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Study of stability of receptor specific radiopharmaceuticals
Hanzalová, Lenka ; Lázníček, Milan (advisor) ; Trejtnar, František (referee)
Thesis: Determination of radiochemical purity and stability compared to two selected receptor-specific radiolabelled peptides. Charles University, Faculty of Pharmacy in Hradec Kralove Lenka Hanzalová, May 2011 Abstract: Radiopharmaceuticals are among medicinal substances which have very a limited application over time. Not only due to the fact that it gradually decreases their activity, depending on the half-life of the radionuclide applied, but it may also lead to destructive reactions in the molecule. In view of these reactions, there are decreases in the percentage of radiopharmaceutical degradation of products, which reduces the value of medicines. Degradation of products containing non-peptide nature radionuclides from the parent substances differ in their distribution in the body, increasing side effects, and radiopharmaceuticals, due to their nature, can accumulate in different tissues and subsequently damage them. It is therefore important to know and be able to assume representation of the evolution of the degradation of products over time. In the presented thesis, the problem of determining stability, or radiochemical purity at different time intervals in two days, is solved. Substances being compared were a synthetic somatostatin analogue, labelled with radionuclides two mA, pure beta-emitter 90...
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Brownfields - comparison of rural areas in the regions of Pelhřimov and Jihlava
HANZALOVÁ, Lenka
This master thesis, entitled "Brownfields - comparison of rural areas of Pelhřimov and Jihlava" focuses on the issue of brownfields, their typology, their characteristics and the terms associated with them. Core of the whole work was a field survey of selected municipalities in the Pelhřimov and Jihlava districts in which these objects were searched. Based on these empirical data, areas were compared not only with each other, but also with the public register of brownfields. The impact of brownfields on the quality of life of local populations emerged from the results of a simple survey. The aim of the thesis was to map the occurrence of brownfields in designated areas and the subsequent comparison between the evidence and the actual state.
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Study of stability of receptor specific radiopharmaceuticals
Hanzalová, Lenka ; Lázníček, Milan (advisor) ; Trejtnar, František (referee)
Thesis: Determination of radiochemical purity and stability compared to two selected receptor-specific radiolabelled peptides. Charles University, Faculty of Pharmacy in Hradec Kralove Lenka Hanzalová, May 2011 Abstract: Radiopharmaceuticals are among medicinal substances which have very a limited application over time. Not only due to the fact that it gradually decreases their activity, depending on the half-life of the radionuclide applied, but it may also lead to destructive reactions in the molecule. In view of these reactions, there are decreases in the percentage of radiopharmaceutical degradation of products, which reduces the value of medicines. Degradation of products containing non-peptide nature radionuclides from the parent substances differ in their distribution in the body, increasing side effects, and radiopharmaceuticals, due to their nature, can accumulate in different tissues and subsequently damage them. It is therefore important to know and be able to assume representation of the evolution of the degradation of products over time. In the presented thesis, the problem of determining stability, or radiochemical purity at different time intervals in two days, is solved. Substances being compared were a synthetic somatostatin analogue, labelled with radionuclides two mA, pure beta-emitter 90...
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The strategic analysis of the OD5K10, z. s.
Hanzalová, Lenka ; Vávrová, Hana (advisor) ; Mikan, Pavel (referee)
The aim of the Master´s Thesis is implementation of the strategic analysis for the non-governmental organization OD5K10, z. s., considering the external environment and also the internal resources, which are available for the organization, and in this way reveal all the factors which have impact on its economy. For analysis of the macro-environment PEST analysis is used. In analysis of the micro-environment there are indetified forces, which can affect an ability of the organization to satisfy the needs of its clients (either customers themselves or competitors, suppliers, community). We can not forget also internal analysis, where resources of this subject, its financial management and its reliability are described and analyzed. The important part of the thesis is the synthesis of the results, where strenghts, weaknesses, opportunities and threats are summarized.
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Unemployment in the EU as a problem for the young generation
Hanzalová, Lenka ; Bič, Josef (advisor) ; Němcová, Ingeborg (referee)
Thesis deals with a very actual issue of unemployment of the young generation in the European Union. The essential part is devoted to the analysis of development, causes and context of the high unemployment rate in the European Union. Another part of my thesis is comparison of conditions for the young people in the labour markets of seven member states of EU. The main objective is to find out which measures are effective, this goal is achieved in the third and fourth chapters, in which I introduce the main strategies and initiatives and other EU practicable steps.
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Marketing strategy of Rodinný pivovar Bernard a.s.
Hanzalová, Lenka ; Mikeš, Jiří (advisor) ; Lipták, Tomáš (referee)
The thesis focuses on marketing strategy of Rodinný pivovar Bernard. The thesis is divided into two main parts - theoretical and practical. The theoretical part deals with general basics of marketing and introduce tools of marketing strategy. In the practical part I analyze company using marketing tools and on that basis I give recommendations to improve the activities of this brewery.
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