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Using business process modeling tools for development of formalized medical guidelines
Mišúr, Juraj ; Nagy, Miroslav (advisor) ; Richta, Karel (referee)
This thesis is analyzing the usage of business process modeling (BPM) tools in the eld of medical guidelines. Business Process Management Notation is used for business process modeling and a sample medical guideline from the eld of cardiology is modeled with it. This guideline is then converted to Business Process Execution Language and executed in runtime environment to simulate the guideline behavior. Learned facts are then used to compare BPMN and BPEL with the existing modeling language for medical guidelines - GLIF. The practical result of this thesis is a prototype application evaluating medical guidelines modeled using BPMN and executed using BPEL. The guideline also communicates with electronic health record for gathering patient's data.
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Optimization of warehouse locations by evolutionary algorithms
Nagy, Marek ; Neruda, Roman (advisor) ; Kratochvíl, Miroslav (referee)
In this thesis, we propose an algorithm to solve the warehouse location-routing prob- lem. The task represents a difficult combinatorial optimization problem that is of great practical importance in logistic applications. It is a combination of multiple well-known problems that cannot be solved separately and therefore we approach this as a new prob- lem completely. We introduce Evolutionary Algorithms and their basic concepts as well as define our specific problem more specifically and we use a branch of Evolutionary Algorithms to optimize the placement of warehouses on a given map. Since our main goal is to optimize delivery time, we also run experiments in order to determine how the algorithm performs compared to Evolutionary Algorithm optimizing distance. We also do not take into consideration cost of warehouse itself nor cost of storing and cost of the trucks since goal of this thesis is to optimize delivery time. 1
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Alkaloids of genus Hippeastrum (Amaryllidaceae): isolation, identification, biological activity
Al Shammari, Latifah Ajaj M ; Cahlíková, Lucie (advisor) ; Nagy, Milan (referee) ; Šmejkal, Karel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Botany Candidate: MSc. Latifah Al Shammari Supervisor: Prof. Ing. Lucie Cahlíková, Ph.D. Title of Doctoral Thesis: Alkaloids of the genus Hippeastrum (Amaryllidaceae): isolation, identification, biological activity. Hippeastrum x hybridum cv. Ferrari was chosen based on results of previous screening studies for detailed phytochemical study for the purpose of isolation of the widest range of AAs. From 25 kg of fresh bulbs was obtained 29,46 g of purified alkaloidal extract, which was processed using column chromatography. Finally, 18 pure alkaloids were isolated including one new homolycorine-type alkaloid (9-O-demethyllycorenine). All compounds were identified by spectrometric techniques (GC-MS, ESI-MS, NMR, optical rotation) and by comparison with literature data. All alkaloids, isolated in sufficient amount, were tested for their biological activities associated with Alzheimer's disease (inhibition of hAChE, hBuChE, and POP), and cytotoxic activity. The inhibitory activity against human cholinesterases was determined in vitro by a modified Ellmanʼs spectrophotometric method. In the hAChE/hBuChE assay, except for 1,2- O,O'-diacetyl-dihydrolycorine which demonstrated a mild hBuChE inhibition potency...
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Clinical Content Harmonisation of Electronic Health Record
Nagy, Miroslav ; Říha, Antonín (advisor) ; Dostálová, Taťjana (referee) ; Veselý, Arnošt (referee)
Title: Clinical Content Harmonisation of Electronic Health Record Author: Mgr. Miroslav Nagy Department: Department of Medical Informatics, Institute of Computer Science v.v.i., Academy of Sciences of the Czech Republic Supervisor: RNDr. Antonín Říha, CSc. Supervisor's e-mail: riha@euromise.cz This PhD thesis deals with the possibilities of clinical content harmonisation in elec- tronic health records (EHR). In the first sections, the current state of the art in the field of EHR and other related fields is summarised, as well as that of the tools supported by current software technologies and the results of research in the field of medical in- formatics. The work is focused on analysis of obstacles in sharing medical data and on proposals of steps for overcoming these obstacles. Next, the utilized tools, modelling approaches, standards and coding systems used during the research are summed up. In the following sections the methods pointing to achieving harmonized clinical models are elaborated on and resulting clinical concepts mappings, supporting tools, developed EHR systems and semantic interoperability platforms are presented. In the conclusion these results are discussed and some future work is proposed. Keywords: electronic health record, semantic interoperability, clinical content, har-...
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Alkaloids of the Amaryllidaceae family as potential drugs in therapy of diseases of affluence
Breiterová, Kateřina ; Cahlíková, Lucie (advisor) ; Nagy, Milan (referee) ; Lapčík, Oldřich (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Botany Candidate: Mgr. Kateřina Breiterová Supervisor: Assoc. prof. Ing. Lucie Cahlíková PhD. Title of Doctoral Thesis: Alkaloids of the Amaryllidaceae family as potential drugs in therapy of diseases of affluence Key words: alkaloids, Amaryllidaceae, analogues, AChE, BuChE, POP, GSK-3β, cell cycle progression, apoptosis Narcissus cv. Professor Einstein was chosen based on results of previous screening studies for detailed phytochemical work for the purpose of isolation of the widest range of AmA. From 34,3 kg of fresh bulbs was obtained 31,7 g of purified alkaloidal extract, which was processed using column chromatography with stepwise elution by light petrol, chloroform and ethanol in different ratios to almost 500 fractions. These fractions were fused into 27 subfractions, which were processed by preparative TLC, vacuum column chromatography and crystallization. Finally, 25 pure alkaloids were isolated. All compounds were identified by GC-MS, ESI-MS, NMR, optical rotation and literature. One compound was identified as a new unpublished alkaloid of lycorine structure type. All alkaloids isolated in sufficient amount were tested for their biological activities associated with Alzheimer's disease (inhibition of...
