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Incidence of a brain structural abnormities (CT, NMR) in patients with affective disorder
Fürst, Daniel ; Kopeček, Miloslav (advisor)
Currently we are experiencing a boom imaging methods. We are constantly improving their accessibility, their distinctive abilities and the possibility of using both in research and in clinical practice. They penetrate well into psychiatry, where he tries as well as in other fields to shed light etiology of diseases contribute to their diagnosis and treatment. The cost of are large, the cost of execution of each test is different, can Thus burden on public budgets in different ways, so it is necessary to were determined and the proper indications. What is the significance of these methods in determine the incidence of brain structural abnormalities in patients with affective disorder and the implications of the findings for these abnormalities alone patients, the aim of the present study.
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International Terrorism in the context of Contemporary Mass Media
Midulová, Katarína ; Druláková, Radka (advisor) ; Rolenc, Jan Martin (referee)
The aim of the Master's thesis is to analyze the phenomenon of international terrorism as a process of communication which exploits the pattern of contemporary mass media. The thesis will result in a practical application of findings of this analysis on chosen recent terrorist attacks. It will mainly focus on evaluating whether the patterns of terrorism as striving for publicity are still present and if/how they have changed with the arrival of web-based communication. First chapter of the thesis is dedicated to defining and framing terrorism. It also gives a brief insight to historical roots of a terrorist's need for attention. Second chapter introduces mass media as a theoretical concept and as a tool in the communication strategy of a terrorist. The final chapter examines chosen attacks in years 2010 and 2011 through the prism of media-centered strategy. It shows almost no changes in the strategy, however, there is a solid evidence for a terrorists' ability to take advantage of the Internet as a mean to enhance the effect of their activity, e.g. recruitment of adherents, resource of information, and spreading messages.
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A comparison of two different routes of administration of L-carninite on antiacetylcholinesterase activity of 7-methoxytacrine.
Novotná, Petra ; Vopršalová, Marie (referee) ; Herink, Josef (advisor)
The aim of this work was to test the ability of L-carnitine (KAR) to increase the permeation of indirect parasympatomimetic 7-methoxytacrine (MEOTA) through the blood-brain barrier. The monitoring of acetylcholinesterase activity (AChE) in the parts of the brain chosen served as index of changes presumed. All experiments were performed in laboratory rats, drugs tested were given systematically. The modificated Ellman's method was used for the determination of the AChE activity. The principle of this method is based on hydrolysis of thiocholin. The prior administration KAR to MEOTA augmented the inhibition of AChE more in the frontal cortex, septum and basal ganglias and less in the hipocampus. Intraperitoneal administration of KAR was somewhat stronger in comparison with peroral one. The results obtained confirmed the hypothesis of augmentation of MEOTA AChE activity by means of previous KAR administration.
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Bioactive peptides as a component of anti-aging cosmetics
Jatzová, Katarína ; Obruča, Stanislav (referee) ; Muthný,, Tomáš (advisor)
Ageing is a natural part of every human life cycle. During ageing there are lots of changes in the organism. One of the main pillars of the cosmetics industry is the development of active compounds that are fighting signs of skin ageing. The components as bioactive peptides are considered to be promising anti-ageing products, mainly because of the possibility to precisely define their chemical structure and therefore achieve more effective biological targeting. One of the signs of skin ageing is the weakening of the connections between epidermal cells and the extracellular matrix, decreasing expression of adhesion molecules and molecular components of dermo-epidermal connection. The most abundant adhesive receptors in the skin are integrins. Their ligands are extracellular matrix molecules, e. g. laminin or fibronectin. The minimal recognition sequence of integrins receptors is the amino acid motif arginine- glycine- aspartic acid (RGD). This sequence is also very interesting in terms of cosmetic applications because it provides the ability to create new and effective bioactive peptides. The subject of present work is basic safety testing of four peptides with RGD motif. A sequence of three peptides was modified by addition of glycine amino acids, or alanine. The expected effect was to improve interaction with integrin receptors. In each of the sample, levels of endotoxin was determined in order to exclude any possible interfering effects on the viability of cells. Subsequently, in NIH3T3 mouse fibroblasts viability was monitored by MTT assay and morphology. The quantity of obtained protein had been determined to increase data interpretation relevance.
