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Biological treatment and its influence on the course of latent viral infections in patients with psoriasis
Laurin, Josef ; Šmahelová, Jana (advisor) ; Janovec, Václav (referee)
There are more than 80 identified autoimmune diseases. One of the most prevalent ones is psoriasis. Its prevalence is around 2-5 % worldwide. The treatment of this inflammatory skin disease can be divided as follows: in cases of low severity, topical therapies are used for local treatment and in the cases of insufficient effect, stronger therapies are used. Phototherapy is used for moderate severity, and systemic therapy is used in moderate to severe disease. Systemic agents include cytostatic methotrexate, immunosuppressant cyclosporin, or retinoids (vitamin A analogues). However, even systemic therapies may not yield the desired effects or may have adverse effects on the overall condition of the patient. In those cases, biological therapy comes to use. Biological therapy is usually conducted using antibodies and fusion proteins, which are made using recombinant technologies. Tumour necrosis factor α (TNF-α) and interleukin 12, 17 and 23 (IL-12, IL-17 and IL-23) inhibitors are the most commonly used in the treatment of psoriasis. During the inhibition of the immune system, it has been confirmed that a reactivation of viral infections can occur. These reactivations may subsequently lead to the development of various diseases caused by latent viral infections.
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Effect Multiple Sclerosis on activities of daily living
Němečková, Jana ; Nikodemová, Hana (advisor) ; Křivková, Jana (referee)
Bibliografický záznam NĚMEČKOVÁ, Jana. Vliv roztroušené sklerózy na aktivity denního života. Praha: Univerzita Karlova, 2. Lékařská fakulta, Ústav ošetřovatelství, 2016. 87 s., přílohy. Vedoucí bakalářské práce PhDr. Hana Nikodemová Abstract In my Bachelor thesis I examine the impact of Multiple sclerosis on a daily life activities. The intention is to present an overview of knowledge of the disease itself and map its impact on the activities of a normal day. The work is divided into theoretical and practical part. The introduction of the theoretical part is devoted to reasons of my decision to describe this topic, I define the aim of the work and the working hypotheses, subsequently there is described the disease itself in tabular form by each areas, such as the characteristics of the disease, duration of disease, diagnosis, treatment etc. Then I pay attention to daily life activities and needs of the patient. In the practical part is performed quantitative research through a questionnaire survey of patients from a specialized center for the treatment of demyelinating diseases in the Department of Neurology at the Motol University Hospital. The obtained data are presented in tabular and graphical reports. Keywords multiple sclerosis , activities of daily living, the impact of disease, attack, human needs
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Case study of physiotherapy treatment of a patient with rheumatoid arthritis
Dostálová, Barbora ; Kozáková, Alena (advisor) ; Jarošová, Hana (referee)
Title: Case study of physiotherapy treatment of a patient with rheumatoid arthritis Aims: The main goal of my thesis was to use knowledge gained during studies of physiotherapy in a practical case of a patient treatment and to get feedback of the therapy that was used. The therapy included: an investigation, a proposal of the therapy, a procedure for the therapy and an evaluation of the effect of the therapy. Methods: The first part of my thesis is focused on the theoretical issue of rheumatoid arthritis. The main topic of this part is a clinical picture through which rheumatoid arthritis can come out. I also focused on arthral and non-arthral, neurological, symptoms. At the end of the thesis the physical therapy is discussed. The second part includes the actual diagnosis elaboration of a case study of physiotherapy treatment of a patient with rheumatoid arthritis. It was created during my practice in the Institute of Rheumatology in Prague, from 11th January until 21st January. The part includes an entry investigation, a short-term and a long-term therapy schedule, therapeutic units, an output investigation and an efficiency of the used therapy. The main aim of the therapy was to reduce pain and to restore the strength of muscles and the latitude of joints Results: With a high support of a medical...
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Effect of biological treatment on functional ability and mobility of patients with ankylosing spondylitis
Hušková, Barbora ; Pavelka, Karel (advisor) ; Smolíková, Libuše (referee)
CHARLES UNIVERSITY IN PRAGUE 2ND FACULTY OF MEDICINE Department of Rehabilitation and Sport Medicine Barbora Hušková The influence of biological treatment on functional ability and mobility of patients with ankylosing spondylitis bachelor thesis Prague 2012 Abstract This thesis is primarily a literature search of knowledge about ankylosing spondylitis (AS), supplemented by two case studies of specific patients. The theoretic part describes the characteristics of AS as the main representative of spondylarthritides, including its diagnosis and testing methods. It also contains an overview of current approaches and strategies of a treatment. It focuses on biological treatment with TNF-α blockers. The practical part of the thesis illustrates the findings on the example of a patient with AS treated with biological therapy. It evaluates the subjective feelings in response to treatment and compares the results of treatment with standard therapy (i.e., without biological treatment) on another patient under otherwise similar conditions.
