conception of purposeful action in which creative and reactive aspects of an action can be separated. Inside this conception I try to make the abovementioned oxymóron intelligible without relying on moral maxims to which would be the action subordinated. To the this goal I progress from a discussion of the hermeneutical metatheoretical principles through a critical analysis of Weber's and Parsons' theory of action. I go through Weber's concept of understanding (verstehende) sociology, the question of access into the perspective of others, the notion of meaning (purpose), end, and rationality and Parsons' discussion of the possibilitties of analytical theory in sociology and the concept of "unit act".
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