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MicroRNAs in Human Cancers Associated with Viral Infections
Dvořáková, Lucie ; Tachezy, Ruth (advisor) ; Drda Morávková, Alena (referee)
MicroRNA (miRNA) are short single-stranded RNAs that do not encode proteins. Their main function is the regulation of the gene expression on the level of translation. This regulation is mediated by the binding of miRNA to the partially complementary segments of mRNA, both cellular or viral. It is estimated that miRNAs affect expression of at least one third of human genes and thereby influence regulation of cellular growth, differentation and apoptosis of cells. Recently the miRNAs encoded mainly by DNA viruses were discovered. These miRNAs enhance the persistence of viral infection in the host and can contribute to malignant transformation. However, the oncogenesis is also significantly affected by the regulation of cellular miRNAs expression by viral proteins. The miRNA research is topical. MiRNAs are considered as potential biomarkers and their utilization as a cancer therapy is being intensely explored. In this thesis, I'm describing the biogenesis and regulatory functions of miRNAs. I'm also presenting an overview of viral miRNAs focusing on human oncogenic viruses which do not only code their own miRNAs but also influence the expression of the host miRNAs. Finally, I am focusing on current clinical applications of miRNA. Key words: viral miRNA, cellular miRNA, oncogenesis, viral infections,...
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Data processing in accounting programs
DVOŘÁKOVÁ, Lucie
This thesis compares and assesses accounting data processing in two chosen programmes Pohoda and Ekonom. The first part of thesis is a literary summary of the theme historical progress of the accounting, particular phases of the progress included, and describes economical infor-mation systems and general standards for the right choice of accounting programme for a firm. In the second part the author compares and describes both of the programmes, describes the way of data processing in programmes Ekonom and Pohoda. The analysis goes in the module of billing, stocks and pay. The author assesses both of the programmes and compares their methods. In the next part of the thesis are given advantages and disad-vantages for users. The last part of thesis describes a concrete firm, her way of account-ing processing included. On the basis of the price calculation of the programmes the author will recommend a system for the accounting data processing.
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Modifications of constitutional law in relation to the accession of the Czech Republic to the European Union
Dvořáková, Lucie ; Reschová, Jana (advisor) ; Syllová, Jindřiška (referee)
MODIFICATIONS OF CONSTITUTIONAL LAW IN RELATION TO THE ACCESSION OF THE CZECH REPUBLIC TO THE EUROPEAN UNION ABSTRACT The accession of the Czech Republic to the European Union was certainly one of the most important moments in the development of Czech legal order. The impact of this step may be seen in every branch of law - including constitutional law. The large number of publications on this issue indicates that the changes of constitutional law are an important issue in the Czech academic society. Yet, the literature is mostly fragmentary and mainly oriented at only some of the problems. This thesis tries to gather all the important changes in the branch of constitutional law, which occurred in relation to the Czech Republic's accession to EU. As the constitutional law is a very broad topic, the focus is laid on its institutional part and on the role of member states (and its institutions) within the EU. This thesis consists of an introduction, four chapters (which are further divided with respect to the single topics), and a final conclusion. In introduction, the focus of the thesis and basic questions are defined. Chapter One briefly follows the process of the Czech Republic's accession to the EU. Chapter Two deals with the position of Member States within the EU. It touches on issues such as the...
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Molecular evaluation of novel BCR/ABL kinase domain variants in patients with chronic myeloid leukemia
Dvořáková, Lucie ; Peková, Soňa (advisor) ; Kozák, Tomáš (referee)
1 Abstract BCR/ABL is a constitutively active tyrosine kinase that has been shown to be at the heart of the development of chronic myeloid leukemia (CML) and about 30% of acute lymphoblastic leukemia (ALL). With the recent advent of tyrosine kinase inhibitors (TKIs), exemplified by Imatinib, Nilotinib, Dasatinib and Bosutinib, patients with Ph+ CML or ALL are candidates for the therapy with these agents. From the available TKIs, Imatinib is considered as front-line therapy for CML patients in chronic phase, while for Ph+ ALL patients, 2nd generation TKIs (nilotinib, dasatinib, bosutinib) might be considered as more effective therapeutic option. Since the treatment with TKIs is a long-term affair, a substantial proportion of patients acquire some sort of mutation in kinase domain of BCR- ABL, which could be a reason of treatment failure. To date, over ninety BCR/ABL kinase domain mutations have been identified, affecting over 50 amino acids. Recurrent BCR/ABL kinase domain mutations have already been in vitro tested to approximate for their in vivo behavior. Our goal is to invent in vitro technique that would allow testing TKI sensitivity of novel BCR/ABL kinase domain mutations, identified at very low MRD levels. The technique makes use of site-directed mutagenesis to create the novel BCR/ABL kinase domain...
