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The influence of water regime and management on the productive capacity of grassland
JANDA, Jiří
The first part of the thesis is devoted to the distribution, importance of permanent grasslands, proper management of grasslands and maintenance of optimal water regime. Water is essential for photosynthesis and plant growth and therefore its availability affects the quantity and quality of biomass produced. The literature on water regime such as rainfall, soil permeability, ground water availability and its effect on grassland production capacity is reviewed. Management techniques such as fertilization and tillage that can help maintain a suitable water and nutrient regi-me for the grassland are also described. In the second and third parts of the thesis, the results of investigating grazed and mown grassland under different water regime and animal load are presented. Furthermore, the climatic conditions of the site are described. The botanical condition of the grassland is elaborated. The influence of the load and water regime on the condition and productivity of the grassland under study is eva-luated. As the water regime increased, the cover of valuable grasses and clovers decreased and the proportion of reticulate and sedge species increased. Measures (fertilization and amendments) were proposed to improve the species composition of the vegetation.
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Ambulatory blood pressure monitoring and hypertension in children with diabetes mellitus type 1
Šuláková, Terezie ; Janda, Jan (advisor) ; Svačina, Štěpán (referee) ; Souček, Miroslav (referee)
Objective: to evaluate the diagnostic efficacy of the office blood pressure (OBP) and ambulatory blood pressure monitoring (ABPM) in the assessment of hypertension (HTN) in children with diabetes mellitus type 1 (DM1). Methods: We analyzed OBP and ABPM measurements in 84 diabetic children (43 boys) obtained at a median age of 14.9 years and 6.3±3.5 years after diagnosis of DM1. OBP and ABPM results were converted into standard deviation scores (SDS). In addition, we analyzed blood pressure loads and nighttime dipping. The comparison between OBP and ABPM was performed using kappa coefficient and receiver operator curve (ROC). Results: HTN was diagnosed in 43/84 (51%) patients using OBP (>95th percentile) and in 24/84 (29%) patients using ABPM (≥95th percentile during 24h, day or night). Both methods were in agreement in 33 ABPM normotensive and 16 ABPM hypertensive patients (most had nighttime HTN); 32% patients had white coat HTN and 9.5% patients had masked HTN. The kappa coefficient was 0.175 (95% CI -0.034 to 0.384) suggesting poor agreement between OBP and ABPM. Diastolic OBP was a better predictor of ABPM HTN (ROC AUC=0.71±0.06) than systolic OBP (AUC= 0.58 ± 0.07). The percentage of non-dippers ranged from 7 to 23% in ABPM normotensive patients and 21-42% in ABPM hypertensive patients who also had...
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Endothelin and renin - the angiotensin system and its relation to hypertension and hypertension organ damage
Dvořák, Pavel ; Červenka, Luděk (advisor) ; Herget, Jan (referee) ; Janda, Jan (referee) ; Tesař, Vladimír (referee)
Renin-angiotensin and endothelin system play important role in blood pressure regulation. ln order to determine the contribution of an interaction between ET-I and ANG II to the development of hypertension and related end-organ damage in an ANG lI-dependent model of hypertension, we utilized a rat strain transgenic for the mouse Ren-2 renin gene (TGR; strain name TGR(mRen2)27). All our experimental studies have confirmed the crucial effect of increased natrium intake in a diet on development of arterial hypertension and hypertensive end- organ damage (especially kidneys and heart) in this model of arterial hypertension. Previous studies have demonstrated the presence of several types of endothelin system receptors - ETA and ET6 receptors with two subtypes- ETBl and ET62. Our study has brought a new knowledge of physiologic and pathophysiologic function of these receptors. The non- selective blockade of ETA and ETB receptors by Bosentan, improves survival rate of both homozygous and heterozygous transgenic animals, declines extent of hypertensive cardiac end-organ damage and reduce proteinuria and glomeru losclerosis. However, this positive effect of nonselective endothelin blockade is not caused due to decrease of arterial blood pressure. The reason for this fact is probably in various effects of...
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User alerts with real-time data monitoring for IVIS framework
Janda, Jan ; Bureš, Tomáš (advisor) ; Horký, Vojtěch (referee)
As the number of IoT devices and the size of CPS grow, the amount of critical data, which needs to be ceaselessly monitored, also increase. IVIS is a web-based data processing and visualization framework for IoT as well as CPS data and it would clearly benefit from the ability to monitor data in real time, issue alerts and send notifications. In this thesis, we extend the IVIS framework with such ability, which has not been developed for the framework yet. This extension can be used to set up an automatic monitoring of incoming data with appropriate level of detail. An emphasis is given to versatility of possible configurations. It is possible to precisely define conditions for the monitoring and rules for the notifications across a wide range of requirements. It is also important that the system has adjustable temporal stability, and therefore is not affected by outliers and random noise.
