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Mitochondrial dysfunction and neurodegenerative diseases
Novotná, Veronika ; Herink, Josef (advisor) ; Kovařík, Miroslav (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Author: Bc. Veronika Novotná Supervisor: doc. MUDr. Josef Herink, DrSc. Title of diploma thesis: Mitochondrial dysfunction and neurodegenerative diseases The diploma thesis deals with mitochondrial dysfunction and neurodegenerative diseases and it is divided into two main parts. The first part summarized the classification of neurodegenerative diseases and general charakteristic of mitochondria.Then a describe of the processes of oxidative stress, excitotoxicity, apoptosis and briefly decribe the nervous system. The second part deals with description of mitochondrial dysfunction in selected nerodegenerative diseases. The recent studies refer to connection between mitochondrial dysfunctions and formation of neurodegenerative diseases. Keywords: excitotoxicity, mitochondrial dysfunction, neurodegenerative disorders, neuronal cell death, oxidative damage
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English gerund and its Czech translation equivalents
Benešová, Adéla ; Brůhová, Gabriela (advisor) ; Quinn Novotná, Veronika (referee)
The purpose of the present work was to analyse the English gerund and its Czech translation equivalents. The gerund and its translation equivalents were gathered from two parallel literary texts: Kazuo Ishiguro's An Artist of the Floating World, translated by Jiří Hanuš, and Joanne K. Rowling's Harry Potter and the Philosopher's Stone, translated by Vladimír Medek. For the research we used ParaConc, concordance software for multilingual parallel corpora. The resulting excerpts were then analysed from the linguistic point of view in order to provide a contrastive description of the English gerund and its Czech equivalent expressions; as a background texts were used comprehensive English and Czech grammar books. The study aimed to illuminate two related areas; namely the types of Czech translation equivalents of gerunds and the correspondence of the types of Czech translation equivalents with various syntactic functions of the gerunds. The analysis provided details about the regularities that occur in the translations of the various syntactic functions of the gerund. It was also proved that the translation of the English gerund into Czech is closely associated with the interpretation of the analytic language into the syntactic language; the confrontation of the language types may be used as background to...
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Exploration of assumptions of the job success for people leaving the children's home.
Novotná, Veronika ; Lorenzová, Jitka (advisor) ; Gulová, Lenka (referee) ; Sekera, Julius (referee)
The topic of the dissertation is the research of the assumptions for employment of people who spent part or all of their childhood and adolescence in children's homes. The thesis is divided into theoretical and empirical parts. The theoretical part is devoted to the analysis of competences that are currently important prerequisites for employment in the labour market, integration of young people from institutional education into professional life, the problems of institutional education and the developmental period of adolescence, in which young people from institutions usually enter the labour market. The methods used in this section include theoretical analysis and interpretation of key concepts and findings presented in the literature, implemented research and other sources in order to provide a basis for the focus and design of the research and relevant data for the discussion of its results. In the empirical part, a mixed- methods research design is presented. The main aim is to find out whether subjective ratings of selected general skills and soft competences important for employment differ between young people from children's homes and young people growing up in families. The investigation is based on a methodological triangulation of qualitative and quantitative research techniques and is...
