|
|
Stress testing of estradiol and ethynylestradiol
Mašková, Kateřina ; Chocholoušová Havlíková, Lucie (advisor) ; Aufartová, Jana (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate: Kateřina Mašková Supervisor: PharmDr. Lucie Havlíková, Ph.D. Title of Diploma Thesis: Stress testing of estradiol and ethynylestradiol This diploma thesis is focused on the implementation of stress testing of two estrogenic hormones estradiol and ethynylestradiol. Both substances have been exposed to oxidation and acid and alkaline pH at increased temperature of 70řC for a predefined time period. The results of these tests should have shown a decrease or an increase of the peak area of estradiol and 17α- ethynylestradiol and a potential formation of degradation products. Peak areas and retention times of degradation products were observed by HPLC. The aim of this thesis was to determine the properties of these hormones under various stress conditions like extreme conditions of production, storage, transport and/or under various external influences. Characterization of degradation products and verification of the suitability of methods used for the analysis of degradation products were also aims of this paper. The method was partially validated. In the experimental part there has been found out that estradiol and ethynylestradiol were stable in water as well as in acetonitrile solution...
|
|
|
D.I. Fonvizin - the analysis of his dramas (drama "Brigadier")
Mašková, Kateřina ; Lendělová, Věra (advisor) ; Uličná, Olga (referee)
Tématem mé diplomové práce je analýza postav v komedii "Brigadýr" (1769) spisovatele D.l. Fonvizina, resp. analýza z mužské a ženské perspektivy v jejím prolínání i diferenciaci. Na drama jsem nahlížela především z hlediska mužských a ženských postav. Kromě toho nám jednotlivé příběhy a jazyková charakteristika hlavních aktérů komedie vypovídají mnohé o době, v níž autor žil a tvořil. Vztahy mezi postavami rovněž odkryjí společensko-sociální pozadí tehdejšího života. Prostřednictvím postav ve hře se také budeme snažit odhalit některé autorovy myšlenky a názory týkající se jeho vztahu k společensko-politické situaci v Rusku té doby, a také k postavení ženy v rodině a ve společnosti. Ženská a mužská problematika je téma stále diskutované, a tak ani drama z 18. století nám není z pohledu moderní doby cizí. Mnohé otázky, které Fonvizin v dramatu řeší jsou nadčasové, a tudíž můžeme konstatovat, že drama je velmi aktuální i v 21. století. Samozřejmě je nesporné, že některé reálie jako např. úděl žen vojáků či počínající emancipace žen jsou typické spíše pro dobu, v níž autor žil a tvořil.
|
|
|
The influence of 3-month exercise program on postural stability in individuals after bariatric surgery
Mašková, Kateřina ; Daďová, Klára (advisor) ; Vilikus, Zdeněk (referee)
Title: The effect of movement program on static postural stability in individuals after bariatric surgery Aims: The aim of this diploma thesis was to find out whether a three-month regular exercise program including strenght and aerobic training has an impact on static postural stability in obese individuals who underwent bariatric surgery. Methodology: The special part was written on the basis of data obtained from posturographic measurement of obese patients who underwent bariatric surgery. The static postural stability was measured using pressure plate a MobileMat from Tekscan. Participants were measured before surgery and approximately 4 months after surgery. A total of 30 subjects aged 31-65 years with BMI values between 35-55 kg/m2 (obesity class II and III) who underwent initial and exit examination including stabilometry, were included in this diploma thesis. They were divided into 2 groups, first group participating in a three-month exercise program (n = 10; age 51 ± 7.3 years; BMI 41.7 ± 6.4 kg/m2 ) and a group undergoing bariatric surgery only (n = 20; age 48 ± 9, 4 years; BMI 43.6 ± 6.5 kg/m2 ). The exercise program included exercise three times a week: once a week one-hour strength training and one-hour aerobic group training, and at least once a week home intervention. Results: In...
|
|
|
The cell wall biosynthesis in gram-positive bacteria and inhibitory effect of antibiotics.
