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Administrative transgressions against the safety and smooth traffic flow on highways
Sárová, Lenka ; Prášková, Helena (advisor) ; Kopecký, Martin (referee)
The presented thesis refers to the administrative transgressions against the safety and smooth traffic flow on highways. This is very actual topic currently, because everybody meets with these administrative transgressions in his life. The thesis is composed of seven chapters. The first chapter introduce us with the history of legislation in the period from the formation of the Czechoslovak republic in 1918 to the presence. The following chapter describes relevant legislation. This chapter contains general regulation of liability for transgressions, as well as discusses the constituent elements of transgressions and ends with characteristic of the constituent elements defined by the Law of highway traffic. In the third chapter, I focused on the comparison of transgressions and crimes. First I compared the general arrangement for liability for crimes and transgressions. Furthermore, I have listed which crimes could be committed in connection with the highway traffic, and then I looked on, in my opinion, mostly committed crimes. The fourth chapter deals with the sanctions that may be imposed for transgressions. The rules on penalties are prescribed by Law of transgressions; the specific amount of sanctions is set by the Law of highway traffic. The administrative transgressions against the safety and smooth...
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Genetic interactions of PRP45 mutantion in S. cerevisiae
Valentová, Anna
Human SKIP/NcoA-62/SNW1 ortholog proteins are nuclear factors which have been found in connection with the regulation of gene expression and subsequent modifications of primary transcripts. Human representative SKIP acts primarily as a transcription factor during the processes involving differentiation, carcinogenesis and other cellular signaling. It operates in the signaling pathways, eg TGFß/Smad, E2F/pRb, Notch/CBF1 and nuclear hormone receptors. SKIP protein is also essential for pre-mRNA splicing and recently its contribution during the elongation phase of RNA polymerase II transcription and contribution to some HIV genes alternative transcripts formation has been identified. The ortholog of S. cerevisiae FUN2O/Prp45 has been shown to participate in pre-mRNA splicing, others processes mentioned have not yet been associated with the function of this factor. Pre-mRNA splicing is a complicated process leading to the formation of native mRNA lacking non-coding regions, introns. In terms of composition of the spliceosome subunits and biochemical principle of its function is this process very well described but despite this knowledge the specific roles of most splicing factors are not known. For Prp45 protein direct interaction partners were identified; these partners derive some of their possible role in...
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Revitalization of Area Afflicted by Mining Shown on Ore Mountains Base Region Example
Svobodová, Eva ; Postránecký, Josef (advisor) ; Šrýtr, Josef (referee)
The thesis consists of several parts. The first one presents basic characteristics of the Usti Region emphasizing its weaknesses and strengths. Interregional and nationwide comparison is used for some indicators. The second part is devoted to mining as the industrial activity so typical for the Usti Region. Here, milestones of the region's mining history and the current operation of mining companies in the region are described, and major mining sites listed and briefly presented. The third part deals with explanation of the term of "restoration, existence of various forms of restoration, their financing or basic documents for them, and importance of post-mining revitalisation in the territory. The final part is devoted to application of revitalisation in the Usti Region. The objective of the thesis is to identify the overall economic cost for restoring the territory affected by mining in its maximum variant - complete exploitation of all the soft coal deposits occurring in the Usti Region territory.
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Communication strategies in the company
Radil, Lukáš ; Říhová, Zora (advisor) ; Ošmera, Jiří (referee)
Application-oriented work on the theme "Communication strategies in the company" is solving problems with corporate communications solution in companies. It is a reaction to the ever-present poor and nonconceptual marketing communication whether it's a small or large firm. The aim of this work is to provide an overview of communication tools and to show on concrete company, that for the formation of functional integrated commercial communication is not always required expensive advertising agency. The theoretical section summarizes the essence of communication strategy and business planning process with emphasis on the concept of IMC - integrated marketing communications followed by a list of commercial communication tools, including brief description and examples from practice. Detail is given to new trends in marketing and the issue of online marketing and use of social networks. In the practical part, the goal is to propose communication strategy for newly founded agency. First step is a detailed analysis of the position, target audience and competition. Then I establish a communication strategy corresponding with business goals and results of analysis. After that, appropriate communication tools are identified and design of use is outlined. In the end I also establish benchmarks for success assessment, timetable and estimated budget for implementation of the proposed strategy.
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Horsce racing and Czech society (for example the course in Pardubice, Velká Chuchle and in Napajedla stud)
Votavová, Šárka ; Pokorná, Magdaléna (advisor) ; Hlavačka, Milan (referee)
The abstract The present work deals with the circumstances and the course of racing in Bohemia since the 70 the 19th the 20th century the 20 century. The work is divided into three parts, the first of which deals with the emergence of the Pardubice racecourse, the second is devoted to the racetrack in the United Chuchle and the last focuses on Napajedla Stud. Each chapter is written the history of the body and the subsequent derivation of the social context as was the fashion, the status of women in racing, the creation of new jobs or the formation of a new type of man. The main goal of the work is to uncover racing sport as a social phenomenon but also a conglomerate of institutions that cannot be separated. Without Stud in Napajedla would hardly ensure a supply of quality horses and without the Great Pardubice and its traditions through the nobility would be difficult to create a racecourse in Great Chuchle. The work is not focused on one-sided description of the races, but understanding the issue overall. Many works dealing with the environment ignores the coherence races, and social aspects of this sport. In the examples of fashion, organizing auctions or race meeting as shown on the one hand were the elite races and issues on the other hand, created new space for entertainment and for entrepreneurs.
