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The therapy of Alzheimer disease
Veselá, Michaela ; Melicharová, Ludmila (advisor) ; Vopršalová, Marie (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxikology Student : Michaela Veselá Supervisit : PharmDr. Ludmila Melicharová Title of diploma thesis : The therapy of Alzheimer's disease Alzheimer's disease is becoming more pressing problem of today's population. It is very serious progressive-neurodegenerative disorder mainly manifested by memory loss, cognitive dysfunction and personality changes. This thesis provides topical summary of the most important aspects of treatment of Alzheimer's disease. There are introduced basic characteristics of Alzheimer's disease, its possible causes and brief summary of currently used and new considered therapeutic approaches.
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Výběr a implementace open source nástroje pro řízení portfolia projektů
Marek, Jan ; Chlapek, Dušan (advisor) ; Kučera, Jan (referee)
Methods and ways of implementation of changes and innovations in companies through project management are in today's society very well established. There exists methodologies, techniques and tools for the management of individual projects. However in a role of project manager, I very often faced the fact that companies are performing the project portfolio management in very intuitive way. This in itself leads to failed and prematurely terminated projects, initiation of the wrong projects or realisation of correct projects, but at the wrong time. Very often I have also recognized, that there is lack of awareness of fact, that there are also Open Source applications that can help with the organization's portfolio. This thesis deals with the definition of requirements, search and selection of proper OSS application and subsequent implementation. In the first part of this thesis I prepare a theoretical framework about PPM, and on that basis then identify and verify a set of requirements for selection of right OSS PPM application. The next section of thesis describes searching for suitable applications from a variety of sources, assessment against the requirements and the final selection. In the last part the implementation project is drafted, which aims to serve other colleagues in project management as one of the possible implementation paths. The outputs are then continuously confronted with experts in matter of projects and project management in the field of IT in order to maximize symbiosis between theory and real life experiences. Virtually every project management methodology defines the collection of already-proven techniques, best practices or lessons learned from the previous similar implementations. The main contribution of this thesis I see in fact that it contains not only the design of the project implementation, but also describes a logical path, what leads to the result. Therefore this thesis could be used as a base or discussed best practice, when a project of implementation of PPM application in place.
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History of vegetational development in the Cheb basin from sedimentary record of the SOOS National Nature Reserve
Suda, Tomáš ; Kuneš, Petr (advisor) ; Bešta, Tomáš (referee)
Vegetation development in the Cheb basin ( W Czech Republic) recorded in the sediments of the SOOS ational ature Reserve This thesis focuses on palaeoecological research of quaternary sediments in the Soos National Nature Reserve (Cheb basin, NW Czech Republic). Quaternary history of this locality is poorly known, despite it is a valuable and protected area with high natural qualities. The Soos basin is also known for its unique geological record, which is expected to cover information on landscape dynamics at least during the Holocene. A lake existed in the Soos basin enabling accumulation of diatomite and peat sediments of a broad palaeoecological potential. Records were analysed with method of pollen analysis and were dated using 14C. The results of this study bring information about vegetation development in the area of Cheb basin as well as development of lake ecosystem. It also gives a new insight on lake's origin and its age. The accumulation of peat sediments started in the Preboreal period and was continuous at least until the Atlantic following with a hiatus, therefore further detection of vegetation development is impossible. The beginning of diatomite accumulation, as well as the existence of the lake goes back to the Bølling interstadial, according to radiocarbon dating. However, this...
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The tax system reduces motivation to return to work among mothers with young children: recommendations and evaluation
Šatava, Jiří
In the Czech Republic, the overall taxation of work, i.e individuals' income tax together with social security and health insurance contributions, places a heavy burden even on the relatively low earnings of so-called second earners in households, i.e. partners with lower earnings. These peoples' work activity is, however, generally very sensitive to the level of taxation. A large group of these earners is made up of mothers with young children. Mothers who are the second earner in their household are subject to a participation tax rate (PTR) up to 30 % higher than their partners, and yet a higher PTR results in lower motivation to work. Women with children and low earning potential are subjected to the highest PTRs in comparison with their partners.
