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Induction of neurogenesis and gliogenesis after ischemic injury of CNS
Filipová, Marcela ; Moravec, Jan (referee) ; Anděrová, Miroslava (advisor)
Ischemic injury (stroke) is one of the most common causes of death and disability in humans. Discovery of adult neurogenesis and possibilities to induce neurogenesis by cytokines brought new approaches and hopes in treating the ischemic lesion in future. The aim of this thesis is to describe cellular and molecular mechanisms of neurogenesis, mainly those discovered within last ten years. The first part describes generation of new neurons in the brain under physiological conditions, which is localized in the dentate gyrus of the hippocampus and in the subventricular zone of the lateral ventricles (i.e. in principal neurogenic regions). The second part describes animal models used for studying ischemic injury in rodents and moreover, it focuses on patophysiology of ischemic brain injury, which is accompanied by astrocyte and microglia activation. Further, the ischemia-induced neurogenesis is described in these two major neurogenic regions. Also the important role of NG2 glial cells in central nervous system (CNS) regeneration is pointed out. According to recent findings NG2 glia that are present in all regions of CNS might serve as a potential source of cells for directed differentiation into oligodendrocytes, astrocytes and even neurons during CNS repair/regeneration. In the last part of this work,...
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Ethical Plausibility of Suicide
Moravec, Jan ; Hogenová, Anna (advisor) ; Blažková, Miloslava (referee)
Diploma thesis "the ethical plausibility of suicide" deals with problem of suicide from philosophical and ethical spectacle. Enthrones essential metodological determination in view on different suicides. Importanat determination is essential enthronement of hierarchy of human questioning for life. In the thesis is showed primary onthological question, secondary qualitative question and tertiary quantitative wuestion. This determination of essential questions should help in inquiry for main thesis question: "in which cases is suicide ethicaly accetable or ethicaly good." Diploma thesis works with different arguments and admitances to suicide. Diploma thesis confrontates this arguments and admitances with offered metodology and with ethical norms and systems from onther philosophers. Those norms and systems are converted to essental three questions and consenquently compared, if they can predicate something about ethical acceptability suicide. Diploma thesis don't only stays on person of self-murderer. Diploma thesis tries to shows a connections between the act of suicide and relations with other people. The moment which draws together different cogitations is moment of toleration. Final admittance is build on teaching of John Locke. Diploma thesis is also forced to consider the problem of human freedom.
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Independent front axletree of the bus
Moravec, Jan ; Prášil, Ludvík (referee) ; Prokeš, František (advisor)
In those diploma work was solved problems of independent trapezoidal axletree for low-floor bus - NB12 CITY firm SOR Libchavy s.r.o . Work was divided into two main features: solving wheel-suspension kinematics and strenght calculation sorted parts of wheel suspension by the help of finite element method. There was effected fatigue calculation sorted parts of wheel suspension according to „Resetova metoda“ of predicting fatigue damage flowing from so – called cutaway methodics of fatigue tests at the close of this work.
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University Campus Bohunice - Construction Technological Project
Moravec, Jan ; Čech, David (referee) ; Štěrba, Martin (advisor)
This diploma thesis addresses the „University Campus Bohunice - Architectural and technological project“. This thesis includes excavation, pile foundation, reinforced concrete foundation slab it also deals with in detail technological regulations on earthworks and deep-pile foundation. The thesis contains solutions to building equipment, schedule of selected stages of the construction situation with the solution of transport routes, designed mechanical assembly required for selected stages and control plan earthworks and deep-pile foundation. This diploma thesis addresses the „University Campus Bohunice - Architectural and technological project“. This project involves construction of two buildings. Building A32 with two basement floors and three floors and second building A 31 with one basement floor and three floors. This thesis includes excavation, pile foundation, reinforced concrete foundation slab, it also deals with technological regulations of earthworks and deep-pile foundation in detail. The thesis contains solutions to construction site equipment, schedule of selected stages of the construction, location of buildings and the solution of transport routes, mechanical equipment required for selected stages of project and control plan of earthworks and deep-pile foundation.
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Proposal of the Company's Financial Plan
Novák, Jindřich ; Moravec, Jan (referee) ; Žižlavský, Ondřej (advisor)
This thesis with title „Proposal of the Company's Financial Plan“ consists of theoretical and practical parts. Theoretical part deals with theoretical ways out of financial planning. In the practical part there are performed the analyses of contemporary state of company. Afterwards there is the financial plan alone made-up for the years 2009 – 2011. The end of my practical part is formed by evaluation of created financial plans.
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