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Changes of landscape structure and scattered greenery in the Jistebnicko region
Štěpán, Jan ; Lipský, Zdeněk (advisor) ; Romportl, Dušan (referee)
The landscape has been profoundly affected by human activity for centuries and the consequences of this interference have been growing in scale with the rising demands of modern society. The processes leading to the landscape's homogeneity, or, on the other hand, its fragmentation, have been focus of many studies which then allow us to understand how the landscape functions in its entirety and are also significant for the process of spatial planning on the local level. The aim of this theses is to assess the changes done to land cover an landscape's (micro)structure with special focus on scattered greenery (non-forest woody vegetation), as well as to examine how these changes have been mapped into the cadastral municipality of Cunkov, located in the Jistebnická vrchovina highlands, throughout the last 180 years. It is then possible to analyze these changes using the GIS and historical materials from three time periods which were beforehand selected - the years 1840, 1953 and 2019. Microstructure of the landscape plays an essential role in landscape's dynamics and for its ecologic stability.
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Hepatitis E infection in hunters from wild cloven-hoofed game animals
Štěpán, Jan ; Kudlová, Jana (advisor) ; Chvojková, Kateřina (referee)
Introduction: In the last ten years there has been a rapid increase of hepatitis E cases (hereinafter as HEV) in the Czech Republic and European Union. In accordance with findings from recent years the prevalence of this infection in boars, deer, roe deer, fallow deer and other cloven-hoofed game has risen too. Under Czech law these animals can be hunted by hunters who are the first ones to come into contact with the hunted animals in the greatest extent which entails the highest risk of infection. This Diploma Thesis deals with viral hepatitis E as an acute zoonotic virus transmissible from wild cloven-hoofed animals to hunters. The author sought to determine the level of awareness of the hunting society of the risks of infection, their awareness of this infection and protection against it to improve possible protection. The theoretic part of the Diploma Thesis deals with, including, but not limited to, basic information about viral hepatitis. Materials used to prepare the theoretic findings of this Diploma Thesis were obtained from a research made by the National Medical Library, from sources found in expert databases (ResearchGate, ScienceDirect, Scopus, PubMed, Web of Science, Google Schollar and others), from the opinions of professional organisations and associations about HEV and their...
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Návrh dvougeneračního rodinného domu
Štěpán, Jan
This diploma thesis deals with design of house for living of two generations. The house is designed with the form of wooden frame structure with the extensive green roof system. In the first part, the thesis is focused to issues of energy efficiency and passive house standard of living. In the next part is described topic of the green roof. In the practical part is described selection of structural system, design of composition structures including requirement for implementation of construction works. Furthermore is performed thermal technical assessment of composition structures and calculation of energy balance according to PHPP. In the end is a brief description of static design of ceiling structure. The drawing part includes project and manufacturing documentation including solutions of important construction details.
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Bone remodeling in rheumatic diseases: Bone loss in juvenile idiopathic arthritis
Brábníková Marešová, Kristýna ; Štěpán, Jan (advisor) ; Blahoš, Jaroslav (referee) ; Hrnčíř, Zbyněk (referee)
Introduction: The inflammation plays the essential role in the bone loss in juvenile idiopathic arthritis (JIA). Proinflammatory cytokines and also glucocorticoids (GCs) may activate bone resorption by osteoclasts. Simultaneously, bone formation can be attenuated, especially by inhibitors of proteins, which control the osteoblast differentiation. The aim was to verify the hypothesis that in patients with highly active JIA, reduction of bone formation via Wingless (Wnt) proteins inhibitors - Dickkopf 1 (Dkk-1) and sclerostin could be found. Except the densitometry measurements of bone and lean mass, we assessed markers of disease activity, bone metabolism and remodeling in young adult patients with JIA before and during 2 years of anti TNFα (tumour necrosis factor α) treatment, which decreases disease activity. Results: In patients with JIA before antiTNFα treatment, bone mineral density (BMD, g/cmš) was significantly reduced compared to controls. Values of BMD and body composition in JIA significantly depended on disease duration and GCs treatment. Serum concentration of sclerostin was significantly elevated in JIA compared to values in healthy controls. Values of the other monitored markers did not differ between JIA and controls. In patients with JIA, Dkk-1 correlated positively with C-reactive...