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The usage of algae in biogas transformation
Paroulkova, P. ; Sukačová, Kateřina ; Murgasová, K. ; Vítěz, T. ; Chovanec, J.
Using of algae in a biogas transformation is still in the beginning. However, the microalgae have large potential from the perspective of growing demands on biogas quality and trend of using,natural resources. First of all, it is their ability to fix carbon dioxide (CO2) using photosynthesis and presumed ability of some algae to metabolize hydrogen sulphide (H2S). Biogas contains not only required methane but also components causing its worse quality such as mentioned CO2 and H2S. Therefore, the algae are potential biological systems for biogas-conditioning. The microalga Chlorella pyrenoidosa Chick (IPPAS C2) was used for fixation of CO2 and H2S in our experiment. The microalgae were cultivated in a medium BG 11. The algal suspension was aerated with the biogas during two weeks. Different values of CO2 concentration measured in the input and output confirmed decrease of CO2 caused by intensive growth of algal culture. Decline of H2S was not confirmed.
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Provision of alternative refuse collection for a real estate surrounded by foreign property
Kvapil, Radek ; Štindl, Michal (referee) ; Klika, Pavel (advisor)
The thesis deals with possible ways of drainage and wastewater disposal. The issue of wastewater discharge to the environment has been closely monitored in recent years, and there is an apparent effort to improve the current situation.The dissertation discusses and compares three selected options – access to improved sanitation, building reservoirs and domestic wastewater treatment plant.The final section is dedicated to a comparison of acquisition and operating costs over time and to subsequent evaluation of the most suitable option. For the sake of clarity and assessment of potential solutions, the locality in the administrative area Vysoké Mýto - Domoradice has been selected as a model. The local authorities have been designing a public storm sewer, and given that it is surrounded by land, this issue will need to be addressed.
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Monitoring of selected parameters in the wastewater treatment process in the various WWTP
Dalajková, Nikola ; Zlámalová Gargošová, Helena (referee) ; Repková, Martina (advisor)
This work is focused on wastewater treatment, specifically the WWTP Brno Modřice. Described herein are the general technological parameters of large and medium-sized wastewater treatment plants and wastewater treatment process in the WWTP Brno Modřice. The greatest emphasis is on biological phase of waste water treatment. Purification employs chemical, biological and physical cleaning processes. To determine the effectivness of the treatment plants various indicators are used such as COD, BOD, Ntotal and Ptotal whose the maximum permissible values are established in accordance to norm. The basis of biological treatment is the activated sludge containing microorganisms, by which the effectiveness of the cleaning process is determined. These microorganisms are determined qualitatively and quantitatively. To compare the efficiency measurements of activated sludge were also made at two other wastewater treatment plants. These values were then compared in the experimental part of the work.
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Study variants of specific wastewater treatment
Pernička, Jan ; Ručka, Jan (referee) ; Hluštík, Petr (advisor)
This diploma thesis explores treatment options of wastewater with a low presence of organic pollution produced by minor pollution sources. The research part describes objects with a low presence of organic pollution in wastewater and possible treatment methods in dependence of pollution source's size. The practical part contains the design of technological options of treatment of wastewater with a low presence of organic pollution for a specific object.
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Influence of the various incubation time on the value of BOD
Debnárová, Andrea ; Dolejš, Petr (referee) ; Rozkošný, Miloš (advisor)
Biochemical Oxygen Demand (BOD) is commonly used for determining how fast biological organisms use up oxygen in a body of water. It is one of the essential methods used in water quality management and assessment. BOD could be considered as a quality level indicator of biologically treated water. This process is very time-dependent but most common period of incubation is five days - BOD(5). In this thesis different periods of incubation are compared - for BOD(5) with five days incubation period and BOD(2+5) with five days incubation period but also placed for two days to lowered temperature environment. These comparative tests were made for different types of water (surface water, waste water - water from mechanical level and biological level of treatment) For all kinds of determination of BOD the dilution method was used (ČSN EN 1899).
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Biological pretreatment sewages water
Veselý, Václav ; Beňo, Zdeněk (referee) ; Pěček, Jan (advisor)
Bachelor's thesis deals with waste water purification at the stage of pre-inflow of water into the biological waste water treatment plants. It is divided into two parts, a theoretical and calculation. The theoretical part deals about sewage water and the method of biological treatment. Design proposal is part of the activation tank for quantity EO.
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