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Cloning, expression and characterization of recombinant growth factors
Svoboda, Ondřej ; Živný, Jan (referee) ; Bartůněk, Petr (advisor)
Cloning, expression and characterization of recombinant growth factors The role of growth factors and cytokines to regulate a variety of biological processes is ever increasing. Many studies have illustrated that this diverse group of proteins are capable of stimulating cellular growth, proliferation, survival, and cellular differentiation. This thesis mainly focuses on the cytokine interleukin-6 and its specific receptor (IL-6R). The IL-6R protein has been shown to exist as both a membrane-bound and soluble form. The soluble form of IL-6R (sIL-6R) signals via a mechanism called "transsignaling" that involves the receptor associating extracellularly with its ligand IL-6 to generate an IL-6/sIL- 6R agonistic complex. This complex subsequently binds directly to another IL-6 receptor, gp130 that in turn activates it to augment a specific response. It is known that the formation of the IL-6/sIL-6R complex can be greatly enhanced by converting it into a single molecule, called Hyper-IL-6. This fusion protein consists of a sIL- 6R located at the N-terminus and IL-6 at the C-terminus separated by a flexible linker sequence. It was more than ten years since human Hyper-IL-6 was first described and since then, this molecule has proven to be an ...
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Comparison of non-commercial CASE tools for UML modelling
Janoušková, Irena ; Pavlíčková, Jarmila (advisor) ; Buchalcevová, Alena (referee)
Subject of this bachelor thesis is comparison of non-commercial tools for UML modeling. The opening chapter is followed by brief description of the UML language in the second chapter. The fundamental mechanisms of the language and mainly the description of all the diagrams we are able to create by the help of UML are introduced here. Software development metodologies and their importance in the modeling process are also mentioned. Third chapter focuses on characteristics and classification of all CASE tools. General description of CASE tools is followed by the list of the best known UML modeling tools, both commercial and non-commercial. A description of four selected commercial products and their features is also added for illustration. Further in this chapter, you can find a list of several non-commercial applications for UML modeling. Seven of them are chosen for evaluation and comparison. Fourth chapter focuses on the multicriteria evaluation of alternatives and presents the methods used in this thesis. In this chapter we can also find the description of chosen criteria and subcriteria and determination of their weights. The fifth chapter aims at evaluation of the selected tools according to the chosen criteria. Calculated criteria values and overall evaluation according to the chosen multicriteria evaluation of alternatives method is presented in the sixth chapter. Results are listed in lucid table format. Tools are ordered by both the overall result and results of particular criteria, so that the reader can perceive the advantages and disadvantages of the evaluated products. In the epilogue I ruminate over the results and their explanatory value.
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Primary preventive care in orofacial clefts
Kaněrová, Hana ; Dušková, Markéta (advisor)
Facial clefts are among the most common congenital defects. Their incidence ranges 1 to 500 to 550 births. The etiological factors are diverse. Most often the formation of clefts cause genetic factors together with environmental factors. Among the genetic factors include the child's sex and genetic predisposition. It discovered several candidate genes that influence the development of orofacial complex. These genes are e.g. TGFα, RARA, BCl3, DLX2, MSX1, TGFB3. Environmental factors are maternal obesity, maternal smoking, alcohol consumption, alcohol, nutritional status of the mother, hypervitaminosis A, folic acid deficiency, effects of pollutants in the workplace and environment, medication teratogenic active drugs, maternal infection, hyperthermia, exposure to ionizing radiation and the effects of stress. The mechanism of the increased risk of defects in maternal obesity may be unknown diabetes with hyperglycemia and hyperinsulinismem, hyperestronismus a lack of folic acid, which is needed in obese women increased. Studies on the influence of maternal smoking on the formation of clefts are not consistent in their results. Alcohol consumption has been repeatedly shown to be a risk while no correlation was found to dose. Increased incidence is evident under fetal alcohol syndrome. The quality of maternal...
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New Perspective on the Role of Gravity Waves in the Stratospheric Dynamics and Variability
Šácha, Petr ; Pišoft, Petr (advisor) ; Dameris, Martin (referee) ; Rieder, Harald (referee)
This thesis is concerned with the role of internal gravity waves (IGWs) in the stratospheric dynamics and variability demonstrating the effect of spatiotemporal distribution of their activity on the stratospheric dynamics and transport. The first part introduces a theoretical overview of the most recent as well as classical approaches used for description of the wave-mean interaction in the middle atmosphere. Methodology for an IGW analysis from the GPS radio occultation density data is described in the next chapter and the advantages of utilization of density data are listed. The third chapter presents results describing the peculiar dynamics and anomalous IGW activity in the Eastern Asia/Northern Pacific region. An important part is dedicated to a discussion of accuracy limits and usability of different IGW activity proxies. The possible impact of the localized IGW activity is investigated using a mechanistic middle and upper atmosphere model in the last chapter. Sensitivity simulations are used to demonstrate an important role of the spatial distribution of IGW activity for a formation of planetary waves and for the longitudinal variability of the Brewer-Dobson circulation. Implications for the middle atmospheric and climate change research are discussed along with consequences for parameterizations of...
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SW processing of audio formats
Chotětický, Martin ; Šimek, Pavel (advisor) ; Vasilenko, Alexandr (referee)
Bachelor thesis has an imminent focus on detailed analysis of audio processing software and their evaluation. The main goal of this work is to compare four most popular programmes used on daily basis in recording studios, which is precisely described in the theoretical part. Secondly, a brief historical development of audio processing software and a detailed list of avaible products on the market are listed. Practical part represents an analysis of convenient product purchase for start-up recording companies. Every single software is evaluaded including its pros and cons.
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