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Parents attitude to integration of children with special needs to common schools focused on integration of children with autism
Žáková, Lenka ; Šumníková, Pavlína (advisor) ; Mrkosová, Eva (referee)
Instututional education of preschool children is based on individual attitude of the educators at nursery schools. Education of children with special needs is for that reason just siutable at nursery schools where these children can be naturally developed in the group of the same-age children and also the attitudes and values to the dissimilarity of another children are developed alongside. The theoretical part first of all deals with the qestion of the preschool education. Than it concentrates on child with special needs, its family and education. The next specific part describes Autism Spectrum Disorders in detail and the supporting educational aspects of children with autism. The last part deals with the integration problems of children with special needs. The practical part presents the results in sphere attitudes of preschools children's parents to the individual integration of children to common nursery schools and also presents one of the successful examples of individual integration of the child with autism to the common nursery school.
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The effect of shoulder girdle stabilization exercises on muscle activity during direct impact in rugby players with subacromial impingement syndrome
Chytilová, Martina ; Šťastný, Petr (advisor) ; Žáková, Lenka (referee)
Title: The effect of shoulder girdle stabilization exercises on muscle activity during direct impact in rugby players with sub-acromial impingement syndrome Objectives: Comparison of muscle activity during direct impact while performing the rugby tackle to tackle bag and to player using electromyographic amplitude analysis before and after intervention programme for players with subacromial impingement syndrome (SIS). Application of intervention programme consisting stabilization excercises for shoulder complex and activation of deep stabilization muscles of the spine. Methods: Theoretical part contains topics about shoulder girdle, rugby and rugby injuries, mainly subacromial impingement syndrome. Mentioned issues are included into the thesis due to the research of current literature from international sources and studies. Practical part regards the aplication of three-months long intervention programme for eight players at junior national level with diagnosis of SIS, when pre-testing a post-testing is realized by clinical tests and EMG measurement. Assessment of enter and control examination is realized with analysis of variance ANOVA. Results: Intervention programme was sufficient for changes in EMG amplitude for two muscle groups in rugby players with SIS. Hypothesis comparing the EMG measure...
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Influence of a complex stretching exercise of lower limb on postural stability
Maier, Ludvík ; Žáková, Lenka (advisor) ; Vomáčková, Helena (referee)
Title: Influence of a complex stretching exercise of lower limb on postural stability Objectives:: The main objective of this diploma these is to find out, using dynamic computerized posturography, whether the increased mobility of the lower limbs has a positive influence on postural stability. Another partial objective is to determine efficiency of the practised stretching exercises. Methods: This is a pilot study where in research participated five probands whose measurement results were evaluated qualitatively. The aged of probands at the time of the first measurement was from 13 to 18 years. All probands are male volleyball league players and during the last two years occurred to a marked grow by all of them. Given their tall stature, it was expected a decrease in the mobility of the lower limbs and muscle shortening. To the data acquisition was used clinical examination of active range of motion and shortened muscle testing according to Janda. Postural stability was measured using computerized dynamic posturography SMART EquiTest System from Neurocom. Measured data were processed using the program NeuroCom Balance Manager software. In the Framework of study were conducted two intrumental measurements in the range of two months. After the first measurement all probands were instructed how to...
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The Presence of Silence in Human Lives and Relationships
Skýpalová, Monika ; Milfait, René (advisor) ; Žáková, Lenka (referee)
This bachelor thesis deals with the presence of silence in human lives. The thesis concretely identifies the silence as a very important part of human lives because the silence helps people to find their spirituality. On the other hand this thesis says that people are afraid of silence because they don't know what could be found in the silence. In the first part of this thesis the conception of silence isspecified. In this part there is also the quality of silence important for human spirituality discussed. This part is also engaged in the development of silence in monasteries where silence is often used. The experience of st. Benedict are especially mentioned. The other part of this thesis is aimed to the fear of silence. It also describes the possibilities how to reduce this fear and how to work with silence in our lives. The applied part of this thesis introduces the own experience of the author with silence in The Silence cafeteria and in the Trappist monastery. It also presents several dialogues about human relation to silence.
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Synthesis of peptides as potential ligands of GCPII protein as identified by phage-display method
Trajhan, Filip ; Konvalinka, Jan (advisor) ; Žáková, Lenka (referee)
Glutamate carboxypeptidase II (GCPII, PSMA-prostate-specific membrane antigen) is a human transmembrane metalloprotease highly expressed in prostate cancer, which makes it a suitable target for diagnostics or targeted cancer therapy. Therefore, specific and tight-binding ligands of GCPII are needed. One way of finding potential low molecular weight peptide ligands is the screening of combinatorial libraries. One of the methods of high-throughput screening is phage display, which uses genetically modified bacteriophages for the study of interaction between peptides and target protein. A library of potential peptide ligands was prepared based on the results of phage display targeted against various forms of GCPII. Parallel peptide synthesiser SPENSER was used for the synthesis and subsequent cyclization of linear peptides. The prepared bicyclic model peptide was characterised and his binding affinity for studied enzyme was confirmed. The possibilities of enhancing the cyclisation efficiency and the use of optimized cyclisation step for preparation of other peptide libraries are discussed. Key words Glutamate carboxypeptidase II, phage display, peptide synthesis, bicyclic peptides, combinatorial chemistry
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Evaluation of hypermobility in school-age children corresponding to a high level of evidence - literature review
Marková, Kamila ; Nováková, Tereza (advisor) ; Žáková, Lenka (referee)
Title: Evaluation of hypermobility in school-age children corresponding to a high level of evidence - literature research Objectives: This diploma thesis is focused on a summary of currently used methods corresponding to a high level of evidence for the diagnosis of joint hypermobility in school-age children. It aims to evaluate the most commonly used methods and procedures that a physiotherapist can use and find out what are the most common limits and problems we may encounter during the examination of joint hypermobility in paediatric patients. Methods: This work is processed in the form of a literature search. It is divided into two parts. The first part of the diploma thesis summarizes the issue of joint hypermobility in general and the specifics of joint hypermobility in the paediatric population. The physiotherapeutic methods, that are used to assess and diagnose joint hypermobility are also described in detail. The second part consists of tables with an overview of research results and the concludes with a discussion of the results concerning the evaluation of the use of individual diagnostic methods with respect to future research. Results: The number of available clinical trials, which would allow us to evaluate which one of the methods, corresponding to a high level of evidence, is the...
