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Position and Potential of the Organic Farming in Rregional Development
Konečná, Marta ; Kadeřábková, Jaroslava (advisor) ; Pělucha, Martin (referee)
The thesis analyses the position and potential of organic farming in regional development or more precisely rural development in local area of farming of particular organic farms in the Czech Republic environment. It judges correlation among socio-economic indicators, share of organic farming land on agricultural land in the local area and share of less favoured area in administrative local unit of the Municipalities with extended competence. The part of the thesis deals with delimitation of term "Rural area" and its specification in particular patterns, and analysis of the same indicators as mentioned above in each of the pattern.
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Factors affecting stock prices of major global insurance companies
Nepšinská, Lucia ; Daňhel, Jaroslav (advisor) ; Fičura, Milan (referee)
This thesis analyzes the impact of selected macroeconomic and firm-specific factors on stock prices of insurance companies. The first part describes four financial theories used to explain the share price development with a focus on fundamental analysis. The aim of the next part is empirical verification of the strong relationship between selected variables in the period from 01/2003 to 01/2013. In case of its existence, the econometric models using correlation and regression analysis are built. Considering the chosen period of time the impact of the financial crisis on potencial changes of direction and intensity of this relationship can be seen. The analysis uses real-world data from MetLife. The last chapter also describes its characteristics and compares them with the industry.
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Air pollution - invisible threat?
Šitinová, Kristina ; Zajíček, Miroslav (advisor) ; Louda, Jiří (referee)
This paper examines the influence of air pollution on humans. Suggesting the possible consequences of each action of air pollutants on human health but also the possible economic impacts of air pollution. It primarily exploers the effects of concentration of suspended particulate matter (PM10) on the incidence of chronic obstructive pulmonary disease. The response variable in the regression model serves to determine the effect of PM10 on the incidence of chronic obstructive pulmonary disease was a percentage share of patients with chronic obstructive pulmonary disease among the clients of the General Health Insurance Company in individual regions of the Czech Republic. Explanatory variables were the mean annual concentration of PM10 and gross added value per capita. The model suggests that there is a statistically significant positive correlation between the incidence of chronic obstructive pulmonary disease in the Czech Republic and PM10 concentrations.
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The impact of polluted air on oxidative damage to DNA.
Švecová, Vlasta ; Šrám, Radim (advisor) ; Stiborová, Marie (referee) ; Rössner, Pavel (referee)
IMPACTS OF AIR POLLUTION ON OXIDATIVE DNA DAMAGE Vlasta Svecova Department of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR, v.v.i. Videnska 1083, 142 20 Prague 4 Tel.: +420 241 062 669, fax.: +420 241 062 785, e-mail: svecova@biomed.cas.cz This thesis deal with impacts of air pollution on human health. The biomarkers of biologically effective dose, biomarkers of oxidative damage to DNA, lipids and proteins, were studied. We aimed at importance of individual pollutants, measured the personal exposure to these pollutants and analyzed the biomarkers of oxidative damage to macromolecules. c-PAHs (carcinogenic polycyclic aromatic hydrocarbons) bound to airborne PM2.5 (particulate matter ≤ 2.5 µm) and volatile organic compounds (benzene, toluene, ethylbenzene and m,p,o-xylenes, BTEX) were studied as ones of the biologically most important pollutants. Personal and outdoor concentrations of c-PAHs together with personal exposure to BTEX were measured. The concentrations of pollutants were correlated with biomarker levels in different seasons and localities. Bus drivers in Prague, 6-10 years old children from Teplice and Prachatice and policemen with office workers from Ostrava region were the model populations. Oxidative damage to DNA were measured by 8-oxodeoxyguanosine (8-oxodG), 15-F2t-...
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Surface ozone as a factor of oxidative stress in mountain forests.
Bendáková, Hana ; Hůnová, Iva (advisor) ; Matoušková, Leona (referee)
This study presents mountain forest Norway spruce (Picea abies) injured by surface ozone and oxidative stress. Norway spruce is not a sensitive species but it is the most representative tree in our country and this is the reason to pay attention on its injury. Study was connected to the ozone measurement by CHMI in Jizerske mountains. Aim of our study was to find influence of surface ozone on the forest and show correlation between ozone concentrations, altitude and Norway spruce injury. Ozone concentrations are growing with the altitude. Increasing percentage of injury with growing concentrations and altitude was expected. Needles were collected at the altitude 750-1100 meters. Collected needle years were 2006, 2007 and 2009. The 2009 year was not evaluated because no symptoms were found. Injury was observed on the maroscopical, microscopical and biochemical level. Visual injury was assessed by percentage of injured needle surface by chlorosis and necrosis. Microscopical analysis studied injury on cross and longitudinal sections of needles. On the longitudinal sections were visible typically bone-cells. These cells have lost its shape by ozone stress and were narrowed in its width. Bone-cells were best visible near the stomata. Four symptoms were observed on the cross sections: tannin...
