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Monitoring of ethological expressions of animals for the purpose of developing sensors assessing various animal movements
KINDLOVÁ, Jana
Breed of beef cattle belongs to one of the most important branches of live-stock production in the Czech Republic. These farm animals are mainly used to produce milk and meat. Since 1989 numbers of beef cattle have strongly declined, this transparent decrease now marking more than a 2 million difference from the early 1990s. The main aim of this thesis is to gather basic information, details and primarily formulate knowledge about the behaviour of dairy cows and their physiological reactions in relation to the process of milking and the consequent response regarding the water requirement and kinetic activities (e.g. the need to relax). The research described in this thesis was conducted in DZV Nova a. s. enterprise, Petrovice, which cultivates an area of nearly 5000 hectares and has 640 dairy cows of Holstein breed in its possession. Vital meter is a device in a sealed box, which hangs on a dairy cow?s neck while registering a certain amount of movements throughout a specific time, one hour in our case. Each hour is divided into two hundred and forty fifteen-second sections. Any movement during this section is therefore registered in a computer through this device?s receiving antenna. A total number of 6 gravid cows of Holstein breed, in a good health condition, with an average daily milk yield between 25 ? 35 litres, was selected for our ethological observation. All these dairy cows had a vital meter placed on their necks, which measured the aforementioned amount of movements an hour. The actual observation took place between the 27th and 28th of October and between the 4th and 6th of December 2012. First, the dairy cows were observed throughout the entire 24-hour period (November 27th, 28th) and then twice in 12-hour periods (December 4th, 6th). The overall time of observation equalled to 48 hours. Temperature conditions ranged from -3 degrees of Celsius to +5 degrees. The animals were gathered and therefore milked in a milking parlour three times a day roughly between 12 ? 13, 20 ? 21 and 3:45 ? 4:30. From the computer records we found out that the vital metres successfully registered all these movements and as a result verified the functionality of these devices and their possible usage as the means of observation of cows? kinetic activities. The outcomes of the dairy cows? observation and the data from vital metres also imply that even if the vital metres correctly registered increased kinetic activity representing a real rise in cows? mobility, they fail to display the particular acts of lying and getting up as well as jumps. After calculating an average from individual daily activities of a dairy cow, these results can be concluded: During a 24-hour period one dairy cow spends three and three quarters of an hour feeding itself, drinks seven times, excretes eleven times, urinates 5 ? 6 times. It places itself at rest nine times and the measured time spent lying accounts for an average of 11 hours and 39 minutes. The process of rumination is connected with lying or standing and lasts for 6 hours and 41 minutes a day. As for the kinetic activity, the average distance walked by one cow amounts 478, 6 metres. There is only one phenomenon contradicting the literary articles/literature ? the process of feeding, which is significantly (75 minutes) shorter and consequently leads to dairy cows producing less urine than they ought to, yet they have more kinetic activities and mobility. As mentioned, a dairy cow walks almost 480 metres a day, while literary sources state less (200 ? 300 metres).