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Comparison of Special Breathing Exercises versus Specialized Physiotherapeutic Interventions for Static Apnea
Šírová, Anna ; Vondrášek, David (advisor) ; Žáková, Lenka (referee)
Title: Comparison of Special Breathing Exercises versus Specialized Physiotherapeutic Interventions for Static Apnea Objectives: The aim of this diploma thesis is to look deeper into the issue of improving performance in static apnea, one of the competitive disciplines of freediving and compare its training with 1) special breathing exercises for divers (Mana, 2018) and 2) physiotherapeutic intevrentions based on working with the diaphragm and deep stabilization system of the spine (Kolář, 2009). The aim was to find out which group achieved a more effective result and what is the overall diference between the training result of both groups in terms of posture quality and performance in static apnea. Methods: The experiment involved 14 healthy people, men and women, aged 19-23 years old. The experiment consisted of three parts: 1) Initial measurement of static apnea and examination of four tests to determine the quality of one's postural muscles, 2) four-week lasting training according to the division into groups (breathing exercises for divers or training based on physiotherapy intervention), 3) final measurement of static apnea and re-examination of posture tests. The obtained data were recorded and processed. Results: It appeared that due to the small amount of statistically signifiant data and...
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IGF2 and preptin, biologically active peptides derived from pro-IGF2
Mrázková, Lucie ; Žáková, Lenka (advisor) ; Janovská, Petra (referee)
Pro-IGF2 is a 156 amino acid long protein and it is a prohormone from which two bio- logically active peptides are formed, IGF2 and preptin. IGF2 is an insulin-like growth factor 2 that, together with IGF1 and insulin, shares a similar 3-D structure and similar biological effects. It is a peptide whose sequence corre- sponds to amino acids 1-67 of pro-IGF2. It is produced mainly by the liver, but it is formed in most cells of our body. It is involved in the regulation of growth, differentiation, embryogenesis and in recent years the interest in IGF2 has been increasing mainly due to its function in the central nervous system. Preptin is a newly isolated 34 amino acid long peptide whose sequence corresponds to amino acids 69-102 (E-domain) of pro-IGF2. Preptin affects glucose metabolism as well as bone homeostasis. Disorders in glucose metabolism usually lead to diabetes mellitus, and disorders in bone homeostasis most often lead to osteoporosis. Preptin has been shown to increase the second phase of insulin secretion and to have a positive effect on the proliferation and differentiation of osteoblasts, bone cells promoting bone growth. Keywords: pro-IGF2, preptin, IGF2, E-domain, gene expression, imprinting IGF2
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Study of interactions between low-molecular mass compounds and the DNA-binding domain of forkhead transcription factor FOXO3
Kohoutová, Klára ; Obšil, Tomáš (advisor) ; Žáková, Lenka (referee)
This bachelor thesis is part of a project focused on studying low-molecular mass compounds able to inhibit the interaction between DNA-binding domain of human forkhead transcription factor FOXO3 and the target DNA. FOXO3 is one of four members of FOXO class transcription factors which belong to forkhead family of transcription factors. Forkhead transcription factors are evolutionary conserved proteins playing important roles in numerous cellular processes. These include cell-cycle regulation, oxidative stress response, control of cellular metabolism and apoptosis. FOXO3 plays an important role in cancer cells where it acts not only as a tumor suppressor but also can enhance their resistance to chemotherapy. Considering its biological functions, the study of small-molecule inhibitors of FOXO3 transcription factor is of particular importance. This bachelor thesis was focused on compound S9 oxalate as a potential inhibitor of FOXO3-DNA interaction. Main goals of this thesis were: (I) preparation of both unlabeled and 15 N labeled DNA- binding domain of FOXO3 transcription factor, (II) characterization of interactions between FOXO3 DBD and compound S9 oxalate using NMR and electrophoretic mobility shift analysis (EMSA), and (III) prediction of binding conformation and interactions between FOXO3 DBD and...
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Physical activity and sports history of children 11 to 19 years old
Babický, Lukáš ; Nováková, Tereza (advisor) ; Žáková, Lenka (referee)
Title: Physical activity and sports history of children 11 to 19 years old Objectives: To analyse the level of leisure physical activity and its specifics on a sample of the adolescent population. To analyse the activity development from the historical perspective of the proband from the initial experience with organized physical activity. The results of the survey are further compared with the conclusions of previous studies on the issue. Methods: A total of 563 respondents (235 boys and 328 girls) from Prague's Gymnasiums (secondary grammar schools) took part in the research. Data were obtained using a questionnaire survey (CAWI) based on preliminary research and evaluated using MS Excel, GraphPad Prism and mathematical software R. Results: The preference of single sport (63.8 %) was found in the examined population with a predominance of the frequency of 2 to 4 trainings per week (61.2 %). The vast majority (93.6 %) stated that they were participated fundamental movement training at a younger school age. More than half (61 %) experienced pain or injury within physical activity, especially in the lower limbs (61.9 %). Less than half of respondents (46.3 %) have already visited a physiotherapist. The main factor in the cessation of physical activity is psychosocial reasons (76.9 %). Increasing age...
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