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Eye-Tracking Control of an Adjustable Bed
Kopeček, Martin ; Kremláček, Jan (advisor) ; Čapek, Lukáš (referee) ; Komzák, Martin (referee)
The origin of this work was based on the need to control an electric positioning bed by patients with no or significantly reduced upper limb motor skills. The key point and objective of the dissertation study was to develop non-contact alternatives to manual controls and to verify that the eye-tracking technique is usable and offers patients a new level of increased self-sufficiency. The thesis is organized into three related parts with experiments conducted at the detached departments and in the laboratory. After an introductory section covering the stages of development and current progressive trends in eye movement tracking, an experimental study of the applicability of bed control with the role of alternating head and leg position changes using on-screen graphical controls is described. This stage was conducted using a virtual bed. In a group of 17 patients with diagnoses of a pentaplegia, tetraplegia, high paraplegia, myopathy, and spinal muscular atrophy, the overall time to solve the task was 67.1 s (median) with a large interindividual variability with interquartile range from 56.7 s to 92.9 s. The solution efficiency (100 % matched to optimal performance) was 45.5 (34.9; 62.0) %. Within each group patients achieved different results for both studied parameters. When evaluating the features of the...
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Physiotherapy during Covid - 19 pandemic within patients with sclerosis multiplex
Knapová, Ivana ; Novotná, Klára (advisor) ; Havlová, Martina (referee)
Name, surname: Ivana Knapová Supervisor: Mgr. Klára Novotná, Ph.D. Title: Physiotherapy during COVID-19 pandemic within patients with sclerosis multiplex Abstract: This work focuses on the possibilities of physiotherapeutic intervention in patients with multiple sclerosis who experience persistent symptoms after recovering from COVID-19 infection. The main aspects of therapeutic intervention include physical therapy and respiratory physiotherapy. The theoretical part of the work introduces the issue of post-COVID syndrome and delves into its terminology, pathogenesis, diagnosis, prevalence of clinical symptoms, and therapeutic possibilities from both general and physiotherapeutic perspectives. Another part is dedicated to the characterization of multiple sclerosis itself, providing a detailed description of the basic characteristics of this disease. In the concluding section of the theoretical part, topics such as pulmonary rehabilitation, respiratory physiotherapy, and physical therapy are thoroughly discussed. The main objective of this work is to provide an overview of the benefits of respiratory physiotherapy and physical therapy for patients with multiple sclerosis who experience post-COVID syndrome symptoms. As part of this objective, a brochure containing exercises suitable for self-therapy...
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Pain in patients with multiple sclerosis
Paulů, Kateřina ; Novotná, Klára (advisor) ; Grosserová, Barbora (referee)
The bachelor thesis deals with the topic of pain in patients with multiple sclerosis. The aim of the thesis is to map the prevalence of pain among patients with multiple sclerosis, its localization, time course, triggering factors, type, character, intensity and some other aspects pain through a shortened Czech form of the standardized questionnaire of McGill University. The thesis consists of theoretical and practical part. The theoretical part deals with the issue of pain in general, but also focuses on the individual types of pain that are characteristic of multiple sclerosis. The practical part relies on data collection by means of a questionnaire survey that focuses on mapping the prevalence of pain, its location, haracter, duration, intensity and other possible related factors. To collect data, I used a shorter form of the Czech version of the standardized McGill University questionnaire. The questionnaire survey was carried out with patients of the Centre for Demyelinating Diseases, Department of Neurology 1. LF UK and VFN in Prague, who were given a paper questionnaire. The information I obtained was processed into graphs and tables. The results showed that pain is present in 60 % of respondents with multiple sclerosis, most often localized in the spine and lower limbs. The intensity of...
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Use of electrostimulation according to Jantsche and Hufschmidt to influence triceps surae muscle spasticity and walking speed in patients with multiple sclerosis
Tichá, Simona ; Demeková, Júlia (advisor) ; Hojková, Klára (referee)
This thesis focuses on comparing the effectiveness of two types of electrostimulations, specifically electrostimulation according to Hufschmidt and Jantsche, in reducing m. triceps surae spasticity and influencing walking speed in patients with multiple sclerosis (MS). The aim of the thesis is to determine which type of electrostimulation is more suitable for patients with MS. The topic was chosen based on two previous theses that examined the effects of these electrostimulations individually. The theoretical part provides basic information about MS, explains the pathophysiology of spasticity and the possible influence of spinal mechanisms on it, describes the examination of spastic patients, and summarizes the possibilities of electrotherapy treatment. The practical part compares the effects of both types of electrostimulations in patients with MS who were partially randomly divided into two groups of three and evaluates short-term and long-term results using the "Five step clinical assessment in spastic paresis" examination and the subjective perception of walking questionnaire MSWS-12 (Multiple Sclerosis Walking Scale). The results of the thesis do not show significant differences in the effects of both electrostimulations. The most significant improvements in both groups were observed in the...
