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Sexual life in Parkinson's disease
Kotková, Petra ; Šivicová, Gabriela (referee) ; Weiss, Petr (advisor)
The diploma thesis deal with the topic of sexual life of people suffering from the Parkinson's disease (PD). The theoretical part contains basic information about PD and the results of researches on sexuality of people with this illness, focusing on the agents that infl uence PD. The empirical part comprises of a research project implemented on a set of 103 people with PD. In order to describe the specifi cs of the patients' sexual lives, two sets of questions were designed (separate for men and women), containing a questionnaire on sociodemographic features, psychological (BDI-II, STAI) and sexuological questionnaires. The acquired data was statistically elaborated by means of the programme SPSS. Results of the sexuological questionnaires (GRISS, FSFI, SFŽ3, SFM, IIEF) show a decrease in sexual functions and a presence of sexual dysfunctions connected with PD. With the help of regressive models, it was elicited that in case of men with this illness, the most infl uential agent on their sexual life is depression and subjectively scoring the illness, in case of women the agent of depression and anxiety.
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Role of the chancellor in the foreign policy of the Federal Republic of Germany: Angela Merkel
Farská, Kateřina ; Druláková, Radka (advisor) ; Dubský, Zbyněk (referee)
This master thesis is concerned with the role of the chancellor in the foreign policy with respect to the institutional possibilities that the German political system provides him, and also with respect to the personality of the chancellor - it strives to answer the question, if it is possible to identify the personality impact in the chancellor foreign policy positions. As the case example the current chancellor Angela Merkel has been chosen, who serves for a period long enough to carry out the research and who is at the same time well-respected personality abroad. The thesis comes to the conclusion that the chancellor has the rights to intervene in the foreign policy and uses those rights. By means of the discourse and content analysis of chancellor's speeches it has been possible to identify foreign policy preferences of the chancellor which can be associated with her personal life experience.
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The effect of analgesics and their combination with neurotropic drugs on pain and brain mediators
Soukupová, Marie ; Kršiak, Miloslav (advisor) ; Farghali, Hassan (referee) ; Rokyta, Richard (referee)
The first aim was to investigate changes in analgesic efficacy of several analgesics in combination with selected drugs affecting nervous system after systemic administration. The second aim was to ascertain changes of levels of pain mediators in vivo in supraspinal brain structures (in periaqueductal gray matter, central amygdala, striatum) in pain and under the drug influence. The analgesic efficacy of combinations of analgesics with neurotropic drugs was investigated in the writhing test in mice. Interactions between analgesics and neurotropic drugs were evaluated by the isobolographic analysis, which enables to distinguish the supra-additive (synergistic) interactions from solely additive and sub-additive ones. A possible negative effect of neurotropic drugs on motor functions was determined in the rota-rod test in mice. Changes of levels of pain mediators in the brain during pain and under the drug influence in rats were measured by microdialysis in vivo coupled with a high performance liquid chromatography. A model of inflammatory pain induced by intraplantar injection of carrageenan and a model of neuropathic pain produced by a spared sciatic nerve injury model were used in rats. We evaluated pain in plantar and von Frey filament test. Our microdialysis experiments revealed that inflammatory pain...
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Study of influence of organic dye structure on their decomposition in the diaphragm discharge in liquids
Pajurková, Jana ; Fasurová, Naděžda (referee) ; Kozáková, Zdenka (advisor)
The main goal of presented thesis is to study the influence of organic dyes structure on its degradation in diaphragm discharge in liquids. Diaphragm discharge is a kind of non-thermal plasma that can be generated in liquids by the application of high voltage. In plasma channels (so-called streamers), many physical and chemical processes are formed. High electrical field, shock waves and last but not least emission of electromagnetic waves in the range of visible and ultra-violet radiation appear among physical processes. The most important chemical process is generation of active species. These species initiate chemical reactions and could attack molecules of organic compounds contained in water solution. The reason why organic dyes were chosen in this study is its visible destruction, because it is related to its decolouration. Further, UV-VIS spectroscopy for the determination of concentration during the experiment can be used. Organic dyes are good models of organic substance often contained in waste water and for which removal classical biological, chemical and physical methods aren’t sufficient. Selected dyes were mostly from the group of azo-dyes: Acid Red 14, Acid Red 18, Acid Yellow 23, Direct Blue 53, Direct Red 79, Direct Red 80, Direct Yellow 29, Food Yellow 3 and further, Acid Blue 74 (indigotic dye) and Direct Blue 106 (oxazine dye). Experiments were carried out in a special batch discharge reactor with the anode and the cathode spaces divided by a non-conductive barrier, where the diaphragm with a pin-hole was placed. Measurement showed different removal in the anode and cathode space. We have supposed it was caused by different streamers features and energetic conditions. Dyes were decomposed with higher efficiency in the anode space where the final concentration reached 40 % of the initial concentration while it remained about 90 % in the cathode space. In this thesis the influence of dyes structure on the dye decomposition by electrical discharge was investigated. Dyes consisted of small molecules and dyes with many substitutes bounded on aromatic ring were decomposed more easily than dyes consisted of big molecules. The shift of characteristic wavelength on both directions (to shorter as well as longer wavelength) was observed during the experiments especially when the Direct dyes were decomposed. This phenomenon was probably due to the formation of intermediate product, which have different characteristic wavelength than the primary compound. In general, colourfulness is given by long conjugated systems of double bonds with substitutes bounded on an aromatic ring. Each change in the molecule structure provides the colour change and this could be the possible reason of the shift of characteristic wavelength. The other task was the comparison of degradation process efficiency by the mean of electrolysis and diaphragm discharge. Results showed that electrolysis (30 W) was more convenient for degradation of dyes consisted of small molecules while diaphragm discharge (130170 W) suited for complex molecules. For degradation of small molecules, oxidation on the anode assumed to be the most effective process that is initiated by electrolysis. For degradation of big molecules, attack of active species produced by the discharge is necessary.
