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Detection of pathologies in ECG signals
Němec, Radek ; Mézl, Martin (referee) ; Kašpar, Jakub (advisor)
This thesis attempts with methods for detection of pathologies in ECG signals. The first part is focused on the basic theory of heart anatomy, electrocardiography and individual heart pathologies. The second part describes the preprocessing of ECG signals, detection of QRS complexes and detection of individual pathologies. In the third part the detector is being tested on CSE database and my own measured data.
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Detection of pathologies in ECG signals
Němec, Radek ; Mézl, Martin (referee) ; Kašpar, Jakub (advisor)
This thesis attempts with methods for detection of pathologies in ECG signals. The first part is focused on the basic theory of heart anatomy, electrocardiography and individual heart pathologies. The second part describes the preprocessing of ECG signals, detection of QRS complexes and detection of individual pathologies. In the third part the detector is being tested on CSE database and my own measured data.
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Correlation of Immunohistochemistry and Molecular Biologic Methods in The Diagnosis of Tumors
Michal, Michael ; Skálová, Alena (advisor) ; Rychlý, Boris (referee) ; Zambo, Iva (referee)
This thesis is a collection of commentaries on altogether 13 first-authored and 20 co- authored publications where morphology, immunohistochemistry (IHC) and molecular genetic methods were used to provide novel clues for arriving at an accurate diagnosis of tumors, as well as to propose novel approaches and refinement of classification of certain tumors. The presented manuscripts are the result of the postgraduate studies of MUDr. Michael Michal at the Charles University in Prague, Faculty of Medicine in Pilsen in the period between 2015-2018. The author focused the main part of his research, particularly his first-authored manuscripts, on soft tissue tumors but also largely participated in research activities focusing on other body systems. Over the course of his studies, four main areas of interests within the topic of soft tissue pathology emerged. The first is oriented on soft tissue tumors of presumed (but unconfirmed) fibroblastic lineage. First two publications regard two related low-grade sarcomas called Myxoinflammatory fibroblastic sarcoma (MIFS) and Pleomorphic hyalinizing angiectatic tumor (PHAT). In the first manuscript, a high-grade variant of the former is described. The latter publication is focused on the morphological and IHC similarities between both MIFS and PHAT. The third and...
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Immunopathology aspects and new treatment options for rheumatoid arthritis
Bartoňová, Michaela ; Šenolt, Ladislav (advisor) ; Drbal, Karel (referee)
Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease, which affects joints. It significantly affects the quality of life and is associated with increased mortality. Although its etiology is not fully known, it is believed that both genetic and environmental risk factors are involved in its outbreak. Knowledge of these risk factors helps us to determine the risk of RA outbreaks in vulnerable populations and provides us with knowledge about possible prevention. Pathogenesis of RA is caused by activated mesenchymal cells and cells of the innate and adaptive immune system, such as endothelial cells, synovial fibroblasts, monocytes, macrophages, dendritic cells, T and B lymphocytes. It is an incurable disease, but there are several medications, which improve disease activity or can even cause remission. Great success has been observed in biological treatment and inhibitors of Janus kinases. In some cases, the response to this relatively new therapy is not sufficient, and new drugs based on other mechanism should be developed. Examples include inhibition of granulocyte and macrophage colony stimulating factor, inhibition of interleukin 6 or interleukin 17 and bispecific antibodies. There is a growing importance of biosimilar drugs, which would make treatment, thanks to a lower price,...