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Support for a beginning teacher in kindergarten
Šmolíková, Hana ; Valášková Vincejová, Eva (advisor) ; Novotná, Veronika (referee)
The subject of this bachelor thesis is the support of beginning teachers in kindergartens. The aim of this paper is to find out what kind of support is offered to novice kindergarten teachers and whether this support is sufficient. The theoretical part contains basic concepts which are used in this paper. Further presented are different kinds of support that beginning kindergarten teachers can make use of. The research part of this thesis describes the process of a survey, which was carried out through eight narrative interviews. Before the interviews took place, respondents filled out an online questionnaire which served as preliminary research. The results of this survey show that novice teachers find the most support in their mentors and in observing lessons given by experienced colleagues. That is why it is necessary to train mentors as well as possible to provide the best support possible. Powered by TCPDF (www.tcpdf.org)
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The role of low-threshold facilities for children and youth in a multidisciplinary solution of socialization problems
Benešová, Johana ; Koťa, Jaroslav (advisor) ; Novotná, Veronika (referee)
This bachelor thesis deals with the role of low-threshold facility for children and youth in a multidisciplinary solution to the difficulties of socialization. The goal is to try to present how a low-threshold facility for children and young people can contribute to solving the socialization difficulties of children and adolescents. In the theoretical part thesis presents the socialization difficulties of children and adolescents from the point of view of the clientele of a low-threshold facility for children and youth based on vocational literature. It proposes possibilities of methodical work supplemented by multidisciplinary cooperation inspired by three-level support of positive behaviour. The research part of the thesis examines the use of methodological work through the case studies of three clients of a low-threshold facility for children and youth, in which socialization difficulties manifest themselves. The research part is based on the hypothesis that client saturates unmet primary needs with his behaviour. From this point of view, part of the thesis tries to define - through the story of client - the hypothesis about the purpose of problem behaviour due to unmet primary needs and to design their saturation in more constructive way. The thesis tries to verify the effectiveness of the...
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Mathematical Methods in Economics
Koudelová, Tereza ; Šustrová, Tereza (referee) ; Novotná, Veronika (advisor)
The bachelor thesis is focused on the analysis of POEX Velké meziříčí a.s company’s basic situation and financial statements. The first part explains financial indicators and statistical methods. The second part is based on the theoretical knowledge, where the calculations of selected economic indicators are performed and the trend of development of these indicators is determined using the application of time series and regression analysis. Lastly, the thesis summarises the financial situation of the POEX company and make suggestions to improve the company’s future behaviour.
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Mathematical Methods in Economics
Hrkeĺ, Jan ; Šustrová, Tereza (referee) ; Novotná, Veronika (advisor)
In my bachelor thesis, I deal with the topic of mathematical methods in economics. I focus on investing the company's free capital in cryptocurrencies, which is illustrated with the help of selected strategies. In the first part of the work, I explain the technical and fundamental requirements of cryptocurrencies, its most important representatives and technical analysis based on mathematical and statistical methods. In the practical part, I analyze four selected cryptocurrencies on two different investment strategies, which are then evaluated.
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Mathematical Methods in Economics
Fajfr, Lukáš ; Šustrová, Tereza (referee) ; Novotná, Veronika (advisor)
The bachelor thesis is focused on analysis of selected economic indicators of company D&D Elektromont using statistical methods. The thesis is divided into three separate parts. The first part is aimed at the introduction of the theoretical foundations needed to complete the analysis. The second part presents the company and analyzes its selected economic indicators. The third part summarizes the findings and proposes specific solution to improve company’s situation.
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Mathematical Methods in Economics
Bednar, Stepan ; Šustrová, Tereza (referee) ; Novotná, Veronika (advisor)
This bachelor thesis deals with the financial analysis of the company Porr, a.s. by using statistical methods. The thesis is consists of two main parts. The first part is theoretical and focuses on financial analysis, describes regression analysis and time series. The second part includes the financial analysis and the prediction of further development for the company by using statistical method. Recommendations for improving the financial situation in the future are suggested as the conclusion of these parts.
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Use of mathematical methods in creating an investment portfolio
Holub, Miroslav ; Novotná, Veronika (referee) ; Janková, Zuzana (advisor)
The bachelor thesis is focused on the use of mathematical methods in creating an investment portfolio, which is designed for small investor. The theoretical part of the thesis describes the necessary knowledge to understand Markowitz model, selected indicators of financial analysis and the Value at Risk method. The practical part contains a selection of investment instruments traded on the US market according to established criteria, the creation of a real portfolio of these investment instruments and the final evaluation of results.
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