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název v anglickém jazyce není uveden
Michalská, Dana ; Štěpán, Jan (advisor) ; Stárka, Luboslav (referee) ; Pavelka, Karel (referee)
Microdamage of bone tissue is one of important aspects of quality of bone. Marked suppression of bone turnover by bisphosphonates is associated with increased accumulation of bone microdamage in animal models. The purpose of our study was to test the hypothesis that long-term treatment with alendronate (ALN) results in accumulation of microdamage in bone in women after menopause and in that case to impairment of bone quality. In this cross-sectional study, 66 women with postmenopausal osteoporosis (mean age of 68.0 years, mean BMD T-score of - 1.7 at total hip and -2.8 at lumbar spine; 62% with prevalent fractures) were evaluated. Thirtyeight had been treated previously with ALN (10 mg/day for a mean duration of 63.6 months) while 28 were treatment naive (TN). Before initiation of ALN treatment, mean serum PINP, plasma CTX, and OC were significantly increased as compared with reference values in premenopausal women (P< 0.05). After 6 months of ALN treatment, the mean of biochemical bone markers indicated significant suppression of bone remodeling (-70.5%, -84.1%, and - 67.3% for PINP, CTX and OC, respectively; P< 0.05). After 43 months of ALN treatment, markers of degradation and synthesis of type 1 collagen were below the lower limit of normal reference range in 50% of women treated with ALN. Without...
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Bone metabolism, infection and ischemia in diabetic foot syndrome
Bém, Robert ; Jirkovská, Alexandra (advisor) ; Štěpán, Jan (referee) ; Broulík, Petr (referee)
The diabetic foot (DF) is one of the most frequent late complications of diabetes, which often leads to limb amputation and effects the quality of life in patients with diabetes. Ischaemia and infection play important role in pathogenesis of DF. One form of DF is Charcot neuroosteoarthropathy (CNO), defined as a noninfectious destruction of bones and joints in the foot due to diabetic neuropathy. The subject of the dissertation thesis was divided into 3 parts: bone metabolism and CNO, ischaemia and infection in DF and new methods in the treatment of DF. (...) In the third study, new quantitative scintigraphic parameters for assessment of CNO activity were defined and confirmed their satisfactory correlation with other parameters of CNO activity. In fourth and fifth study,good reproducibility was verified and efficiency of power spectral analysis of heart rate variability as a new method for diagnosis of autonomic neuropathy in patients with CNO. Sixth study refered to rare causes of atypical localization of CNO in the knee joint. Ischaemia and infection in DF were resolved in one study. In multivariate analysis of seventh study we approved, that risk factors for difficulty healing after minor amputation of the foot were low level of transcutaneous oxygen tension and high level of C-reactive protein before...
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Vascular Calcification and Bone Demineralization in Patiens with Chronic Renal Failure
Mareš, Jan ; Opatrná, Sylvie (advisor) ; Topolčan, Ondřej (referee) ; Spustová, Viera (referee) ; Štěpán, Jan (referee)
Background: Patients treated with chronic dialysis show extreme mortality, particularly due to cardiovascular disease. Renal failure is associated with different risk factors of cardiovascular complications than those defined for non-renal population. One of these factors, currently considered most important, are vascular calcifications. At the same time, patients on dialysis regularly suffer from derrangements of calcium-phosphate metabolism, including skeletal demineralization. As a consequence, both incidence and prevalence of bone fractures are high. Aims: This study therefore investigates vascular calcifications and skeletal demineralization, their clinical implications and associations in patients treated with long-term dialysis. Methods: Two groups of patients were examined in a prospective manner (follow-up > 1 year); 32 patients treated with peritoneal dialysis and 72 treated with regular hemdodialysis. Treatment parameters and biochemical markers of calcium-phosphate metabolism were monitored throughout the study. Bone mineral density of lumbar spine (together with vertebral fractures) as well as coronary artery, valvular and aortic calcifcations were determined repeatedly. All radiological parameters were measured during one computed-tomography scanning session. Results: A significant...
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