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Access to Information and Access to Justice in Environmental Matters in the Republic of Irealand and the Czech Republic
Vítková, Martina ; Stejskal, Vojtěch (advisor) ; Sobotka, Michal (referee)
This diploma thesis deals with access to environmental information and access to justice in environmental matters introduced by Aarhus Convention in the specific conditions of Czech Republic and Ireland. These rights are considered to be very important tools for environmental protection. At a time when people threaten their own existence by negative interference with the environment it is necessary that effective means for its protection exist. These means are access to environmental information and access to justice in environmental matters, which together can be called as environmental procedural rights. The first chapter of this thesis presents the sources of environmental procedural law and observes the development of law at international, European and national level. The most important international document in this field is the Aarhus Convention that was adopted in 1998 by most of the European countries and that provides for access to environmental information, access to justice and public participation in environmental decision-making. This convention has largely affected the law of the European Union, where several directives has been adopted, including most importantly the Directive 2003/4/EC on access to environmental information and the Directive 2003/35/EC on public participation in...
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Awareness of women about nutrition problems such as breast cancer prevention
STAŇKOVÁ, Denisa
This thesis focuses on the awareness of women of the nutrition issue as the prevention of breast cancer. The aim of this thesis is to find out whether the women have enough information about nutrition and life style as the prevention of breast carcinoma, where they look for information, if they are interested in this issue and whether they consume food that could work as the prevention. Another goal is to detect possible differences in the attitude to the prevention between women without the potential risk and women with the increased risk, i.e. women over 45. Research questions were determined as follows: "What is the knowledge of women about the issues of nutrition as the prevention of breast cancer?", "What is the proportion of the food that has preventive effect on the rise of breast carcinoma and, on the contrary, the food that supports the tumour growth in the eating habits of women?", "Where do women get information on this issue?", "What is the difference in awareness and consumption of food between women without the potential risk and women with the increased risk, i.e. over 45. The thesis is divided into two parts, a theoretical and a practical one. In the theoretical part I focus on the breast anatomy, basic information on breast cancer and risk factors that are divided into influenceble ones and non-influenceble ones. In the most extensive part of my thesis focuses on the influenceble factors, that is nutrition and life style. I focus especially on nutriments, food and other life style factors that are most connected with breast cancer and have antitumour effects or, conversely, support the tumour growth. The practical part was made by means of a questionnaire which I placed on the Internet and handed out in the waiting room at the general practitioner. The questionnaire was anonymous with 34 questions of a closed and semi-enclosed type. Questions concerned nutrition and life style in relation to the risk of breast cancer and were devised to answer previously defined research questions. The questionnaire survey took place in January and February 2013. I acquired 105 filled in questionnaires from which I randomly chose 86 to obtain two numerously equal groups of women without the potential risk and with the increased risk, i.e. over 45. The result of the research part is that women do not have much information on the life style in connection with the breast cancer. Some respondents, while selecting food with preventive effect, were only guessing and often also marked food which was not related to the breast carcinoma at all. About one third of the respondents even believe that nutrition and other factors are not related to this disease at all. One third of the respondents also stated that they had no interest in learning more information on this issue. Women that have some information usually get it from the magazines and from the Internet. In terms of eating habits, the food of most respondents does not reach the needed quantity to have preventive effects. On the other hand, the food and drinks that support tumour growth do not occur on the menu of the respondents very often. While comparing answers of the women younger 45 and the older group of respondents, it was found out that the younger respondents showed greater unawareness of this issue. No significant differences were recorded in other questions. The results of the survey are graphically processed and evaluated in the final part of this thesis. I suppose this thesis is the contribution to clarifying the current situation of this issue. I believe that the topic of my thesis is up-to-date and that I managed to summarize the most significant information regarding this topic and fulfil the aims I set down. I would be very glad if my work led to the contemplation of this issue and subsequently to a more extensive propagation of the breast cancer prevention.
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Introduction to bio art
Šperanda, Nina ; SILVERIO, Robert (advisor) ; JANOŠČÍK, Václav (referee)
Bio art is a contemporary art practice that works with living organisms (except humans) or is created in cooperation with living organisms. It is relatively new art movement that is rooted deeply inside the history of evolution, domestication of animals and plants, technological discoveries, their development and science. Never before was art questioning its ethics and aesthetics in such profound, molecular and sub-molecular way.
In this work I will consider the historical influences and conditions that led to current developments in the field. I will also try to explain the problematics of defining what bio art is and try to clarify the associated terminology. Most relevant and ground breaking works in the field will be mentioned as some new recent developments.
Aesthetics of bio art is also an important subject often set aside by the ado around ethics of it. It is an extremely important subject to be considered when talking about bio art and I will try to sketch out a brief outline of it with references to philosophy and contemporary bio art theory.