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Ecclesiology in the works of Silvestr Maria Braito OP
Diviš, Patrick ; Mohelník, Tomáš (advisor) ; Brož, Prokop (referee)
Ecclesiology in the works of Silvester Mario Braito OP This bachelor thesis is concerned with the development of ecclesiology in the works of the Catholic priest Silvester Mario Braito OP. The thesis has three parts. In the first part, it describes the events in the life of S. M. Braito, mainly with respect to their importance for his publishing activities. It also offers an outline of the development of Catholic ecclesiological thinking in the time when Braito was active. The second part then offers an analysis of S. M. Braito's ecclesiological articles in the bulletin Na hlubinu (Into the deep). The third part takes into consideration his ecclesiological thoughts in books. The work contains a review of Braito's church doctrine, defines the main concepts of his ecclesiological reflection and shows the sources he uses. At the end of this thesis, we evaluate Braito's contribution to the development of modern ecclesiology and sets the junctions with the church doctrine, as it has been defined by the Second Council of Vatican. Keywords: church * ecclesiology * S. M. Braito * Na hlubinu * mystical body of Christ
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Cunsumer behavior of Neoluxor customers in charity support point of view
Bíbová, Barbora ; Koudelka, Jan (advisor) ; Zamazalová, Marcela (referee)
The main goal of the thesis is to learn the dominant factors of consumers behaviour of Neoluxor customers and the influence of institution support in their determination processes. The starting point for customer decisions is the attitude towards the nonprofit sector in general. The theoretical part describes the characteristics of the fundamental activities and terms which are used further in the practical part. The crossing of profit and nonprofit sector in the thesis requires to differentiate understanding of marketing in individual points of view. Corporal responsibility becomes an influencing factor in the strategy of both profit (Neoluxor) and nonprofit organizations (TERIBEAR, Konto Bariéry, ADRA). The practical part selects useful information of secondary research and also, with the results of the questionare, it makes the image of the dominating features of decision making of present and potential customers. The thesis is concluded by the evaluation of results of the research and recommends a more effective cooperation of institutions with the market using Neoluxor network.
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The unconventional Technology of Cutting Water Jet
Šimíček, Václav ; Slaný, Martin (referee) ; Osička, Karel (advisor)
This diploma thesis deals with the unconventional technology of cutting water jet. The aim of this thesis is analysis of technological possibilities of water jet, possible operating modes (techniques) and entering technological data and influence of technical parameters on quality and accuracy of cutting. The thesis contains several experiment at which was examined achieved quality and accuracy of cuts, and simultaneously there is solved technoeconomic evaluation of this technology.
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Hyaluronan ionocomplexes for cosmetic and farmaceutical applications
Cimalová, Jana ; Obruča, Stanislav (referee) ; Pekař, Miloslav (advisor)
This bachelor thesis is focused on the study of a system of cationic surfactant – hyaluronan. Using fluorescent spectroscopy the critical micellar concentration of Carbethopendecinium bromide (Septonex) was determined in three environments – water, 0,15 M NaCl, and buffer PBS, with three fluorescent probes – pyrene, perylene, and nile red. It was found that the physiological environments (buffer and NaCl) reduce the value of CMC about one order. During the experiments with native hyaluronan, precipitate and gel formation were observed. The following part dealt with aggregate behaviour of the new biologically acceptable amphoteric surfactant tetradecylfosfocholine (TPC) in the environment of water and NaCl according to the increasing molar molecular weight of hyaluronan. As a fluorescent probe perylene was used. These measurements showed that the molar molecular weight or a change of ionic force has no effect on the value of CMC and therefore there are no interactions with hyaluronan. The last surfactant to study was 1,2-dihexadecanoyl-3-dimetylammonium-propan (DPTAP), which is water insoluble. DPTAP is soluble in chloroform, but after evaporation of chloroform and after addition of hyaluronan, it precipitated. The results so far, have confirmed that in terms of research of aggregation by fluorescence spectroscopy the new cationic surfactants TPC and DPTAP are not suitable for complexation with hyaluronan.
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Implementation of philosophy of CRM in selected company in airline industry
Pavelka, Jakub ; Koliš, Karel (advisor) ; Konvalinka, Michal (referee)
The aim of this Bachelors Thesis is to define the philosophy, individual phases and the most important principles in building the customer relationship management and their theoretical concepts applied in selected company in airline industry. Based on the identification of places and processes that have the most significant impact on interaction between customers and company will be formulated fundamental measures for the implementation of the philosophy.
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