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Study of Common Pathogenetic Factors of Alzheimer Disease and Type 2 Diabetes Mellitus
Vacínová, Gabriela ; Vaňková, Markéta (advisor) ; Lukášová, Petra (referee)
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are aging-associated diseases that have rising prevalence in all industrialized countries. AD is a neurodegenerative disease characterized by progressive loss of cognitive functions. It is a complex disease which formation involves both genetic factors and environmental factors. The most important marker associated with this disease is the risk allele ε4 in APOE gene. From the latest genome-wide association study emerged another ten candidate genes. As the most significant from those genes appears the minority G allele of rs744373 polymorphism in the gene BIN1. AD is connected with many metabolic and immune disorders. To the markers of interest belongs also the new parameter visfatin which can act as a pro-inflammatory cytokine. T2DM is a chronic disease characterized by raised levels of blood glucose, which is also characterized by neurological disorders. In the case of both of these diseases can be found a large number of metabolic disorders. One of the most important disorders is insulin resistance. This thesis consists of two parts - the biochemical and genetic one. The biochemical part of the thesis studies the visfatin level in patients with AD and healthly control and studies whether visfatin is related to AD. In this part of the...
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Diabetes mellitus, environmental and genetic risk factors
Procházková, Iveta ; Hubáček, Jaroslav (advisor) ; Kovacs, Peter (referee)
Diabetes mellitus (DM) is globally widespread group of diseases characterised by increased blood glucose. There are several types, the most common is type 1 DM and type 2 DM. Multifactorial polygenic inheritance is typical for DM with exeption of couple monogenic forms. Type 1 DM is autoimmune form usually manifesting since childhood. Its manifestation is influenced mostly by HLA system genotype, but also by non-HLA genes together with environmental factors, amongst which nutrition of the children is predominant. Type 2 DM develops usually in adulthood. The development is influenced by obesity and lack of movement, but the individual sensitivity to type 2 DM is also genetically determined. Main genetic factors are variations in genes TCF7L2 and FTO as well as in genes coding cyclin dependent kinases.
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Development of mortality on diabetes mellitus in developed countries, focusing on the Czech Republic
Koňařík, Martin ; Burcin, Boris (advisor) ; Hulíková Tesárková, Klára (referee)
Development of mortality on diabetes mellitus in developed countries, focusing on the Czech Republic Abstract This thesis addresses the development of diabetes mellitus mortality in selected developed countries between 1950 and 2008 and compares this development with the situation in Czechoslovakia, the Czech Republic respectively. This development is analyzed by sex, age and type of diabetes. Furthermore it also deals with diabetes morbidity and the share of diabetes mortality from the total mortality. The main approach used in this thesis is analysis of standardized mortality rates and this analysis was done both for whole long-term time series and time series within each International Classification of Diseases for individual countries. Based on the results, it was found that the development of diabetes mellitus mortality was similar across selected countries. It could be divided into several phases. Differentiation between mortality rates of males and females that occurred during reference period was so significant that mortality rates of females which were always higher had dropped below the rates of males. This effect is called in this thesis as a transition from higher female mortality to higher male mortality and it occurred in different countries at different times and also had variable-length...
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New regulatory metabolic factors in patients with obesity and type 2 diabetes mellitus
Matějková, Mirka ; Haluzík, Martin (advisor) ; Flachs, Pavel (referee)
Fibroblast growth factors are proteins with diverse biological function in development, tissue repair, and metabolism. The human FGF gene family consists of 22 members. FGF 19 subfamily includes FGF 19, FGF 21, and FGF 23. They act as systemic factors in an endocrine manner. FGF 19 subfamily requires klotho protein as a cofactor for its action. FGF 19 produced by intestine acts mainly in the liver through FGFR4, where it inhibits bile acid and fatty acid synthesis. FGF 21 is produced by the liver and contributes to the regulation of carbohydrate and lipid metabolism through modulation of glucose uptake in adipocytes. Serum FGF 21 levels are increased in patients with obesity and type 2 diabetes mellitus. Serum FGF 19 levels are on the contrary decreased in patients with obesity and type 2 diabetes mellitus and more probably depend on the nutritional status of the organism than on the glucose metabolism and insulin sensitivity. Key words: type 2 diabetes mellitus, FGF 19, FGF 21, obesity, adipose tissue
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A type 2 diabetes nutrition - recommendation and reality
MÍČKOVÁ, Veronika
The given bachelor thesis elaborates on the issue of type 2 diabetes and the approach of the patients, suitability of their education about the recommended diet and formation of potential risks as a result of this disease. Two main objectives were set for this study. The first objective consisted of a survey on education of the patients about the recommended diet and health risks if they fail its observance. The second objective analysed the survey which was conducted in order to reveal factual eating habits of these patients. The first and purely theoretical part. The second part focuses on qualitative research which was conducted by using a semi-structured interview as a data collection method. The focus group consisted of six respondents - two men and four women. The gathered facts reveal that the education and knowledge instructed by the doctor is more or less satisfactory. Four respondents out of six indicated to be satisfied with their doctor. Only one respondent was utterly unsatisfied and one assessment provided by a female respondent was considered as biased considering her old age and a long course of the illness. Her negative approach towards the doctor´s education was not taken into account either, due to the fact that the given patient must have changed several doctors during her lifetime. The results also demonstrate that the majority of respondents observe a recommended diabetes diet, eating at least five or six meals a day. According to their answers, most of them eat vegetables, lean meat and whole-grain bread and drink water, tea, or coffee. Five respondents out of six prioritise the recommended food preparation techniques, such as steaming, stir-frying and stewing. They all agree on types of food they try to avoid in majority sweets. Then the conducted survey points out situations during which the given diet is not observed. However, these situations are exceptional, so they should not be regarded as a non-observance of the diet provided that the answers given are truthful. Furthermore, the respondents observe, or try to observe, the diet recommendations, as evidenced by their regular doctor´s appointment and steady glycaemic index. Finally, the given research included two questions which were supposed to highlight the possibilities of the respondents depending on their place of residence. The first question should indicate the variation in size of the place and number of inhabitants. It was proved that the size did not have a remarkable influence on the diabetes education. The second question focused on assortment and price of diabetes food products. The bigger the agglomeration is, the cheaper and wider assortment of these products can be found. The final assessment based on interviews and results obtained was more or less positive and in comparison to other publications specifying the same recommended diet reached similar conclusions.
