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Technological aspects of solid solution formulations
Beneš, Michal ; Doležal, Pavel (advisor) ; Bělohlav, Zdeněk (referee) ; Dohnal, Jiří (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Candidate PharmDr. Michal Beneš Supervisor Doc. RNDr. Pavel Doležal, CSc. Title of Doctoral Thesis Technological aspects of solid solution formulations Solid solutions are two- or multicomponent, single phase mixtures of solids, typically consisting of a polymeric carrier and an active substance (API) in amorphous state. The main advantage of solid solutions is the potential to increase the solubility of the API contained. The utilization of solid solutions is however complicated by many factors, which prevents its wider application. These include among other things the difficulty to determine solubility of the API in a polymeric carrier, poor predictability of physical stability as well as the complexity of appropriate selection of manufacturing process and its scalability. The experimental part is divided in three sections all associated with the technology of solid solutions. In the first of them, polymer films containing the API (dabigatran etexilate) were applied on glass plates and evaluated by spectral imaging techniques (infrared and Raman microspectrometry). Samples containing Kollidon VA64, Povidone K30 and Soluplus as polymer carriers, each loaded with 10, 25, 50 and 75 % (w/w) of the API...
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Party SMER-SD and its Position in the Slovak Party System
Beneš, Michal ; Just, Petr (advisor) ; Brunclík, Miloš (referee)
The aim of this thesis is to place Slovak political party SMER in the political and party system of the Slovak Republic and attempt to analyse ideological and programmatic development of this party. The author devotes attention to development of SMER from the emergence in 1999 until last general elections in 2012. First chapter seeks to describe evolution of socialism and following ideologies including the concept of the Third way which was reflected by some Western European social democratic parties. The second chapter is dedicated to left-wing political parties in Czechoslovakia and lately in Slovak Republic. This chapter is divided into two sections. The first section is about parties existing before 1989 and the second one devotes attention to parties after Velvet Revolution in 1989. Next part of this work is focused on the SMER itself. Author describes three phases of development of this party including emergence in 1999, opposition activities between 2002 and 2006 and phase of hegemony following after 2006. The purpose of the last part of the thesis is to analyse ideological and programmatic development of SMER and highlight some problematic features of proclaimed social democratic orientation.
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Nanofiber membranes as carriers of drugs 1. Chitosan, polyamide 6, polyurethane.
Beneš, Michal ; Vachek, Josef (referee) ; Doležal, Pavel (advisor)
9. Abstract The theoretical part deals, in the introduction, with the questions of the transdermal administration of medicines and also with the current overview of the transdermal preparations registered by the FDA Agency (U.S. Food and Drug Administration). The basic principles of the non-woven fabric production technology focused on the electrospinning method, which is used in the production of nanofiber membranes and evaluated further in the experiment, are described. The next part is dedicated to the characteristics and production of polymers which compose the tested membranes. Some physical tests which were used for the continued characterization of the nanofiber membranes are shown. The first chapter of the experimental part gives the results of the three physical and technical characteristics of the nanofiber membranes produced by electrospinning, from chitosan, polyamide 6 and polyurethane. A piece of the samples from these polymeric non-woven nanomembranes was radiosterilized. From the tensile strength point of view the nanofiber membrane made of polyurethane fibres was the most stable. The radiation sterilization process caused the lessening of the strength of the nanomembrane made of chitosan, of the other two membranes the sterilization process had no significant influence. The membranes made...
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Nanofiber Membranes as Drug Carriers 5.
Beneš, Michal ; Vachek, Josef (referee) ; Doležal, Pavel (advisor)
M. Beneš Abstract The theoretical part of this work deals with chitosan polymer and its derivates. A polymer molecule is described in more detail, its solubility and chemical modifications are described separately. In the next part biocompatibility and biodegradability of chitosan are dealt with. Parameters of the electrospinning of chitosan end this chapter. The experimental part is first dedicated to the determination of aquosity in the samples of 3 different nanofiber membranes and to their gravimetric changes by keeping in the desiccator. The samples of membranes absorb water at the most up to 1,5% (m/m) and there is not a big difference among them. The second part quantifies changes in the composition of the saturated excipients which were used for the impregnation of the samples of nanomembranes. The highest amount of caffeine was absorbed by the membrane 3, namely in case of both saturating media. The evaluation of the amount of caffeine which the tested membranes are able to release from their surface in vitro follows. In case of the saturation of membranes by the aqueous solution of caffeine and by the caffeine suspension is the maximum of the subsequent liberation into the acceptor phase reached from the 120th minute. In case of the ethanolic and chloroform saturated solution is the maximal...
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Evaluation of the importance of international trade for Finland
Beneš, Michal ; Regnerová, Olga (advisor) ; Zdeněk, Zdeněk (referee)
The diploma thesis is focused on Finnish international trade and its importance for the national economy. The thesis is divided into two parts: theoretical part and practical part.
The theoretical part is done using the method of literature research and contains relevant information about the international trade. It is focused on foreign market entry modes, delivery and payment terms, the importance of international trade in the national economy and economic sanctions using in international trade.
The practical part first describes the Finnish economy using the key economic indicators and then analyses the Finnish international trade. The analysis is mainly focused on the international trade with goods and contains chapters about development indicators, commodity and territorial structure, major export-oriented companies and government export support services. The thesis also analyses international trade between Czech Republic and Finland and the impact of Russian economic sanctions on Finnish exporters. In the final part, the results are summarized and evaluated and there are proposals to increase Finnish exports and strategies and recommendations for Czech exporters when trading with Finland.
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Financial Analysis of ZVVZ-Enven Engineerins, a.s.
Beneš, Michal ; Mikan, Pavel (advisor) ; Brabec, Martin (referee)
The main goal of this bachelor's thesis was the application of financial analysis on company ZVVZ-Enven Engineering in 2008-2012, which should reveal the overall financial health, to show its strengths and weaknesses, and to compare selected indicators of competition in the industry. Methods that have been used are described in the theoretical-methodological part and then applied to the analyzed company in the practical part. These include absolute, differential and ratio indicators, balance sheet rules or economic normals. There were also included pyramidal decomposition of return on equity, economic value added or bankruptcy and credibility models. All figures have been obtained from publicly available documents, primarily from annual reports and financial statements. The conclusion summarizes the results of the analysis on which was concluded the overall evaluation of the company.
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Communication and cooperation as core competencies of manager
BENEŠ, Michal
The main goal of this thesis was to describe and analyse communication and cooperation, as the basic manager´s skills. Choose forms to find and measurement of these competences, with evaluation and describe actual level of management and suggest alternative to growth his skills in lifelong learning.
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