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Glycophenotype of the Epidermis under Physiological and Pathological Conditions
Lacina, Lukáš ; Smetana, Karel (advisor) ; Zámečník, Josef (referee) ; Arenberger, Petr (referee)
Galectins-1,-3 and -7 are expressed in human epidermis. Galectin-1 and his binding sites are expressed there in the nuclei of cells which are closely related to or are identical with the stem cell population. Expression pattern of galectin-3 is differentiation-dependent in tissue as well as in vitro. Binding sites for this galectin are present in the similar manner. Expression of galectin-7 is not observed in differentiation-dependent manner. Binding sites for this member of galectins family were never observed in the epidermis. Galectin-2 is expressed in the nuclei of fibroblast under stress conditions. Expression of observed galectins and their binding sites in basal cell carcinoma and in psoriatic plaque refers to the differentiation level. We emphasize the lack of galectin-7 and binding sites for galectin-3 in basal cell carcinoma epithelium. Highly typical is abundant presence of galectin-1 in the stroma of basal cell carcinoma and in dermis of psoriatic plaque. We have also observed the dependence of galectin-7 expression on differentiation of squamous cell carcinoma. This relationship has no correlation to the survival of patients. The biological activity of stromal fibroblast toward to normal keratinocytes resulting in induction of "cancer-like" phenotype is the highlight of this study.
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The principles of modelled training in tennis game
Čihák, Jan ; Hošek, Václav (advisor) ; Kočíb, Tomáš (referee)
BIBLIOGRAFICAL IDENTIFICATION Title of thesis: THE PRINCIPLES OF MODELLED TRAINING IN TENNIS GAME The goal of thesis: The main goal of this diploma's thesis is to verify the occurence of most common models of stress in competitive situation and answer a scientific question - "Can a stress environment, which is already simulated in training, improve stress environment in tennis match? To fulfil the main goal a following hypothesis was set up - H: During training preparation tennis coaches are more engaged in modelling of technical aspect of game situation than a modelling of psychosocial stress of tennis game. Method: This diploma's thesis as a main method of research uses the statistic explorative method of research whose main component is questionning on the anonymus way (29 questions) among coaches. Nonstandard questionary was set up on the base of expert leading of Professor PhDr. Václav Hošek, DrSc., literature retrieval, tutions with an specialist in area of tennis PhDr. Jiří Šlédr and natural experiences of author. Results: Set up hypothesis was verified - During training preparation tennis coaches are more engaged in modelling of technical aspect of game situation of specific situation than a modelling of psychosocial stress of tennis game. Keywords: Modelled training, Stress, Oppress, Psychics,...
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Use of fitness training in hereditary neuropathy
Vránová, Michaela ; Horáček, Ondřej (referee) ; Matouš, Miloš (advisor)
The aim was to assess exercise habits, handle the issue condition in patients with hereditary neuropathy and to clarify the possibility of using fitness training in this disease. We managed to show a reduced fitness of patients with hereditary neuropathy and its relationship with the severity of neurologic disability and mobility habits of individuals. The study results also show the positive effect of physical stress on condition of patients with hereditary neuropathy. Powered by TCPDF (www.tcpdf.org)
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Problem of knowledge of a patient indicated for colonoscopy
ČERNÁ, Miroslava
The colonoscopic examination is no only a diagnostic method, but also a therapeutic method applied in gastroenterology. The colonoscopic examination is performed by the flexible endoscope and it is possible to examine the whole mucous membrane of the large intestine and to perform here also minor surgical operations. The necessity for the colonoscopic examination is as perfect as possible defecation of intestines, however, also this depends on the sufficient knowledge of the patient of the examination performance and preparation. This examination is quite stressing and strenuous for the patients. The target of the thesis was to find out the difference in knowledge of clients indicated for colonoscopy within hospitalization and clients coming as outpatients. 