National Repository of Grey Literature 5 records found  Search took 0.02 seconds. 
Clinicopathological, Morphological, Immunohistochemical, and Molecular Biological Features of Tumors of Genitourinary Tract
Rogala, Joanna Dominika ; Pivovarčíková, Kristýna (advisor) ; Pitra, Tomáš (referee) ; Rychlý, Boris (referee)
The thesis "Clinicopathological, morphological, immunohistochemical and molecular biological features of tumours of genitourinary tract" includes seven commented articles from the area of genitourinary (GU) tract neoplasms. Due to the wide spectrum of tumours of the GU tract, the presented dissertation is limited only to morphologic, immunohistochemical and molecular aspects of renal tumours - in the field of pathology, we have observed fundamental changes in recent years and where molecular techniques have begun to play an integral role in pathological examination. The introduction comments current 5th edition of WHO classification of kidney tumours, it emphasizes changes and new entities defined by distinctive morphology and molecular signature as well as comments on new insights in well-established entities. In the results, there are presented recently published original publications describing variant morphologies of common tumours with their immunohistochemical and molecular profile, as well as newly describe entity with its immunohistochemical and molecular characteristics. In the conclusion, dynamics of changes in renal tumours classification is discussed together with the importance of molecular testing, its therapeutic implications and limitations.
Correlation of Immunohistochemistry and Molecular Biologic Methods in The Diagnosis of Tumors
Michal, Michael ; Skálová, Alena (advisor) ; Rychlý, Boris (referee) ; Zambo, Iva (referee)
This thesis is a collection of commentaries on altogether 13 first-authored and 20 co- authored publications where morphology, immunohistochemistry (IHC) and molecular genetic methods were used to provide novel clues for arriving at an accurate diagnosis of tumors, as well as to propose novel approaches and refinement of classification of certain tumors. The presented manuscripts are the result of the postgraduate studies of MUDr. Michael Michal at the Charles University in Prague, Faculty of Medicine in Pilsen in the period between 2015-2018. The author focused the main part of his research, particularly his first-authored manuscripts, on soft tissue tumors but also largely participated in research activities focusing on other body systems. Over the course of his studies, four main areas of interests within the topic of soft tissue pathology emerged. The first is oriented on soft tissue tumors of presumed (but unconfirmed) fibroblastic lineage. First two publications regard two related low-grade sarcomas called Myxoinflammatory fibroblastic sarcoma (MIFS) and Pleomorphic hyalinizing angiectatic tumor (PHAT). In the first manuscript, a high-grade variant of the former is described. The latter publication is focused on the morphological and IHC similarities between both MIFS and PHAT. The third and...
HPV Asociované karcinómy hlavy a krku: morfologická, klinická a molekulovo biologická korelácia
Švajdler, Marián ; Skálová, Alena (advisor) ; Vošmik, Milan (referee) ; Rychlý, Boris (referee)
This doctor thesis comprises two studies. (i) A retrospective study was performed on 22 patients who presented with cystic head and neck squamous cell carcinoma (SCC) metastases. The purpose of the study was to find out whether histomorphology, p16 protein expression, HPV and EBVstatus could be useful in predicting the localization of the primary tumor. The primary site was identified in 20 of 22 patients and included the oropharynx in 14 patients (63.6%), the nasopharynx in 3 patients (13.6%), the lungs in 2 cases (9%), and the skin of the auricle in one case (4.5%). No primary was found in two patients (9%). Sixteen of 17 cases (94.1%) originating in Waldayer's ring, and both cases with an unknown primary showed morphology of non-keratinizing SCC or non-keratinizing SCC with maturation. All tumors with oropharyngeal primary and both cases with unknown primary showed diffuse p16 staining and presence of HPV DNA. All three cystic metastases of nasopharyngeal carcinoma (NPCa) were EBV-positive and p16/HPV negative. In contrast, cutaneous and pulmonary metastases showed morphology of a well differentiated keratinizing SCC and poorly differentiated keratinizing SCC, respectively, and were HPV/EBV-negative. We confirmed that cystic SCC lymph node metastases of the head and neck region are strongly...
Correlation of Immunohistochemistry and Molecular Biologic Methods in The Diagnosis of Tumors
Michal, Michael ; Skálová, Alena (advisor) ; Rychlý, Boris (referee) ; Zambo, Iva (referee)
This thesis is a collection of commentaries on altogether 13 first-authored and 20 co- authored publications where morphology, immunohistochemistry (IHC) and molecular genetic methods were used to provide novel clues for arriving at an accurate diagnosis of tumors, as well as to propose novel approaches and refinement of classification of certain tumors. The presented manuscripts are the result of the postgraduate studies of MUDr. Michael Michal at the Charles University in Prague, Faculty of Medicine in Pilsen in the period between 2015-2018. The author focused the main part of his research, particularly his first-authored manuscripts, on soft tissue tumors but also largely participated in research activities focusing on other body systems. Over the course of his studies, four main areas of interests within the topic of soft tissue pathology emerged. The first is oriented on soft tissue tumors of presumed (but unconfirmed) fibroblastic lineage. First two publications regard two related low-grade sarcomas called Myxoinflammatory fibroblastic sarcoma (MIFS) and Pleomorphic hyalinizing angiectatic tumor (PHAT). In the first manuscript, a high-grade variant of the former is described. The latter publication is focused on the morphological and IHC similarities between both MIFS and PHAT. The third and...
HPV Asociované karcinómy hlavy a krku: morfologická, klinická a molekulovo biologická korelácia
Švajdler, Marián ; Skálová, Alena (advisor) ; Vošmik, Milan (referee) ; Rychlý, Boris (referee)
This doctor thesis comprises two studies. (i) A retrospective study was performed on 22 patients who presented with cystic head and neck squamous cell carcinoma (SCC) metastases. The purpose of the study was to find out whether histomorphology, p16 protein expression, HPV and EBVstatus could be useful in predicting the localization of the primary tumor. The primary site was identified in 20 of 22 patients and included the oropharynx in 14 patients (63.6%), the nasopharynx in 3 patients (13.6%), the lungs in 2 cases (9%), and the skin of the auricle in one case (4.5%). No primary was found in two patients (9%). Sixteen of 17 cases (94.1%) originating in Waldayer's ring, and both cases with an unknown primary showed morphology of non-keratinizing SCC or non-keratinizing SCC with maturation. All tumors with oropharyngeal primary and both cases with unknown primary showed diffuse p16 staining and presence of HPV DNA. All three cystic metastases of nasopharyngeal carcinoma (NPCa) were EBV-positive and p16/HPV negative. In contrast, cutaneous and pulmonary metastases showed morphology of a well differentiated keratinizing SCC and poorly differentiated keratinizing SCC, respectively, and were HPV/EBV-negative. We confirmed that cystic SCC lymph node metastases of the head and neck region are strongly...

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