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Molecular mechanisms involved in genotoxicity of industrially important monomers (styrene, 1,3-butadiene)
Kuricová, Miroslava ; Vodička, Pavel (advisor) ; Černá, Marie (referee) ; Machala, Miroslav (referee)
1 ABSTRACT The evaluation of individual health risk in workers occupationally exposed to industrial xenobiotics requires the use of a large number of parameters reflecting external exposure, internal exposure, biological effects and individual susceptibility. Environmental, occupational and life style-related exposure to mutagenic agents may contribute to cancer risk in humans. To prevent the potentially hazardous effects of such agents it is important to understand their mechanisms of action. Styrene is one of the most important monomer for producing polymers and copolymers in plastics, latex paints and together with 1,3-butadiene (BD) in the manufacture of synthetic rubbers. In this thesis, a large set of parameters, including markers of external and internal exposure and biomarkers of biological effects and susceptibility have been studied in relation to the occupational exposure to both styrene and BD. First part of the present study was focused on evaluating the role of various biomarkers to assess genotoxic effects of above mentioned xenobiotics. Biomarkers reflecting styrene- and BD-induced genotoxicity and mutagenicity: O6 -styrene guanine DNA adducts, haemoglobin adducts, single-strand breaks (SSBs), SSB Endo III sites, chromosomal aberrations (CA), hypoxanthine-guanine phosphoribosyltransferase...
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METABOLISM AND EFFECTS OF NEW ANTHELMINTIC DRUG IN HELMINTHS AND ITS HOSTS
Stuchlíková, Lucie ; Skálová, Lenka (advisor) ; Kučera, Radim (referee) ; Machala, Miroslav (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate Mgr. Lucie STUCHLÍKOVÁ Supervisor prof. RNDr. Lenka SKÁLOVÁ, Ph.D. Title of Doctoral Thesis METABOLISM AND EFFECTS OF NEW ANTHELMINTIC DRUG IN HELMINTHS AND ITS HOSTS Diseases caused by helminths, called helminthoses, are one of the most serious problems in veterinary and human medicine. These diseases are treated by anthelmintics but their effectiveness is often not sufficient due to resistance of helminths against common anthelmintics. The global anthelmintic resistance encouraged the developing of new drugs with a different mode of action. Monepantel (MOP) belongs to a new class of anthelmintic drugs known as amino- acetonitrile derivatives (AADs) that act on the nicotinic acetylcholine receptors. In 2011, MOP was approved for the treatment of gastrointestinal diseases caused by nematodes in the veterinary practice in the Czech Republic. It is produced commercially under the trade name Zolvix® (Novartis AG). The aim of this doctoral thesis was to study metabolism and effects of MOP and other AADs in order to contribute to the global research in this field. For this purpose, adults nematodes Haemonchus contortus (the sensitive strain ISE and the resistant strain WR) and its hosts Ovis...
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Spa Švabľovka
Machala, Martin ; Mašek, Radomír (referee) ; Marek, Jiří (advisor)
In the Saris region there are several sulfur mineral springs. The most important is spring Svablovka. A small local spa existed near the spring visited mainly by citizens of Sabinov and surrounding nobility. After secend world war operation of the spa was not restorted. Tradition persist and need of the spa becomes actual. Create silent and calm place for resting body. The new spa is embedded in the slope above the town in the narrow site. Minimalistic shape do not want to compete with surroundings. Restaurant and terrace open into entrance space of the site. It is link between lobby and exterior. Basin part is otherwise closed with own atmosphere and intimacy. The centre is water. The spaces is based on Roman hypocaust system. The main basin is embosomed by hotter sauna and fire bath. Used water is recycled for heating
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Operation and Competitive Advantages of VLJ Aircraft
Machala, Marek ; Mahovský, Daniel (referee) ; Kujal, Tomáš (advisor)
Master’s thesis deals with problematic of operating aspects and competitiveness of VLJ aircraft in Czech and Europe market. The Thesis contain information about different types of VLJ, their operational costs and comparisons with competitors, some information about aircraft fractional ownership and their operation. There is written a market analysis for this aircraft and air taxi service in analyzed.
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Design of tool for thinn walled tubes bending
Machala, Martin ; Matušková, Jarmila (referee) ; Samek, Radko (advisor)
MACHALA Martin: Design of tool for thin walled tubes bending. Project elaborated in the frame of the Bachelor study branch Manufacturig Technology (2303R002) is concerned with the summary methods and forming processes of tubes. On the basis of the literaty study dealing with problems of thin wallded tubes bending a description of basic methods of thin walled tubes bending was created with regard to usability and danger of defects generation. The main target of this project is to make a draft a manual tool for thin walled tubes bending.
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Community halls ventilation requirements
Machala, Martin ; Košner, Jan (referee) ; Hejčík, Jiří (advisor)
Bachelor’s thesis deals with ventilation systems and requirements for ventilation of cultural rooms. First of all author focuses on basic ventilation systems. This should be useful to create some theoretical view about this theme. In next topic hygienic requirements for cultural rooms with specification on theatres are discussed in details. In final part author presents suitable ventilation systems capable to fit stated hygienic requirements.
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Marketing Strategy for the New Product Line
Machala, Martin ; Hačunda, Pavol (referee) ; Chlebovský, Vít (advisor)
Diploma thesis deals with the proposal of marketing strategy for an existing company, which is producing platforms for disabled people. This company will expand and distribute also lifts. The marketing strategy is based on the theory and analysis of the state of the company. Implementations should lead to getting into the awareness of new clients and entry of the company into a new market.
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