2 hypotheses were postulated: Hypothesis 1: {\clqq}The scope of information of dietary measures before colonoscopy provided to hospitalized clients is different than the scope of information provided to ambulatory clients``. The hypothesis 2: {\clqq}The scope of information about the procedure of the examination before the colonoscopy provided to hospitalized clients is different than the scope of information provided to ambulatory clients``. The method of questioning - technology of a questionnaire was applied to the collection of data. The questionnaire was completely anonymous and was determined for patients indicated to colonoscopic examination. The questionnaire included 22 closed and half-closed questions. 130 questionnaires were distributed in the gastro-enterologic ward in the Hospital of České Budějovice a.s. After returning the questionnaires and elimination of the incompletely filled in and empty questionnaires, the examined group consisted of 106 respondents, thereof 53 were ambulatory respondents and 53 hospitalized respondents. The target of the thesis was achieved. It followed from the results that both hypotheses were confirmed, there is really a certain difference in knowledge before the colonoscopic examination between the ambulatory and hospitalized respondents. In both hypotheses, the ambulatory respondents were informed better. This bachelor´s thesis points out the importance of giving the information to the patients and of co-operation between the patient, nurse and physician. To improve the knowledge of patients indicated for colonoscopy I created the draft of a leaflet, summarizing information the patient should know before this examination. The results of this thesis will be provided to the head and management of gastro-enterologic ward of the Hospital České Budějovice a.s. Its topic could be of help to the medical staff in better informing the patients.
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Stress I - Posttraumatic stress disorder.
Řežábková, Helena ; Kudláčková, Zděnka (advisor) ; Klusoňová, Hana (referee)
Author: Helena Řežábková Title of diploma thesis: Stress I - Posttraumatic stress disorder Thesis Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Field: Pharmacy Background: The aim of this work was to create a historical overview of insight into Post-traumatic stress disorder (PTSD), to describe the major manifestations and the most common situations which they may occur during the development of PTSD, both in the Czech Republic and in selected foreign situations. Another objective was also to establish a comprehensive overview of the therapeutic possibilities of PTSD. Main findings: PTSD was clearly defined in 1980 in DMS III (Diagnostic and Statistical Manual of the American Psychiatric Association). Post-traumatic stress disorder develops as a reaction to heavy and continuous stress, it interferes with effective mechanisms for dealing with it. This reaction occurs as a delayed or prolonged response to traumatic stressful event. The situation as torture, rape, natural disaster or military action usually exceeds the normal human experience. It is individual for each, this situation causes pervasive anxiety. PTSD usually develops within six months after the event. As the late effects of PTSD can occur depression, panic disorder,...
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Quality of life after urogynecologic surgery Comparation of change of quality of life after urogynecologic surgery in relation to anatomy of the pelvis foor
Drahorádová, Petra ; Mašata, Jaromír (advisor) ; Zachoval, Roman (referee) ; Naňka, Ondřej (referee)
Introduction: Stress urinary incontinence is a common problem which affects a high percentage of women. Anti-incontinent surgery has played an important role in the treatment of stress urinary incontinence. Burch colposuspension was considered a gold standard in anti-incontinence surgery, with good long-term results. However, over the past decade this procedure has been largely replaced by the application of various types of TVTs (tensionfree vaginal tapes). In our study we have focused on comparing developments in the quality of life and the occurrence of complications in a long-term follow-up after TVT, TVT O and colposuspension. For subjective assessment of urinary incontinence we have chosen a validated specialized Incontinence Quality of Life questionnaire (I-QoL). The aim of our study was to monitor the trends with quality of life after TVT, TVT O and colposuspension procedures and to establish whether the occurrence of complications affects the quality of life (QoL) and compare of the quality of life among anti-incontinence procedures and longterm subjective and objective outcome. Methods: The study included 215 women who underwent a TVT, TVT O or Burch procedure between 1.6.2002 - 31.5.2005. Women were completely urogynecologic examined and urodynamic stress incontinence was documented....