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Pathological gambling
Šimůnková, Nikola ; Dočkal, Jan (advisor) ; Mašát, Vladimír (referee)
This bachelor thesis is focused on the problem of pathological gambling as a socio- pathological phenomenon. The aim of this work is to gather and sum up information about pathological gambling. First chapter of this work is devoted to the characteristics of pathological gambling as a socio-pathological phenomenon. This chapter also deals with types of socio-pathological phenomena and the causal theory. Next chapter focuses on the definition of pathological gambling, types of games and causes of pathological gambling. Third chapter describes the impact of pathological gambling to the gambler's family and the gambler itself. Gambler typology and phases of pathological gambling are also mentioned. Methods and types of prevention, as well as high-risk groups, are described in fourth chapter. Fifth chapter deals with pathological gambling treatment, including brief description of each treatment method. To supplement the gathered information, interviews with former pathological gambler and dr. Karel Nešpor, addiction treatment specialist, are included in this work. Keywords player, gambling,pathologicalgambling, prevention, treatment, gamble,hazard, pathology
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Spirituality and Mental Disorder: The Role of Spirituality in the Lives of People with Experience of Psychosis
Motl, Jiří ; Říčan, Pavel (advisor) ; Smékal, Vladimír (referee) ; Janošová, Pavlína (referee)
D I S E R T A Č N Í P R Á C E Autor: Mgr. Jiří Motl Spiritualita a duševní nemoc Role spirituality v životě lidí se zkušeností s psychotickým onemocněním Spirituality and Mental Disorder: The Role of Spirituality in the Lives of People with Experience of Psychosis Abstract The dissertation investigates the relationship of mental illness and religion. It focuses on the role of spirituality in people with experience of psychosis. In the theoretical part, the problem of drawing the line between pathological and normal spirituality is discussed, stressing the importance of a functional point of view and the need for a dialogic relationship with the ill person. The theoretical part goes on with mapping the potential of spirituality in the recovery process. Spirituality often helps the afflicted to perceive their illness as a meaningful process, making it easier to cope with the illness. At the end of the theoretical part, four alternative or complementary conceptual frameworks are presented. The empirical part consists of a qualitative research of nine subjects (believers with the experience of psychosis). The data collection and analysis is based mainly in the IPA method (interpretative phenomenological analysis). The research aims to map how mental illness affected the subjects' spirituality and vice versa....
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Copper and its pato/physiological importance in human organism
Bechná, Klára ; Mladěnka, Přemysl (advisor) ; Hrdina, Radomír (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Klára Bechná Supervisor: Přemysl Mladěnka, PharmD., Ph.D. Title of diploma thesis: Copper and its pato/physiological importance in human organism Copper is an indispensable trace element of our organism. This thesis summarizes the current knowledge about copper, its role in the human body and diseases connected with copper dysbalance. The first part of the thesis deals with the physiological aspects. Functions of copper in the body are described here in detail, in particular the structure and properties of copper- containing enzymes - so-called cuproenzymes. The next section summarizes the current knowledge of the kinetics of copper in the body at the cellular and whole-body levels, including interactions with other trace elements. Details are also presented for each of the factors involved in the homeostasis of copper in the human organism. The second part of the thesis deals with patophysiology of copper. It is focused on the most important diseases that are directly linked to disorders of copper homeostasis in the organism. The greatest emphasis is given mainly on two of them - Wilson's disease and Menkes disease. The former is associated with an excess of copper in the body while...
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Morphology of Fascioloides magna life stages and histopathological changes in selected species of definitive hosts
Košťáková, Monika ; Kašný, Martin (advisor) ; Hodová, Iveta (referee)
Fascioloides magna is a trematode originating in North America. It is a significant pathogen, especially in cervids, but it can also infect ruminants kept for agricultural purposes.Adult trematodes are found in the liver tissue of their definitive hosts, where they can survive for a long period of time and produce large quantity of eggs. Those are passed through bile ducts and intestine with feces into the external environment. This thesis is focused on the morphology of individual developmental stages of F. magna. To this date only very limited number of literary resources concerning the topic had been published. Recorded results are compared with literary resources on Fasciola hepatica, a closely related trematode. The morphological characteristics of the individual developmental stages were studied by using histological, electron-miscroscopical and other methods (fluorescent labelling). The thesis also describes pathological changes of the definitive hosts' liver tissue. By means of the stated methods, the thesis expands the existing knowledge on the morphology of F. magna especially of surface structures and the distribution of the senzoric organs, some of which have been described for the very first time. Powered by TCPDF (www.tcpdf.org)
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