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Retrospective diagnosis of unknown cause of sudden infant death
Strnadová, Kristina ; Lebl, Jan (advisor) ; Janda, Jan (referee) ; Plavka, Richard (referee) ; Vízek, Martin (referee)
Background: Sudden infant death syndrome (SIDS) is defined as sudden unexpected death of an infant that remains unexplained after thorough post-mortem examination, investigation of the scene of death and case history. The autopsy findings and the physiological characteristics of these infants suggest a possible role of insufficient cardiorespiratory control and arousal mechanisms. The etiology is probably multifactorial based on a genetic predisposition combined with environmental factors. Several candidate genes have been studied, e.g. those involved in serotonin transport, autonomic nervous system embryology, inflammation, energy production, nicotine and glucose metabolism. A small number of cases may be caused by monogenic diseases that can lead to sudden death and leave no characteristic autopsy findings and thus imitate SIDS. Fatty acid beta-oxidation disorders (FAOD) have been associated with SIDS since 1976 and it is nowadays estimated that they may be responsible for about 1% of SIDS cases. Congenital long QT syndrome, a cardiac channelopathy, that may cause a fatal arrhythmia was a logical candidate for SIDS and indeed it was found out that about 9,5% of SIDS cases carry a mutation or a function changing variant in one of seven cardiac ion channel genes. We assumed that the severe salt...
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Endothelin and renin - the angiotensin system and its relation to hypertension and hypertension organ damage
Dvořák, Pavel ; Červenka, Luděk (advisor) ; Herget, Jan (referee) ; Janda, Jan (referee) ; Tesař, Vladimír (referee)
Renin-angiotensin and endothelin system play important role in blood pressure regulation. ln order to determine the contribution of an interaction between ET-I and ANG II to the development of hypertension and related end-organ damage in an ANG lI-dependent model of hypertension, we utilized a rat strain transgenic for the mouse Ren-2 renin gene (TGR; strain name TGR(mRen2)27). All our experimental studies have confirmed the crucial effect of increased natrium intake in a diet on development of arterial hypertension and hypertensive end- organ damage (especially kidneys and heart) in this model of arterial hypertension. Previous studies have demonstrated the presence of several types of endothelin system receptors - ETA and ET6 receptors with two subtypes- ETBl and ET62. Our study has brought a new knowledge of physiologic and pathophysiologic function of these receptors. The non- selective blockade of ETA and ETB receptors by Bosentan, improves survival rate of both homozygous and heterozygous transgenic animals, declines extent of hypertensive cardiac end-organ damage and reduce proteinuria and glomeru losclerosis. However, this positive effect of nonselective endothelin blockade is not caused due to decrease of arterial blood pressure. The reason for this fact is probably in various effects of...
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Hodnocení stavu břehových porostů toku Libochůvka včetně návrhu optimalizace jeho pramenné části
Janda, Jan
The thesis is focused on the problematics of stream-bank vegetation and it’s devided into two parts. First, analytic part, is focused on evaluating the condition of the stream-bank vegetation of Libochůvka river. Author defines methodology of its evaluation which is afterwards applied in field study. The result of analytic part is evaluation of actual condition of stream-bank vegetation and proposal the solution of identified problems. Second part, project part, is focused on proposing of specific solutions for the river section from 37,5 to 37,9 river km, which was identify as the worst one. This part is processed as complete project documentation, which was evolved in cooperation with river manager Lesy ČR, s. p.
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Interactions of human immune system with saliva of bloodfeeding Nematocera
Jelínková, Kristýna ; Kolářová, Iva (advisor) ; Janda, Jozef (referee)
In humans, the bites of bloodfeeding insects from the suborder Nematocera induce an immune reaction, both humoral and cell-mediated. Some antigens presented in the saliva of some insect families - Psychodidae, Culicidae, Simuliidae and Ceratopogonidae - are studied more deeply to reveal their immunomodulatory and antigennic properties. Most studies are focused on mosquitos (Culicidae) and sand flies (Psychodidae). Mosquito saliva elicits primarily IgG and IgE antibodies. The level of antibodies in the sera of bitten individuals reflects the length and intensitity of previous exposure to insect bites. Anti-saliva IgE antibodies play an important role in response to the mosquito bites and are frequently associated with allergic reactions. On the other hand, sand fly saliva elicits primarily IgG antibodies. Cell-mediated human immune response to mosquito bites is a neglected research topic. It has been proven that the saliva of sand flies (genus Phlebotomus and Lutzomyia) stimulates proliferation of PBMC from repeatedly bitten humans. Cytokine production by human PBMC and expression of costimulatory molecules in human monocytes, macrophages, and dendritic cells are also influenced by the presence of sand fly saliva. So far as we know, there are only few studies on human immune response to black fly...
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