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Preliminary Crystallographic Study of ç-D-Crystalline Obtained from Patient`s Eye
Brynda, Jiří ; Řezáčová, Pavlína ; Štouračová, Renata ; Ondráček, Jan ; Kmoch, B. ; Asfaw, B. ; Elleder, M. ; Bezouška, K. ; Filipec, M. ; Sedláček, Juraj
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Protein chimistry and massspectromtry in strictural analysis of large proteins
Bezouška, Karel ; Man, Petr ; Pompach, Petr ; Novák, P. ; Havlíček, Vladimír ; Hilgenfeld, R. ; Plíhal, Ondřej ; Sklenář, Jan ; Pišvejcová, Andrea ; Křen, Vladimír
According to the textbook knowledge the use of automated Edman degradation and protein mass spectrometry for the determination of complete primary stricture is limited to small proteins with molecular size less than 10 kDa.
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Úloha sacharidových struktur v NKR-P1 zprostředkované interakci efektorových a cílových buněk
Fišerová, Anna ; Svoboda, J. ; Kuldová, Markéta ; Pucová, Alexandra ; Bezouška, Karel ; Pesta, M. ; Vannucci, Luca ; Pospíšil, Miloslav
Masking oligosaccharide sequences can assist transformed cells to escape immune surveillance. N-acetyl-glucosamine coated dendrimers have binding affinity for NKR-P1 receptor and can also modify cancer cell glycosylation profile. Effects of treatment on immune cell subpopulations were analyzed in blood, lymphoid tissues and organs, and inside tumor in B16F10 melanoma bearing mice. Treatment enhanced tumor cell immunogenicity, and induced maturation,differentiation and homing of cytotoxic cells to tumor microenvironment.
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