National Repository of Grey Literature 80 records found  1 - 10nextend  jump to record: Search took 0.01 seconds. 
Virulence of Bordetella pertussis from an Omics Perspective
Novák, Jakub ; Šebo, Peter (advisor) ; Černý, Jan (referee) ; Novák, Petr (referee)
The Gram-negative aerobic coccobacillus Bordetella pertussis is one of the few exclusively human pathogens and the main causative agent of the respiratory infectious disease called pertussis, or whooping cough. Despite global vaccination programs, pertussis remains an important public-health burden and still accounts for over 100,000 infant deaths and over a dozen of millions of whooping cough cases every year. Substantial effort is devoted to studies on the mechanisms of action of virulence factors of B. pertussis, but the biology of interactions of B. pertussis with its human host remains largely underexplored. Evolution, genetics and adaptation of B. pertussis to the complex environment of human nasopharynx and the mechanisms enabling B. pertussis to overcome host innate and adaptive mucosal immune defenses, remain poorly understood. In such situations, unbiased exploratory omics approaches represent valuable tools for uncovering of unknown aspects of host-pathogen interactions and open the path to detailed analysis of virulence-underlying processes by mechanistic studies. In this thesis, I am presenting the results of three omics projects on B. pertussis biology that involved high-throughput proteomics. In the inital phosphoprotemics project, we analyzed the kinase signaling pathways hijacked...
CARAVAN
Balková, Natálie ; Novák, Jakub (referee) ; Tobola, Ondřej (advisor)
The diploma thesis deals with possible layout plan of a camper van and considers different possibilities of its utilization and tries to find the best possible ways of comfortable living on roads. The goal of the thesis is to show meaningful ways of connecting the sanitary, living and sleeping zone to achieve ideal balance among those. When living in the cramped space of the camper van, the goal is to provide ergonomic environment without any obstacles caused by poor design of the interior. The thesis shows the layout plan that would comply with comfort both on short trips and also on longer tours. Important thing is to deal with the design of windows to utilize the possibilies of using the natural daylight as a source of lighting. Larger windows would also contribute to a better connection with van’s surroundings. The outcome of the thesis is visualisation of 3D model, architectural study showing possible layouts, physical model and additional visualisations.
The deposition of Ga and GaN nanostructures on silicon and graphene substrate
Novák, Jakub ; Jarý, Vítězslav (referee) ; Mach, Jindřich (advisor)
The thesis is focused on the study of properties of GaN nanocrystals and Ga structures on the surface of silicon and graphene substrate. In the theoretical part of this thesis, the basic properties of Ga/GaN and graphene are described, as well as their applications or connection of both structures together in different devices. The ability of metal nanoparticles to enhance not only photoluminescence, due to the interaction of the material with surface plasmons, is also shown in several examples. The experimental part of the work first deals with the production and characterization of graphene sheets prepared by Chemical Vapor Deposition. Ga/GaN growth on both types of substrates was performed in a UHV chamber using an effusion cell for Ga deposition and an atomic ion source for nitridation. Prepared structures were characterized using various methods (XPS, SEM, AFM, Raman spectroscopy or photoluminescence). In the last step, GaN nanocrystals were coated with Ga islands to study the photoluminescence enhancement.
Space Missions to Mercury
Novák, Jakub ; Šťastná, Dagmar (referee) ; Froehling, Kenneth (advisor)
Cílem této práce je se seznámit s předešlými i současnými vesmírnými misemi na planetu Merkur, a to konkrétně na předchozí misi NASA Messenger a současnou společnou misi ESA a JAXA, BepiColombo. Tato práce popisuje cíle a dosavadní výsledky, dále se zaměřuje na použité vědecké technologie, včetně detailního popisu vědeckých instrumentů a výzkumu návrhu konstrukce obou sond.
Mobile Phone Location Data: Possibilities of Use in Geographical Research
Novák, Jakub
Charles University in Prague Faculty of Science Department of Social Geography and Regional Development Jakub Novák MOBILE PHONE LOCATION DATA: POSSIBILITIES OF USE IN GEOGRAPHICAL RESEARCH Synopsis of PhD Thesis Prague 2010 Supervisor: Assoc. Prof. Zdeněk Čermák Jakub Novák Synopsis of PhD Thesis 1 Jakub Novák Synopsis of PhD Thesis 2 INTRODUCTION Spatial mobility of world population has been unbelievably changing during the last decades. People from poor countries are moving thousands of kilometers to developed countries with the vision of material prosperity. Airplanes transport thousands of people in hours to places, where people had travelled much longer recently. Similarly, also an ordinary weekday is for the majority of population connected with relatively long moves between different places of daily activities. Traveling between home, work, kindergartens and schools, shops and leisure activities takes the significant part of our daytime. To capture the measureless amount of particular human creatures in their day-to-day moves through time and space seems to be almost impossible. In fact, it is not so unrealistic. Currently, we are surrounded by a number of electronic devices, which dispose with information about its location or record moving objects in their vicinity. Mobile phone is one of such...
Expansion of the abdominal wall as a consequence of intrabdominal pressure
Podskalská, Patricie ; Novák, Jakub (advisor) ; Kobesová, Alena (referee)
The thesis examines the relationship between the level of intra-abdominal pressure and abdominal wall expansion. The theoretical part brings an overview of knowledge about the function of intra-abdominal pressure and about the possibilities of objectification of postural functions. There are described studies which dealt with the influence of intra-abdominal pressure on the stability of spine. Theoretical part also includes detailed description of individual invasive and non-invasive methods of measurement of intra-abdominal pressure and activation of abdominal muscles. Work methodology: In the practical part the intra-abdominal pressure was measured using anorectal manometry and abdominal wall expansion by utilizing DNS brace device. 31 healthy examinees with average age of 26.77 (SD 3.01) were measured in five different standing postural situations: during resting breathing, Valsalva Maneuver, Müller's maneuver, diaphragm test and in the situation with added external load in the form of static holding of dumbbell. Results of the thesis: Among the values of the pressure gathered from the DNS brace device and from anorectal manometry was proven statistically important correlation (p < 0.001) in all five tested situations. In all situations the Pearson Correlation Coefficient was higher than 0.6...
The incidency of injury among men players in the highest floorball league during years 2014-2019
Honzová, Petra ; Urbářová, Eliška (advisor) ; Novák, Jakub (referee)
The topic of this diploma thesis is the description of injury rate at floorball in the men's highest competition within the years 2014-2019. The work consists of theoretical and practical part. The rules of floorball, the popularity, and unions (federations) of this sport in our country and abroad, the concept of the season and the characteristics of the player's movement, including muscle imbalances are described in the theoretical part. A general division of sports injuries and a description of the most common injuries at floorball is a part of theory, as well as their prevention, registration, and treatment. In addition to contact with another person, glasses, shoes, the surface, the age of the player and, in the case of goalkeepers, knee protectors can influence injuries at this indoor sport. Further the method of educating coaches in the Czech Republic and the content of a seminar on compensation, which is presented to coaches at trainings, is also described there. The practical part is focused on the collection of injury rate data from paper and electronic records from matches in the seasons from 2014/2015 to 2018/2019. These results are compared with respect to the presence of a physiotherapist, the player's age, the surface in the halls, the phase of the season and the occurrence of an...

National Repository of Grey Literature : 80 records found   1 - 10nextend  jump to record:
See also: similar author names
50 NOVÁK, Jakub
79 NOVÁK, Jan
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