National Repository of Grey Literature 188 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Relief of Pain during Vaccination in Children. The Efficacy of Thermomechanical Distraction Device.
Steinbauerová, Blanka ; Svobodová, Hana (advisor) ; Dvořáková, Sandra (referee)
Over a period of three months, the Buzzy® thermomechanical device was offered in a Prague general practitioner's office for children and adolescents as a relief from pain and fear associated with vaccination. Of the group of children and parents (n-34) studied, the majority were interested in learning more about the product and using it during vaccination. It was confirmed that both children and parents were interested in some form of pain and fear relief during the invasive procedure. The device was held on the arm by the children themselves or their parents at the point above the needle insertion. After the Buzzy® vaccination, the children rated their perception of pain during the injection and application of the vaccine as "does not hurt" or "hurts a little" according to the five-point VAS scale. Most children found the device effective. On the same VAS scale, the vibration and coolness of the Buzzy® ladybird were mostly rated favourably by the children. Some children were not comfortable with the vibration and coolness of the aid. Due to individual perceptions of pain and fear, the Buzzy® cannot be considered a guaranteed "cure" for children who are sensitive and anxious. However, within a sensitive, empathic and individualized approach to both young and older patients, Buzzy® can effectively...
The effect of green tea polyphenols on antioxidant enzymes in mice in vivo
Kvita, Vojtěch ; Svobodová, Hana (advisor) ; Matoušková, Petra (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Vojtěch Kvita Supervisor: PharmDr. Hana Bártíková, Ph.D. Title of diploma thesis: The effect of green tea polyphenols on antioxidant enzymes in mice in vivo Antioxidant enzymes belong to compounds with proven effects on human organism. Their main purpose is to defend cells against oxidative stress. In order to support this process, we are taking substances called antioxidants either in regular diet or as dietary supplements. Recently there are a lot of companies on the market, offering the supplement, promising wight loss or defence against cancer. Green tea contains many natural substances, such as polyphenolic compounds which include catechins, which have proven effects on our bodies, but the specific way they act on selected antioxidant enzymes is still matter of study. The aim of this work was to determine the effect of green tea polyphenols on antioxidant enzymes in mice. We studied 8 groups (4 normal, obese 4) wherein the two groups were left as a control which means without administration of Polyphenon. Three groups were given a Polyphenon enriched diet and for various period of time (28 days, 3 days) and at different concentrations (0.1%, 0.01%). Activity was studied in liver...
Biotransformation of selected anthelmintics in sheep tapeworm (Moniezia expansa)
Němečková, Aneta ; Svobodová, Hana (advisor) ; Lamka, Jiří (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Aneta Bečanová Supervisor: Mgr. Hana Bártíková, Ph.D. Title of diploma thesis: Biotransformation of selected anthelmintics in sheep tapeworm (Moniezia expansa) Biotransformation of anthelmintics is a process that prevents the parasite from adverse effects of xenobiotics. Therefore, it is the main factor that causes the reduction of an anthelmintic effect, resistance development and thus the failure of drug therapy of helminthosis. Therefore many studies focused on anthelmintics biotransformation in helminths have been published. This experiment was aimed at the biotransformation of albendazole, flubendazole and mebendazole in the sheep tapeworm (Moniezia expansa) and the activity of its biotransformation enzymes. Tapeworms were obtained from sheep intestines. Biotransformation of benzimidazoles was determined in in vitro and ex vivo experiments. Flubendazole and mebendazole were metabolized in much greater extent than albendazole. The activity of antioxidative enzymes, which also can participate in drug biotransformation, was detected mainly in the cytosol. Neither cytochromes P 450 nor flavin-containing monooxygenases were detected. Reductive enzymes were determined by means of specific...

National Repository of Grey Literature : 188 records found   1 - 10nextend  jump to record:
See also: similar author names
34 SVOBODOVÁ, Hana
16 SVOBODOVÁ, Helena
2 Svobodová, Hana,
1 Svobodová, Hedvika
16 Svobodová, Helena
2 Svobodová, Hermína
Interested in being notified about new results for this query?
Subscribe to the RSS feed.