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System of employees evaluation in the company ELTODO EG, a.s.
Kovalčuková, Lenka ; Němec, Otakar (advisor) ; Pulchartová, Naďa (referee)
This graduation theses is about creation and implementing the system of employees evaluation in the company ELTODO EG, a.s. At first the analysis of working stations was done. The results of the analysis were job descriptions and role specifications. And then the competence model of the company was done. Further we had to specify the aims, areas and criteria of evaluation. We also had to choose available methods and create the evaluation form. The substance of this system is the evaluation interview. This interview serves for appreciation of the job performance and the competence of employees and for determination of their performance and developing aims. At the end of this theses the methodology of evaluation was created. This methodology contains the important information about persons and term of evaluation.
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Marketing Strategy of a Newly Established Company
Slámová, Pavla ; Pospíšilová, Vendula (referee) ; Chalupský, Vladimír (advisor)
The main objective of the thesis is to work on a marketing strategy intended for a newly established private charter company. The general principles, marketing concept and strategy layout applied to the company in question are elaborated on. The primary objective is to conduct the analysis of both external and internal environment terms, to conduct a competitor analysis and to deduce the market potential for the particular market area. The next objective is then to identify the client and their requirements, to select the target of the client demand as well as to compare the client demands with the company potential supply. Based on the market survey, the marketing goals are specified and executable strategies are presented. The marketing strategy includes a future profit prediction based on the defined goals and a proposal for verification activities for a parallel plan-keeping control. In general, the aim of the present thesis is to create a marketing strategy that would be integrated in the company management and its business activities.
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Managerial skills
Štěpánková, Pavlína ; Kříž, Josef (advisor) ; Zdeněk, Zdeněk (referee)
Nowadays we meet managers in the vast majority of businesses. They are the major representatives of different companies, because on their shoulders carries a large part of the responsibilities associated with running the company. On the managerial competence and skills are therefore kept high demands.
Explanation of basic concepts related to management and managers is mentioned in first, theoretical part of this thesis. Simultaneously this section attempts to answer the question, what the ideal manager should be. Therefore this part of thesis is focused on the personality of the manager, his skills, roles, functions, competencies and abilities.
The second part deals with the practical application of acquired knowledge to the company Lazne Belohrad Inc. The company is briefly described in terms of historical and contemporary developments. Based on the survey managerial skills of staff, managers of middle management are analysed. Based on the research it was investigated the interconnection of hard skills and soft skills. At the same time there were suggested possible ways of improving and developing managerial skills.
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Modular authoring environment for creating digital learning objects
Kasálek, Jindřich ; Štípek, Jiří (advisor) ; Jeřábek, Tomáš (referee)
This Bachelor thesis deals with the problems of using digital learning objects (DLO) and affiliated applications in context with the use in practice by the teachers themselves. The thesis focuses on creating suitable DLO, which will suit both pedagogical demands and requirements of teachers from the demands of the competence views for ICT. The first part of the thesis deals with the theoretical assumptions, which are necessary to set the right targets and procedures to reach them. The second part deals with searching for the problematic points and proposals of the countermeasures, and their realizations.
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An innovation audit as a tool of improvement of innovation efficiency of organization
Jakúbek, Marek ; Špaček, Miroslav (advisor) ; Kubovský, Josef (referee)
The ability of an organization to innovate, creates one of the most sufficient standards to keep the competitive position and ensure further growth. There exists a well-founded assumption that small and middle sized companies do not pay enough attention to innovation management. The thesis investigates a process called an innovation audit - it is a tool used for evaluation of innovation management and its current state in a company called Memsource a.s. The goal of the thesis is by using innovation audit to identify strengths and weaknesses of all spheres that affect innovations and also suggest efficient improvements in all areas related to innovative management in Memsource a.s. The results of a process of the innovation audit provides us with a whole scheme of a truthful and profound situation concerning innovation management of the company. The suggestions were made in order to enhance innovation efficiency of the company.
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