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East Timor - the Role of the United Nations on its Way to Independence
Dvořáková, Lucie ; Karásek, Tomáš (advisor) ; Karlas, Jan (referee)
Diploma thesis "East Timor - The Role of the United Nations on its Way to Independence" evaluates the way of the East Timor towards independence with the involvement of the UN. Following an overview of the historical context, the thesis analyses the situation in the second half of the 20th century, focusing on the UN 's performance during Indonesia occupation and then on the popular consultation and following peace operations. Thesis tries to identify the factors that enabled the occupation lasted so long and discusses lessons to be learned from the recent peace operations. Powered by TCPDF (www.tcpdf.org)
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Financial analysis of selected enterprises
Dvořáková, Lucie ; Slaboch, Josef (advisor) ; Kotyza, Pavel (referee)
The thesis deals with the financial analysis of the company Breweries Lobkowicz Group a.s. in 2010 - 2014 period. It is divided into theoretical and practical part.
Theoretical part focuses on general problematics of the financial analysis. Fundamental terms as balance sheet, profit and loss account, cash flow account are explained in this part of the thesis. However it also analyzes each indicator used in the practical part. Firstly, horizontal and vertical analysis of the financial records are introduced, also differential and ratio indicators are explained, specifically current ratio, quick ratio, cash ratio, profitability of total property and ordinary capital, rentability of sales. Subsequently the thesis describes the rate of indebtedness of the company and indicators of the activity - turnover of the individual components of the assets side. The final subtopic is the overall indexes of rating, specifically as for solvency models Kralick´s Quicktest and as for bankruptcy ones Altman´s model and Index IN05.
The practical part introduces the company Breweries Lobkowicz Group a.s. and the individual methods and indicators mentioned in the theoretical part are applied. Using these indicators the financial analysis itself is carried out. To summarize, the company is long-term loss-making but year-on-year the loss is decreasing. The company registered big progress in 2014 when its own capital reached positive numbers. This change has a positive impact on the development of most of the indicators used in the financial analysis.
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Analýza boutique hotelů
Dvořáková, Lucie
The Diploma thesis "Boutique Hotels Analysis" is focused on tourism and hotel industry in the Czech Republic. The theoretical part encompasses essential terms and pieces of knowledge in both sectors; the practical part is based on boutique hotel Buddha-Bar Hotel Prague. Provided services, position among competitive subjects in hotel industry market and satisfaction of staff are analyzed. Based on results, strategy for further development and suggestions for increasing competitiveness are recommended.
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Marketing Mix of Company Alcon
Svobodová, Jana ; Dvořáková, Lucie (referee) ; Mráček, Pavel (advisor)
The theme of this thesis is an analysis of Alcon Pharmaceuticals Ltd. Czech Republic, engaged in the sale and manufacture products for eye care on the basis of the marketing mix. My goal is to help improve the care of existing customers and find the best combination of funds that will lead to entirely new customer acquisition. In my work I focus mainly on the division of CLC (Contact Lenses Care).
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Dopady změn při uplatňování DPH v oboru stavebnictví
Dvořáková, Lucie
This thesis deals with the impact of significant changes to the VAT Act in the con-struction industry. It evaluates the impacts of the introduction of the reverse charge regime for construction and assembly work on the economic indicators of construction companies and VAT collection. The work also evaluates the effects of changes in the rates of value added tax on economic indicators of construction company, construction work prices, property prices and VAT collection. Based on the results, the author puts forward suggestions and recommendations.
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