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Study of influence of cellulose derivatives on eye drop weight
Zdráhalová, Anna ; Šklubalová, Zdeňka (advisor) ; Šnejdrová, Eva (referee)
STUDIUM VLIVU PŘÍSADY DERIVÁTŮ CELULOSY NA HMOTNOST OČNÍCH KAPEK Zdráhalová Anna Summary In this rigorous work the influence of the ingredient of the derivates of cellulose on the weight of eye drops obtained from the compressible plastic vial in combination with the plastic dropper tip ("Bralen") was observed. The dropping of the solutions of methylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose and sodium carboxymethylcellulose in the concentration range of 0,15 - 1,00%, a significant influence was observed on the weight of the eye drops in both dispensing angles, 90ř (vertical dropping) and 45ř (inclined dropping). The addition of the 0,15% MC and HPMC increased the weight at least 8%, while the 1% additive increased the weight more than doubled in comparison to water. HEC and NaCMC had significantly less influence on the weight of drops in comparision with MC and HPMC, which became evident in the slight increase of the weight of the drop in correlation with the increase of the concentration of the polymer. The 1% solution of NaCMC showed a maximum increase of the weight of the drop of 13% compared to water. As a result of changing dispensing angle from 90ř to 45ř, a significant decrease of the drop's weight was shown only in the case of the additives, HEC and NaCMC. The wetting of outer...
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Pregnancy proteins - molecular biological and biochemical analysis
Muravská, Alexandra ; Kalousová, Marta (advisor) ; Černá, Marie (referee) ; Průša, Richard (referee)
The aim of this thesis was to establish methods for selected PAPP-A (Pregnancy- Associated Plasma Protein A) gene polymorphisms analysis and to study genetic background of PAPP-A and biochemical background of PAPP-A and PlGF (Placental Growth Factor) in relation to risk pregnancy. Secondly, the aim was to establish method for two-dimensional (2D) electrophoresis of amniotic fluid. Methods for analysis of ten PAPP-A gene polymorphisms were established. These polymorphisms, PAPP-A and PlGF levels were studied in together 165 women in third trimester pregnancies complicated with threatening preterm labor (n=98), preeclampsia (n=35), IUGR (Intrauterine Growth Restriction) (n=34) and ICP (Intrahepatic Cholestasis of Pregnancy) (n=15). 114 healthy pregnant women served as controls. The method for 2D electrophoresis of amniotic fluid was established. Preeclamptic patients had significantly higher frequency of TT genotype of Cys327Cys (C/T) PAPP-A gene polymorphism compared to controls. Patients with ICP had increased serum levels of PAPP-A compared to controls, in patients with threatening preterm labor PAPP-A levels were rather decreased. PlGF levels did not differ from control group in patients with ICP and threatening preterm labor. Positive correlation was found between PAPP-A and PlGF in group of...
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Analysis of the market concentration in public procurement markets
Kolorosová, Barbora ; Pavel, Jan (advisor) ; Dufek, Luboš (referee)
This master thesis is focused on the market concentration in six sectors of public procurements in the Czech Republic, and the relationship between level of market concentration, profitability of the companies, final price and number of bids. The analyzed procurements refer to food industry, electricity, postal and telecommunications services, solar energy, IT and automotive sector from period of 2007-2010. Concentration ratio, Herfindahl-Hirschman index and Gini coefficient were used to quantify market concentration. The first four of above mentioned public procurement markets seem to be highly concentrated according to these indicators; the remaining two cases are unconcentrated or moderately concentrated. Correlation analysis was used for each sector. The analyzed variables were: market shares of the companies, their profitability, average number of bids and average proportion of the final and expected price in tenders which the company won. Further, the relationship between market concentration indicators and average variables for the relevant sectors was assessed.
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Exprese a role P-glykoproteinu a BCRP transportního proteinu a karcinomu prsu
Kvaková, Lucia ; Čečková, Martina (advisor) ; Štaud, František (referee)
ABC (ATP-binding cassette) proteins form the largest known transporter gene family. P- gp and BCRP are so far the most described members of the ABC family that translocate a variety of endogenous as well as exogenous compounds including drugs across cellular compartments. In this way the transporters protect human healthy tissues from xenobiotic compounds which can impair structure or function of the tissue. In recent years, many studies have been done to find the correlation between the expression of ABC transporters in breast tumor cells and failure of the breast cancer therapy. It has been confirmed that P-gp and BCRP (two specific ABC transporters) are expressed in breast tumors in a higher degree and can be responsible for the decrease of cytotoxic drugs inside the cell leading to the noneffective therapy. Many modulators of P-gp and BCRP have been developed to inhibit transporter expression causing the subsequent sensivity to cytotoxic drugs. There are new perspective treatment strategies formed, such as the combination of chemotherapeutics with substances inhibiting and/or preventing drug resistance of cancer cells, that could be used in clinical practise in the future.
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Options of continual glycemia monitoring in critically ill patients and treatment of hyperglycemia with the use of insulin algorithms
Bláha, Jan ; Haluzík, Martin (advisor) ; Matějovič, Martin (referee) ; Vaněk, Tomáš (referee)
Glycaemia control is nowadays one of the most discussed topics in intensive care. The landmark Leuven study, which has brought hyperglycaemia in intensive care to the centre of interest, demonstrated that tight glycaemia control (TGC) targeted to maintain euglycaemia between 4.4 to 6.1 mmol/l reduced mortality and frequency of organ complications associated with critical illness. Although this study was published eight years ago, there is still no general agreement about approach to tight glycaemia control in critically ill patients. Doubts have been raised about both the universality of intensive glycaemia control, and especially its safety in terms of potential damage to patients by episodes of hypoglycaemia. Our studies did not focus on questions of importance or risk of TGC, but we concentrated on key point of hole TGC concept - on glycaemia control in critically ill patients itself. The aims of our studies were the research of subcutaneous adipose tissue as an alternative-site for continuous glucose measurements in ICU patients, and comparison and development of insulin algorithms for hyperglycaemia treatment and normoglycaemia management. We demonstrated good correlation between arterial and interstitial subcutaneous glucose concentrations in critically ill patients undergoing deep hypothermia. We...
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