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Multiple sclerosis: correlation of gene expression and response to immunomodulatory therapy
Kleinová, Pavlína ; Kubala Havrdová, Eva (advisor) ; Taláb, Radomír (referee) ; Musil, Zdeněk (referee)
KLEINOVÁ, Pavlína. Roztroušená skleróza mozkomíšní: korelace genové exprese a odpovědi na imunomodulační léčbu [Multiple sclerosis: correlation of gene expression and response to immunomodulatory therapy]. Praha, 2023. 107 s., 3 přílohy. Disertační práce. 1. lékařská fakulta Univerzity Karlovy v Praze. Vedoucí práce Eva Kubala Havrdová. Abstract Multiple sclerosis is a chronic autoimmune disease of the central nervous system with a genetic component, modifiable with immunomodulatory therapy. It is assumed that genetic factors influence the course of the disease and the therapeutic response. The thesis presents the results of two studies investigating the genetic background of multiple sclerosis. In the first study, the influence of the (GT)n polymorphism of the promoter of the HMOX1 gene for heme oxygenase 1 affecting its expression was investigated in people with multiple sclerosis. No effect of this polymorphism on the course of the disease was observed. We confirmed the effect of immunomodulatory therapy on delaying disease progression. The second study, called the Genotype/Phenotype Project, is a multicentre international genome-wide association study aimed at detecting single nucleotide polymorphisms associated with severity of multiple sclerosis. It has been shown that common genetic variants with...
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Hand training in people with multiple sclerosis in home enviroment
Boudová, Alžběta ; Novotná, Klára (advisor) ; Klimošová, Sylva (referee)
BACHELOR THESIS ABSTRACT Name, Surname: Alžběta Boudová Supervisor: Mgr. Klára Novotná, Ph.D. Consultant: Mgr. Eliška Rotbartová Title: The practice of a hand functioning in patients suffering from multiple sclerosis at their home environment Abstract: The bachelor thesis focuses on the training of hand function in patients with multiple sclerosis in the home environment. Multiple sclerosis is an autoimmune disease leading to demyelination of nerve fibres and their subsequent loss. The aim of the bachelor thesis is to compare the feasibility and effect of different types of therapies aimed at improving upper limb function in people with multiple sclerosis. The types of therapy include conventional outpatient occupational therapy intervention, outpatient intervention with elements of music therapy, telerehabilitation occupational therapy intervention, telerehabilitation intervention with elements of music therapy. The bachelor thesis contains a practical part and a theoretical part. The theoretical part describes the disease multiple sclerosis, risk factors, clinical picture, forms of the disease and treatment options. It also deals with the function of the upper limb and the possibilities of assessment, the possibilities of training hand function are mentioned. Methods of telerehabilitation and music...
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The Independency Training in Person with Multiple Sclerosis in Home Environment
Fabriková, Anna ; Novotná, Klára (advisor) ; Rodová, Zuzana (referee)
BACHELOR THESIS ABSTRACT Name, Surname: Anna Fabriková Supervisor: Mgr. Klára Novotná, Ph.D. Consultant: Mgr. Eliška Rotbartová Title: The Independency Training in Person with Multiple Sclerosis in Home Environment Abstract: This theoretical and practical bachelor thesis deals with the possibilities of occupational therapy for increasing or maintaining self-sufficiency in patients with multiple sclerosis (MS) with higher degree of neurological disability (i.e., patients with EDSS>7). The MS disease, issues of self-sufficiency, palliative care, and some options for social benefits, are described in the theoretical part. The practical part includes 3 case reports of patients of the Centre for Demyelinating Diseases of the Neurological Clinic of the 1st Faculty of Medicine of the Charles University in Prague. All patients completed 6 individual occupational therapy sessions in their home environment. The therapy effect was evaluated by the Barthel Index, modified Frenchay scale and by the Canadian Occupational Performance Measure (COPM). Key words: multiple sclerosis, occupational therapy, rehabilitation, independency, activities of daily living, home environment
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Role of glial cells in pathophysiology of demyelinating diseases of the nervous system
Holásek, Michal ; Kriška, Ján (advisor) ; Pivoňková, Helena (referee)
Glial cells, such as oligodendrocytes, Schwann cells, NG2 glia, astrocytes, and microglia, play a major role in the homeostasis of the nervous system, including the myelin sheath maintenance. Enveloping myelin sheaths produced by oligodendrocytes and Schwann cells, provide a mechanical, isolating, and trophic support to the axons. Importantly, a disruption of a certain component or a dysregulation of a specific process may lead to the collapse and the loss of the myelin sheath, known as demyelination. Axonal demyelination is a pathological condition characteristic of different neurological diseases, such as multiple sclerosis, acute disseminated encephalomyelitis, Charcot-Marie- Toth disease, or Lyme neuroborreliosis. Since, demyelinating diseases are still more prevalent in the population, a suitable and effective treatment is crucial for the patients. However, treatment is not available, which results from an insufficient understanding of pathological mechanisms, low permeability through the blood-brain barrier, and a limited regenerative capacity of the nervous system. Therefore, further research in the field of demyelinating diseases is necessary. Key words: oligodendrocyte precursor cell, oligodendrocyte, Schwann cell, myelination, acute disseminated encephalomyelitis, multiple sclerosis,...
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