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The Physical activity of seniors with type II Diabetes Mellitus
TRAJKOVA, Andrea
This thesis deals with the topic of "Physical Activity of Seniors with Type 2 Diabetes Mellitus". The theoretical part characterizes terms relating to old age, its symptoms and health problems associated with it; type 2 diabetes mellitus; physical activity playing an essential role in the prevention; and non-pharmacological treatment of this disease. The practical part focuses on monitoring physical activities of seniors with type 2 diabetes mellitus. To collect the data for the research a standardized IPAQ long questionnaire was used. A selected group was monitored using Yamax Digiwalker SW 700 pedometers as regards to the number of steps they made. The obtained results were analyzed and compared with the recommendations for physical activities.
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Possibilities of observanceof recommendet sodium intake in accordance with nutrition recommendation for adults with type 2 diabetes
DRDOVÁ, Martina
Type 2 diabetes mellitus in the most common acquired metabolic disorder which can be characterised by the relative lack of insulin leading to the insufficient use of glucose in the organism. The general diagnostic disorder is the imbalance between secretion and effect of insulin in the glucose metabolism. Every year the registered number of people suffering from diabetes in the Czech Republic increases by 55,000. Nowadays, every fourth adult suffers from hypertension or high blood pressure. Hypertension with regard to the people with diabetes occurs twice as often as in case of healthy people. The biggest problem whitch is the main cause of high blood pressure is formed by unhealthy life style with the lack of physical activity leading to obesity, salty and fatty foods, excessive consumption of alcoholic drinks and smoking. The work is divided into the theoretical and practical part. The theoretical part describes the characteristics of type 2 diabetes mellitus, its treatment and education of people with diabetes. The second part deals with the issue of sodium and hypertension in connection with diabetes. The practical part is based on qualitative research. For collecting the appropriate data, the diets, interviews and observation are used. 13 patients in the age of 48 to 69 years, 6 women and 7 men, participated in the research. Two main objectives are set in this thesis. The first one determines whether the people with type 2 diabetes observe the rules of the specific diet. The second one detects received amount of sodium in food with regard to the people with type 2 diabetes mellitus and whether this amount complies with the recommended daily amount. Two research questions are thus posed: How the patients with type 2 diabetes follow the diet? What is the amount of received sodium in the food of the people with type 2 diabetes? What is the influence of received sodium on health of these people? What is the importance of education for the people with type 2 diabetes? Both objectives were accomplished and all questions were answered. The increased reception of sodium was detected in the majority of patients. On the other hand, mineral substances found in their blood were within the standarts. However, blood preasure reading measured in eight people with diabetes increased the amount of 140/90. All the patients try to follow the diabetic diet, with exceptions, such as Christmas or Sunday visits. The education of these people with regard to diabetes can be evaluated as partially successful because weight-loss was recorded in case of nine patients, however there were no radical changes in their diets.
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Effect of healthy life for people aged 60 ? 80 years diagnosed with Diabetes mellitus using yoga exercises
KRAJÍČKOVÁ, Simona
In my Bachelor thesis I investigate the influence of Yoga practice on patients suffering from, and being treated for, Diabetes Mellitus Type 2. The research deals with the impact of a 12 week Yoga intervention program. The theoretical study of the subject includes a wide range of comprehensive and relevant literature available. The research part also describes the methodology. Input and output measurements of anthropometric as well as metabolic parameters were gathered, analyzed, discussed and prepared for presentation in cooperation with specialists from the field of Diabetology. In addition the following methods and research tools were employed: ?Quality of Life? questionnaire (PETR, 2000) and the projective technique ?Method of unfinished sentences? (VALKOVA, 2000). Nine selected individuals from the local Diabetes Association participated voluntarily in the research. In the period from November 2011 to January 2012 this group experienced the 12 week Yoga intervention program. Following the programs completion results were processed according to previously presented methods. The observed data shows that the applied Yoga intervention program positively affected the value orientation of the participants as well as positively impacting metabolic parameters (Glycated hemoglobin). The general improvement in overall life quality is evident in the research. Based on these results it can recommend applied Yoga intervention programs for all people diagnosed with Type 2 Diabetes Mellitus.
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