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Physical fitness of female students at University of South Bohemia
RŮŽIČKOVÁ, Lucie
In last several years the amount of physical activities during our day time seriously decreased. That phenomenon was caused by reduction of physically demanding works in our jobs and sitting way of spending free time. The result of the previous fact is population fitness worsening and consequently worsening of the labour productivity and health condition. The fitness is tightly connected with the relationship between a man and a movement and sporting activities. It should become the important part of the healthy life style and influence the formation of proper manners of every single man. The fitness is one of the markers of the cardiovascular system condition. And it is considered to be the certain sum of preconditions for optimal reaction on the stress of whatever cause. The regular training, the physical activity and the daily reasonable energetic income are the safest and the least economically demanding ways how to prevent civilisation diseases. The first task of the theses was to assess the fitness of women students of The University of South Bohemia. The fitness was assessed on the base of Ruffier?s test. The second task was to compare the fitness of several groups of students which represented every single faculty of The University of South Bohemia. The both tasks were completed. Two hypotheses were settled and confirmed in purpose to reach the goal of the theses. H1: The numerological value of the Rufier?s test of women students of the Faculty of Education is lower than the result of women from the other faculties. H2: Women students whose result of Ruffier?s test is 0-5 are spending more time by performing physical activity than other students. In this theses, Ruffier?s test as a non-direct way of assessing the fitness has been chosen to confirm the both hypotheses. Ruffier?s test is a simple test to asses the fitness which uses changes of the hearth rate before and after exercising. The test is based on the general premise that the hard body exercising which last for a longer period of time is connected with the rising of heart rate. The heart rate was recorded by sport tester. Heart rate values were set into the pattern for counting the index of Ruffier?s test and consequently classified. Averages of the Ruffier?s index of each faculty were measured and compared. The questionnaire was ad to the Ruffier?s index for better assessing the fitness of students. The questionnaire was composed by thirteen questions. Some of questions were of open and some of close type. The questionnaires were anonymous. Hypothesis H1 was confirmed. The average value of the Ruffier?s index for women students of the pedagogical faculty was 10,7. And the average value of the Ruffier?s index for women students of other faculties was 13. It means the average fitness of women students of pedagogical faculty is better than the average fitness of women students of other faculties. Hypothesis H2 confirmed the correlation between the time spending by physical exercising and the better fitness. The more times weekly women students exercise for more than 30 minutes a day the lower value of the Ruffier?s index they have. The assumption of the average values of the Ruffier?s index of those women from 0 to 5 was overstated. Women student in this project had the average values from 10 to 15 which mean worse values of fitness. Despite the worse values of Ruffier?s index, the correlation between the spending time by exercising and better fitness was confirmed. To sum up, there is a recommendation to compensate the simple monotone physical activity by wide spectrum of physical activities. The sport should be introduced into the life style. The person with a good fitness has less problems with movement, can work for a longer time without break, is strong and capable to fulfil everyday tasks with reserves. The process of improving the fitness is a run for a long distance but it should be the goal of all people no matter of how old they are.
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Synthesis of novel cardioprotective iron chelators
Hrušková, Kateřina ; Roh, Jaroslav (referee) ; Vávrová, Kateřina (advisor)
Oxidative stress participates in patophysiology of many serious cardiovascular diseases. Free intracellular iron occurs as a catalyst of Haber-Weiss and Fenton reaction between superoxides and peroxides increasing the formation of highly toxic hydroxyl radicals, which cause cell damage. Iron chelators diminish the pool of free iron and thus become perspective agents in therapy of various diseases, e.g. anthracycline-induced cardiotoxicity. Aroylhydrazones group, such as salicylaldehyde-isonicotinoylhydrazone (SIH), appear to be highly efficient chelators. Unfortunately, pharmacokinetic studies focused on these compounds revealed their low stability in plasma. Therefore, I synthesised a series of SIH analogs in order to increase their stability together with preserving the ability to chelate free intracellular iron and to define their structure-activity relationships. A basic hypothesis in design of the novel chelators was using substituted ketone instead of aldehyde, leading potentially to an enhanced stability of hydrazone bond. SIH Two different methods were used during the reactions, a conventional heating in an oil bath and heating in a microwave reactor. The latter caused a significant shortening of the reaction time. In vitro studies of novel compounds showed their higher stability in plasma,...
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Pharmacological screening of substances with iron chelating activity
Havránková, Lenka ; Jahodář, Luděk (referee) ; Mladěnka, Přemysl (advisor)
v anličtině Iron is an important element involved in many vital processes. Its defficiency stops of cell growth and can lead even to a cell death. On the other hand excess of iron is dangerous for organism because of its catalytic participation on free radical formation. Therefore the amount of iron in the organism has to be meticulously regulated. Iron chelators are used when the organism is iron-overloaded. Flavonoids are vegetal polyphenols derivated from a heterocyclic compounds named flavan. They are an important components of the antioxidant system and are able to react with free radicals and to chelate some metal ions. In this study, nine flavonoids (apigenin, kaempferol, quercetin, rutin, hesperetin, hesperidin, naringenin, naringin and catechin) were tested for their chelation activity and compared with clinically used iron chelator desferrioxamine. Suitable experimental conditions with use of ferrozine as an ferrous ion indicator were found for spectophotometric assesment of iron-chelation efficiency. For assessment of the total chelation, hydroxylamine was used as the reductant. Chelator with the highest chelation activity was clinically used desferrioxamine, from tested flavanoids was the most effective apigenin. Practically ineffective flavanoids were catechin hesperetin, hesperidin,...