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Stress-strain analysis of aortic aneurysms
Man, Vojtěch ; Janíček, Přemysl (referee) ; Burša, Jiří (advisor)
This master thesis is focused on stress-strain analysis abdominal aortic aneurysm using ANSYS software. The model of abdominal aortic aneurysm are based on CT scans of five specific patients. The branching arteries are included to the model and one goal of this thesis is decision about their influence of the wall stress. In this thesis was used a hyperelastic materiál model, which is based on mechanical tests done on human arterial samples.
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Determinant of origin of alcoholism and its effects on quality of an individual and his/her family members.
KRUMANOVÁ, Andrea
The bachelor thesis on ?Determinant of origin of alcoholism and its effects on quality of an individual and his/her family members? is divided into two parts. The theoretical section deals in general with alkohol dependence ? it includes a description of classification, typology, developmental stages and signs of alcoholism, biological, psychological, family and social factors of origin of the dependence, its effect, prevention, and the end of the charter deals with life quality. The practical section includes the objektive of the thesis and hypotheses thesis are defined, which begins the research described here. Then a chapter calleds ?Methods? comes, where the research process and means used for affirmation or disproof of specified goal and hypotheses are descroption. The next chapter ?Results? includes tables and charts with resultant values and their description. Information obtained from the reesarch are discussed there. The objectives of the thesis is - in research: I. to find the most frequent cause of alcoholism in a sample of 156 people addicted to alkohol, to describe them and confirm H1 hypothesis:? Cause of alcoholism are multifactorial and a dominating factor cannot be unambiguously specified?. And then in research II, to describe in a set consisting of 48 people (one exact half of them was those dependt on alkohol and the other one were their relatives) effect of alcoholism on quality of life of the person and his/her family members and to confirm or disprove H2 hypothesis: ? Alcoholism reduces quality of life of both the dependent person and his\her family members?. The third, final goal is to summarize facts and findings and suggest possible preventive solutions related to research results. Data in both researches were collected from selected patients using questionnaires and a quantitative method of asking. Our own questionnaire was used to investigate the first objective thesis and a standard SF-36 one on Health Related Qualiy of Life dealing with eight domains was used for verification of the other aim. It results from research I that determinants of alcoholism origin are multifacorial and a dominanting factor cannot be unambiguously found. More than a half of clients came for incomplete families, alcohol problems occurred in their families, they felt lack of love from their fathers, smaller percentage even from their mothers, they had no fixed rules in their education, low ? self confidence and no meaningful leisure time activities (interests), they suffered from stress in their job or were unemployed, more than half of them health disorders and unsatisfactory partnership, they felt alone etc. So the causes look like multifactorial and confirm H1 hypothesis. Research II results show that alcohol effect on the patients and their relatives unambiguously reduce quality of their lives, mostly in the field of emotions and social restriction of their roles, mental health and vitality. A decrease in their physical performance and overall health including pain perception also shows not negligible drop in comparison with the Oxford standard. Dependent responents´ relatives having relationship to a close person dependent to a great extent on alcohol felt emotional restriction on their roles and a drop in vitality where they did not reach even a half of the European standard score. So to achieve the third aim of the work and considering the above conclusions and results I suggest possible preventive measures at the level of the individual, family, school and society.
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Stress and coping strategies of exposed profession
Bieliková, Liliana ; Pauknerová, Daniela (advisor) ; Franková, Emilie (referee)
The aim of the thesis is to point out the stress factors present in the profession of a firefighter, define the concept of stress and suggest the options of coping with stressful and challenging situations. The thesis consists of theoretical and empirical part. The theoretical part is focused on clarifying the definition of the concept of stress, its types, manifestations and potential stressors. In addition, conditions such as post-traumatic stress disorder, burnout, coping with stressful situations and Eysenck personality typology factors are explained. The empirical part is focused on the analysis of coping strategies, used by firefighters on the selected workplace and their connection to temperament, age and years of service. Based on the analysis, recommendations for management in HaZZ Nitra are suggested.
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