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Organizational Culture as a Significant Element of Establishing a Strong Employer Brand and Increasing Employees' Work Performance
Salačová Svobodová, Hana ; Fonville, Alexandra (referee)
The rigorous thesis analyses the organisational culture and its role in building a strong employer brand with implications for improving work performance. The thesis describes the correlation between contemporary employees' values, organizational culture enabling employees to realize their values, the transparently communicated image of the organization imprinted in the employer brand and employee performance. The Means-End Chain theory and the Employee Value Proposition tool are introduced. Their use in forming a happy organizational culture, building a strong employer brand, and improving employees' performance is presented. The aim of the qualitative research is to analyse the link between organizational culture and employer branding with the impact on employees' performance, from the perspective of top management of various organizations. The data are collected from the semi-structured interviews, supplemented by a questionnaire survey. Data are analysed to get an insight and understanding of the practices of the organizations. Keywords Organizational Culture, Values, Happiness Management, Employer Brand, Employee Value Proposition, Work Performance
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Organizational Culture as a Significant Element of Establishing a Strong Employer Brand and Increasing Employees' Work Performance
Salačová Svobodová, Hana ; Fonville, Alexandra (referee)
The rigorous thesis analyses the relationship between organizational culture, building a strong employer brand and increasing employee performance. Using the Employee Value Proposition (EVP) tool, the thesis defines the prerequisites for an organizational culture in which employees feel joy, and meaning, and are immersed in their job, which has a positive impact on their engagement as well as on their work performance. The EVP tool is also connected with the employer branding activities to be as effective as possible when the organization efforts to gain the loyalty of the best current and future employees. The aim of the qualitative research is to analyse the organisational culture of the eight small and medium-sized Central Bohemian organisations using the EVP tool, focusing on the factors of increasing work performance and building a strong employer brand. Data collection takes the form of semistructured interviews with the directors of these organisations, supplemented and enriched by a questionnaire survey. Keywords Engagement, Well-Being, Employee Value Proposition, organizational culture, work performance, meaningfulness, employer brand.
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Business Plan – Establishment of a New Company
Svobodová, Hana ; Ptáček, Roman (referee) ; Heralecký, Tomáš (advisor)
This bachelor's thesis deals with the creations of a business plan for the establishment of a new company offering hookahs. The work consists of theoretical, analytical and design parts. The first part focuses on the definition of terms related to the topic. The second part analyzes the current state of the market using selected methods. The third part contains the elaboration of the business and financial plan, which is substantiated in the previous sections.
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The impact of selected sesquiterpenes on the activity of antioxidant enzymes in the differentiated Caco-2 cell line
Verešová, Erika ; Svobodová, Hana (advisor) ; Szotáková, Barbora (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Erika Verešová Supervisor: PharmDr. Hana Bártíková, Ph.D. Title of thesis: The impact of selected sesquiterpenes on the activity of antioxidant enzymes in the differentiated Caco-2 cell line The cases of cancer diagnosis rapidly continue to grow across the population. It is a modern trend to buy more and more often a variety of herbal food supplements in order to strengthen or restore human health. Many scientists have been researching Myrica rubra plant for its potential therapeutic effects. In our research we used sesquiterpenes isolated from this plant, in order to determine their effects on the activity levels of antioxidant enzymes in a differentiated Caco-2 cell line derived from intestinal epithelium tumor that have maintained characteristics of healthy cells. Caco-2 cells are being used as a basis for testing of substances and their effects on non-cancerous cells. The cells were incubated for 24 and 48 hours with a concentration 25 µg/ml of tested substances. Essential oil from Myrica rubra and selected individual sesquiterpenes (α- humulene, β-caryophyllene and trans-nerolidol) were chosen to be tested. Of the antioxidant enzymes, we determined the enzymes glutathione-S-transferase,...
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Surface expression of Tim-3 inhibitory molecule on antigen-specific CD8+ T cells expanded in vitro using dendritic cells for cell-based cancer immunotherapy
Svobodová, Hana ; Smrž, Daniel (advisor) ; Funda, David (referee)
Cancer is the second most common cause of death in the world, and the number of people with the disease increases each year. The therapy of the disease currently stands on four pillars; surgery, chemotherapy, radiotherapy, and immunotherapy. Through the past few years, immunotherapy has become the fastest developing treatment modality. However, despite its unprecedented efficacy in some patients, the majority of patients still does not respond to the therapy. Therefore, there is a need to investigate the mechanisms that make immunotherapy inefficient. Cell-based cancer immunotherapy is the treatment modality which uses live ex vivo-produced tumor-targeting immune cells to treat cancer. One of the mechanisms that may compromise its therapeutic efficacy is the expression of inhibitory molecules on the surface of the produced immune cells. Tim-3 is the inhibitory molecule which attracts attention in recent years. Tim-3 expression in the tumor cells and the tumor-infiltrating immune cells is often associated with worse prognosis and more aggressive forms of the disease. However, its role in the in vitro or ex vivo-produced immune cells is difficult to predict. In this work, an in vitro study model which is based on in vitro-produced antigen-specific CD8+ T cells with high expression of Tim-3 has been...
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Modification of selected biotransformation enzymes during ageing (in rat)
Vyskočilová, Erika ; Boušová, Iva (advisor) ; Svobodová, Hana (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Erika Vyskočilová Supervisor: PharmDr. Iva Boušová, Ph.D. Title of diploma thesis: MODIFICATION OF SELECTED BIOTRANSFORMATION ENZYMES DURING AGEING (IN RAT) Ageing is an inevitable biological process characterized by progressive functional decline of all organ systems with simultaneous increase in oxidative damage as a result of reactive oxygen species (ROS) accumulation. Increased activity of antioxidant enzymes, such as peroxidase and catalase, is related to increased production of ROS during ageing. Activity of biotransformation enzymes such as cytochrome P450 (CYP) and glutathion-S-transferase (GST) changes during ageing too. In general, activity of enzymes is lower in very young and very old individuals than in the period of adulthood. The aim of the present work was to study age-related changes in activities and expression of selected xenobiotic-metabolizing enzymes (GST, CYP 1A, CYP 2B, CYP 3A4) and antioxidant enzymes (catalase, peroxidase, superoxiddismutase) in rat liver. Male Wistar rats were sacrificed by decapitation under ether anesthesia at the age of 6 weeks and 21 months (6 individuals in each group). Subsequently, liver specimens were processed to obtain the subcellular...
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