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The Investment Evaluation of the Machinery Company
Nagy, Martin ; Zinecker, Marek (referee) ; Luňáček, Jiří (advisor)
This thesis is focused on the investment evaluation of a machinery company. The theoretical part describes the technology of drilling, investment project, investment decision making, financing of the investment, its efficiency evaluation by dynamic methods. The practical part introduces the investment project and summarizes theoretical solutions. Moreover, the author carried out the company’s balance sheet and the prognosis of its sales by performing multiple factors linear regression analysis using software Gretl, determined the type of the investment financing and selected the investment project based on the point criteria and the theoretical solutions. Furthermore, the efficiency of the chosen project was evaluated by the dynamic methods described in the theoretical part. Finally, the author created a Net Present Value sensitivity analysis and compared results of the static and dynamic methods. These results become fundamentals for recommendation of the investment project realization.
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Alkaloids of the Amaryllidaceae family as potential drugs in therapy of diseases of affluence
Breiterová, Kateřina ; Cahlíková, Lucie (advisor) ; Lapčík, Oldřich (referee) ; Nagy, Milan (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Botany Candidate: Mgr. Kateřina Breiterová Supervisor: Assoc. prof. Ing. Lucie Cahlíková PhD. Title of Doctoral Thesis: Alkaloids of the Amaryllidaceae family as potential drugs in therapy of diseases of affluence Key words: alkaloids, Amaryllidaceae, analogues, AChE, BuChE, POP, GSK-3β, cell cycle progression, apoptosis Narcissus cv. Professor Einstein was chosen based on results of previous screening studies for detailed phytochemical work for the purpose of isolation of the widest range of AmA. From 34,3 kg of fresh bulbs was obtained 31,7 g of purified alkaloidal extract, which was processed using column chromatography with stepwise elution by light petrol, chloroform and ethanol in different ratios to almost 500 fractions. These fractions were fused into 27 subfractions, which were processed by preparative TLC, vacuum column chromatography and crystallization. Finally, 25 pure alkaloids were isolated. All compounds were identified by GC-MS, ESI-MS, NMR, optical rotation and literature. One compound was identified as a new unpublished alkaloid of lycorine structure type. All alkaloids isolated in sufficient amount were tested for their biological activities associated with Alzheimer's disease (inhibition of...
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Phytochemical study of individual plant species of Bergenia genus
Hendrychová, Helena ; Tůmová, Lenka (advisor) ; Nagy, Milan (referee) ; Šmejkal, Karel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmacognosy Candidate: Mgr. Helena Hendrychová Supervisor: doc. PharmDr. Lenka Tůmová, CSc. Title of Doctoral Thesis: Phytochemical study of individual plant species of Bergenia genus Bergenia, native to central Asia, is promising source of medicinal compounds mainly in the system of Chinese and Indian traditional medicine. These species have been used for centuries in therapy of various diseases. They are valued for their ability to dissolve kidney or bladder stones. Bergenia plants are used for therapy of pulmonary diseases and cold. They have demonstrated antioxidant, antibacterial, antiviral, immunostimulant, anti-inflammatory, anticancer, antidiabetic, antitussive, hepatoprotective and diuretic effects. The main aim of this thesis was to determine the content of secondary metabolites (arbutin, total polyphenols, bergenin and anthocyanins) in three taxons of Bergenia genus - Bergenia crassifolia (L.) Fritsch, Bergenia ciliata (Haw.) Sternb. a Bergenia x ornata Stein., to compare their biological activities and to identify the most appropriate kind of Bergenia plants with the greatest potential for use in therapy. Plant hybrid B. x ornata was evaluated on the content of phenolic compounds and biological activity...
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The influence of grammatical profiles of Czech nouns on their acquisition by non-native speakers
Vokáčová, Martina ; Lehečková, Eva (advisor) ; Nagy, Marek (referee)
The present thesis examines the influence of Czech nouns frequency features on their acquisition by non-native speakers. The first theoretical part summarizes the ongoing discussion regarding the importance of frequency for the entrenchment of grammatical categories in one's mind as outlined by cognitive and psycho-linguists abroad. The second introduces the research methodology, collection method and annotation of 20 lemmas obtained from non-native Czech speaker corpus CzeSL-SGT. Subsequently, an analysis of selected nouns is carried out with regard to their grammatical profiles (comprising two or three most frequent case forms as found in SYN2015). Based on its results, the production of non-native speakers shows a tendency to follow grammatical profiles as demonstrated by high correspondence of frequency features of nouns on the one hand and by low error rate in morphology of most frequent forms on the other. Additionally, cases where lower rate does not correspond to the above mentioned model can be explained using type frequency, i.e. the productivity of particular declension models having simultaneously more far-reaching effect, and higher relevance of nominative as the default form for non-native speakers.
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