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Nutrition of pregnant - reccomendation and reality
FAJMONOVÁ, Simona
For my bachelor thesis I have chosen the theme : Nutrition of pregnant women recommendations and reality. The theoretical part includes the specifics of nutrition in preconception period and pregnancy, risk groups of pregnant women, high-risk behavior and a chapter about dietary supplementation in pregnancy. Pregnancy is an important period in a woman's life. The changes that accompany pregnancy also impose increased demands on the supply of the body with nutrients. I have chosen the method of a survey for the processing of the research part of my thesis. The practical part includes the results of the survey, which was attended by 80 women in the 7th-9th month of pregnancy. The questionnaire asked for basic information besides the weight, height and weight gain in pregnancy, also eating habits, fluid intake, inadequate habits (alcohol, smoking), use of dietary supplements, awareness of pregnant women and their physical activity. The questionnaires were processed in Microsoft Excel using tables and graphs. All collected pieces of information about dietary habits were compared with the recommendations for pregnant women. The aim of this thesis was to find out what is the reality of eating habits of pregnant women compared with recommendations. Another aim was to determine, whether pregnant women are well informed about the nutrition recommendations during their pregnancy and where they get the information from. Further aim was to explore, whether pregnant women use nutritional supplements before or during pregnancy and what kind of them. The last aim was to determine some of the bad habits during pregnancy (e.g. alcohol , smoking). The results of the questionnaire survey showed that by the majority of pregnant women the reality and recommendations coincided in water intake and beverage preference. Most of them preferred water or tea. Coffee consumption was also by the majority of them problem-free. Eating meat and eggs corresponded with the recommendations for a large group of respondents. As for legumes, fish and fish products, their consumption corresponded with the recommendations by only about half of the women. Eating fruits and vegetables were in the majority of pregnant women unfortunately insufficient as well as the consumption of milk and dairy products, nuts and seeds. It would be very appropriate to increase consumption of these groups of food. Conversely, the consumption of sausages and sweets, which turned out to be more frequent, should be reduced . Most women were well informed about the nutrition recommendations during their pregnancy, in most cases from the media or pregnancy counseling from a doctor. Here, I would suggest creating a website for pregnant women offering really reliable information. Nutritional supplements related to pregnancy were used by about half of the respondents. Only less than a half of the surveyed women supplemented folic acid in preconception period. I would suggest to create some information leaflets about the suitability of folic acid supplementation in preconception period and place them in the gynecological outpatient's clinics . Pregnant women ordinarily didn't smoke and consume alcohol. Occasional alcohol consumption stated 14 % of women. It seems that women are informed enough about the risk of smoking and alcohol consumption.
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Dance education of preschool hyperactive children
Lacková, Ivana ; LÖSSL, Jiří (advisor) ; FRIČOVÁ, Marie (referee)
The topic of this diploma thesis is Dance education of preschool hyperactive children. Goal of research is to describe teaching of hyperactive children especially dance lessons.
There is described Attention Deficit Hyperactivity Disorder in the first part of thesis. There is written about special needs of children with ADHD focused on education.
Second part is focused on practical dance lesson of ADHD children. There is described example dance lesson based on theory and practical experience of experts.
The result of research is that supply of special lessons is very limited and it is big pity. In the diploma thesis was recognized that the education with special program should help to children with ADHD and it can be good supplement to standard medical therapy.
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Evaluation of the effectiveness of teaching vocational subjects depending on physical activity before schooling.
Janošíková, Martina ; Hanušová, Marie (advisor)
The period of transition to secondary school brings substantial changes in the requirements for study obligations, autonomy, communication, expression, or separated from their families in the form of staying at the dormitory. Students enrolled in sport centers, in addition to these changes, still struggling with the responsibilities associated with sport. Because they are students first through fourth grades of secondary schools and secondary vocational schools, an age when image self-I am, what I believe in, arises in interactions with the outside world and their own experience, plays a very important role to influence the environment, educators, teachers and trainers, with which students spend most of their time in practice. This study looks at students comprehensively in terms of personal development as a multifactorial biopsychosocial unit, in terms of cognitive and motivational processes, states and properties from the perspective of social psychology dealing with the interactions, relationships and communication, psychology of individuals within the social group and its importance for the development of the individual . It monitors conditions and educational outcomes in terms of educational psychology, dealing with forming properties, opinions, attitudes and value orientation from the perspective of educational psychology.
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