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Establishment of The Shooting Range
Nečasová, Silvie ; Pulicar, Jaroslav (referee) ; Koráb, Vojtěch (advisor)
This thesis considers the proposed business plan – establishment of the shooting range, which outlines the present difficult conditions which exist in the society. Thesis is conceived as a project for investor with sufficient funding for implementation. It is derived from a complex analyses of the external and internal factors, changes and estimates of internal performance parameters aligned to the agreed strategic design. The aim is to produce a essential document which sets out a clear statement of the future direction of the business and its desired position including the identification of the resources required to achieve that goal.
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Hurdle course in the gymnasium
Grygarová, Kateřina ; Hrabinec, Jiří (referee) ; Kuhnová, Věra (advisor)
The dissertation concentrates on the theme "The hurdle course in the gymnasium". There are two sections - theoretical and practical. The theoretical section is intent on movement evolution ofchildren between the birth and the end of pre-school age (0 - 6 years). This section also eontains the basic informations about the movement organism and about the most frequent orthopaedistic defects. The theoretical section also contains the summary of movement games and how to do them safety. The authoress is also warning about limits some of movement with regard to the evolution ofchildren in pre-school age. The practical part concentrates on the action research, which is aimed on facilities of P. T. (physical training) equipment and also on the attitude of kindergardens of Prague 7 have gym and garden. This section also indudes descriftion how to build the original hurdle traction and the reaction of pupils and teachers. To reach for the goal the methode of the interview, research was choosen and pedagogical experiment. Due to the interview were the informations partly prooved in class plans. . exercise, movement evolution, movement activity, movement apparatus, defects, movement restrictrietion
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Antifungal Drug Discovery: Focus on Incrustoporin Derivatives
Silva, Luis André Vale ; Buchta, Vladimír (advisor) ; Heidingsfeld, Olga (referee) ; Hamal, Petr (referee)
1 CONCLUSIONS In the context of Medical Mycology today, the development of new more effective antifungal agents is a priority. In fact, there are still only about six drugs in use to treat invasive fungal infections, concretely the polyene amphotericin B (including its new lipidic formulations), the antimetabolite flucytosine, the triazoles fluconazole, itraconazole, and voriconazole, and the echinocandin caspofungin. Simultaneously, the incidence of invasive opportunistic mycoses has been increasing steadily with the increasing number of immunocompromised patients, caused both by HIV (human immunodeficiency virus) infection and AIDS and the development of medical techniques, particularly referring to oncology or transplant patients. In this setting, the relevance of the development of new antifungal agents and, hence, our work presented here, is easily understandable. The group of the acyloxymethylated incrustoporin derivatives is now in a higher stage of development, after being previously studied concerning structure-antifungal activity relationship and tuning of antifungal activity. Our work has shown the best derivatives from the group, compounds LNO6-22, LNO15-22, and LNO18-22, to have broad spectrum in vitro antifungal activity and high potency, inhibiting growth of a variety of pathogenic yeasts and...
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The future of central banking in the economic system of developed countries on a basis of evalution of the experience from the last decade
Vilt, Lukáš ; Ševčík, Miroslav (advisor) ; Munzi, Tomáš (referee)
Thesis is dealing with the development of the central banking on the basis of experience from the last decade. Hypothesis is the statement, whether the central banks of the developed economies are increasingly less capable of the effective reactions on the accelerating development of the global economy and their position in the money emission and regulation of the banking sector is and will be more and more weakened by the alternative banking and monetary systems. This hypothesis is successfully disproved because of the behavior of the four chosen central banks which are CNB, FED, ECB and BoJ. The main reason was an increase in their activities and interventions causing among others multiplication of their balance sheets. On the other hand the alternative in the free banking is further from the reality than before. Virtual currencies also did not show threatening growth of the national currencies substitution in the reference period. Thesis also provides insight into new and potentially new instruments of the central banks.
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