Mašková, Kateřina ; Ulrych, Aleš (advisor) ; Lichá, Irena (referee)
The cell wall of Gram-positive bacteria includes, in addition to the core peptidoglycan molecule, unique polysaccharides such as teichoic acids, capsular polysaccharides and exopolysaccharides, and covalently bound surface proteins. Together, they create a strong and durable layer that provides protection but also communication with the external environment. Peptidoglycan biosynthesis in Gram-positive bacteria can be divided into three phases: cytoplasmic, membrane and extracytoplasmic phase. The individual phases consist of specific reactions that are catalyzed by often conserved bacterial enzymes, which are potential targets for antibiotic molecules. Most known antibiotics effective against Gram-positive bacteria are aimed at inhibiting the process of cell wall synthesis. The mechanisms of action of individual antibiotics are described with varying degrees of detail. Some are known and widely used in medicine or veterinary practice, and some have so far only shown the potential to become drugs. Another use of antibiotics is in the basic research itself, especially in the study of cell wall biosynthesis and bacterial division. In this work, I have compiled a summary of knowledge about cell wall biosynthesis of Gram-positive bacteria and a list of antibiotics and a description of the mechanisms of...
|
|
|
The influence of 3-month exercise program on postural stability in individuals after bariatric surgery
Mašková, Kateřina ; Daďová, Klára (advisor) ; Vilikus, Zdeněk (referee)
Title: The effect of movement program on static postural stability in individuals after bariatric surgery Aims: The aim of this diploma thesis was to find out whether a three-month regular exercise program including strenght and aerobic training has an impact on static postural stability in obese individuals who underwent bariatric surgery. Methodology: The special part was written on the basis of data obtained from posturographic measurement of obese patients who underwent bariatric surgery. The static postural stability was measured using pressure plate a MobileMat from Tekscan. Participants were measured before surgery and approximately 4 months after surgery. A total of 30 subjects aged 31-65 years with BMI values between 35-55 kg/m2 (obesity class II and III) who underwent initial and exit examination including stabilometry, were included in this diploma thesis. They were divided into 2 groups, first group participating in a three-month exercise program (n = 10; age 51 ± 7.3 years; BMI 41.7 ± 6.4 kg/m2 ) and a group undergoing bariatric surgery only (n = 20; age 48 ± 9, 4 years; BMI 43.6 ± 6.5 kg/m2 ). The exercise program included exercise three times a week: once a week one-hour strength training and one-hour aerobic group training, and at least once a week home intervention. Results: In...
|
|
|
The Diagnosis of Paranoid Schizophrenia from the Perspective of Parents of the Diagnosed Individuals
Mašková, Kateřina ; Šivicová, Gabriela (advisor) ; Onder, Jakub (referee)
In this bachelor's thesis, I deal with the experiences of parents whose descendants were diagnosed with paranoid schizophrenia. At the beginning of the theoretical part, I first describe several points of view which can be used when referring to psychotic states: a diagnostic perspective, non-diagnostic perspectives, and an anti-diagnostic perspective. Subsequently, I cover the diagnosis of paranoid schizophrenia both from the medical point of view, through its diagnostic manifestations, progressive forms and possibilities of treatment, and as a factor significantly affecting the quality of life. Furthermore, I focus on attitudes, emotions, behavioral patterns and needs of the parents of the diagnosed descendants. The theoretical part of the thesis is concluded with a chapter concerning with various options of psychosocial support for a family system one of whose members has got an experience with a psychotic episode. The empirical part is focused on the experiences of parents whose descendants were given the diagnosis in the age of fifteen or later. I conducted eight in-depth semi-structured interviews and for analyzing the obtained data I used the open coding method. As instances of the topics that the parents from my research sample reflected repeatedly, I would mention the disrespectful...
|
|
|
Case study of physiotherapy care of a patient after liver transplantation
Mašková, Kateřina ; Kubová, Simona (advisor) ; Charvát, Robert (referee)
Title: Case study of physiotherapy care of a patient after liver transplantation. Aims: The aim of this bachelor thesis is to summarize the theoretical knowledge about the issue of liver transplantation and to present an example of physiotherapeutic care on specific case of a patient after liver transplantation. Methodology: This thesis is divided into theoretical and professional part. The theoretical part contains information about the anatomy, physiology and pathologic physiology of the liver, liver transplantation and physiotherapy treatment after liver transplantation. These information were obtained from the scientific sources. Professional part was created as a research with case study during my professional experience in the Institute of Clinical and Experimental Medicine in Prague between 8 January 2018 and 2 February 2018, where I worked with a patient hospitalized after liver transplantation. It is processed as a case study of physiotherapeutic care, including physical examination, recording of therapies and evaluation of the effect of therapies. Results: The patient mainly improved muscle strength, respiratory stereotype and overall physical condition, increased range of motion and improved joint play of some small joints. During the last therapeutic units, the patient was able to do a...
|
|
|
Stress testing of estradiol and ethynylestradiol
Mašková, Kateřina ; Chocholoušová Havlíková, Lucie (advisor) ; Aufartová, Jana (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate: Kateřina Mašková Supervisor: PharmDr. Lucie Havlíková, Ph.D. Title of Diploma Thesis: Stress testing of estradiol and ethynylestradiol This diploma thesis is focused on the implementation of stress testing of two estrogenic hormones estradiol and ethynylestradiol. Both substances have been exposed to oxidation and acid and alkaline pH at increased temperature of 70řC for a predefined time period. The results of these tests should have shown a decrease or an increase of the peak area of estradiol and 17α- ethynylestradiol and a potential formation of degradation products. Peak areas and retention times of degradation products were observed by HPLC. The aim of this thesis was to determine the properties of these hormones under various stress conditions like extreme conditions of production, storage, transport and/or under various external influences. Characterization of degradation products and verification of the suitability of methods used for the analysis of degradation products were also aims of this paper. The method was partially validated. In the experimental part there has been found out that estradiol and ethynylestradiol were stable in water as well as in acetonitrile solution...
|
|
|
Media and negative political campaign: czech parliamentary election in 2013
Mašková, Kateřina ; Křeček, Jan (advisor) ; Štětka, Václav (referee)
The main objective of the thesis is to analyse the role of selected Czech dailies and online news servers during the assertion of negative political campaigns before Czech parliamentary elections in 2013. The research led to answering the question, how were the newspapers, in comparison to the servers, concerned with the transfer of negative contents performed by Czech political subjects during the period of election campaigning. As the source of analysed data, the thesis used dailies Mlada fronta Dnes and Pravo and online news servers Aktualne.cz and iHNed.cz. The thesis observed a share of negative evaluative remarks in the news content dealing with the topic of Czech political campaign which was concerned with the negative campaigning of Czech political parties, as well as the way in which was this topic commented by the selected media. Crucial part of the thesis is a comparison of the parliamentary elections of 2013 with the preceding elections of 2006 and 2010. The aim was to show how the elections of 2013 fit in a trend of utilisation of negative political communication in Czech setting and how has changed the media coverage of the phenomenon during the observed years. From the thesis emerges the result that the dailies covered negative political assertions much more often than the online...
|
|
|
Development of Public Libraries of the Pilsen Region 1990-2010
Mašková, Kateřina ; Slámová, Hana (advisor) ; Černá, Milena (referee)
This thesis analyzes the development of public libraries in the Pilsen Region in 1990-2010. The work focuses on the major issues of development of public libraries from the perspective of the Pilsen Region macrosystem, especially the volume of data and system changes. In the first three chapters are given general information about public libraries and their functions, information about the Pilsen Region (former West Region) and library legislation. The main characteristic of the work of bringing the two periods, 1990-1999 and 2000-2010, public libraries in the Pilsen Region. These chapters analyze the changes that affected the functioning of libraries in the monitored phases. The consequences of changes thesis looks through the selected statistical indicators of the years. These changes illustrated in graphic form furnished comments. The last section concludes and evaluates the development of public libraries of the Pilsen Region in 1990-2010. Thesis is equipped with text and spreadsheet attachments. [Author's abstract].
|
guest ::
RSS feed.